Article
Multidisciplinary Sciences
Dena Esfandyari, Bio Maria Gheo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grueter, Melanie Annemarie Meier, Anna Christina Naeger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Summary: MicroRNA-365 regulates human cardiac action potential by modulating key cardiac repolarizing channels.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Rebekah P. Nash, Lily Wang, Bradley N. Gaynes, Jennifer E. Flythe
Summary: This study investigated the use of oral atypical antipsychotics and compared the cardiac safety between those with FDA warnings for QT prolongation and those without among outpatients receiving hemodialysis. The results showed that quetiapine, which carried an FDA warning for QT prolongation, did not increase the cardiac risk compared to atypical antipsychotics without warnings among hemodialysis outpatients.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Gianfranco Piccirillo, Federica Moscucci, Andrea Corrao, Myriam Carnovale, Ilaria Di Diego, Ilaria Lospinuso, Cristina Caltabiano, Martina Mezzadri, Pietro Rossi, Damiano Magri
Summary: This study used bio-impedance and ECG data to compare HFrEF and HFpEF patients, and analyzed responders and non-responders to optimal medical therapy. The study found that these non-invasive parameters were able to highlight the differences between different types of heart failure patients and their response to medication.
Article
Medicine, General & Internal
Musa Ilker Durak, Beyza Algul Durak
Summary: This study compared the electrocardiographic results of renal transplant patients with normal healthy individuals and found no significant difference in QT dispersion and QTc dispersion between the two groups. The results suggest that renal transplantation can reverse the increased QT dispersion and pathophysiological mechanisms commonly observed in uremic patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Elena E. E. Vaiman, Natalia A. A. Shnayder, Nikita M. M. Zhuravlev, Marina M. M. Petrova, Azat R. R. Asadullin, Mustafa Al-Zamil, Natalia P. P. Garganeeva, German A. A. Shipulin, Paul Cumming, Regina F. F. Nasyrova
Summary: Antipsychotic-induced prolongation of the QT interval is a risk factor for sudden death syndrome in patients with schizophrenia, influenced by a variety of factors including drug dosage and genetic predisposition. Genetic studies have provided insights into personalized risk assessment strategies for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tadashi Nakajima, Shuntaro Tamura, Masahiko Kurabayashi, Yoshiaki Kaneko
Summary: Most causal genes for inherited arrhythmia syndromes encode cardiac ion channel-related proteins. Genotype-phenotype studies and functional analyses have revealed the pathophysiology of IASs. Utilization of iPSC technology provides insights into the pathophysiology of IASs and novel therapeutic strategies, especially in long QT syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mengya Yuan, Heqiang Lian, Pan Li
Summary: Sudden cardiac death (SCD) is a major cause of death worldwide, often caused by acute ventricular arrhythmias (VAs) triggered by early afterdepolarizations (EADs). This study developed a tissue model to investigate the spatial-temporal dynamics of EADs in T-wave abnormalities. The results suggest possible mechanistic links between the complex spatial dynamics of EADs and T-wave morphologies.
Article
Physiology
Zi-liang Song, Yang Liu, Xu Liu, Mu Qin
Summary: This study revealed that Rgs5(-/-) plays a significant regulatory role in ventricular tachyarrhythmia in mice by prolonging ventricular repolarization and increasing spatial dispersion in the ventricle.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Agnieszka Smoczynska, Errol W. Aarnink, Albert Dunnink, Alexandre Bossu, Valerie Y. H. van Weperen, Veronique M. F. Meijborg, Henriette D. M. Beekman, R. Coronel, Marc A. Vos
Summary: This study compared the temporal and spatial dispersion of repolarization in the arrhythmogenesis of torsades de pointes arrhythmias. It found that an increase in temporal dispersion contributes to the initiation of single ectopic beats, while an increase in spatial dispersion is important for the perpetuation of non-self-terminating torsades de pointes arrhythmias.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sejal Mistry, Ramkiran Gouripeddi, Candace M. Reno, Samir Abdelrahman, Simon J. Fisher, Julio C. Facelli
Summary: Distinct patterns of electrocardiogram heartbeats were identified that correlated with different glycemic levels, diabetes status, and mortality. Some patterns were specific to hypoglycemia conditions, while others were specific to severe hypoglycemia conditions and exhibited arrhythmogenic waveforms.
Article
Cardiac & Cardiovascular Systems
Duo Li, Yibing Weng, Genshen Zhen, Li Jiang
Summary: This study investigated the prognostic value of Tp-Te and Tp-Te/QT in patients with sepsis. The results showed that Tp-Te and Tp-Te/QT were significantly higher in patients with sepsis and heart failure compared to the control group. The increase of Tp-Te and Tp-Te/QT was more prominent in patients with heart failure than in patients with sepsis. Tp-Te/QT, SOFA, and LVEF were found to have predictive values for death in patients with sepsis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Salma I. Patel, Wojciech Zareba, Bonnie LaFleur, Jean-Phillipe Couderc, Xiaojuan Xia, Raymond Woosley, Imran Y. Patel, Daniel Combs, Saif Mashaqi, Stuart F. Quan, Sairam Parthasarathy
Summary: Sleep-disordered breathing is associated with some measures of ventricular repolarization but does not modify the association between ventricular repolarization and overall mortality.
Review
Psychiatry
Temi Toba-Oluboka, Philip G. Tibbo, Kara Dempster, Martin Alda
Summary: This article reviews the interplay between genetic risk and medication exposure in psychiatric treatment, specifically focusing on medication-induced QT prolongation (MIQTP). The findings suggest a genetic contribution to MIQTP and highlight the importance of monitoring heart parameters and potential role of genetic profiling in increasing treatment safety in psychiatry.
PSYCHIATRY RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Elham Mahmoudi, Reza Mollazadeh, Pejman Mansouri, Mohammad Keykhaei, Shayan Mirshafiee, Behnam Hedayat, Mojtaba Salarifar, Matthew F. Yuyun, Hirad Yarmohammadi
Summary: This study evaluated the electrocardiogram markers of repolarization heterogeneity in patients hospitalized with COVID-19 and found significant increases in Tp-Te, TpTe/QT, QRS width, and iCEB. The meta-analysis confirmed the significant increase of TpTe interval, TpTe/QT, and TpTe/QTc ratios in COVID-19 patients.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Adjani A. Peralta, Joel Schwartz, Diane R. Gold, Brent Coull, Petros Koutrakis
Summary: This study explores the impact of PM2.5 components and temperature on ventricular repolarization as measured by QT interval. Higher sulfate levels and colder temperatures were associated with longer QTc interval, while other particles had varying effects. Diabetic status did not modify the association between PM2.5 components and QTc interval.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Croatto, Davy Vancampfort, Alessandro Miola, Miriam Olivola, Jess G. Fiedorowicz, Joseph Firth, Ovidiu Alexinschi, Marcel A. Gaina, Vladimir Makkai, Fernanda Cunha Soares, Leandro Cavaliere, Giorgia Vianello, Brendon Stubbs, Paolo Fusar-Poli, Andre F. Carvalho, Eduard Vieta, Samuele Cortese, Jae Il Shin, Christoph U. Correll, Marco Solmi
Summary: People with mood disorders are at increased risk of comorbid medical diseases. Interventions such as psychological therapies, exercise, and certain medications can improve physical health outcomes in mood disorders, but some medications may have negative effects. It is important to consider evidence from other disorders and individual RCTs when prioritizing effective treatments with beneficial or physically neutral profiles.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Christoph U. Correll, Evan Stein, Christine Graham, Lauren DiPetrillo, Sarah Akerman, Arielle D. Stanford, Ying Jiang, Sergey Yagoda, David McDonnell, Craig Hopkinson
Summary: OLZ/SAM treatment is associated with a reduced risk of worsening cardiometabolic risk factors related to obesity, hypertension, and metabolic syndrome compared to olanzapine.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Samuele Cortese, Marco Solmi, Giorgia Michelini, Alessio Bellato, Christina Blanner, Andrea Canozzi, Luis Eudave, Luis C. Farhat, Mikkel Hojlund, Ole Kohler-Forsberg, Douglas Teixeira Leffa, Christopher Rohde, Gonzalo Salazar de Pablo, Giovanni Vita, Rikke Wesselhoeft, Joanna Martin, Sarah Baumeister, Natali S. Bozhilova, Christina O. Carlisi, Virginia Carter Leno, Dorothea L. Floris, Nathalie E. Holz, Eline J. Kraaijenvanger, Seda Sacu, Isabella Vainieri, Giovanni Ostuzzi, Corrado Barbui, Christoph U. Correll
Summary: Neurodevelopmental disorders such as ADHD, autism spectrum disorder, and intellectual disability can be identified early in development. However, there is a lack of valid and reliable biomarkers for the timely diagnosis of these disorders. A systematic review of studies on candidate diagnostic biomarkers for these disorders in children and adolescents found that none of the biomarkers met the criteria of specificity and sensitivity of at least 80% in two or more independent studies. Future research should focus on multivariable and multi-level approaches to identify valid candidate biomarkers.
Review
Psychiatry
Elena Dragioti, Joaquim Radua, Marco Solmi, Corentin J. Gosling, Dominic Oliver, Filippo Lascialfari, Muhammad Ahmed, Samuele Cortese, Andres Estrade, Gonzalo Arrondo, Mary Gouva, Michele Fornaro, Agapi Batiridou, Konstantina Dimou, Dimitrios Tsartsalis, Andre F. Carvalho, Jae Il Shin, Michael Berk, Silvia Stringhini, Christoph U. Correll, Paolo Fusar-Poli
Summary: Empirical evidence suggests that there is a significant bidirectional association between mental disorders and physical diseases, but the prospective impact of mental disorders on clinical outcomes of physical diseases has not been fully examined. This umbrella review analyzed systematic reviews with meta-analysis to identify the association between mental disorders and clinical outcomes of physical diseases. The study found that mental disorders increase the risk of adverse clinical outcomes in various physical diseases, and prevention targeting these disorders can reduce the incidence of negative outcomes. Rating: 7/10
Article
Psychiatry
Christoph U. Correll, Marco Solmi, Samuele Cortese, Maurizio Fava, Mikkel Hojlund, Helena C. Kraemer, Roger S. McIntyre, Daniel S. Pine, Lon S. Schneider, John M. Kane
Summary: Despite progress in pharmacotherapy, many mental disorders remain insufficiently treated due to limited knowledge of pathophysiology, lack of biological markers, and challenges in drug development and testing. This paper discusses promising drugs and innovative mechanisms of action undergoing testing for various psychiatric disorders, as well as the clinical trial parameters that need to be considered for successful drug development. It also highlights the hurdles and perils in new drug development and testing and emphasizes the importance of considering these factors for increased chances of success.
Article
Psychiatry
Celso Arango, Andrea Fagiolini, Philip Gorwood, John M. Kane, Sergio Diaz-Mendoza, Navdeep Sahota, Christoph U. Correll
Summary: This study investigated the use of long-acting injectable antipsychotics (LAIs) in patients with first-episode psychosis (FEP) and early-phase (EP) schizophrenia. The expert consensus concluded that LAIs can decrease the risk of relapse, rehospitalization, and functional dysfunction, and highlighted the potential for multidimensional longer-term functional recovery beyond symptomatic remission.
Editorial Material
Psychology, Developmental
Samuele Cortese, Marco Solmi, Christoph U. Correll
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Guillaume Fond, Martin Vidal, Morgane Joseph, Damien Etchecopar-Etchart, Marco Solmi, Dong Keon Yon, Christoph U. Correll, Laurent Boyer
Summary: In schizophrenia, self-stigma is influenced by psychotic and depressive symptomatology, workplace stigma, and varies across countries. This meta-analysis synthesizes observational studies on self-stigma and its associated factors. The results show that self-stigma levels remain consistent over time and are influenced by factors such as living in non-urban areas, low income, unemployment, high antipsychotic dose, and low functioning. Additionally, self-stigma dimensions differ between European and other regions. The study highlights the need to explore additional factors to improve interventions targeting self-stigma.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Fabian Huth, Leonardo Tozzi, Michael Marxen, Philipp Riedel, Kyra Broeckel, Julia Martini, Christina Berndt, Cathrin Sauer, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Florian Thomas-Odenthal, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Silvia Biere, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig, Pavol Mikolas
Summary: The pathophysiology of bipolar disorder (BD) is unclear, but a valid biomarker is needed for early detection. This study used structural MRI to compare volumes of hippocampus, amygdala, and their subfields/nuclei in individuals at risk for BD. Although there were no volume differences between risk groups, machine learning could still predict the risk for BD based on certain criteria. This suggests that neural changes may have prognostic value in BD.
Article
Clinical Neurology
Jonathan M. Meyer, Christoph U. Correll
Summary: Patients with schizophrenia have an increased risk of cardiometabolic abnormalities due to various factors, including illness severity, disease heterogeneity, lifestyle behaviors, and antipsychotic side effects. Adequate treatment with antipsychotics has been found to decrease mortality rates and reduce cardiometabolic risk factors in these patients. Recent discoveries in the pathophysiology of schizophrenia have opened up new possibilities for novel treatments that target metabolic dysfunction and offer therapeutic advancements.
Article
Biochemistry & Molecular Biology
Marco Solmi, Georgios Seitidis, Dimitris Mavridis, Christoph U. U. Correll, Elena Dragioti, Synthia Guimond, Lauri Tuominen, Aroldo Dargel, Andre F. F. Carvalho, Michele Fornaro, Michael Maes, Francesco Monaco, Minjin Song, Jae Il Shin, Samuele Cortese
Summary: The Global Burden of Diseases, Injuries, and Risk Factors Study data shows that the prevalence, incidence, and burden of schizophrenia have been increasing since 1990. In countries with high socio-demographic index, both prevalence and burden have increased, while in countries with low socio-demographic index, the incidence has decreased but the burden remains stable. These findings highlight the need for improved detection and treatment of schizophrenia in low socio-demographic index countries and the increasing prevalence of the disorder.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Peter J. Uhlhaas, Christopher G. Davey, Urvakhsh Meherwan Mehta, Jai Shah, John Torous, Nicholas B. Allen, Shelli Avenevoli, Tolulope Bella-Awusah, Andrew Chanen, Eric Y. H. Chen, Christoph U. Correll, Kim Q. Do, Helen L. Fisher, Sophia Frangou, Ian B. Hickie, Matcheri S. Keshavan, Kerstin Konrad, Francis S. Lee, Cindy H. Liu, Beatriz Luna, Patrick D. McGorry, Andreas Meyer-Lindenberg, Merete Nordentoft, Dost Oenguer, George C. Patton, Tomas Paus, Ulrich Reininghaus, Akira Sawa, Michael Schoenbaum, Gunter Schumann, Vinod H. Srihari, Ezra Susser, Swapna K. Verma, T. Wilson Woo, Lawrence H. Yang, Alison R. Yung, Stephen J. Wood
Summary: Most mental disorders have an onset between 12 and 25 years of age, emphasizing the importance of this period for understanding and addressing mental ill-health. This perspective highlights the interactions between risk and protective factors and brain development in the emergence of psychopathology in youth. It proposes the need for novel approaches to early diagnosis and interventions that reflect the evolving nature of psychopathology and promote knowledge exchange between science and practitioners. Overall, it advocates for a transformative early intervention paradigm to enhance mental health in young people and shift towards preventing severe mental disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Rene S. Kahn, John M. Kane, Christoph U. Correll, Christina Arevalo, Adam Simmons, Christine Graham, Sergey Yagoda, Beibei Hu, David McDonnell
Summary: This 12-week study aimed to evaluate the weight effects of combination olanzapine and samidorphan (OLZ/SAM) versus olanzapine in patients with early-phase schizophrenia or bipolar I disorder (BD-I). The results showed that OLZ/SAM treatment resulted in less weight gain compared to olanzapine. Rating: 8/10.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
Christoph Correll, Francois Laliberte, Guillaume Germain, Sean MacKnight, Huy-Binh Nguyen, Sally Wade, Mousam Parikh, Andrew Cutler
Meeting Abstract
Clinical Neurology
John Edwards, Suresh Durgam, Susan G. Kozauer, Jason Huo, Robert E. Davis, Sharon Mates, Christoph U. Correll