Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Tanja Sprave, Vivek Verma, Alexander Fabian, Alexander Ruehle, Dimos Baltas, Anca-Ligia Grosu, Nils H. Nicolay
Summary: This study is the first to demonstrate from the perspective of the German healthcare system that the addition of chemotherapy to radiotherapy is cost-effective and does not result in a significant decline in health-related quality of life in selected elderly head and neck cancer patients.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Grace M. M. Spiro, Philip C. C. Doyle, Nedeljko Jovanovic, Melissa Nash, Kevin Fung, Danielle MacNeil, Anthony Nichols, John Yoo
Summary: This study investigated the degree of perceived fatigue in individuals treated for head and neck cancer (HNCa). Results showed that more than half of the participants reported clinically significant levels of fatigue. There was an inverse relationship between fatigue and overall health-related quality of life, suggesting that as fatigue increases, perceived HRQOL decreases.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Primoz Strojan, Ales Groselj, Gregor Sersa, Christina Caroline Plaschke, Jan B. Vermorken, Sandra Nuyts, Remco de Bree, Avraham Eisbruch, William M. Mendenhall, Robert Smee, Alfio Ferlito
Summary: Electrochemotherapy, based on reversible electroporation and intracellular accumulation of hydrophilic drug molecules, is considered an effective and safe treatment for tumors, including mucosal cancer of the head and neck. Limited experience with ECT in mucosal HNC due to poor accessibility of tumors highlights the need for further research to confirm its potential as a treatment option in selected patients.
Article
Oncology
Nandini S. Menon, Vanita Noronha, Vijay Maruti Patil, Amit Joshi, Atanu Bhattacharjee, Devanshi Kalra, Sarbani Ghosh Laskar, Vijayalakshmi Mathrudev, Kavita Nawale, Arati S. Bhelekar, Kumar Prabhash
Summary: This study found that the use of once-every-3-weeks cisplatin with radiation did not have a negative impact on the quality of life for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), compared to once-a-week cisplatin. However, there were significant differences in the scales of constipation, reduced sexuality, and financial difficulty between the two treatment arms.
Article
Oncology
Ines Leao, Catarina Garcia, Pedro Antunes, Ana Campolargo, Isabel Dias, Edite Coimbra, Pedro Oliveira, Horacio Zenha, Horacio Costa, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Ana Joaquim
Summary: Head and neck cancer treatment can have negative impact on health-related quality of life and treatment efficacy. Exercise training may bring benefits to these patients. This study aimed to analyze the acute effects of treatment on patients and their preferences for exercise training. The findings suggest that an exercise training program can improve the physical fitness of patients and reduce toxicities.
Review
Oncology
Linda Chen, Nadeem Riaz, Nancy Lee, Sean McBride
Summary: Management of HPV-related head and neck cancer requires a multidisciplinary approach to balance treatment outcomes and toxicity. Considerations include radiation dose, target delineation, chemoradiation, postoperative radiotherapy, and definitive radiotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Shirin Jalili, Ramin Ghasemi Shayan
Summary: Health assessment data is crucial for developing care plans and understanding patient needs. The Quality of Life of cancer patients is significantly impacted by the disease, with symptoms such as pain having a negative effect.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Otorhinolaryngology
Wataru Okano, Ryuichi Hayashi, Kazuto Matsuura, Takeshi Shinozaki, Toshifumi Tomioka
Summary: The study indicates that targeted neck dissection (ND) after definitive chemoradiotherapy is an effective intervention for patients with cervical disease recurrence, showing promising survival rates and control rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Hans Paul van der Laan, Arjen van der Schaaf, Lisa Van den Bosch, Erik W. Korevaar, Roel J. H. M. Steenbakkers, Stefan Both, Johannes A. Langendijk
Summary: The study evaluated the feasibility of semi-automatic QOL-weighted NTCP-guided VMAT treatment plan optimization in head and neck cancer patients and compared it to conventional treatment. Results showed that QOL-weighted NTCP-guided VMAT plans were clinically acceptable, prioritizing sparing of organs at risk related to high-impact toxicities, leading to an improvement in predicted QOL compared to conventional VMAT plans.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Alexandria Harris, Jinhong Li, Karley Atchison, Christine Harrison, Daniel Hall, Tyler VanderWeele, Jonas T. Johnson, Marci L. Nilsen
Summary: This study evaluates the relationship between demographics, clinical characteristics, and posttreatment symptom burden with the subjective sense of flourishing among head and neck cancer survivors. The results suggest that late- and long-term side effects of treatment and financial hardship are associated with lower levels of flourishing.
Article
Oncology
Nandini Menon, Vijay Patil, Vanita Noronha, Amit Joshi, Atanu Bhattacharjee, Balajirao J. Satam, Vijayalakshmi Mathrudev, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: The addition of nimotuzumab to cisplatin based chemoradiation in locally advanced head and neck squamous cell carcinoma improved progression-free, locoregional, and disease-free survival without negatively impacting quality of life. Most function and symptom scales of QoL showed significant changes over time, but no significant difference was observed between the two treatment arms.
Article
Otorhinolaryngology
Michele Fiorella, Angela Alnemri, Sarah Sussman, Anusha Koka, Jennifer Johnson, David Cognetti, Joseph Curry, Leila Mady, Brooke Worster, Amy E. Leader, Adam Luginbuhl
Summary: This study aimed to investigate the impact of head and neck squamous cell carcinoma diagnosis and treatment on patient and partner perceived intimacy, as well as whether a diagnosis of HPV-related head and neck squamous cell carcinoma affects patient-partner intimacy. The results showed that patient and partner intimacy levels remained stable or improved throughout the study, and there was generally agreement between couples in their levels of perceived intimacy. A diagnosis of HPV did not significantly affect intimacy scores.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Chandrika Gibson, Moira O'Connor, Rohen White, Melanie Jackson, Siddhartha Baxi, Georgia K. B. Halkett
Summary: This qualitative study explores the experiences of head and neck cancer (HNC) patients in communicating with health professionals. The loss of speech capacity is found to be distressing and traumatic for survivors of HNC. Tensions arise in the communication between patients and health professionals, including abrupt, hurried communication versus slower, more mindful communication. Disparities in health literacy levels and a lack of empathy are also observed.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Otorhinolaryngology
L. J. Visser, J. A. U. Hardillo, D. A. Monserez, M. H. Wieringa, R. J. Baatenburg de Jong
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2016)
Article
Oncology
Simone Punt, Emilie A. C. Dronkers, Marij J. P. Welters, Renske Goedemans, Senada Koljenovic, Elisabeth Bloemena, Peter J. F. Snijders, Arko Gorter, Sjoerd H. van der Burg, Robert J. Baatenburg de Jong, Ekaterina S. Jordanova
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2016)
Article
Oncology
Maria J. De Herdt, Stefan M. Willems, Berdine van der Steen, Rob Noorlag, Esther I. Verhoef, Geert J. L. H. van Leenders, Robert J. J. van Es, Senada Koljenovic, Robert J. Baatenburg de Jong, Leendert H. J. Looijenga
Article
Dentistry, Oral Surgery & Medicine
R. W. H. Smits, Ivo ten Hove, E. A. C. Dronkers, T. C. Bakker Schut, H. Mast, R. J. Baatenburg de Jong, E. B. Wolvius, G. J. Puppels, S. Koljenovic
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2018)
Article
Chemistry, Analytical
F. L. J. Cals, T. C. Bakker Schut, P. J. Caspers, R. J. Baatenburg de Jong, S. Koljenovic, G. J. Puppels
Article
Otorhinolaryngology
Martine Hendriksma, Yda van Loon, W. Martin C. Klop, Marieke M. Hakkesteegt, Bas J. Heijnen, Ibtissam el Hasnaoui, Martin de Jong, Ton P. M. Langeveld, Peter Paul G. van Benthem, Robert J. Baatenburg de Jong, Elisabeth V. Sjogren
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2019)
Article
Oncology
A. van der Hout, K. Holtmaat, F. Jansen, B. Lissenberg-Witte, C. F. Van Uden-Kraan, G. A. P. Nieuwenhuijzen, J. A. Hardillo, R. J. Baatenburg de Jong, N. L. Tiren-Verbeet, D. W. Sommeijer, K. de Heer, C. G. Schaar, R. J. E. Sedee, K. Bosscha, M. W. M. van den Brekel, F. Petersen, M. Westerman, J. Honings, R. P. Takes, I Houtenbos, W. T. van den Broek, R. de Bree, P. Jansen, S. E. J. Eerenstein, C. R. Leemans, J. M. Zijlstra, P. Cuijpersa, L. V. Van De Poll-Franse, I. M. Verdonck-de Leeuw
Summary: The study found that Oncokompas is most effective in improving HRQOL in cancer survivors with lower self-efficacy, higher personal control, and higher health literacy. It also showed that survivors with heavier tumor-specific symptoms, such as head and neck cancer and colorectal cancer survivors, benefited more from Oncokompas in symptom reduction.
Review
Oncology
Lorraine J. Lauwerends, Hidde A. Galema, Jose A. U. Hardillo, Aniel Sewnaik, Dominiek Monserez, Pieter B. A. A. van Driel, Cornelis Verhoef, Robert J. Baatenburg de Jong, Denise E. Hilling, Stijn Keereweer
Summary: Laryngeal cancer is a common head and neck malignancy with poor prognosis, especially in advanced stages. Current optical imaging techniques are limited in deep margin assessment, highlighting the need for new technologies to guide surgical resection and reduce local recurrence rates.
Article
Otorhinolaryngology
Maarten C. Dorr, Arta Hoesseini, Aniel Sewnaik, Jose A. Hardillo, Robert J. Baatenburg de Jong, Marinella P. J. Offerman
Summary: The study found that the use of the prognostic model OncologIQ can provide assistance in the decision-making process of head and neck cancer, especially for older patients, patients with a WHO performance score >= 2, or patients with a high tumor stage. This individualized decision-making model plays an important role in facilitating multidisciplinary consultation decisions.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Ajay T. Bakas, Harmke A. Polinder-Bos, Fleur Streng, Francesco U. S. Mattace-Raso, Gijsbertus Ziere, Rob J. Baatenburg de Jong, Aniel Sewnaik
Summary: This study found that the G8 is a valid screening tool to identify frail patients in younger patients with head and neck cancer, and it is associated with mortality.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Hanneke Doremiek van Oorschot, Dominique Valerie Clarence de Jel, Jose Angelito Hardillo, Ludi E. Smeele, Robert Jan Baatenburg de Jong, Dutch Head and Neck Audit Grp
Summary: The study aimed to assess and improve the quality of head and neck cancer care. By analyzing data from DHNA, it was found that waiting times have gradually improved, with four hospitals exceeding the quality standard.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Chemistry, Analytical
Hamed Abbasi, Lorraine J. Lauwerends, Tom Bakker C. Schut, Ines P. Santos, Peter J. Caspers, Jose A. U. Hardillo, Senada Koljenovic, Alexander L. Vahrmeijer, Robert J. Baatenburg de Jong, Stijn Keereweer, Gerwin J. Puppels
Summary: This paper describes a Raman spectroscopy setup capable of recording high-quality Raman spectra from tissue containing near-infrared exogenous fluorescent agents by avoiding spectral overlap. The optimal wavelength interval (900-915 nm) for Raman excitation is identified to avoid both excitation of fluorescent dyes and Raman signal self-absorption by the tissue. This combined novel setup could pave the way for clinical trials benefiting from both fluorescence imaging and Raman spectroscopy to avoid positive margins in cancer surgery.
Article
Health Care Sciences & Services
Anouk M. I. A. van Alphen, Eline M. Krijkamp, Benjamin Y. Gravesteijn, Robert J. Baatenburg de Jong, Jan J. Busschbach
Summary: Physicians value health states higher than citizens, but these differences only result in minor changes in rankings. Therefore, HRQoL values obtained from physicians are sufficient for supporting decision models during crises.
QUALITY OF LIFE RESEARCH
(2023)
Article
Environmental Sciences
Kira S. S. Van Hof, Arta Hoesseini, Maarten C. C. Dorr, Irma M. M. Verdonck-de Leeuw, Femke Jansen, C. Rene Leemans, Robert P. P. Takes, Chris H. J. Terhaard, Robert Jan Baatenburg de Jong, Aniel Sewnaik, Marinella P. J. Offerman
Summary: This prospective cohort study investigates the burden of caregiving for head and neck cancer patients among informal caregivers, and explores its impact on their distress and quality of life, as well as the relationship between caregivers and patients. The study reveals that caring for HNC patients imposes a significant burden on caregivers, which affects their psychological well-being and daily life, and highlights the interaction between caregivers and patients. Healthcare professionals are advised to include caregivers in counseling and support.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Angelina M. M. Santoso, Femke Jansen, Carel F. W. Peeters, Robert J. Baatenburg de Jong, Ruud H. Brakenhoff, Johannes A. Langendijk, C. Rene Leemans, Robert P. Takes, Chris H. J. Terhaard, Annemieke van Straten, Irma M. Verdonck-de Leeuw
Summary: This study analyzed data from newly diagnosed head and neck cancer (HNC) patients and found that poor sleep quality, fatigue, CRP, and IL-6 play an important role in the connections between psychoneurological symptoms and biomarkers of stress and inflammation.
