Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Microbiology
Farha Husain, Prerna Pathak, Elvira Roman, Jesus Pla, Sneh Lata Panwar
Summary: C. albicans utilizes the HOG MAPK pathway to alleviate ER stress and attenuate the Ire1-dependent UPR activity. This study integrates the HOG pathway into the less characterized frame of ER stress adaptation pathways in C. albicans.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Shumei Kato, Robert Porter, Ryosuke Okamura, Suzanna Lee, Ori Zelichov, Gabi Tarcic, Michael Vidne, Razelle Kurzrock
Summary: The study found that patients with tumors harboring RAS alterations with high MAPK activity had significantly longer median progression-free survival (PFS) and overall survival when treated with MEK inhibitors. This correlation between RAS-mutant cancers with greater MAPK signaling and PFS suggests potential clinical benefit of MEK inhibitor treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Plant Sciences
Chuang Cheng, Qiqi Wu, Mei Wang, Donghua Chen, Jie Li, Jianlin Shen, Shuguo Hou, Pengcheng Zhang, Li Qin, Biswa R. Acharya, Xiaoduo Lu, Wei Zhang
Summary: High temperature induces stomatal opening, but uncontrolled stomatal opening is dangerous for plants. We identified a high-temperature sensitive mutant in maize linked to a single base change in ZmMPK20 gene. The mutant exhibited increased stomatal opening and water loss rate, as well as decreased thermotolerance. Overexpression of ZmMPK20 decreased stomatal apertures, water loss rate, and enhanced plant thermotolerance.
Article
Plant Sciences
Zahra Ayatollahi, Vaiva Kazanaviciute, Volodymyr Shubchynskyy, Kotryna Kvederaviciute, Manfred Schwanninger, Wilfried Rozhon, Michael Stumpe, Felix Mauch, Sebastian Bartels, Roman Ulm, Salma Balazadeh, Bernd Mueller-Roeber, Irute Meskiene, Alois Schweighofer
Summary: This study reveals the crucial role of different types of MAPK phosphatases in plant stress responses and the tight control of MAPK activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Fisheries
Yuanlan Wu, Xuelin Zhao, Yangxi Xiang, Ming Guo, Chenghua Li
Summary: In this study, the echinoderm MAPK family was identified and analyzed, revealing insights into its evolutionary history and immune function.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Allergy
Johanna Theodorou, Elisabeth Nowak, Andreas Boeck, Michael Salvermoser, Claudia Beerweiler, Kathrin Zeber, Paulina Kulig, Miranda S. Tsang, Chun-Kwok Wong, Gary W. K. Wong, Marjut Roponen, Joerg Kumbrink, Fahd Alhamdan, Florian Michel, Holger Garn, Vinko Tosevski, Bianca Schaub, Omer Kalayci
Summary: The study found that children with asthma have lower levels of DUSP1, but after exposure to farm dust stimulation, their DUSP1 expression is upregulated, and inflammatory MAPK is downregulated at the gene and protein level. The farm environment regulates inflammatory MAPK in various immune cell types, contributing to anti-inflammatory characteristics.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Ester Diaz-Mora, Diego Gonzalez-Romero, Marta Meireles-da-Silva, Juan Jose Sanz-Ezquerro, Ana Cuenda
Summary: Mitogen- and Stress-activated Kinase (MSK) 1 is a nuclear protein that modulates the production of certain cytokines in macrophages, and it is activated by p38 alpha Mitogen-Activated Kinase (MAPK) and extracellular signal-regulated kinase (ERK1/2). Our study shows that p38 delta, another p38MAPK, is also involved in the phosphorylation and activation of MSK in LPS-stimulated macrophages. The activation of MSK by p38 delta is crucial for the expression of various inflammatory molecules involved in immune innate response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mengmeng Zhang, Shuqun Zhang
Summary: This review provides a historic and recent understanding of the role of mitogen-activated protein kinase (MAPK) cascades in plant immunity, response to environmental stresses, and normal growth and development. The signaling specificity of MAPKs in plants is an interesting topic of research and is influenced by factors such as activation kinetics, spatial and temporal expression patterns, and functional characterization of MAPK substrates.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Plant Sciences
Ye Chen, Lin Chen, Xiaomeng Sun, Shuang Kou, Tiantian Liu, Jianke Dong, Wei Tu, Yiling Zhang, Botao Song
Summary: The study identified key genes in the MAPK pathway of both S. acaule and S. tuberosum through comparative genomics analysis, showing increased expression of SaMKK2 and SaMAPK16 in cold-tolerant S. acaule. The interaction between SaMKK2 and SaMAPK4/7 may positively promote cold resistance in potato.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Oncology
Tomohiko Ishikawa, Shinichi Fukushige, Yuriko Saiki, Katsuya Hirose, Takako Hiyoshi, Takenori Ogawa, Yukio Katori, Toru Furukawa
Summary: Long non-coding RNAs (lncRNAs) play important roles in various cancers, including pancreatic cancer. However, the mechanisms of their aberrant expression in cancer remain largely unknown. In this study, we found that MAPK regulates the expression of lncRNAs in pancreatic cancer, with LINC00941 being consistently upregulated by MAPK. High expression of LINC00941 was associated with poor prognosis in pancreatic cancer patients. Additionally, LINC00941 was involved in multiple biological processes. These findings suggest that MAPK-associated lncRNAs may serve as potential therapeutic targets and diagnostic biomarkers for pancreatic cancer.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Plant Sciences
Yuzhen Li, Shimiao Hui, Yaxin Yuan, Yahong Ye, Xiaohan Ma, Xiaolu Zhang, Shasha Zhang, Chunguang Zhang, Yuling Chen
Summary: Red light promotes the phosphorylation of MKK2-MPK2 cascade in guard cells, which is essential for stomatal opening. Phytochrome B (phyB) plays a positive role in mediating red light-induced stomatal opening, but the mechanism is poorly understood. Our study reveals that MKK2 and MPK2 are sequentially phosphorylated by phyB in response to red light, and this phosphorylation is necessary for stomatal opening.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Nana Liu, Ge Liu, Haihong Jiang, Jing Yu, Yunqin Jin, Hong Wang
Summary: The role of ferroptosis in human acute lymphoblastic leukemia and its molecular mechanisms of action were investigated in this study. Erastin was used to inhibit the growth of Molt-4 cells, and the effects were partially reversed by ferroptosis inhibitor Ferrostatin-1 and p38 MAPK inhibitor. Erastin treatment caused mitochondrial alterations, increased reactive oxygen species and malondialdehyde levels, decreased glutathione levels, decreased SLC7A11 and GPX4 mRNA levels, and increased p38 MAPK, ERK, and c-Jun N-terminal kinase expression levels in Molt-4 cells. These findings suggest that erastin-induced ferroptosis in Molt-4 cells is associated with inhibition of the cystine/glutamate antiporter system and GPX4, as well as activation of p38 MAPK and ERK1/2.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Phillip A. Dumesic, Magnus A. Rosenblad, Tore Samuelsson, Tiffany Nguyen, James J. Moresco, John R. Yates, Hiten D. Madhani
NUCLEIC ACIDS RESEARCH
(2015)
Article
Multidisciplinary Sciences
Christopher A. Desjardins, Neil D. Sanscrainte, Jonathan M. Goldberg, David Heiman, Sarah Young, Qiandong Zeng, Hiten D. Madhani, James J. Becnel, Christina A. Cuomo
NATURE COMMUNICATIONS
(2015)
Article
Microbiology
Christina M. Homer, Diana K. Summers, Alexi I. Goranov, Starlynn C. Clarke, Darin L. Wiesner, Jolene K. Diedrich, James J. Moresco, Dena Toffaletti, Rajendra Upadhya, Ippolito Caradonna, Sarah Petnic, Veronica Pessino, Christina A. Cuomo, Jennifer K. Lodge, John Perfect, John R. Yates, Kirsten Nielsen, Charles S. Craik, Hiten D. Madhani
CELL HOST & MICROBE
(2016)
Article
Biochemistry & Molecular Biology
Maki Inada, Robert J. Nichols, Jahan-Yar Parsa, Christina M. Homer, Ruby A. Benn, Reyal S. Hoxie, Hiten D. Madhani, Stewart Shuman, Beate Schwer, Jeffrey A. Pleiss
NUCLEIC ACIDS RESEARCH
(2016)
Article
Microbiology
Starlynn C. Clarke, Phillip A. Dumesic, Christina M. Homer, Anthony J. O'Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D. Madhani, Charles S. Craik
Article
Cell Biology
Jahan-Yar Parsa, Selim Boudoukha, Jordan Burke, Christina Homer, Hiten D. Madhani
GENES & DEVELOPMENT
(2018)
Article
Multidisciplinary Sciences
Bassem Al-Sady, Rachel A. Greenstein, Hana J. El-Samad, Sigurd Braun, Hiten D. Madhani
Article
Biochemistry & Molecular Biology
Cedric A. Brimacombe, Jordan E. Burke, Jahan-Yar Parsa, Sandra Catania, Teresa R. O'Meara, Jessica N. Witchley, Laura S. Burrack, Hiten D. Madhani, Suzanne M. Noble
Article
Biochemistry & Molecular Biology
Edward W. J. Wallace, Corinne Maufrais, Jade Sales-Lee, Laura R. Tuck, Luciana de Oliveira, Frank Feuerbach, Frederique Moyrand, Prashanthi Natarajan, Hiten D. Madhani, Guilhem Janbon
NUCLEIC ACIDS RESEARCH
(2020)
Article
Genetics & Heredity
Diana K. Summers, Joseph Heitman, Daniela S. Perry, Beiduo Rao, Hiten D. Madhani
Article
Biochemistry & Molecular Biology
Jade Sales-Lee, Daniela S. Perry, Bradley A. Bowser, Jolene K. Diedrich, Beiduo Rao, Irene Beusch, John R. Yates, Scott W. Roy, Hiten D. Madhani
Summary: The study identified that certain conserved spliceosomal proteins affect splicing efficiency and suppress splice errors in intron-rich fungi, potentially through kinetic proofreading mechanisms, facilitating greater intron diversity.
Article
Biochemistry & Molecular Biology
Juncheng Wang, Sandra Catania, Chongyuan Wang, M. Jason de la Cruz, Beiduo Rao, Hiten D. Madhani, Dinshaw J. Patel
Summary: Epigenetic evolution in Cryptococcus neoformans is mediated by DNMT5, a maintenance type cytosine methyltransferase. The study reveals the mechanism of DNMT5 in achieving high fidelity methylation reaction through specific structural changes and ATP binding.
Article
Genetics & Heredity
Manning Y. Huang, Meenakshi B. Joshi, Michael J. Boucher, Sujin Lee, Liza C. Loza, Elizabeth A. Gaylord, Tamara L. Doering, Hiten D. Madhani
Summary: The study explores the use of CRISPR-Cas9 for genome editing in Cryptococcus neoformans, optimizing CnoCAS9 for efficient editing and simplifying donor design to enhance transformation efficiency without compromising virulence. A universal tagging module for protein localization and purification studies was also introduced.
Editorial Material
Microbiology
Manning Y. Huang, Hiten D. Madhani
Summary: Identification and analysis of mutator strains in the human fungal pathogen Cryptococcus neoformans show that natural loss of RNA interference triggers massive accumulation of Cnl1 retroelements at subtelomeric regions.
NATURE MICROBIOLOGY
(2022)
Biographical-Item
Biochemistry & Molecular Biology
David A. Brow, Hiten D. Madhani