Review
Cardiac & Cardiovascular Systems
Helder Santos, Mariana Santos, Ines Almeida, Sofia B. Paula, Margarida Figueiredo, Guilherme Portugal, Bruno Valente, Pedro Silva Cunha, Lurdes Almeida, Mario Oliveira
Summary: Endocardial left ventricular pacing is effective in improving cardiac function, left ventricular ejection fraction, and QRS width, but is associated with significant rates of complications and mortality during follow-up.
Review
Cardiac & Cardiovascular Systems
Nadeev Wijesuriya, Mark K. Elliott, Vishal Mehta, Baldeep S. Sidhu, Jonathan M. Behar, Steven Niederer, Christopher A. Rinaldi
Summary: This systematic review and meta-analysis assesses the safety and efficacy of leadless left ventricular endocardial pacing for cardiac resynchronization therapy (CRT) in patients with dyssynchronous heart failure. The results indicate that leadless LV endocardial pacing is effective as a second-line therapy for patients who are unable to undergo or are unresponsive to standard CRT. However, procedure-related complications and mortality rates are relatively high, highlighting the need for further improvement in safety.
Article
Cardiac & Cardiovascular Systems
Baldeep Singh Sidhu, Benjamin Sieniewicz, Justin Gould, Mark K. Elliott, Vishal S. Mehta, Timothy R. Betts, Simon James, Andrew J. Turley, Christian Butter, Martin Seifert, Lucas V. A. Boersma, Sam Riahi, Petr Neuzil, Mauro Biffi, Igor Diemberger, Pasquale Vergara, Martin Arnold, David T. Keane, Pascal Defaye, Jean-Claude Deharo, Anthony Chow, Richard Schilling, Jonathan M. Behar, Christophe Leclercq, Angelo Auricchio, Steven A. Niederer, Christopher A. Rinaldi
Summary: This study compared procedural and long-term outcomes in patients undergoing coronary sinus (CS) CRT upgrades with high-risk and previously failed CRT upgrades undergoing LV endocardial upgrades. Despite prior failed upgrades and high-risk patients with more comorbidities, WiSE-CRT upgrades had high rates of procedural success and similar improvements in CCS and LV remodelling with CS upgrades.
Article
Cardiac & Cardiovascular Systems
Frederic Anselme, Mohammad Albatat, Christelle Marquie, Christophe Leclercq, Philippe Ritter, Jean-Francois Ollivier, Nicolas Shan, Filippo Ziglio, Delphine Feuerstein
Summary: Analysis of venograms in CRT patients revealed the presence of venous collaterals between LV veins, facilitating the potential for accessing multiple LV sites with a single LV microlead implantation.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Caio V. Spaggiari, Sergio F. de Siqueira, Camila Parente de Oliveira, Cinthya I. Guiarao I. Gomes, Maria Janieire de N. N. Alves, Martino Martinelli Filho
Summary: This study aimed to evaluate the feasibility of physiological pacing rate (PPR) in cardiac resynchronization therapy (CRT) patients. The results showed that PPR improved functional capacity in mildly symptomatic CRT patients, but further confirmation is needed through controlled randomized trials.
Article
Biology
Mohammad Albatat, Hermenegild Arevalo, Jacob Bergsland, Vilde Strom, Ilangko Balasingham, Hans Henrik Odland
Summary: This study aimed to investigate the performance of a newly developed method to analyze electrical wavefront propagation in a heart model and compare it to clinical benchmark studies. The results demonstrated the utility of maximum activation front (MAF) in predicting optimal electrode placements in different pacing scenarios including scar and multi-site LV pacing, showing the potential value of computational simulations in understanding and planning CRT.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mark K. Elliott, Vishal S. Mehta, Baldeep Singh Sidhu, Steven Niederer, Christopher A. Rinaldi
Summary: Endocardial left ventricular (LV) pacing is an alternative therapy for patients with heart failure who do not respond to conventional CRT. It offers advantages such as pacing at various sites without anatomical restrictions, and evidence suggests superior electrical resynchronization and hemodynamic response compared to epicardial CRT.
Article
Cardiac & Cardiovascular Systems
Shengjie Wu, Lan Su, Pugazhendhi Vijayaraman, Rujie Zheng, Mengxing Cai, Lei Xu, Ruiyu Shi, Zhouqing Huang, Zachary Whinnett, Weijian Huang
Summary: Left bundle branch pacing (LBBP) appears to be a promising method for delivering cardiac resynchronization therapy (CRT), showing similar improvements in symptoms and left ventricular function compared with His bundle pacing (HBP) but more significant than biventricular pacing (BVP).
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Physiology
Marina Strocchi, Nadeev Wijesuriya, Mark K. Elliott, Karli Gillette, Aurel Neic, Vishal Mehta, Edward J. Vigmond, Gernot Plank, Christopher A. Rinaldi, Steven A. Niederer
Summary: Biventricular endocardial pacing and left bundle pacing are new delivery methods for cardiac resynchronization therapy. Leadless pacing can be used to avoid risks associated with traditional lead systems. This study investigated the impact of RV-LV delay, RV lead location, and left bundle capture on the efficacy of leadless pacing.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Carlos Diaz, William H. Sauer, Mauricio Duque, Bruce A. Koplan, Eric D. Braunstein, Jorge Eduardo Marin, Julian Aristizabal, Cesar Daniel Nino, Oriana Bastidas, Juan Manuel Martinez, Carolina Hoyos, Carlos D. Matos, Nestor Lopez-Cabanillas, Nathaniel A. Steiger, Sunil Kapur, Thomas M. Tadros, David T. Martin, Paul C. Zei, Usha B. Tedrow, Jorge E. Romero
Summary: This study compares the outcomes of LBBAP and BiVp as initial implant strategies for CRT. The results show that LBBAP as an initial CRT strategy can reduce the risk of hospitalization due to heart failure compared to BiVp, and improvements in procedural and fluoroscopy times, QRS duration, and left ventricular ejection fraction were observed.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Physiology
Nadeev Wijesuriya, Mark K. Elliott, Vishal Mehta, Felicity De Vere, Marina Strocchi, Jonathan M. Behar, Steven A. Niederer, Christopher A. Rinaldi
Summary: Non-responders to Cardiac Resynchronization Therapy (CRT) are a high-risk and challenging group of heart failure patients to treat. Research has shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. This review examines the current evidence for four pacing interventions as potential alternatives for treating non-responders to conventional CRT.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jiyi Liu, Fengzhi Sun, Zefeng Wang, Jiao Sun, Xue Jiang, Weilong Zhao, Zhipeng Zhang, Lu Liu, Shulong Zhang
Summary: In patients with heart failure eligible for cardiac resynchronization therapy (CRT), left bundle branch area pacing (LBBAP) showed significant improvements in QRS duration, left ventricular ejection fraction, left ventricular end-diastolic dimension, New York Heart Association class, and CRT response compared to biventricular pacing (BVP). The current evidence from non-randomized studies suggests that LBBAP is a promising method for CRT, offering more remarkable improvements in symptoms and cardiac function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jialin Li, Jiaqi He, Haibo Yu, Guoqing Xu, Yang Gao, Baige Xu, Zulu Wang, Yaling Han, Yanchun Liang
Summary: This study evaluated the effectiveness of QRS narrowing by bilateral septal pacing (BSP) in combination with coronary venous pacing (CVP) for cardiac resynchronization therapy (CRT). The results showed that BSP-CRT had a significant advantage in QRS narrowing and could be considered as an alternative to CRT for patients with QRS duration more than 130 ms. At 3-month follow-up, left ventricular ejection fraction improved.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hye Ree Kim, Kyunghee Lim, Seung-Jung Park, Jong-Sung Park, Ju Youn Kim, Suryeun Chung, Dong-Seop Jung, Kyoung-Min Park, Young Keun On, June Soo Kim
Summary: This study compared the outcomes of patients with epicardial LV leads and endocardial LV leads for cardiac resynchronization therapy. It found that both approaches achieved comparable acute and post-discharge outcomes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Bela Merkely, Robert Hatala, Jerzy K. Wranicz, Gabor Duray, Csaba Foldesi, Zoltan Som, Marianna Nemeth, Kinga Goscinska-Bis, Laszlo Geller, Endre Zima, Istvan Osztheimer, Levente Molnar, Julia Karady, Gerhard Hindricks, Ilan Goldenberg, Helmut Klein, Matyas Szigeti, Scott D. Solomon, Valentina Kutyifa, Attila Kovacs, Annamaria Kosztin, BUDAPEST CRT Upgrade Invest
Summary: De novo implanted cardiac resynchronization therapy with defibrillator (CRT-D) reduces the risk of morbidity and mortality in patients with left bundle branch block, heart failure and reduced ejection fraction (HFrEF). However, among HFrEF patients with right ventricular pacing (RVP), the efficacy of CRT-D upgrade is uncertain.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Chiara Meucci, Jan Stassen, Anton Tomsic, Meindert Palmen, Filippo Crea, Jeroen J. Bax, Nina Ajmone Marsan, Victoria Delgado
Summary: Impaired left ventricular global longitudinal strain (GLS) is independently associated with worse outcomes in patients with atrial functional mitral regurgitation (AFMR).
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Francesca Prevedello, Federico Fortuni, William K. F. Kong, Gurpreet K. Singh, Arnold C. T. Ng, Rebecca Perry, Kian Keong Poh, Ana G. Almeida, Ariana Gonzalez, Mylene Shen, Tiong Cheng Yeo, Miriam Shanks, Bogdan A. Popescu, Laura Galian Gay, Marcin Fijalkowski, Michael Liang, Nina Ajmone Marsan, Joseph B. Selvanayagam, Fausto Pinto, Jose L. Zamorano, Philippe Pibarot, Arturo Evangelista, Jeroen J. Bax, Victoria Delgado
Summary: The aim of this study was to determine the prevalence and prognostic implications of significant mitral regurgitation (MR) in patients with bicuspid aortic valve (BAV). The study found that significant MR is uncommon in patients with BAV, and it is only associated with adverse prognosis in patients with moderate to severe aortic regurgitation.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jan Stassen, Catherina Tjahjadi, Robert Adam, Philippe Debonnaire, Mathias Claeys, Bogdan A. Popescu, Ruxandra Jurcut, Victoria Delgado, Jeroen J. Bax, Nina Ajmone Marsan
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Xavier Galloo, Maria Chiara Meucci, Jan Stassen, Marlieke F. Dietz, Edgard A. Prihadi, Pieter van der Bijl, Nina Ajmone Marsan, Jerry Braun, Jeroen J. Bax, Victoria Delgado
Summary: This study examined the changes in right ventricular dimensions and function after tricuspid valve surgery and their impact on long-term outcomes. The results showed that the degree of reverse remodeling in the right ventricle was associated with better survival rates.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Cardiac & Cardiovascular Systems
Ramesh Nadarajah, Peter Ludman, Cecile Laroche, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milasinovic, Chris P. Gale
Summary: This study examines the relationship between presentation, care, and outcomes of non-ST-segment elevation myocardial infarction (NSTEMI) and country income classification. The findings suggest that NSTEMI patients in low-income countries are younger, more likely to have diabetes and be current smokers, but have fewer comorbidities. Although the rate of invasive coronary angiography is higher in low-income countries, the overall quality of care is not as high. Low-income countries have higher rates of acute heart failure, stroke/transient ischaemic attack, in-hospital mortality, and 30-day mortality compared to high-income countries.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Joan F. Andres-Cordon, Victoria Vilalta, Xavier Millan, Abdel H. Moustafa, Eduard Fernandez-Nofrerias, Ignasi Julia, Xavier Carrillo, Victoria Delgado
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca T. Hahn, Stamatios Lerakis, Victoria Delgado, Karima Addetia, Daniel Burkhoff, Denisa Muraru, Sean Pinney, Mark K. Friedberg
Summary: Right ventricular (RV) size and function assessed by multimodality imaging are associated with outcomes in various cardiovascular diseases. Understanding RV anatomy and physiology is crucial for comprehending the strengths and weaknesses of current imaging methods and providing context for these measurements. The adaptation of the RV to different types and severities of stress, especially over time, is specific to the cardiovascular disease process. Multimodality imaging parameters, which determine outcomes, reflect the ability to image the initial and longitudinal RV response to stress. This paper reviews the standard and novel imaging methods for assessing RV function and discusses the impact of these parameters on outcomes in specific disease states.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vasileios Anastasiou, Stylianos Daios, Dimitrios Moysidis, Thomas Zegkos, Alexandros C. Liatsos, Nikolaos Stalikas, Matthaios Didagelos, Dimitrios Tsalikakis, Pantelis Sarafidis, Victoria Delgado, Christos Savopoulos, Antonios Ziakas, Vasileios Kamperidis
Summary: This study aimed to explore the ability of right ventricular global longitudinal strain (RV GLS) to predict in-hospital mortality in patients with first acute myocardial infarction (AMI). The study found that RV GLS was the only RV performance index that differed significantly between different patients, and it outperformed conventional RV function indexes in predicting in-hospital mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lauren S. Ranard, Robert O. Bonow, Rick Nishimura, Michael J. Mack, Vinod H. Thourani, Joseph Bavaria, Patrick T. O'Gara, Jeroen J. Bax, Philipp Blanke, Victoria Delgado, Jonathon Leipsic, Roberto M. Lang, Hector I. Michelena, Joao L. Cavalcante, Torsten P. Vahl, Martin B. Leon, Vera H. Rigolin
Summary: This article summarizes a global multidisciplinary workshop on the multimodality diagnostic evaluation of aortic regurgitation (AR) and the optimal timing of aortic valve intervention. Key concepts include the primary use of echocardiography for assessing AR severity, the importance of assessing left ventricular size and function in determining intervention timing, the need for further scrutiny of current intervention cutpoints for asymptomatic severe AR patients, the potential of left ventricular end-systolic volume index as an additional parameter for intervention timing, and the importance of investigating additional factors for future research.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan M. Pio, Diego Medvedofsky, Jan Stassen, Victoria Delgado, Farnaz Namazi, Neil J. Weissman, Paul Grayburn, Saibal Kar, D. Scott Lim, Zhipeng Zhou, Maria C. Alu, Bjoern Redfors, Samir Kapadia, Joann Lindenfeld, William T. Abraham, Michael J. Mack, Federico M. Asch, Gregg W. Stone, Jeroen J. Bax
Summary: Improvement in LV global longitudinal strain is associated with improved outcomes in patients with heart failure and severe mitral regurgitation, regardless of treatment with transcatheter edge-to-edge repair or medication alone, leading to reduced risk of death or hospitalization.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Tanja Rudolph, Clare Appleby, Victoria Delgado, Helene Eltchaninoff, Catherine Gebhard, Christian Hengstenberg, Wojtek Wojakowski, Nathan Petersen, Jana Kurucova, Peter Bramlage, Sabine Bleiziffer
Summary: The management of patients with severe aortic stenosis (AS) may differ according to patient age. This analysis aimed to describe patterns of aortic valve replacement (AVR) use in European countries stratified by age. The study found considerable variation in the rates of AVR use and the adoption of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (sAVR) between countries, with TAVI use increasing in recent years, particularly for older patients.
Meeting Abstract
Cardiac & Cardiovascular Systems
Hoi Wai Wu, Federico Fortuni, Steele Butcher, F. van der Kley, Rodolfo de Paula Lustosa, Catherina Tjahjadi, Arend de Weger, Victoria Delgado, Johan Wouter Jukema, Jeroen J. Bax, Nina Ajmone Marsan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rinchyenkhand Myagmardorj, Jan Stassen, Maria Chiara Meucci, Steele Butcher, Xavier Galloo, Frank Van Der Kley, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Vasileios Anastasiou, Andreas S. S. Papazoglou, Dimitrios V. V. Moysidis, Stylianos Daios, Dimitrios Tsalikakis, George Giannakoulas, Theodoros Karamitsos, Victoria Delgado, Antonios Ziakas, Vasileios Kamperidis
Summary: RV longitudinal strain is a powerful prognosticator in heart failure patients, with worsening strain associated with increased risk of all-cause mortality and the composite outcome.
HEART FAILURE REVIEWS
(2023)
Correction
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Waha, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Eustachio Agricola, Dan Foldage, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casade, Chris P. Gale
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
