Hypoxia and Fungal Pathogenesis: To Air or Not To Air?

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter

(2012) Bridget M Barker et al.   BMC GENOMICS

Aspergillus fumigatusmitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis

(2012) Nora Grahl et al.   MOLECULAR MICROBIOLOGY

SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)

(2011) Sara J. Blosser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Local Adaptation to Soil Hypoxia Determines the Structure of an Arbuscular Mycorrhizal Fungal Community in Roots from Natural CO2Springs

(2011) Irena Maček et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sch9 Kinase Integrates Hypoxia and CO 2 Sensing To Suppress Hyphal Morphogenesis in Candida albicans

(2011) Catrin Stichternoth et al.   EUKARYOTIC CELL

Fusarium oxysporum Adh1 has dual fermentative and oxidative functions and is involved in fungal virulence in tomato plants

(2011) Alma Rosa Corrales Escobosa et al.   FUNGAL GENETICS AND BIOLOGY

Analysis of theAspergillus fumigatusProteome Reveals Metabolic Changes and the Activation of the Pseurotin A Biosynthesis Gene Cluster in Response to Hypoxia

(2011) Martin Vödisch et al.   JOURNAL OF PROTEOME RESEARCH

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

(2011) Michael Blatzer et al.   PLoS Genetics

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

(2011) Xizhi Feng et al.   PLoS Pathogens

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

(2011) Nora Grahl et al.   PLoS Pathogens

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

(2010) Oumaïma Ibrahim-Granet et al.   BMC MICROBIOLOGY

Regulation of the Hypoxic Response in Candida albicans

(2010) John M. Synnott et al.   EUKARYOTIC CELL

Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis

(2010) Clara M. Bien et al.   EUKARYOTIC CELL

The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albicans

(2010) Wei Liu et al.   FEMS YEAST RESEARCH

Candida albicans- a pre-whole genome duplication yeast - is predominantly aerobic and a poor ethanol producer

(2010) Elżbieta Rozpȩdowska et al.   FEMS YEAST RESEARCH

Ergosterol Regulates Sterol Regulatory Element Binding Protein (SREBP) Cleavage in Fission Yeast

(2010) Joshua R. Porter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?

(2010) Nora Grahl et al.   MEDICAL MYCOLOGY

Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia

(2010) Shunsuke Masuo et al.   MOLECULAR GENETICS AND GENOMICS

The iron-responsive, GATA-type transcription factor cir1 influences mating in Cryptococcus neoformans

(2010) Won Hee Jung et al.   MOLECULES AND CELLS

Genetic control of Candida albicans biofilm development

(2010) Jonathan S. Finkel et al.   NATURE REVIEWS MICROBIOLOGY

Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

(2010) Nadine Werth et al.   PLoS One

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans

(2010) Won Hee Jung et al.   PLoS Pathogens

Mitochondria and Hypoxic Signaling

(2009) Robert O. Poyton et al.   Annals of the New York Academy of Sciences

Hypoxic Adaptation by Efg1 Regulates Biofilm Formation by Candida albicans

(2009) C. Stichternoth et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites

(2009) R. Ben-Ami et al.   BLOOD

Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance inCryptococcus neoformans

(2009) Yun C. Chang et al.   EUKARYOTIC CELL

Correlation between Biofilm Formation and the Hypoxic Response inCandida parapsilosis

(2009) Tristan Rossignol et al.   EUKARYOTIC CELL

Cryptococcus neoformansSite-2 protease is required for virulence and survival in the presence of azole drugs

(2009) Clara M. Bien et al.   MOLECULAR MICROBIOLOGY

Is it possible to predict which patients with mild pneumonias will develop hypoxemia?

(2009) Francisco Sanz et al.   RESPIRATORY MEDICINE

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Biofilm Matrix Regulation by Candida albicans Zap1

(2009) Clarissa J. Nobile et al.   PLOS BIOLOGY

Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans

(2009) Christopher Askew et al.   PLoS Pathogens

Susceptibility Testing of Anidulafungin and Voriconazole Alone and in Combination against Conidia and Hyphae of Aspergillus spp. under Hypoxic Conditions

(2008) S. Perkhofer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bioluminescent Aspergillus fumigatus, a New Tool for Drug Efficiency Testing and In Vivo Monitoring of Invasive Aspergillosis

(2008) M. Brock et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Responses to hypoxia in fungal pathogens

(2008) Joachim F. Ernst et al.   CELLULAR MICROBIOLOGY

Hypoxia-Independent Activation of HIF-1 by Enterobacteriaceae and Their Siderophores

(2008) Hanna Hartmann et al.   GASTROENTEROLOGY

Pharmacologic Augmentation of Hypoxia‐Inducible Factor–1α with Mimosine Boosts the Bactericidal Capacity of Phagocytes

(2008) Annelies S. Zinkernagel et al.   JOURNAL OF INFECTIOUS DISEASES

Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions

(2008) Grazyna J. Sosinska et al.   MICROBIOLOGY-SGM

Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms

(2008) S. J. Hoot et al.   MICROBIOLOGY-SGM

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions

(2008) Motoyuki Shimizu et al.   PROTEOMICS

Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride

(2008) Susham S. Ingavale et al.   PLoS Pathogens

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens

Mechanisms of tissue hypercarbia in sepsis

(2007) Arnaldo Dubin   Frontiers in Bioscience-Landmark

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans

(2003) Ekkehard Leberer et al.   MOLECULAR MICROBIOLOGY