Article
Clinical Neurology
Marco Riva, Stephen M. Wilson, Ruofan Cai, Antonella Castellano, Kesshi M. Jordan, Roland G. Henry, Maria Luisa Gorno Tempini, Mitchel S. Berger, Edward F. Chang
Summary: Electrocortical stimulation mapping (ECS) was used during awake surgery in 6 patients to investigate sentence-level processing. Stimulation of the inferior frontal gyrus disrupted comprehension of passive sentences in all subjects, while simpler tasks remained unaffected. These findings suggest the presence of language regions that contribute differently to sentence processing, and sentence-level tasks are best for identifying them. The functional consequences of resecting these sites need further investigation.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Kenji Ibayashi, Araceli R. Cardenas, Hiroyuki Oya, Hiroto Kawasaki, Christopher K. Kovach, Matthew A. Howard, Michael A. Long, Jeremy D. W. Greenlee
Summary: The study found that focal cortical cooling (CC) is a safe alternative to electric cortical stimulation (ECS) for intraoperative functional mapping in neurosurgery. CC may complement ECS as a potential technique, with comparable outcomes in terms of intraoperative and postoperative seizure incidence as well as long-term effects on seizure outcome.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Gewalin Aungaroon, Kishore Vedala, Anna W. W. Byars, Brian Ervin, Leonid Rozhkov, Paul S. S. Horn, S. K. Z. Ihnen, Katherine D. D. Holland, Jeffrey R. R. Tenney, Kelly Kremer, Susan L. L. Fong, Nan Lin, Wei Liu, Todd M. M. Arthur, Hisako Fujiwara, Jesse Skoch, James L. L. Leach, Francesco T. T. Mangano, Hansel M. M. Greiner, Ravindra Arya
Summary: This study compared the functional responses, afterdischarges (ADs), and unwanted ESM-induced seizures (EISs) between stereoelectroencephalography (SEEG) and subdural electrodes (SDE) for electrical stimulation mapping. The results showed that SEEG had a higher likelihood of identifying sensory areas and a lower incidence of ADs and EISs compared to SDE. The relationship between functional and AD thresholds was also more favorable for SEEG, indicating its superior safety and neurophysiologic validity.
Article
Neurosciences
Yujing Wang, Mark A. Hays, Christopher Coogan, Joon Y. Kang, Adeen Flinker, Ravindra Arya, Anna Korzeniewska, Nathan E. Crone
Summary: Functional human brain mapping is commonly performed during invasive monitoring with intracranial electroencephalographic (iEEG) electrodes prior to resective surgery for drug-resistant epilepsy. The current gold standard, electrocortical stimulation mapping (ESM), is time-consuming and sometimes elicits pain. Passive iEEG spatial-temporal functional mapping (STFM) has emerged as a potential alternative to ESM, but there is less correspondence between STFM and ESM maps of language function compared to maps of motor function. The study suggests that incongruities between ESM and STFM may arise in part from propagation of stimulation effects to a broader network of cortical language sites, indicating the need for further research with larger patient populations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Agnes Trebuchon, Renata Racila, Francesco Cardinale, Stanislas Lagarde, Aileen McGonigal, Giorgio Lo Russo, Didier Scavarda, Romain Carron, Roberto Mai, Patrick Chauvel, Fabrice Bartolomei, Stefano Francione
Summary: A retrospective analysis of 346 patients with drug-resistant focal epilepsy who underwent surgery revealed that MRI findings, specific etiologies, and seizures induced by electrical stimulation were significantly correlated with seizure outcomes. Further research indicated that seizure induction by low frequency electrical stimulation could serve as a positive predictive factor for favorable seizure outcomes post-surgery.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Ee Ling Tan, Marlene Tahedl, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. Mclaughlin, Orla Hardiman, Kai Ming Chang, Eoin Finegan, Peter Bede
Summary: This study evaluated the structural and functional integrity of language-associated brain regions and networks in patients with PLS. The results showed cortical thickness reductions in language areas, alterations in fractional anisotropy and increased radical diffusivity in specific brain tracts. Functional connectivity changes were also observed.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Miguel Ley, Nazaret Pelaez, Alessandro Principe, Klaus Langohr, Riccardo Zucca, Rodrigo Rocamora
Summary: Direct cortical stimulation (DCS) is a standard technique for presurgical evaluation of drug-resistant epilepsy (DRE). This study reports validity measures of DCS in detecting the seizure onset zone (SOZ) during stereoelectroencephalography (SEEG), showing high specificity but low sensitivity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Behavioral Sciences
Xiaoxia Zhou, Jianbin Wen, Tao Yu, Liang Qiao, Xiaohua Zhang, Duanyu Ni, Tianyi Zhou, Xueyuan Wang, Guojun Zhang, Liankun Ren, Xiaoli Li, Yongjie Li
Summary: The study developed and tested a trial-free online-based language mapping method for localizing the eloquent cortex in epilepsy surgery. Patients underwent two rounds of mapping within 10 minutes during surgery, aiming to resect EZs while preserving the mapped eloquent cortex. Postoperative follow-up showed good outcomes for most patients, with two experiencing temporary aphemia that resolved within one week and three months respectively.
EPILEPSY & BEHAVIOR
(2021)
Article
Biology
Bin Wan, Seyma Bayrak, Ting Xu, H. Lina Schaare, Richard A. Bethlehem, Boris C. Bernhardt, Sofie L. Valk
Summary: The functional organization of the human cerebral cortex exhibits asymmetry, which is linked to language and higher order cognitive functions. This asymmetry is heritable and phylogenetically conserved between humans and macaques.
Article
Behavioral Sciences
Bridget Dolan Wozniak, Michelle M. Loman, Jennifer Koop
Summary: This study aims to evaluate the language functioning of pediatric epilepsy patients post-surgery and proposes a method to assess their risk accurately. Patients were categorized into minimal risk or greater risk groups based on the proposed method. The results showed significant improvement in Boston Naming Test scores post-surgery, suggesting the effectiveness of the risk assessment method.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Timothy Holloway, James L. Leach, Jeffrey R. Tenney, Anna W. Byars, Paul S. Horn, Hansel M. Greiner, Francesco T. Mangano, Katherine D. Holland, Ravindra Arya
Summary: This systematic review and meta-analysis compared the diagnostic validity of functional magnetic resonance imaging (fMRI) and electrical stimulation mapping (ESM) for pre-surgical language mapping. The results showed that fMRI has moderate sensitivity and specificity for language localization compared to ESM. However, due to high unmeasured heterogeneity and confidence intervals close to the line of no effect, fMRI may not be used as the sole modality for language localization in neurosurgical decisions at present.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
Ja Hye Kim, Ji-Hyung Park, Junehawk Lee, Jung Woo Park, Hyun Jung Kim, Won Seok Chang, Dong-Seok Kim, Young Seok Ju, Eleonora Aronica, Jeong Ho Lee
Summary: In this study, we aimed to investigate the genetic etiology of focal cortical dysplasia type II (FCDII) by detecting brain somatic mutations in mTOR pathway genes. Despite the use of deep sequencing and analytics, about 40% of cases remained genetically unexplained. By isolating cells exhibiting phosphorylation of the S6 ribosomal protein (p-S6) in brain tissues and performing whole-genome sequencing, we found ultra-low level somatic mutations and germline structural variations in a significant portion of mutation-negative FCDII patients. Our method significantly increased the genetic diagnostic rate for FCDII.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Chifaou Abdallah, Helene Brissart, Sophie Colnat-Coulbois, Ludovic Pierson, Olivier Aron, Natacha Forthoffer, Jean-Pierre Vignal, Louise Tyvaert, Jacques Jonas, Louis Maillard
Summary: The study evaluated the decline in visual object naming in drug-resistant temporal lobe epilepsy patients after dominant temporal lobe resection according to the resection status of the basal temporal language area identified by cortical stimulation during stereoelectroencephalography. The results showed that resection of the basal temporal language area was associated with specific and early naming decline, with BTLA+ patients experiencing lower naming scores compared to their baseline even in the long run. Seamless mapping helps predict postoperative language outcomes after dominant temporal lobe resection.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Bertrand Mathon, Stephane Clemenceau, Alexandre Carpentier
Summary: This study evaluated the efficacy of ultrasound SWE techniques for intraoperative detection of FCDs, showing that SWE was more sensitive in detecting FCDs compared to conventional B-mode imaging. Stiffness ratios were significantly different between MRI-positive and -negative cases. Interoperative SWE more frequently detected FCDs in women and in patients with FCD visible on MRI, with good seizure outcomes at 1 year post-surgery and last follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Yukihiro Yamao, Riki Matsumoto, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto
Summary: Neurosurgeons must understand the brain's structure, vasculature, and function to preserve postoperative brain function. Intraoperative CCEP mapping allows for real-time monitoring and mapping of cortical network functions, contributing to the preservation of brain function.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)