Oligomers of α-synuclein: picking the culprit in the line-up

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

(2013) Nikolai Lorenzen et al.   FEBS LETTERS

Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching

(2012) Niels Zijlstra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Oligomers: an Amyloid Pore?

(2012) Martin T. Stöckl et al.   MOLECULAR NEUROBIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

(2010) Benedetta Bolognesi et al.   ACS Chemical Biology

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

(2010) Lise Giehm et al.   ANALYTICAL BIOCHEMISTRY

Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

(2010) Marta Robotta et al.   CHEMPHYSCHEM

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

(2010) Bart D. van Rooijen et al.   PLoS One

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core

(2009) Bart D. van Rooijen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tryptophan Fluorescence Reveals Structural Features of α-Synuclein Oligomers

(2009) B.D. van Rooijen et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane binding of oligomeric α-synuclein depends on bilayer charge and packing

(2008) Bart D. van Rooijen et al.   FEBS LETTERS

Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein

(2008) Dong-Pyo Hong et al.   JOURNAL OF MOLECULAR BIOLOGY