期刊
EQUINE VETERINARY JOURNAL
卷 47, 期 3, 页码 291-295出版社
WILEY
DOI: 10.1111/evj.12286
关键词
horse; clinical signs; lower airway disease; lung function; histamine; airway hyperresponsiveness
资金
- ISME Equine Research Group
- Swiss National Science Foundation [310030-138295, 310030-129837/1]
- Swiss National Science Foundation (SNF) [310030_129837, 310030_138295] Funding Source: Swiss National Science Foundation (SNF)
Reasons for performing studyIn clinical practice, veterinarians often depend on owner-reported signs to assess the clinical course of horses with recurrent airway obstruction (RAO). ObjectivesTo test whether owner-reported information on frequency of coughing and observation of nasal discharge are associated with clinical, cytological and bronchoprovocation findings in RAO-affected horses in nonstandardised field conditions. Study designCross-sectional study comparing healthy and RAO-affected horses. MethodsTwenty-eight healthy and 34 RAO-affected Swiss Warmblood horses were grouped according to owner-reported coughing frequency' and nasal discharge'. Differences between these groups were examined using clinical examination, blood gas analyses, endoscopic mucus scores, cytology of tracheobronchial secretion and bronchoalveolar lavage fluid, and airway hyperresponsiveness determined by plethysmography with histamine bronchoprovocation. ResultsFrequently coughing horses differed most markedly from healthy control animals. Histamine bronchoprovocation-derived parameters were significantly different between the healthy control group and all RAO groups. Mucus grades and tracheobronchial secretion and bronchoalveolar lavage fluid neutrophil percentages had particularly high variability, with overlap of findings between groups. Owner satisfaction with the clinical status of the horse was high, even in severely affected horses. ConclusionsOwner-reported coughing and nasal discharge are associated with specific clinical and diagnostic findings in RAO-affected horses in field settings. While airway hyperresponsiveness differentiates best between healthy horses and asymptomatic RAO-affected horses, the absence of coughing and nasal discharge does not rule out significant neutrophilic airway inflammation. Owner satisfaction with the clinical status of the horse was uninformative.
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