期刊
ANNALS OF EPIDEMIOLOGY
卷 25, 期 1, 页码 46-54出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2014.10.011
关键词
Alcohol; Birth outcomes; Low birthweight; Preterm delivery; IUGR
资金
- National Institutes of Health [DA05484, AI41040]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041040] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA005484] Funding Source: NIH RePORTER
Purpose: To estimate whether low-to-moderate prenatal alcohol exposure is associated with selected birth outcomes. Methods: Low-to-moderate prenatal alcohol drinking and effects on low birthweight, preterm delivery, intrauterine growth restriction, and selected neonatal outcomes were evaluated among 4496 women and singleton infants. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression, controlling for confounding variables. Results: Early pregnancy drinking was associated with reduced odds of low birthweight, OR, 0.66 (95% CI, 0.46-0.96) and birth length less than 10th percentile, OR, 0.74 (95% CI, 0.56-0.97). Drinking during the first 3 months showed lower odds for birth length and head circumference less than 10th percentile, OR, 0.56 (95% CI, 036-0.87) and OR, 0.69 (95% CI, 0.50-0.96), respectively. Third trimester drinking was associated with lower odds for low birthweight, OR, 0.56 (95% CI, 0.34-0.94) and preterm delivery, OR, 0.60 (95% CI, 0.42-0.87). Conclusions: Our results suggest low-to-moderate alcohol exposure during early and late gestation is not associated with increased risk of low birthweight, preterm delivery, intrauterine growth restriction, and most selected perinatal outcomes. (C) 2015 Elsevier Inc. All rights reserved.
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