期刊
EUROPACE
卷 15, 期 12, 页码 1725-1732出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/eut147
关键词
Left ventricular hypertrophy; MRI; Atrial fibrillation; Catheter ablation; Structural remodelling
Therapeutic effectiveness of ablation of atrial fibrillation (AF) is related to cardiovascular comorbidities. We studied the relationship between left ventricular hypertrophy (LVH) and left atrial tissue structural remodelling (LA-SRM), in patients presenting for AF ablation. We identified 404 AF patients who received a late gadolinium enhancement magnetic resonance imaging (LGE-MRI) prior to catheter ablation. Left ventricular hypertrophy was defined as LV mass index 116 g/m(2) in men and 104 g/m(2) in women. One hundred and twenty-two patients were classified as the LVH group and 282 as the non-LVH group. We stratified patients into four stages based on their degree of LA-SRM (minimal, 5 fibrosis; mild, 520; moderate, 2035; and extensive, 35). All patients underwent catheter ablation with pulmonary vein isolation and posterior wall and septal debulking. The procedural outcome was monitored over a 1-year follow-up period. The mean LA-SRM was significantly higher in patients with LVH (19.4 13.2) than in non-LVH patients (15.3 9.8; P 0.01). Patients with LVH generally had extensive LA-SRM (moderate and extensive stages; 38.5 of LVH group) as compared with non-LVH patients (23.1 of non-LVH group; P 0.01). A Cox regression analysis showed that patients with LVH also had significantly higher AF recurrence rates than non-LVH patients (43.2 vs. 28; P 0.008) during the 1-year follow-up period post-ablation. Patients with LVH tend to have a significantly greater degree of LA-SRM, when compared with patients without LVH. Moreover, LA-SRM is a predictor for procedural success in patients undergoing AF ablation procedure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据