Article
Pharmacology & Pharmacy
Lixia He, Meng Ke, Wanhong Wu, Jiarui Chen, Guimu Guo, Rongfang Lin, Pinfang Huang, Cuihong Lin
Summary: The study established a maternal-fetal physiologically based pharmacokinetic (PBPK) model to analyze the changes in drug behavior during pregnancy, suggested dose adjustments for OXC in pregnant women, and compared different methods for predicting drug placental penetration.
Article
Biochemistry & Molecular Biology
Monika Banach, Monika Rudkowska, Agata Sumara, Kinga Borowicz-Reutt
Summary: Experimental studies suggest that amiodarone may enhance the antielectroshock activity of oxcarbazepine and pregabalin, while causing memory disturbances when used in combination with certain antiepileptic drugs. There is a potential risk of elevated brain concentrations of amiodarone when coadministered with oxcarbazepine, topiramate, or pregabalin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jia Shi, Chenghui Zhou, Wei Pan, Hansong Sun, Sheng Liu, Wei Feng, Weijian Wang, Zhaoyun Cheng, Yang Wang, Zhe Zheng
Summary: This study compared the efficacy and adverse events of high-dose vs low-dose tranexamic acid in patients undergoing cardiac surgery with cardiopulmonary bypass. The results showed that the high-dose group had a modest reduction in the proportion of patients who received allogeneic red blood cell transfusion and met the criteria for noninferiority with respect to a composite primary safety end point.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Chemistry, Multidisciplinary
Jinny Claire Lee, Lisa M. Eubanks, Bin Zhou, Kim D. Janda
Summary: The opioid epidemic is a global public health crisis that current pharmaceutical treatments have failed to alleviate. Immunopharmacotherapy, as an alternative treatment model, has faced little clinical advancement for heroin abuse. However, through the examination of four unique monoclonal antibodies, particularly monoclonal antibody 11D12, promising insights have been gained for future heroin immunopharmacotherapy development.
ACS CENTRAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Sofie A. M. Brookhuis, Karel Allegaert, Lidwien M. Hanff, Marjolijn N. Lub-de Hooge, Andre Dallmann, Paola Mian
Summary: This review provides an overview of acetaminophen pharmacokinetics changes during pregnancy, showing an increase in distribution volume and clearance of acetaminophen in pregnant women compared to non-pregnant women. Gaps in knowledge, such as fetal and placental pharmacokinetic parameters, have been identified for further exploration before evidence-based dosing adjustments can be suggested.
Article
Pharmacology & Pharmacy
Sidra Nasir, Amjad Hussain, Nasir Abbas, Nadeem Irfan Bukhari, Fahad Hussain, Muhammad Sohail Arshad
Summary: The study aimed to enhance the dissolution rate of poorly soluble drug OXC by fabricating drug loaded microfibers via CMS technique. The results showed stable, amorphous fibers with high loading efficiency and rapid in-vitro and in-vivo dissolution, improving bioavailability parameters. The addition of PVP and sucrose base improved the extrusion process, stability of fibers, and masked the taste of OXC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Microbiology
Sean N. Avedissian, Gwendolyn M. Pais, Michelle Pham, Jiajun Liu, Jack Chang, Khrystyna Hlukhenka, Walter Prozialeck, Brooke Griffin, Anil Gulati, Medha D. Joshi, Ying Mu, Marc H. Scheetz
Summary: This study aims to understand the distribution of vancomycin in pregnant women, finding that vancomycin can cross the placental barrier and reach the fetus, and the accumulation in the kidneys varies depending on the trimester.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Paola Coppola, Andrew Butler, Susan Cole, Essam Kerwash
Summary: This paper highlights the importance of considering changes in total and free drug concentrations during pregnancy. Changes in pregnancy-related plasma protein binding can lead to increased free drug concentrations, which may have clinical significance and affect dose adjustment for highly bound drugs. Physiologically based pharmacokinetic (PBPK) models show promise in understanding the impact of plasma protein binding changes and simulating free drug concentrations during pregnancy to support dosing decisions.
Review
Immunology
Million A. Tegenge, Iftekhar Mahmood, Evi B. Struble, Zuben Sauna
Summary: Pharmacokinetics (PK) studies are crucial for determining safe and effective dosages of both small and large molecule drugs. While PK studies have been conducted for small molecules during pregnancy, there is limited research on macromolecules such as monoclonal and polyclonal antibodies. This review provides an overview of macromolecule drugs and their PK differences compared to small molecules, as well as the physiological changes during pregnancy. Further investigations are needed to fully understand the impact of pregnancy on PK properties of macromolecules.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anesthesiology
Paul Jacques Zufferey, Julien Lanoiselee, Billal Graouch, Baptiste Vieille, Xavier Delavenne, Edouard Ollier
Summary: The study found that in cardiac surgery, low-dose tranexamic acid is an appropriate regimen for reducing bleeding outcomes. While high-dose regimens increased the risk of seizures, the difference was clinically meaningful only in prolonged open-chamber surgery.
Article
Multidisciplinary Sciences
Yoonhyuk Jang, Seonghae Yoon, Tae-Joon Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee
Summary: This study aimed to develop a population PK model of oxcarbazepine using sparse sampling data from patients with epilepsy, and found that dizziness symptom was significantly associated with both the MHD trough and the AUC. The model better reflects the actual clinical situation.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Laura Dickinson, Stephen Walimbwa, Yashna Singh, Julian Kaboggoza, Kenneth Kintu, Mary Sihlangu, Julie-Anne Coombs, Thokozile R. Malaba, Josaphat Byamugisha, Henry Pertinez, Alieu Amara, Joshua Gini, Laura Else, Christie Heiberg, Eva Maria Hodel, Helen Reynolds, Landon Myer, Catriona Waitt, Saye Khoo, Mohammed Lamorde, Catherine Orrell
Summary: The study investigated dolutegravir pharmacokinetics in pregnant women with untreated HIV presenting in late pregnancy, showing the relationship between dolutegravir concentrations in maternal plasma, umbilical cord, and breast milk, as well as the duration of prophylaxis for infants post maternal dolutegravir cessation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Natalia Erenburg, Roa'a Hamed, Chanan Shaul, Emilio Perucca, Meir Bialer
Summary: This study compared the antiseizure activity of fenfluramine and its metabolite norfenfluramine in rodent seizure models, and investigated their pharmacokinetics in plasma and brain. The results showed that all compounds tested were active against MES-induced seizures, but not against 6-Hz seizures. The concentration of all enantiomers in brain tissue was higher than in plasma, suggesting that the parent compound was primarily responsible for seizure protection. These findings suggest that l-fenfluramine and l-norfenfluramine may be attractive candidates for the development of a novel antiseizure medication.
Article
Pharmacology & Pharmacy
Richard Court, Kamunkhwala Gausi, Buyisile Mkhize, Lubbe Wiesner, Catriona Waitt, Helen McIlleron, Gary Maartens, Paolo Denti, Marian Loveday
Summary: This study aimed to explore the effects of pregnancy on the pharmacokinetics of bedaquiline and describe the exposure of bedaquiline in the breast milk of mothers treated for rifampicin-resistant tuberculosis. The results showed lower exposure of bedaquiline in pregnant women and higher concentrations in breast milk. Breastfed infants received doses of bedaquiline equivalent to maternal doses.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Thomas K. Wiersma, Marijn C. Visschedijk, Nanne K. de Boer, Marjolijn N. Lub-de Hooge, Jelmer R. Prins, Daan J. Touw, Paola Mian
Summary: This systematic review examined the impact of pregnancy and inflammatory bowel disease (IBD) on the pharmacokinetics (PK) of drugs used for IBD. Limited studies have been conducted on the PK parameters during pregnancy for these drugs, highlighting the need for more extensive research to determine PK values and develop evidence-based dosing regimens.
Article
Behavioral Sciences
Allan Lohse, TroelsW. Kjaer, Anne Sabers, Peter Wolf
EPILEPSY & BEHAVIOR
(2015)
Article
Clinical Neurology
A. T. Guld, A. Sabers, T. W. Kjaer
ACTA NEUROLOGICA SCANDINAVICA
(2017)
Article
Veterinary Sciences
N. Fredso, N. Toft, A. Sabers, M. Berendt
BMC VETERINARY RESEARCH
(2017)
Article
Clinical Neurology
Lene Duez, Sandor Beniczky, Hatice Tankisi, Peter Orm Hansen, Per Sidenius, Anne Sabers, Anders Fuglsang-Frederiksen
CLINICAL NEUROPHYSIOLOGY
(2016)
Article
Clinical Neurology
Sandor Beniczky, Lene Duez, Michael Scherg, Peter Orm Hansen, Hatice Tankisi, Per Sidenius, Anne Sabers, Lars Hageman Pinborg, Peter Uldall, Anders Fuglsang-Frederiksen
CLINICAL NEUROPHYSIOLOGY
(2016)
Article
Clinical Neurology
Torbjorn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Anne Sabers, Sanjeev V. Thomas, Frank Vajda
Article
Clinical Neurology
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2016)
Article
Clinical Neurology
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2016)
Article
Veterinary Sciences
N. Fredso, A. Sabers, N. Toft, A. Moller, M. Berendt
VETERINARY JOURNAL
(2016)
Article
Clinical Neurology
Anne Sabers, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Sanjeev V. Thomas, Torbjorn Tomson, Frank Vajda
Article
Clinical Neurology
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2017)
Letter
Clinical Neurology
Anne Sabers, Line Buchgreitz, Winfried Neuhuber
Review
Pharmacology & Pharmacy
Guido Rubboli, Anne Sabers, Peter Uldall, Kristina Malmgren
CURRENT PHARMACEUTICAL DESIGN
(2017)
Article
Clinical Neurology
Vaiva Petrenaite, Inger Ohman, Lena Ekstrom, Ditte Saebye, Thomas Folkmann Hansen, Torbjorn Tomson, Anne Sabers
Article
Clinical Neurology
Lise Cronberg Salem, Anne Sabers, Troels W. Kjaer, Christian Musaeus, Martin N. Nielsen, Anne-Grete Nielsen, Gunhild Waldemar
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
(2015)