Article
Chemistry, Analytical
Meenakshi Pundir, Liubov Lobanova, Silvana Papagerakis, Xiongbiao Chen, Petros Papagerakis
Summary: This study presents the development of a novel colorimetric assay for the rapid and sensitive detection of salivary melatonin. The assay showed high sensitivity and selectivity, and could be used in a point-of-care system to accurately diagnose and monitor circadian rhythm sleep disorders.
ANALYTICA CHIMICA ACTA
(2023)
Article
Psychiatry
Francy Cruz-Sanabria, Ugo Faraguna, Miriam Violi, Simone Bruno, Davide Gravina, Chiara Bonelli, Andrea Bazzani, Leonardo Massoni, Laura Musetti, Marly Simoncini, Paolo Frumento, Liliana Dell 'Osso, Claudia Carmassi
Summary: The present study evaluates the effect of exogenous melatonin on sleep and circadian parameters in patients with bipolar disorder and delayed sleep-wake phase disorder. Results indicate that personalized treatment with exogenous melatonin can modify self-reported chronotype, sleep onset time, and sleep efficiency and duration in patients with comorbid bipolar disorder and delayed sleep-wake phase disorder, suggesting potential efficacy in improving sleep patterns in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Xue-Lei Yin, Jing-Cao Li, Rui Xue, Shuo Li, Yang Zhang, Hua-Jin Dong, Ying Li, Heng-Lin Wang, You-Zhi Zhang
Summary: Postoperative sleep disorders are common in patients after surgery, with general anesthesia-induced circadian rhythm disturbances playing a significant role. Prolonged propofol anesthesia affects sleep, body temperature, activity, and endogenous melatonin secretion, leading to reduced oscillation amplitude. Melatonin pretreatment shows potential therapeutic effects in restoring circadian rhythm and preventing over-synthesis of melatonin after propofol anesthesia.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Yu Jiang, Nan Gen, Peisong Wang, Ninghang Feng, Xiaojie Lu
Summary: This study investigated the effects of prednisolone (PN) on sleep in zebrafish. The results showed that PN decreased melatonin secretion, shortened sleep time, and disrupted the internal circadian rhythm. The mechanism behind these effects involves the repression of certain genes via the glucocorticoid receptor, leading to a decrease in melatonin secretion and subsequent sleep disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Andrew D. Krystal, Aurelia Mittoux, Annika Lindsten, Ross A. Baker
Summary: The study indicates that adjunctive brexpiprazole may help correct circadian dysfunction in patients with MDD. The phase angle between peak cortisol and DLMO could be a potential biomarker for depression and therapeutic response.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Elena Martinez-Cayuelas, Teresa Gavela-Perez, Maria Rodrigo-Moreno, Milagros Merino-Andreu, Claudia Vales-Villamarin, Iris Perez-Nadador, Carmen Garces, Leandro Soriano-Guillen
Summary: This study found that individuals with autism have different melatonin secretion patterns compared to neurotypical individuals, and these patterns are related to sleep and circadian parameters. These findings are important for understanding sleep problems in autism spectrum disorder.
FRONTIERS IN NEUROLOGY
(2022)
Article
Genetics & Heredity
Christos M. Polymeropoulos, Justin Brooks, Emily L. Czeisler, Michaela A. Fisher, Mary M. Gibson, Kailey Kite, Sandra P. Smieszek, Changfu Xiao, Sarah H. Elsea, Gunther Birznieks, Mihael H. Polymeropoulos
Summary: The study confirmed that tasimelteon significantly improved sleep quality and total sleep time in patients with Smith-Magenis syndrome.
GENETICS IN MEDICINE
(2021)
Article
Behavioral Sciences
Shu-Mei Hao, Zhi-Gang Zhong, Wei-Min Qu, Zhi-Li Huang, Feng-Yan Sun, Mei-Hong Qiu
Summary: The study found that daily intraperitoneal administration of melatonin during the subacute phase after stroke significantly reduces brain tissue damage, improves motor function deficits, and promotes sleep quality by modulating sleep patterns. Melatonin treatment not only helps with neuronal survival and motor recovery, but also alleviates post-stroke sleep disturbances.
BRAIN AND BEHAVIOR
(2021)
Review
Cell Biology
Md Farhad Hossain, Ni Wang, Ruijun Chen, Siwen Li, Jaydeep Roy, Md Giash Uddin, Zhong Li, Lee Wei Lim, You-Qiang Song
Summary: Melatonin plays crucial roles in Alzheimer's disease by promoting autophagy, improving sleep quality, and counteracting oxidative stress. The therapeutic potential of melatonin in AD may involve its multifunctional properties.
AGEING RESEARCH REVIEWS
(2021)
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Neurosciences
Srishti Banerjee, Sandipan Ray
Summary: Aging leads to deterioration of daily rhythms and disruption in sleep-wake cycles. Mutations in core clock genes contribute to premature aging and sleep irregularities. Targeting the molecular clock or dosing time-oriented medications may provide novel therapeutic strategies for aging attenuation and sleep disorders.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: This study examined the relationships between impulsivity, sleep and circadian rhythm disturbance, and symptoms in individuals at high-risk for or with recent-onset bipolar spectrum disorders. The findings revealed that less total sleep time predicted increased next-day mood symptoms, and the relationship between impulsivity and mood symptoms was moderated by sleep time and circadian rhythm alterations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: Impulsivity, sleep disturbance, and circadian rhythm alterations are closely associated with bipolar spectrum disorders. Less total sleep time predicts increased mood symptoms, and individuals with less sleep and later circadian rhythms are more likely to exhibit a positive relationship between impulsivity and mood symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Balthazar Bazin, Pierre A. A. Geoffroy, Helene Benzaquen, Julia Maruani, Alix Romier, Michel Lejoyeux, Marie-Pia D'ortho, Justine Frija-Masson
Summary: This case report describes a 46-year-old man with autism spectrum disorder (ASD) and agoraphobia who was referred for suspected obstructive sleep apnea syndrome (OSAS). Polysomnography confirmed moderate OSAS associated with hypoventilation, and treatment with continuous positive airway pressure (CPAP) showed excellent results. However, follow-up revealed an irregular sleep-wake rhythm, which was effectively treated with melatonin and light therapy. This case highlights the importance of addressing sleep and circadian rhythm sleep-wake disorders (CRSWD) in individuals with psychiatric disorders, and suggests that CPAP data could be an objective alternative to sleep diary.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Jonathan S. Emens, Melissa A. St Hilaire, Elizabeth B. Klerman, Daniel J. Brotman, Amber L. Lin, Alfred J. Lewy, Charles A. Czeisler
Summary: This study found no evidence of circadian dysfunction in sighted individuals with non-24-hour sleep-wake rhythm disorder. Instead, sleep-wake timing appeared to dissociate from the circadian timing system, and the disorder may be light- and/or behaviorally induced.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)