Article
Clinical Neurology
Diana Lehmann Urban, Mohamed Mohamed, Albert C. Ludolph, Jan Kassubek, Angela Rosenbohm
Summary: This study aimed to analyze the efficacy of muscle MRI, EMG, and muscle biopsy in diagnosing suspected myopathy patients. The results showed that qualitative muscle MRI could not differentiate between different types of neuromuscular diagnostic groups, while quantitative muscle MRI was useful in assessing disease progression and exploring patterns of muscle group involvements in certain genetic myopathies.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Oncology
Toshiaki Ando, Atsushi Kasamatsu, Kohei Kawasaki, Kazuya Hiroshima, Reo Fukushima, Manabu Iyoda, Dai Nakashima, Yosuke Endo-Sakamoto, Katsuhiro Uzawa
Summary: Circular RNAs (circRNAs) are covalently closed loop structures that have longer circulatory half-lives compared to linear RNAs, and can regulate miRNA and target gene expression as competing endogenous RNAs. The down-regulation of circRNA-102450 is identified as a novel tumor suppressor in oral squamous cell carcinoma, potentially serving as a marker for regional lymph node metastasis.
Article
Critical Care Medicine
Ga Young Lee, Jin-Haeng Chung, Sukki Cho, Yeon Bi Han, Young Mi Park, Hyung-Jun Kim, Myung Jin Song, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Yeon Wook Kim
Summary: This study examined the correlation between preoperative biopsy procedure and the risk of tumor spread through airspaces (STAS) in surgically treated stage I NSCLC. The findings showed an insignificant association between preoperative biopsy and STAS risk. STAS was found to be a significant risk factor for cancer recurrence.
Article
Clinical Neurology
Antonino Lupica, Rosaria Oteri, Sara Volta, Daniele Ghezzi, Selene Francesca Anna Drago, Carmelo Rodolico, Olimpia Musumeci, Antonio Toscano
Summary: Clinical features and symptoms of patients with multiple acyl-CoA dehydrogenase deficiency are highly variable, making diagnosis difficult. Laboratory tests, such as blood and tissue examination, play an important role in the diagnosis. Riboflavin supplementation has a positive effect on patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Yu-xin Song, Zheng Xu, Ming-xing Liang, Zhen Liu, Jun-chen Hou, Xiu Chen, Di Xu, Yin-jiao Fei, Jin-hai Tang
Summary: Targeted axillary lymph node biopsy (TLNB) is a novel, less invasive surgical approach that allows for marking metastatic axillary nodes before neoadjuvant systemic therapy (NST) and performing targeted dissection and biopsy intraoperatively. TLNB has a high identification rate (IFR) and a low false-negative rate (FNR), making it a valuable tool for individualized axillary management.
Article
Cell Biology
Valentina F. Sangiorgio, Hasan Rizvi, Joseph Padayatty, Nagendra Thayur, Taiki Fujiwara, Francis A. Anyanwu, Maria Calaminici
Summary: Radiologically guided percutaneous core needle biopsy of the spleen is a valuable diagnostic tool, providing quick and reliable histological diagnoses while avoiding the complications and risks of splenectomy. The procedure yielded sufficient material for histological examination in majority of cases, with haematological malignancies being the most commonly diagnosed conditions. Minor complications occurred in a small percentage of cases, while major complications were not reported.
Article
Clinical Neurology
Marco Veneruso, Chiara Fiorillo, Paolo Broda, Serena Baratto, Monica Traverso, Alice Donati, Salvatore Savasta, Raffaele Falsaperla, Maria Margherita Mancardi, Marina Pedemonte, Chiara Panicucci, Gianluca Piatelli, Mattia Pacetti, Andrea Moscatelli, Luca Antonio Ramenghi, Lino Nobili, Carlo Minetti, Claudio Bruno
Summary: The role of muscle biopsy in diagnosing floppy infants is controversial as it is invasive and often non-specific, but still crucial in early infancy. Through a retrospective analysis, this study found that muscle biopsy results were consistent with genetic tests in 90% of cases, highlighting its importance in the diagnostic algorithm for hypotonia in infants.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Rigiroli, Omar Hamam, Hadiseh Kavandi, Alexander Brook, Seth Berkowitz, Muneeb Ahmed, Bettina Siewert, Olga R. Brook
Summary: This study aims to analyze the malignancy rate in concordant, discordant, and indeterminate non-malignant results of CT-guided lung biopsies. Routine radiology-pathology concordance evaluation correctly identifies patients at high risk for missed diagnosis of malignancy. Repeat biopsy is the fastest method to reach diagnosis.
EUROPEAN RADIOLOGY
(2023)
Review
Immunology
Valery Daubie, Houssein Chalhoub, Bob Blasdel, Hafid Dahma, Maya Merabishvili, Tea Glonti, Nathalie De Vos, Johan Quintens, Jean-Paul Pirnay, Marie Hallin, Olivier Vandenberg
Summary: As the global burden of disease caused by multidrug resistant bacteria is a major concern, exploring credible clinical alternatives to antibiotic therapy, such as personalized phage therapy, is crucial. However, the development of an easy to implement diagnostic tool for determining phage susceptibility remains an open issue. This review summarizes existing methods for determining phage activity on bacteria and discusses potential techniques for implementing a phage susceptibility testing tool in routine clinical microbiology.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela A. Ferraro, Anton S. Becker, Benedikt Kranzbuhler, Iliana Mebert, Anka Baltensperger, Konstantinos G. Zeimpekis, Hannes Grunig, Michael Messerli, Niels J. Rupp, Jan H. Rueschoff, Ashkan Mortezavi, Olivio F. Donati, Marcelo T. Sapienza, Daniel Eberli, Irene A. Burger
Summary: This study assessed the performance of PSMA-PET/MRI in detecting and localizing clinically significant prostate cancer, demonstrating high accuracy and potential as a promising tool for selecting patients with suspicion of prostate cancer for biopsy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
DengYong Zhang, GuanRu Zhao, Wanliang Sun, Dongdong Wang, Shuo Zhou, Zhong Liu, Zheng Lu
Summary: Analysis of bile in the microenvironment of perihilar cholangiocarcinoma (pCCA) using metabolomics and statistical methods can aid in clinical diagnosis. A study collected clinical information and bile samples from patients with pCCA and gallstones, analyzing the bile samples with untargeted metabolomics methods. Through multivariate and univariate analyses, potential differential metabolites were screened and changes in the pCCA pathway and therapeutic targets were explored. Significant differences were found in blood indicators between the two groups, and a significant correlation was observed between clinical parameters and certain metabolites in the metabolic group. The study suggests that bile untargeted metabolomics combined with statistical analysis techniques can be used for the diagnosis and treatment of pCCA.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Antonio Facciorusso, Daryl Ramai, Maria Cristina Conti Bellocchi, Laura Bernardoni, Erminia Manfrin, Nicola Muscatiello, Stefano Francesco Crino
Summary: This study compared percutaneous and endoscopic ultrasound methods for liver biopsy, with results showing that although percutaneous liver biopsy yielded specimens with greater total sample length, the diagnostic adequacy and accuracy were similar between the two procedures.
Article
Medicine, General & Internal
Deborah Tolomeo, Daniele Orsucci, Claudia Nesti, Jacopo Baldacci, Roberta Battini, Claudio Bruno, Giorgia Bruno, Denise Cassandrini, Stefano Doccini, M. Alice Donati, Annarita Ferrari, Simona Fiori, Chiara Fiorillo, Renzo Guerrini, Francesco Mari, Martino Montomoli, Francesca Pochiero, Elena Procopio, Lucia Ruggiero, Simone Sampaolo, Federico Sicca, Chiara Ticci, Anna Rubegni, Filippo M. Santorelli
Summary: Mitochondrial diseases (MDs) are a group of genetically determined multisystem disorders characterized by diagnostic challenges and a lack of genetic studies. Neuroimaging evidence of basal ganglia (BG) involvement and psychomotor regression are important predictors for diagnosing MD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Bernadette Jeremiasse, Alida F. W. van der Steeg, Marta Fiocco, Monique G. G. Hobbelink, Johannes H. M. Merks, Jan Godzinski, Barry L. Shulkin, Marc H. W. A. Wijnen, Cecilia E. J. Terwisscha van Scheltinga
Summary: The study found that the sentinel node procedure is recommendable for pediatric patients with extremity rhabdomyosarcoma, as it can change lymph node status and sample patients in a more targeted way.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Jenni M. Lehtonen, Mari Auranen, Niklas Darin, Kalliopi Sofou, Laurence Bindoff, Omar Hikmat, Johanna Uusimaa, Paivi Vieira, Mar Tulinius, Tuula Lonnqvist, Irenaeus F. de Coo, Anu Suomalainen, Pirjo Isohanni
Summary: The study demonstrates that in the diagnosis of mitochondrial disease, the value of serum biomarkers FGF21 and GDF15 is higher than traditional muscle histological analysis. Additionally, if both biomarkers are elevated and the patient exhibits muscle manifesting symptoms and is affected by mitochondrial DNA expression, the likelihood of diagnosing mitochondrial disease is higher.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
