期刊
EQUINE VETERINARY JOURNAL
卷 44, 期 1, 页码 107-111出版社
WILEY-BLACKWELL
DOI: 10.1111/j.2042-3306.2011.00390.x
关键词
horse; bovine papillomavirus; sarcoid; vaccine; virus-like particles
资金
- AVIR Green Hills Biotechnology, Vienna
- Centre for Innovation and Technology of the City of Vienna (ZIT), Austria
Reasons for performing study: Infection with bovine papillomaviruses types 1 and 2 (BPV-1, BPV-2) can lead to the development of therapy-resistant skin tumours termed sarcoids and possibly other skin diseases in equids. Although sarcoids seriously compromise the welfare of affected animals and cause considerable economic losses, no prophylactic vaccine is available to prevent this common disease. In several animal species and man, immunisation with papillomavirus-like particles (VLP) has been shown to protect efficiently from papillomaviral infection.
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