Article
Cardiac & Cardiovascular Systems
Tobias Zimmermann, Jeanne du Fay de Lavallaz, Joan Elias Walter, Ivo Strebel, Thomas Nestelberger, Lydia Joray, Patrick Badertscher, Dayana Flores, Velina Widmer, Nicolas Geigy, Oscar Miro, Emilio Salgado, Michael Christ, Louise Cullen, Martin Than, Francisco Javier Martin-Sanchez, Salvatore Di Somma, W. Frank Peacock, Dagmar Keller, Juan Pablo Costabel, Desiree Nadine Wussler, Damian Kawecki, Jens Lohrmann, Danielle Menosi Gualandro, Michael Kuehne, Tobias Reichlin, Benjamin Sun, Christian Mueller
Summary: In patients aged 40 years and older with syncope, a combination of seven ECG criteria enables rapid assessment of the likelihood that syncope was due to a cardiac cause. The study found that heart rate, QTc-interval, rhythm, atrioventricular block, ST-segment depression, bundle branch block, and ventricular extrasystole/non-sustained ventricular tachycardia were significant predictors for identifying a cardiac cause of syncope.
Review
Cardiac & Cardiovascular Systems
Vivetha Pooranachandran, Will Nicolson, Zakariyya Vali, Xin Li, G. Andre Ng
Summary: Dilated cardiomyopathy is a common and challenging cardiac disease, with current risk stratification mainly relying on left ventricular ejection fraction and New York Heart Association class. However, these markers have limitations, and exploring new imaging, electrophysiological, and genetic risk markers is crucial for improving patient identification and treatment effectiveness in DCM.
Article
Medicine, General & Internal
Hyun Jin Lee, A. Reum Choe, HaeJu Lee, Dong Ryeol Ryu, Ea Wha Kang, Jung Tak Park, Su Hwan Lee, Junbeom Park
Summary: The rate of sudden cardiac death is significantly higher in hemodialysis patients, with QTpe interval and ECG parameters being potential predictors for predicting SCD risk in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Carlo Mannina, Zhezhen Jin, Kenji Matsumoto, Kazato Ito, Angelo Biviano, Mitchell S. V. Elkind, Tatjana Rundek, Shunichi Homma, Ralph L. Sacco, Marco R. Di Tullio
Summary: In a study on subclinical atrial fibrillation and risk of ischemic stroke, it was found that elderly individuals have a higher frequency of other arrhythmias, with men and hypertensive patients more prone to certain arrhythmias, and differences in arrhythmia frequencies among ethnic groups such as whites, Blacks, and Hispanics.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Tsai-Min Chen, Yuan-Hong Tsai, Huan-Hsin Tseng, Kai-Chun Liu, Jhih-Yu Chen, Chih-Han Huang, Guo-Yuan Li, Chun-Yen Shen, Yu Tsao
Summary: A smart health care system has been developed using cloud-based deep learning algorithms and portable/wearable devices for automatic cardiac arrhythmias classification. A DL-based ECG signal super-resolution framework (SRECG) has been proposed to enhance low-resolution ECG signals through joint consideration of accuracy for high-resolution multiclass classification. Experimental results demonstrate significant improvement in classification accuracies using SRECG compared to traditional interpolation methods.
IEEE TRANSACTIONS ON CONSUMER ELECTRONICS
(2023)
Article
Agriculture, Dairy & Animal Science
Indre Poskiene, Renata Gruodyte, Jurgita Autukaite, Vida Juozaitiene, Ramunas Antanaitis
Summary: The study found significant changes in blood parameters of Arabian horses during endurance races, with faster speeds. The FEI considers equestrian endurance racing as the second largest discipline in the world. Arabian horses are recognized as the leading breed in endurance competitions with significant differences in muscle tissue structure.
Article
Cardiac & Cardiovascular Systems
Hikaru Hagiwara, Masaya Watanabe, Takahide Kadosaka, Takuya Koizumi, Yuta Kobayashi, Taro Koya, Motoki Nakao, Satonori Tsuneta, Yoshiya Kato, Hirokazu Komoriyama, Rui Kamada, Toshiyuki Nagai, Kohsuke Kudo, Toshihisa Anzai
Summary: This study aimed to investigate the association between fragmented QRS (fQRS) and clinical outcomes in patients with cardiac sarcoidosis (CS). The results showed that patients with fQRS had a higher risk of adverse events, particularly late-onset ventricular tachyarrhythmias (VTs). Therefore, fQRS may serve as an independent predictor of adverse events in CS patients.
Article
Pharmacology & Pharmacy
Jason Kho, Adam Ioannou, Amit K. J. Mandal, Constantinos G. Missouris
Summary: Acetylcholinesterase inhibitors like donepezil delay the progression of Alzheimer's dementia by increasing acetylcholine concentrations in the central nervous system. However, these inhibitors may also have effects outside of the brain, leading to peripheral cholinergic side effects and adverse cardiac arrhythmias like Torsades de Pointes which are reversible upon discontinuation of the medication. Increased acetylcholine concentrations and I-Kr inhibition in cardiomyocytes caused by donepezil are thought to be responsible for these effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fiorenzo Gaita, Natascia Cerrato, Carla Giustetto, Annamaria Martino, Laura Bergamasco, Michele Millesimo, Lorella Barbonaglia, Paula Carvalho, Domenico Caponi, Andrea Saglietto, Giacomo Bonacchi, Francesca Bianchi, Elisa Silvetti, Cinzia Crescenzi, Stefano Canestrelli, Melissa De Maio, Gaetano Maria De Ferrari, Giuseppe Musumeci, Francesco Rametta, Marco Scaglione, Leonardo Calo
Summary: The study evaluated the long-term prognosis of a large cohort of asymptomatic patients with Brugada ECG pattern. The entire population of asymptomatic patients with BrECG exhibited a relatively low event rate per year, with those having spontaneous type-1 BrECG and positive EPS showing higher risk. Asymptomatic patients with drug-induced-only BrECG had minimal arrhythmic risk, but ongoing follow-up was recommended to detect the appearance of spontaneous type-1 BrECG pattern.
Article
Rheumatology
May Y. Choi, Brittany Weber, Emma Stevens, Hongshu Guan, Jack Ellrodt, Emily Oakes, Marcelo Di Carli, Usha Tedrow, William Sauer, Karen H. Costenbader
Summary: This study examined the frequency of ECG testing among new HCQ/CQ users and found that a significant proportion of female patients developed prolonged QTc during follow-up. Prospective studies are needed to guide the management of HCQ/CQ therapy in patients with rheumatic diseases.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Guido Mandilaras, Pengzhu Li, Robert Dalla-Pozza, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
Summary: This study aimed to investigate the acute cardiovascular effects of energy drinks on healthy children and teenagers. The results showed that energy drinks increased the number of supraventricular extrasystoles, decreased heart rate, but had no effect on QTc intervals. This trial demonstrated the cardiovascular and rhythmological effects of energy drinks in minors for the first time, showing potential adverse effects on heart rhythm.
Review
Medicine, General & Internal
Mario Bo, Attilio del Rosso
Summary: Suspected transient loss of consciousness and syncope are common causes of hospitalization in older patients, with arrhythmias being the most common cardiac cause. A 12-lead electrocardiogram (ECG) is the recommended instrumental test for initial evaluation. This paper reviews the current literature on ECG diagnostic criteria and findings for cardiac syncope, highlighting its importance in identifying patients with high likelihood of arrhythmic syncope.
Article
Cardiac & Cardiovascular Systems
Clara Damascene Makatu, Reuben Kato Mutagaywa, Ponsian Peter, Aileen Barongo, Engerasiya Kifai
Summary: This study aimed to determine the prevalence, clinical characteristics, and echocardiographic parameters of arrhythmias among patients with rheumatic heart disease (RHD) attending JKCI. The study found a high prevalence of arrhythmias among RHD patients, with independent predictors including left atrium dilatation and NYHA functional class III-IV.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Chemistry, Analytical
Radek Martinek, Martina Ladrova, Michaela Sidikova, Rene Jaros, Khosrow Behbehani, Radana Kahankova, Aleksandra Kawala-Sterniuk
Summary: This paper provides an extensive literature review of digital signal processing methods for cardiac bioelectrical signals commonly used in clinical practice, covering the definition of bioelectrical signals and various approaches to reducing noise contamination, such as digital adaptive and non-adaptive filtering, signal decomposition methods based on blind source separation, and wavelet transform.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Morten S. Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to characterize the onset and progression of subclinical atrial fibrillation (AF) by analyzing 12-lead electrocardiogram (ECG) parameters. The results showed that P-wave duration (PWD) and interatrial block (IAB) were strongly associated with the onset, burden, and progression of AF.
Article
Veterinary Sciences
Eva Hesselkilde, Dominik Linz, Arnela Saljic, Helena Carstensen, Rayed Kutieleh, Thomas Jespersen, Prashanthan Sanders, Rikke Buhl
Summary: The study describes the use of high-density three-dimensional electroanatomical mapping in standing horses to provide detailed information about activation patterns and electrogram characteristics in the right atrium.
EQUINE VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Rikke Buhl, Eva M. Hesselkilde, Helena Carstensen, Merle F. Fenner, Thomas Jespersen, Jacob Tfelt-Hansen, Stefan Michael Sattler
Summary: This study tested the ability of ILRs to detect atrial fibrillation in horses and found that signal quality varied depending on the implant site, with the sixth intercostal space on the left side being the best position. Despite insufficient signal quality during exercise, ILRs were suitable for AF detection in horses at rest.
EQUINE VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Rikke Buhl, Sarah D. Nissen, Marie L. K. Winther, Sofie K. Poulsen, Charlotte Hopster-Iversen, Thomas Jespersen, Prashanthan Sanders, Helena Carstensen, Eva M. Hesselkilde
Summary: Limited information is available on paroxysmal atrial fibrillation (PAF) in horses. However, implanting a small ECG device (implantable loop recorder, ILR) subcutaneously allows the continuous and automatic detection of PAF, showing potential as a useful tool for diagnosing PAF in horses with poor performance. The study found that ILRs were able to detect PAF episodes and could facilitate long-term assessment of AF development in horses, although further studies are needed to learn more about PAF prevalence in racehorses.
EQUINE VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Ditte Marie Top Adler, Klaus Hopster, Charlotte Hopster-Iversen, Merle Fenner, Rikke Buhl, Stine Jacobsen
Summary: The study aimed to develop an experimental surgical procedure providing access to the entire circumference of the heart in horses and investigate the effect of thoracotomy on pulmonary gas exchange. Results showed a significant decrease in arterial oxygen partial pressure during the procedure, but arterial carbon dioxide levels remained within normal limits.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Eva M. Hesselkilde, Jonas L. Isaksen, Bettina V. Petersen, Helena Carstensen, Thomas Jespersen, Steen Pehrson, Jorgen K. Kanters, Rikke Buhl
Summary: An improved method for obtaining 12-lead ECGs in horses, the Copenhagen method, was developed based on electrophysiology and cardiac electrical vectors. Repositioning the limb electrodes to the thorax significantly decreased variation in the mean electrical axis, resulting in stable and repeatable ECG configurations. The Copenhagen method provided more consistent and reliable ECG recordings compared to existing guidelines, potentially allowing for expanded use of 12-lead ECGs in equine medicine.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
G. Van Steenkiste, J. Carlson, A. Decloedt, L. Vera, R. Buhl, P. G. Platonov, G. van Loon
Summary: The study compared atrial fibrillatory rate derived from a local right atrial intracardiac recording and a single-lead surface electrocardiogram during atrial fibrillation in horses. The results showed a moderate correlation between the two methods, but neither could predict the minimal defibrillation threshold for transvenous electrical cardioversion (TVEC).
JOURNAL OF VETERINARY CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Arnela Saljic, Thomas Jespersen, Rikke Buhl
Summary: Atrial fibrillation is becoming a serious health problem in the aging population. Animal models, particularly large animals like pigs, goats, dogs, and horses, are important tools in understanding the mechanisms of AF and testing new pharmacological interventions. This review focuses on anti-arrhythmic investigations in large animals, discussing commonly used methods for inducing AF and exploring potential new AF medication candidates.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Annelies Decloedt, Glenn Van Steenkiste, Lisse Vera, Rikke Buhl, Gunther van Loon
Summary: For horses with severe atrial fibrillation, cardioversion should be avoided to prevent recurrence, while pharmacological cardioversion has a success rate of around 80%; electrical cardioversion has a success rate above 95%, but recurrence rate can be up to 39%. It is important to consider risk factors for recurrence such as long AF duration, large atrial size, etc.
VETERINARY JOURNAL
(2021)
Article
Physiology
Merle Friederike Fenner, Giulia Gatta, Stefan Sattler, Marion Kuiper, Eva Melis Hesselkilde, Ditte M. T. Adler, Morten Smerup, Ulrich Schotten, Ulrik Sorensen, Jonas Goldin Diness, Thomas Jespersen, Sander Verheule, Arne Van Hunnik, Rikke Buhl
Summary: The study revealed that NS8593 had divergent effects on the right and left atrium in horses with persistent atrial fibrillation, leading to an increase in AF complexity in the right atrium but no significant change in the left atrium. Despite prolonging the AF cycle length, NS8593 was not sufficient to induce cardioversion.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pietro Mesirca, Shu Nakao, Sarah Dalgas Nissen, Gabriella Forte, Cali Anderson, Tariq Trussell, Jue Li, Charlotte Cox, Min Zi, Sunil Logantha, Sana Yaar, Helena Cartensen, Isabelle Bidaud, Luke Stuart, Luca Soattin, Gwilym M. Morris, Paula A. da Costa Martins, Elizabeth J. Cartwright, Delvac Oceandy, Matteo E. Mangoni, Thomas Jespersen, Rikke Buhl, Halina Dobrzynski, Mark R. Boyett, Alicia D'Souza
Summary: The study found that atrioventricular block in athletes is mainly caused by electrical remodeling. Trained animals and mice showed atrioventricular node dysfunction, characterized by prolonged PR intervals and reduced expression of key ion channels. miRNAs such as miR-211-5p and miR-432 were identified as direct regulators of Ca(V)1.2 and HCN4.
CIRCULATION RESEARCH
(2021)
Article
Veterinary Sciences
Rikke Buhl, Eva M. Hesselkilde, Helena Carstensen, Charlotte Hopster-Iversen, Gunther van Loon, Annelies Decloedt, Glenn van Steenkiste, Celia M. Marr, Virginia B. Reef, Colin C. Schwarzwald, Katharyn J. Mitchell, Katarina Nostell, Nora Nogradi, Soren S. Nielsen, Jonas Carlson, Pyotr G. Platonov
Summary: This study demonstrates that high atrial fibrillatory rate (AFR) is associated with the failure of quinidine cardioversion and recurrence of atrial fibrillation (AF) after successful electrical cardioversion. AFR, as a noninvasive marker obtained from surface ECG, can be clinically useful in predicting the probability of response to quinidine treatment and maintaining sinus rhythm (SR).
EQUINE VETERINARY JOURNAL
(2022)
Article
Veterinary Sciences
Sarah D. Nissen, Rikke Weis, Elisabeth K. Krag-Andersen, Eva M. Hesselkilde, Jonas L. Isaksen, Helena Carstensen, Jorgen K. Kanters, Dominik Linz, Prashanthan Sanders, Charlotte Hopster-Iversen, Thomas Jespersen, Steen Pehrson, Rikke Buhl
Summary: This study assessed the effect of training on cardiac conduction in Standardbred racehorses. The results showed that trained horses had lower heart rates and increased frequency of second-degree atrioventricular block.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Sofie Troest Kjeldsen, Sarah Dalgas Nissen, Rikke Buhl, Charlotte Hopster-Iversen
Summary: Paroxysmal atrial fibrillation is a common cardiac arrhythmia in horses that can lead to poor performance. The pathophysiology, diagnostic tools, and treatment methods are similar to those in humans. Early diagnosis is crucial for the treatment and prevention of permanent atrial fibrillation.
Article
Agriculture, Dairy & Animal Science
Rikke Weis, Helena Carstensen, Stefan M. Sattler, Rikke Buhl, Eva M. Hesselkilde
Summary: This study aimed to investigate the ECG changes seen with a 12-lead ECG in a horse with induced myocardial infarction. The results suggest that a 12-lead ECG can potentially be used to detect signs of myocardial infarction in horses and elucidate certain translational connections between human and veterinary medicine. During acute myocardial infarction, the ischemia and necrosis of the infarcted tissue result in local electrophysiological changes, leading to deviations of the ST segment and T wave.
Article
Agriculture, Dairy & Animal Science
Sarah Dalgas Nissen, Arnela Saljic, Sofie Troest Kjeldsen, Thomas Jespersen, Charlotte Hopster-Iversen, Rikke Buhl
Summary: Second-degree atrioventricular (AV) block is a common cardiac arrhythmia in horses, and it can lead to syncope and collapse. The diagnosis and identification of the cause of this condition are difficult. In this report, a horse with a high burden of second-degree AV blocks and multiple collapses was examined. Various tests did not reveal any underlying cardiovascular disease, but an abnormality was found in the AV nodal region. The implantable loop recorder detected consecutive AV blocks and pauses. However, the exact cause of the collapses remains uncertain.