Article
Cardiac & Cardiovascular Systems
Soraya Anys, Marine Arnaud, Damien Minois, Annabelle Rajalu, Beatrice Guyomarch, Aurelie Thollet, Jean-Baptiste Gourraud, Vincent Probst
Summary: The study demonstrated significant variability in dose response to nadolol in patients with LQTS, highlighting the need for personalized dosages for each patient. Intraindividual analysis showed a relatively constant dose-response relationship, allowing guided dose adaptation after the first exercise test.
Article
Cardiac & Cardiovascular Systems
Simon Wernhart, Maria Papathanasiou, Amir Abbas Mahabadi, Tienush Rassaf, Peter Luedike
Summary: Beta blockers (BB) have an impact on exercise capacity and oxygen uptake efficiency slope (OUES) in heart failure with preserved ejection fraction (HFpEF) patients. BB has a significant effect on the high-risk group but not on the low-risk group. Direct quantification of O 2 pulse may improve the discrimination of HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Alessio Gasperetti, Cynthia A. James, Marina Cerrone, Mario Delmar, Hugh Calkins, Firat Duru
Summary: Physical exercise can influence the progression and arrhythmia risk of arrhythmogenic right ventricular cardiomyopathy (ARVC), guidelines currently recommend individuals with ARVC to avoid competitive or high-intensity endurance exercise, as exercise-induced physiological changes may mimic classic features of ARVC.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, Research & Experimental
Juliana Fernanda Calhado Belli-Marin, Edimar Alcides Bocchi, Silvia Ayub-Ferreira, Nelson Carvas Junior, Guilherme Veiga Guimaraes
Summary: This study indicates that in patients with HF, medical therapy with beta blockers can reverse exercise oscillatory ventilation (EOV), helping to improve symptoms and exercise capacity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Matthew D. McCoy, Aman Ullah, W. Jonathan Lederer, M. Saleet Jafri
Summary: Mutations in the calcium-sensing protein calmodulin (CaM) can cause cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with different severities. The CaM mutants associated with LQT14 disrupt the calcium-dependent inactivation of the L-Type calcium channel (LCC), while CPVT4 mutants have changes in their affinity to the ryanodine receptor. Simulations in a model for excitation-contraction coupling show that LQT14 variants can lead to a CPVT4 phenotype under certain conditions. These findings emphasize the importance of calcium-dependent inactivation in heart function.
Editorial Material
Cardiac & Cardiovascular Systems
Audrey L. Khoury, Kristin Weiss, Benjamin E. Haithcock, Paul B. Tessmann, Thomas G. Caranasos
Summary: The case describes a 73-year-old male patient with persistent ventricular tachycardia leading to recent syncopal episodes, requiring left ventricular assist device placement and bilateral sympathectomies. The use of thoracoscopy greatly assisted with visualization during the sympathectomy procedure.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ify R. Mordi, Wouter Ouwerkerk, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Marco Metra, Leong L. Ng, Nilesh J. Samani, Dirk J. van Veldhuisen, Faiez Zannad, Adriaan A. Voors, Chim C. Lang
Summary: The study found that undertreatment is common among patients with heart failure, and increasing the dosage of ACEI/ARB and beta-blockers can improve outcomes. Achieving high doses of ACEI/ARB was associated with better outcomes regardless of age, while higher doses of beta-blockers were only beneficial for younger patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Puck J. Peltenburg, Sanjeev N. J. Pultoo, Kathryn E. Tobert, J. Martijn Bos, Krystien V. V. Lieve, Michael Tanck, Sally-Ann B. Clur, Nico A. Blom, Michael J. Ackerman, Arthur A. M. Wilde, Christian van der Werf
Summary: This study aimed to test the repeatability of ventricular arrhythmia characteristics on the exercise-stress test (EST) in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). The results showed that the repeatability of the maximum ventricular arrhythmia score (VAS) was moderate, and the repeatability of the heart rate at the first premature ventricular contraction (PVC) was substantial. The use of medication was associated with a higher odds for a Delta VAS > 1.
Article
Physiology
Angela F. Dulhunty
Summary: Mutations in the cardiac ryanodine receptor Ca2+ release channel (RyR2) can lead to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by increased cytoplasmic Ca2+ concentrations during diastole due to Ca2+ leak from the sarcoplasmic reticulum (SR). The influx of Na+ through the sodium calcium exchanger (NCX) decreases cytoplasmic Ca2+ but triggers delayed after depolarizations (DADs) and arrhythmias. Current therapies have side effects and can affect other target processes.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Matthew Amoni, Eef Dries, Sebastian Ingelaere, Dylan Vermoortele, H. Llewelyn Roderick, Piet Claus, Rik Willems, Karin R. Sipido
Summary: Ischemic heart disease is a common cause of lethal ventricular arrhythmias and sudden cardiac death, with implantable cardioverter defibrillators and ablation therapy being the most effective treatments. Advances in mechanistic insights and technological innovation have led to improved interventional approaches, while pharmacological management still needs improvement.
Article
Cardiac & Cardiovascular Systems
Chiara Cappelletto, Caterina Gregorio, Giulia Barbati, Simona Romani, Antonio De Luca, Marco Merlo, Luisa Mestroni, Davide Stolfo, Gianfranco Sinagra
Summary: The study found that in ARVC patients with long-term follow-up, only beta-blockers administered at >50% target dose were associated with lower risk of SCD/recurrent MVA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Michelle Kortas, Viktor Szatmari
Summary: This retrospective case series investigated the effect of oral atenolol therapy on severe DLVOTO in cats. The results showed a short-term resolution of SAM in some cats, but long-term benefit was limited and there was a risk of cardiac-related death.
Article
Cardiac & Cardiovascular Systems
Noriaki Iwahashi, Jin Kirigaya, Takeru Abe, Mutsuo Horii, Hironori Takahashi, Yohei Hanajima, Yuichiro Kimura, Yugo Minamimoto, Kozo Okada, Yasushi Matsuzawa, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura
Summary: Echocardiography, specifically changes in left ventricular outflow tract-velocity time integral (LVOT-VTI), during Landiolol treatment plays a significant role in predicting the prognosis of patients with acute decompensated heart failure (ADHF) and rapid atrial fibrillation (AF). Deterioration of LVOT-VTI at minimum dose Landiolol suggests high-risk patients for major adverse cardiac events (MACE) and indicates poor prognosis.
JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mohammad A. Ebrahim, Ali A. Alkhabbaz, Buthaina Albash, Ali H. AlSayegh, Gregory Webster
Summary: We present a unique case of TECRL-CPVT with cardiac arrest. After resuscitation, the patient developed ventricular tachycardia with left Purkinje system morphology. The arrhythmia was successfully suppressed with flecainide and isolated ventricular ectopy caused secondary T-wave changes. A diagnosis was eventually made through whole exome sequencing, highlighting the need for a high index of suspicion.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniele Muser, Gaetano Nucifora, Maurizio Pieroni, Simon A. Castro, Ruben Casado Arroyo, Shingo Maeda, Daniel A. Benhayon, Ioan Liuba, Mouhannad Sadek, Silvia Magnani, Andres Enriquez, Jackson J. Liang, Biagio Sassone, Benoit Desjardins, Sanjay Dixit, Rajat Deo, Fermin C. Garcia, David J. Callans, David S. Frankel, Joseph B. Selvanayagam, Francis E. Marchlinsk, Pasquale Santangeli
Summary: The study showed that in patients with apparently idiopathic nonsustained ventricular arrhythmias, a specific phenotype of LV scar characterized by a ringlike pattern is associated with malignant arrhythmic events and higher prognostic risk.
Article
Cardiac & Cardiovascular Systems
Eivind W. Aabel, Monica Chivulescu, Oyvind H. Lie, Einar Hopp, Erik Gjertsen, Margareth Ribe, Thomas M. Helle-Valle, Thor Edvardsen, Finn Hegbom, Lars A. Dejgaard, Kristina H. Haugaa
Summary: This prospective study aimed to describe the incidence and morphology of ventricular arrhythmia in patients with arrhythmic mitral valve syndrome and propose risk stratification. The yearly incidence of ventricular arrhythmia was high in these patients, especially in those with secondary preventive implantable cardioverter-defibrillators (ICD). Predictors of first severe arrhythmic event included frequent premature ventricular complexes, non-sustained ventricular tachycardias, greater left ventricular diameter, and greater posterolateral mitral annular disjunction distance.
Letter
Cardiac & Cardiovascular Systems
Avi Sabbag, Benjamin Essayagh, Maurice Enriquez-Sarano, Kristina Hermann Haugaa
Article
Cardiac & Cardiovascular Systems
Bernard Cosyns, Leyla Elif Sade, Bernhard L. Gerber, Alessia Gimelli, Denisa Muraru, Gerald Maurer, Thor Edvardsen
Summary: The European Heart Journal-Cardiovascular Imaging, launched in 2012, has become one of the leading multimodality cardiovascular imaging journals over the years. It currently ranks 19th among all cardiovascular journals, with an impressive impact factor of 9.130. The most important studies published in the journal in 2021 will be highlighted in two reports, with Part II focusing on valvular heart disease, heart failure, cardiomyopathies, and congenital heart disease, while Part I has focused on studies related to myocardial function, risk prediction, myocardial ischemia, and emerging techniques in cardiovascular imaging.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Bjorkvik Erevik, Oyunn Kleiven, Vidar Froysa, Magnus Bjorkavoll-Bergseth, Monica Chivulescu, Lars Gunnar Klaeboe, Lars Dejgaard, Bjorn Auestad, Oyvind Skadberg, Tor Melberg, Stig Urheim, Kristina Haugaa, Thor Edvardsen, Stein Orn
Summary: This study aimed to determine the effect of prolonged, high-intensity endurance exercise on myocardial function. The results showed that increased exercise duration and intensity resulted in increased myocardial wasted work without alterations in left ventricular ejection fraction and global longitudinal strain. These findings suggest that markers of myocardial inefficiency may precede reduction in global left ventricular function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Inngjerdingen Forsa, Anders W. Bjerring, Kristina H. Haugaa, Marit Kristine Smedsrud, Sebastian Sarvari, Hege W. Landgraff, Jostein Hallen, Thor Edvardsen
Summary: This study aimed to investigate the effect of sex on cardiac remodelling during adolescence in athletes. The results showed that male adolescent athletes displayed greater cardiac remodelling compared to females, and this difference increased throughout adolescence. The left ventricular end-diastolic volumes and left ventricular mass index of males showed a progressive increase from age 12 to 18.
Article
Cardiac & Cardiovascular Systems
Kristine Andreassen, Chloe Rixon, Marie H. Hansen, Ida Marie Hauge-Iversen, Lili Zhang, Mani Sadredini, Pugazendhi M. Erusappan, Ivar Sjaastad, Geir Christensen, Kristina H. Haugaa, Thor Edvardsen, Ida G. Lunde, Mathis K. Stokke
Summary: The effect of exercise training initiated before phenotype development on cardiac fibrosis, morphology, and function in a mouse model of hypertrophic cardiomyopathy (HCM) was investigated. The results showed that early aerobic exercise training attenuated left atrial dilatation and had no detrimental effects on left ventricular function in HCM mice, but did not have a significant impact on cardiac fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Kristina H. Haugaa, Anna I. Castrini
Article
Cardiac & Cardiovascular Systems
Christian K. Five, Nina E. Hasselberg, Linda T. Aaserud, Anna Isotta Castrini, Katarina Vlaisavljevic, Oyvind Lie, Christine Rootwelt-Norberg, Eivind W. Aabel, Kristina H. Haugaa
Summary: This study found no clear association between moderate lifetime exercise dose and severe ventricular arrhythmias in patients with mitral valve prolapse. However, an upper threshold for safe levels of exercise cannot be excluded. Further studies are needed to explore the relationship between exercise and risk of severe ventricular arrhythmias.
Article
Cardiac & Cardiovascular Systems
Feddo P. Kirkels, Christine Rootwelt-Norberg, Laurens P. Bosman, Eivind W. Aabel, Steven A. Muller, Anna Castrini, Karim Taha, Nick van Osta, Oyvind H. Lie, Folkert W. Asselbergs, Joost Lumens, Anneline S. J. M. te Riele, Nina E. Hasselberg, Maarten J. Cramer, Kristina H. Haugaa, Arco J. Teske
Summary: This study found that regional functional abnormalities measured by echocardiographic deformation imaging can provide additional prognostic value and further refine personalized arrhythmic risk prediction in ARVC patients. All tested left and right ventricular deformation parameters were univariate predictors for first-time ventricular arrhythmia. Importantly, all patients with abnormal regional right ventricular deformation patterns at baseline experienced arrhythmia within 5 years.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, General & Internal
Thuy Mi Nguyen, Daniela Melichova, Eivind W. Aabel, Oyvind H. Lie, Lars Gunnar Klaeboe, Bjornar Grenne, Benthe Sjoli, Harald Brunvand, Kristina Haugaa, Thor Edvardsen
Summary: This study aimed to compare long-term outcomes between NSTEMI and STEMI patients in Southern Norway. The results showed that mortality remained high and unchanged in NSTEMI patients, while mortality decreased in STEMI patients over a decade of treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Forsa, Marit K. Smedsrud, Kristina H. Haugaa, Anders W. Bjerring, Andreas Fruh, Sebastian Sarvari, Hege W. Landgraff, Jostein Hallen, Thor Edvardsen
Summary: This study compared left ventricular (LV) hypertrophy in early adolescent athletes and hypertrophic cardiomyopathy (HCM) genotype positive patients. The results showed that LV hypertrophy was found in a similar proportion in both groups, but only HCM genotype positive patients showed progression of hypertrophy. The study also identified a potential grey zone of LV hypertrophy with septum thickness Z-scores ranging from 2.0 to 3.3. LV volumes remained larger in athletes. These findings can help clinicians distinguish physiological LV hypertrophy from early HCM.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Esra Kaya, Kristoffer Andresen, oyvind H. Lie, Lars Aaberge, Kristina H. Haugaa, Thor Edvardsen, Helge Skulstad
Summary: Left ventricular mechanical dispersion (MeDi) can be used as a predictor of the need for permanent pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI), independent of other factors.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)