期刊
EUROPACE
卷 14, 期 1, 页码 46-51出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/eur275
关键词
Atrial fibrillation; Pulmonary veins; Voltage mapping; Electroanatomic mapping
资金
- National Heart Foundation of Australia
- National Health and Medical Research Council
- Pfizer
- Cardiac Society of Australia
- Cardiac Society of New Zealand
- Victoria Government's OIS
Aims Increasing age is a significant risk factor for developing atrial fibrillation (AF). Pulmonary vein (PV) triggers are critical in the mechanism of AF, but little is known of the substrate changes that occur within the PVs with ageing. Therefore, we sought to identify whether ageing is associated with electroanatomic changes within the pulmonary veins. Methods and results Twenty-five patients undergoing ablation for left-sided supraventricular tachycardia had high-density 3D electroanatomic maps of all four PVs created. Patients were divided into two groups: group 1 aged,50 years and group 2 aged < 50 years. Mean-voltage (MV), % low-voltage (LV < 0.5 mV), conduction, signal complexity, and PV muscle sleeve length and diameter were assessed. Age was 33 +/- 8 vs. 66 +/- 8 years for groups 1 and 2, respectively (P < 0.001). Group 2 demonstrated: (i) lower MV within the PVs (1.66 +/- 1.1 vs. 1.88 +/- 1.1 mV, P < 0.001); (ii) increased % LV (5.0 vs. 1.1%, P < 0.001), and increased voltage heterogeneity within the PVs (65 +/- 14 vs. 55 +/- 8%, P < 0.05); (iii) regional and global conduction slowing in the PVs; and (iv) increased % complex signals within the PVs (1.4 vs. 0.4%, P = 0.009). There was no difference in PV sleeve length or diameter. Conclusion Increasing age is associated with PV electroanatomic changes characterized by a significant reduction in PV voltage, conduction slowing, and increasing signal complexity. These observations provide new insights into the potential mechanisms behind the increased prevalence of AF with advancing age.
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