Review
Cardiac & Cardiovascular Systems
Jiyi Liu, Fengzhi Sun, Zefeng Wang, Jiao Sun, Xue Jiang, Weilong Zhao, Zhipeng Zhang, Lu Liu, Shulong Zhang
Summary: In patients with heart failure eligible for cardiac resynchronization therapy (CRT), left bundle branch area pacing (LBBAP) showed significant improvements in QRS duration, left ventricular ejection fraction, left ventricular end-diastolic dimension, New York Heart Association class, and CRT response compared to biventricular pacing (BVP). The current evidence from non-randomized studies suggests that LBBAP is a promising method for CRT, offering more remarkable improvements in symptoms and cardiac function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Yang Gui, Lifang Ye, Liuyang Wu, Haohui Mai, Qiqi Yan, Lihong Wang
Summary: This meta-analysis compared the clinical outcomes of His-Purkinje system pacing (HPSP) with biventricular pacing (BIVP) in patients with heart failure. The results showed that HPSP was associated with higher left ventricular ejection fraction (LVEF), shorter QRS duration, and higher New York Heart Association (NYHA) functional class compared to BIVP in the cardiac resynchronization therapy (CRT) population. In terms of pacing threshold and R-wave amplitude, left bundle branch pacing (LBBP) outperformed His-bundle pacing (HBP).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Carlos Diaz, William H. Sauer, Mauricio Duque, Bruce A. Koplan, Eric D. Braunstein, Jorge Eduardo Marin, Julian Aristizabal, Cesar Daniel Nino, Oriana Bastidas, Juan Manuel Martinez, Carolina Hoyos, Carlos D. Matos, Nestor Lopez-Cabanillas, Nathaniel A. Steiger, Sunil Kapur, Thomas M. Tadros, David T. Martin, Paul C. Zei, Usha B. Tedrow, Jorge E. Romero
Summary: This study compares the outcomes of LBBAP and BiVp as initial implant strategies for CRT. The results show that LBBAP as an initial CRT strategy can reduce the risk of hospitalization due to heart failure compared to BiVp, and improvements in procedural and fluoroscopy times, QRS duration, and left ventricular ejection fraction were observed.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shengjie Wu, Lan Su, Pugazhendhi Vijayaraman, Rujie Zheng, Mengxing Cai, Lei Xu, Ruiyu Shi, Zhouqing Huang, Zachary Whinnett, Weijian Huang
Summary: Left bundle branch pacing (LBBP) appears to be a promising method for delivering cardiac resynchronization therapy (CRT), showing similar improvements in symptoms and left ventricular function compared with His bundle pacing (HBP) but more significant than biventricular pacing (BVP).
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yao Wang, Haojie Zhu, Xiaofeng Hou, Zhao Wang, Fengwei Zou, Zhiyong Qian, Yongyue Wei, Xiang Wang, Longyao Zhang, Xiaofei Li, Zhimin Liu, Siyuan Xue, Chaotong Qin, Jiaxin Zeng, Hui Li, Hongping Wu, Hong Ma, Kenneth A. Ellenbogen, Michael R. Gold, Xiaohan Fan, Jiangang Zou
Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yixiu Liang, Jingfeng Wang, Xue Gong, Hongyang Lu, Ziqing Yu, Lei Zhang, Minghui Li, Lei Pan, Xueying Chen, Jie Cui, Weiwei Zhang, Ruogu Li, Xiaohong Zhou, Weijian Huang, Yangang Su, Junbo Ge
Summary: The study compared the acute improvement of left bundle branch pacing (LBBP) and biventricular pacing (BVP) in patients with heart failure. The results showed that LBBP provided greater improvements in electrical and mechanical synchrony, as well as hemodynamics, compared to BVP.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Antonio da Silva Menezes, Maria Gabriella Zordan Melo, Laura Pedriel Barreto
Summary: Cardiac resynchronization can be used to treat severe heart failure with pharmacological optimization, left bundle branch block, and an ejection fraction <35%. However, a significant percentage of patients do not respond to therapy. HBP may be a potential alternative to biventricular pacing. This study compared the effectiveness of HBP versus BiV in heart failure patients.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Review
Cardiac & Cardiovascular Systems
Ya Wang, Fangchao Liu, Mengyao Liu, Zefeng Wang, Xiangfeng Lu, Jianfeng Huang, Dongfeng Gu
Summary: This study provides a comprehensive assessment of His-Purkinje system pacing (HPSP) as an alternative to biventricular pacing (BVP) in cardiac resynchronization therapy (CRT). The results show that HPSP is associated with shorter QRS duration, improved left ventricular function, decreased heart failure hospitalization rate, and comparable all-cause mortality compared to BVP.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Pugazhendhi Vijayaraman, Parikshit S. Sharma, Oscar Cano, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Francesco Zanon, Marek Jastrzebski, Jiangang Zou, Mihail G. Chelu, Kevin Vernooy, Zachary I. Whinnett, Girish M. Nair, Manuel Molina-Lerma, Karol Curila, Dipen Zalavadia, Abdul Haseeb, Cicely Dye, Sharath C. Vipparthy, Ryan Brunetti, Pawel Moskal, Alexandra Ross, Antonius van Stipdonk, Jerin George, Yusuf K. Qadeer, Mishal Mumtaz, Jeffrey Kolominsky, Syeda A. Zahra, Mehrdad Golian, Lina Marcantoni, Faiz A. Subzposh, Kenneth A. Ellenbogen
Summary: This study compared the clinical outcomes between left bundle branch area pacing (LBBAP) and biventricular pacing (BVP) in patients with cardiac resynchronization therapy (CRT). The results showed that LBBAP improved clinical outcomes compared to BVP and may be a reasonable alternative.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Hua, Chenxi Wang, Qiling Kong, Yichu Zhang, Qijun Wang, Ziyi Xiong, Jinzhu Hu, Juxiang Li, Qi Chen, Kui Hong
Summary: The network meta-analysis showed that compared to biventricular pacing (BVP), left bundle branch area pacing (LBBAP) and His bundle pacing (HBP) resulted in greater improvement in left ventricular ejection fraction (LVEF) and narrower QRS duration for cardiac resynchronization therapy (CRT). Additionally, LBBAP had lower pacing thresholds and similar clinical outcomes compared to HBP. These findings suggest that LBBAP may offer advantages over HBP for CRT.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yixiu Liang, Zilong Xiao, Xi Liu, Jingfeng Wang, Ziqing Yu, Xue Gong, Hongyang Lu, Shengwen Yang, Min Gu, Lei Zhang, Minghui Li, Lei Pan, Xiao Li, Xueying Chen, Yangang Su, Wei Hua, Junbo Ge
Summary: This study compared the morbidity and mortality associated with left bundle branch area pacing (LBBAP) and biventricular pacing (BVP) in patients undergoing cardiac resynchronization therapy (CRT). The results showed that there was no significant difference in the risk of morbidity and mortality between LBBAP and BVP in patients with indications for CRT.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Cao, Craig M. Stolen, Rezwan Ahmed, Edward J. Schloss, John H. Lobban, Brian Kwan, Niraj Varma, John P. Boehmer
Summary: Lower BiV pacing percentages are associated with multiple sensor changes indicative of worsening HF in patients with chronic heart failure. Patients in HeartLogic alert state are more likely to have suboptimal BiV pacing. This suggests that even small decreases in BiV percent pacing can lead to worsening HF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jitae A. Kim, Seulgi E. Kim, Kenneth A. Ellenbogen, Pugazhendhi Vijayaraman, Mihail G. Chelu
Summary: Through analyzing the existing data, it was found that conduction system pacing (CSP) has significant advantages over conventional biventricular pacing (BiVP) in terms of clinical outcomes, including reducing all-cause mortality and heart failure hospitalization. However, further large-scale randomized trials are needed to verify these observations.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wen Liu, Chunqiang Hu, Yanan Wang, Yufei Cheng, Yingjie Zhao, Yang Liu, Shaoxin Zheng, Haiyan Chen, Xianhong Shu
Summary: LBBAP effectively improves cardiac function, mechanical synchronization, and mechanical efficiency in heart failure patients, suggesting it as a promising alternative for cardiac resynchronization therapy compared to traditional BVP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Margarida Pujol-Lopez, Rafael Jimenez-Arjonad, Paz Garre, Eduard Guasch, Roger Borras, Adelina Doltra, Elisenda Ferro, Cora Garcia-Ribas, Mireia Niebla, Esther Carro, Jose L. Puente, Sara Vazquez-Calvo, Eric Invers-Rubio, Ivo Roca-Luque, M. Angeles Castel, Elena Arbelo, Marta Sitges, Josep Brugada, Jose M. Tolosana, Lluis Mont
Summary: The study compared ventricular resynchronization achieved by CSP vs BiVP in patients with cardiac resynchronization therapy indication. The results showed that CSP could achieve similar degrees of cardiac resynchronization, ventricular reverse remodeling, and clinical outcomes as compared to BiVP, indicating that CSP may be a feasible alternative to BiVP.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)