Article
Veterinary Sciences
Natasha E. Lean, Samantha H. Franklin, Cate Steel, Lucy Woolford, Jason White, Benjamin J. Ahern
Summary: This study compared the histological and immunohistochemical characteristics of the left recurrent laryngeal nerve (Lrln) and left cricoarytenoideus dorsalis (LCAD) muscle between domestic and feral horses. The results showed evidence of nerve regeneration suggesting recurrent laryngeal neuropathy (RLN) in the domestic population, but the higher proportion of type IIX muscle fibers in the feral population did not support RLN. Further investigation is needed to clarify the significance and wider occurrence of these differences.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Catherine M. Steel, Elizabeth A. Walmsley, Garry A. Anderson, Chantal A. Coles, Benjamin Ahern, Jason D. White
Summary: This study found that horses clinically affected with RLN exhibit significant fibre-type grouping and decreased fibre diameter in the L-CAD muscle, with expression of embryonic myosin indicating regenerative capacity. Despite some remaining fibres showing hypertrophy, there is an overall atrophy of fibres, loss of IIX fibres, and depletion of type IIX fibres in affected horses.
EQUINE VETERINARY JOURNAL
(2021)
Article
Clinical Neurology
Hans Baertsch, David J. Cvancara, Randal C. Paniello, Allen D. Hillel, Neel K. Bhatt
Summary: This study aimed to explore the feasibility of performing recurrent laryngeal motor nerve conduction studies (rlMNCS) in a rat model. The results showed that rlMNCS are feasible in understanding laryngeal neurophysiology and could provide a potential animal model for studying neuromuscular conditions affecting voice, breathing, and swallowing.
Article
Medicine, Research & Experimental
Michael S. Benninger, Brooke A. Quinton, William S. Tierney, Victoria L. Gau, Rebecca C. Nelson, Candace M. Hrelec, Paul C. Bryson
Summary: This study investigated the effect of superior laryngeal nerve (SLN) block in patients with non-cough complaints relating to the larynx. The results showed that most patients experienced some degree of improvement in their symptoms, especially those with spasmodic dysphonia, odynophagia, and hyoid bone syndrome. However, patients with globus sensation had a lower response to this therapy. Further research is needed to confirm the efficacy of this treatment.
Article
Otorhinolaryngology
Jia-Qian Hu, Peng-Cheng Yu, Li-Cheng Tan, Wen-Jun Wei, Zhong-Wu Lu, Yu Wang, Qing-Hai Ji, Yu-Long Wang
Summary: This study demonstrates a novel method for reconstructing the right recurrent laryngeal nerve by transforming it into a nonrecurrent nerve. The procedure was successfully performed in a patient with advanced thyroid carcinoma, showing improved postoperative outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, Research & Experimental
Akihito Watanabe, Yuki Kimura, Shinji Tsukamoto, Masanobu Taniguchi, Suguru Ito
Summary: In this retrospective study, the feasibility, safety, and efficacy of using a collagen conduit for recurrent laryngeal nerve (RLN) reconstruction were evaluated. Seven cases were included, and different vocal cord conditions were observed before surgery. Voice examination and laryngeal endoscopy were conducted at multiple time points after surgery. The results showed that the collagen conduit could be a favorable option for RLN reconstruction, especially in cases where direct anastomosis or ansa cervicalis to RLN anastomosis is not possible.
Article
Surgery
Masami Yuda, Katsunori Nishikawa, Yoshitaka Ishikawa, Keita Takahashi, Takanori Kurogochi, Yujiro Tanaka, Akira Matsumoto, Yuichiro Tanishima, Norio Mitsumori, Toru Ikegami
Summary: The study shows that using intraoperative nerve monitoring (IONM) during esophagectomy significantly reduces the incidence of postoperative RLN palsy. However, there was no significant impact of IONM on the occurrence of postoperative pneumonia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Endocrinology & Metabolism
Yongliang Mu, Xuehai Bian, Junjie Yang, Yang Li, Yushuai Zhang, Gianlorenzo Dionigi, Yishen Zhao, Hui Sun
Summary: This study retrospectively assessed the efficacy of intraoperative neural monitoring (IONM) in parathyroid surgery. The results showed that IONM played an active role in protecting the recurrent laryngeal nerve (RLN) and reducing the risk of RLN injury.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Surgery
Yu-Chen Liu, Chuan-Lu Shen, Zi-Yue Fu, Yu-Chen Zhang, Yan-Xun Han, Bang-Jie Chen, Yuan Jiang, Si-Yue Yin, Zhi Tao, Shu-Yan Sheng, Jian-Peng Wang, Bing-Yu Liang, Liang Zhang, Dong Wang, Kai-Le Wu, Hai-Feng Pan, Ye-Hai Liu
Summary: The effectiveness of intraoperative nerve monitoring (IONM) in endoscopic thyroid surgery was explored in this study. The results showed that IONM significantly reduced the incidence of transient recurrent laryngeal nerve (RLN) palsy, but did not significantly reduce the incidence of permanent RLN palsy. However, there was a significant reduction in total RLN palsy. Additionally, IONM effectively reduced the localization time of the RLN and increased the identification rate of the superior laryngeal nerve. Therefore, the use of IONM is recommended for malignant tumors.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Satoru Miyamaru, Daizo Murakami, Kohei Nishimoto, Narihiro Kodama, Joji Tashiro, Yusuke Miyamoto, Haruki Saito, Hiroki Takeda, Momoko Ise, Yorihisa Orita
Summary: The study aimed to determine the optimal management of unilateral RLN involvement in thyroid cancer and found that sharp dissection should be performed first, followed by a simultaneous RLN reconstruction procedure if necessary. This approach helps preserve vocal function in patients with thyroid cancer.
Article
Oncology
Rick Schneider, Andreas Machens, Carsten Sekulla, Kerstin Lorenz, Henning Dralle
Summary: A study of 258 children with suspected or confirmed thyroid cancer showed that intermittent nerve stimulation led to nerve damage and vocal cord palsy, while continuous nerve stimulation did not. This demonstrates that continuous nerve stimulation is safer in preventing postoperative complications in pediatric thyroid surgery.
Article
Medicine, General & Internal
Maowei Pei, Siqi Zhu, Chunjie Zhang, Guoliang Wang, Mingrong Hu
Summary: Reoperative thyroidectomy is challenging due to the higher incidence of recurrent laryngeal nerve (RLN) injury. In this study, intraoperative nerve monitoring (IONM) was found to improve RLN identification rate and reduce surgeon-related RLN injury rate, but did not significantly reduce tumor-related or scar-related RLN injury rate. Larger prospective studies may be needed to further evaluate the role of IONM in thyroid reoperations.
Article
Otorhinolaryngology
Amit Ritter, Roy Hod, Yonatan Reuven, Thomas Shpitzer, Aviram Mizrachi, Eyal Raveh, Gideon Bachar
Summary: This study found that the use of IONM during pediatric thyroid surgery significantly reduced the rate of recurrent laryngeal nerve injury, particularly in children under 10 years of age and patients undergoing central neck dissection.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Clinical Neurology
Alexandre Berger, Evelina Carapancea, Simone Vespa, Venethia Danthine, Pascal Doguet, Jean Delbeke, Antoine Nonclercq, Riem El Tahry
Summary: The objective of this study was to record Laryngeal Motor Evoked Potentials (LMEPs) in Vagus Nerve Stimulation (VNS)-implanted patients with Drug-Resistant Epilepsy (DRE). The characteristics of LMEPs were evaluated and compared between responders (R) and non-responders (NR). A Support Vector Machine (SVM) model was built to discriminate between R and NR based on LMEPs and dose-response curves features. The study suggests a possible link between vagus nerve recruitment characteristics and treatment effectiveness.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Claire M. Lawlor, Jay Meisner, Russell W. Jennings, Benjamin Zendejas, Sukgi S. Choi
Summary: This retrospective study aimed to determine the feasibility and effectiveness of recurrent laryngeal nerve (RLN) monitoring techniques in pediatric patients, finding that NIM type RLN monitoring had superior success rates, but all forms of monitoring offered similar rates of nerve protection.
Article
Veterinary Sciences
Sandra Felten, Kaspar Matiasek, Stefanie Gruendl, Laura Sangl, Gerhard Wess, Katrin Hartmann
JOURNAL OF FELINE MEDICINE AND SURGERY
(2017)
Article
Veterinary Sciences
Stefanie Gruendl, Kaspar Matiasek, Lara Matiasek, Andrea Fischer, Sandra Felten, Konrad Jurina, Katrin Hartmann
JOURNAL OF FELINE MEDICINE AND SURGERY
(2017)
Article
Veterinary Sciences
Andrea M. Wahle, Karina Raith, Barbara Posch, Lina Eddicks, Kaspar Matiasek, Konrad Jurina
VETERINARY RADIOLOGY & ULTRASOUND
(2017)
Article
Veterinary Sciences
Sandra Felten, Kaspar Matiasek, Stefanie Gruendl, Laura Sangl, Katrin Hartmann
VETERINARY OPHTHALMOLOGY
(2018)
Article
Multidisciplinary Sciences
Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei Bogdanov, Friederike Laemmer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing
SCIENTIFIC REPORTS
(2018)
Article
Veterinary Sciences
Elspeth M. Milne, R. Scott Pirie, Caroline N. Hahn, Jorge del-Pozo, Dawn Drummond, Sharon Moss, Bruce C. McGorum
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2019)
Article
Genetics & Heredity
Christopher A. Jenkins, Lajos Kalmar, Kaspar Matiasek, Lorenzo Mari, Kaisa Kyostila, Hannes Lohi, Ellen C. Schofield, Cathryn S. Mellersh, Luisa De Risio, Sally L. Ricketts
Article
Veterinary Sciences
Nicola Meixner, Marie F. Sommer, Nelly Scuda, Kaspar Matiasek, Matthias Mueller
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2020)
Review
Veterinary Sciences
Ann M. Derham, Jim Schumacher, John M. O' Leary, Ger Kelly, Caroline N. Hahn
Summary: The lack of detailed knowledge of the neural anatomy of the equine thoracolumbar region has implications for diagnostic localization of back pain, treatment, and surgery outcomes in horses.
EQUINE VETERINARY JOURNAL
(2021)
Article
Genetics & Heredity
Marjo K. Hytonen, Riika Sarviaho, Christopher B. Jackson, Pernilla Syrja, Tarja Jokinen, Kaspar Matiasek, Marco Rosati, Cristina Dallabona, Enrico Baruffini, Ileana Quintero, Meharji Arumilli, Geoffray Monteuuis, Jonas Donner, Marjukka Anttila, Anu Suomalainen, Laurence A. Bindoff, Hannes Lohi
Summary: The study investigated the clinical, genetic, and pathological characteristics of a severe juvenile brain disorder in Parson Russell Terriers. A novel early-onset PITRM1-related neurodegenerative canine brain disorder with mitochondrial dysfunction, A beta accumulation, and lethal epilepsy was described. The findings highlight the essential role of PITRM1 in neuronal survival and strengthen the connection between mitochondrial dysfunction and neurodegeneration.
Article
Microbiology
Susanna Samoilowa, Kim S. Giessler, Carlos E. Medina Torres, Gisela Soboll Hussey, Allison Allum, Robert Fux, Christin Jerke, Matti Kiupel, Kaspar Matiasek, Dodd G. Sledge, Lutz S. Goehring
Summary: This study investigated the distribution of EHV-1 viral DNA in the bodies of horses and found that the virus primarily distributes in neural and lymphoid tissues, but not in PBMC. Differences in tissue tropism were observed between the wild type Ab4 virus and two mutant viruses, leading to varying tissue pathology.
Article
Multidisciplinary Sciences
Kaspar Matiasek, Florian Pfaff, Herbert Weissenboeck, Claudia Wylezich, Jolanta Kolodziejek, Sofia Tengstrand, Frauke Ecke, Sina Nippert, Philip Starcky, Benedikt Litz, Jasmin Nessler, Peter Wohlsein, Christina Baumbach, Lars Mundhenk, Andrea Aebischer, Sven Reiche, Pia Weidinger, Karin M. Olofsson, Cecilia Rohdin, Christiane Weissenbacher-Lang, Julia Matt, Marco Rosati, Thomas Flegel, Birger Hornfeldt, Dirk Hoeper, Rainer G. Ulrich, Norbert Nowotny, Martin Beer, Cecilia Ley, Dennis Rubbenstroth
Summary: 'Staggering disease', a neurological illness that has posed a threat to European domestic cats for almost five decades, has finally been linked to the Rustrela virus (RusV). RusV, a relative of rubella virus, was detected in the brains of cats with clinical signs of 'staggering disease' from Sweden, Austria, and Germany, but not in unaffected control cats. Additionally, RusV was found to infect wood mice in Sweden. This discovery suggests that RusV may be responsible for neuropathologies in other mammals, including humans.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Tiina Heinonen, Thomas Flegel, Hanna Mueller, Alexandra Kehl, Sruthi Hundi, Kaspar Matiasek, Andrea Fischer, Jonas Donner, Oliver P. Forman, Hannes Lohi, Marjo K. Hytoenen
Summary: In this study, a Miniature Australian Shepherd family with symptoms similar to hereditary hyperekplexia in humans was reported. Whole genome sequence data analysis revealed a 36-bp deletion in the GLRA1 gene, which was found to be completely associated with the disease in pedigree samples and additional cohorts of related dog breeds. This study establishes a spontaneous large animal disease model for human hereditary hyperekplexia by associating a variant in the canine GLRA1 gene with the disorder for the first time.
Letter
Veterinary Sciences
Daniel R. Rissi, Taryn A. Donovan, Claudio S. L. Barros, Molly E. Church, Jennifer W. Koehler, Kaspar Matiasek, Andrew D. Miller, Brian F. Porter
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2023)
Article
Veterinary Sciences
Sandra Felten, Christian M. Leutenegger, Hans-Joerg Balzer, Nikola Pantchev, Kaspar Matiasek, Gerhard Wess, Herman Egberink, Katrin Hartmann
BMC VETERINARY RESEARCH
(2017)