Article
Computer Science, Information Systems
Yonghua Yang, Rani A. Sarkis, Rima El Atrache, Tobias Loddenkemper, Christian Meisel
Summary: Automated detection of generalized tonic-clonic seizures (GTCSs) from videos using deep learning has been proven feasible and effective, showing better performance and potential compared to traditional methods. Results demonstrate that deep learning networks based on video sequences outperform detection based on individual frames, with an average sensitivity of 88% and specificity of 92%, and a detection latency of approximately 22 seconds.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Veterinary Sciences
Junya Hirashima, Miyoko Saito, Tsukasa Kuriyama, Taketo Akamatsu, Minoru Yokomori
Summary: This study aimed to establish a wearable seizure detection system using acceleration data and the Mahalanobis distance, and preliminarily investigate its feasibility among dogs. The results showed that the system effectively identified seizures and non-seizure activities, and the feasibility test in dogs with epilepsy was successful.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Jelena Drulovic, Tatjana Pekmezovic, Olivera Tamas, Ivan Adamec, Dejan Aleksic, Marko Andabaka, Vanja Basic Kes, Silva Butkovic Soldo, Mirjana Cukic, Livija Despinic, Evica Dincic, Jasminka Djelilovic Vranic, Sanja Grgic, Mario Habek, Sonya Ivanova Hristova, Jovana Ivanovic, Aleksa Jovanovic, Vanja Jovicevic, Magdalena Krbot Skoric, Igor Kuzmanovski, Gorica Maric, Sarlota Mesaros, Ivan Gospodinov Milanov, Svetlana Miletic Drakulic, Osman Sinanovic, Ingrid Skarpa Prpic, Josip Sremec, Daliborka Tadic, Gordana Toncev, Dragoslav Sokic
Summary: The health-related quality of life of people with multiple sclerosis is usually deteriorated, and comorbidities may have a negative influence on the quality of life of these individuals. This study aimed to assess the impact of comorbid seizure/epilepsy on the HRQoL in people with multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Margarita Maltseva, Susanne Schubert-Bast, Johann Philipp Zoellner, Thomas Bast, Thomas Mayer, Sarah von Spiczak, Susanne Ruf, Regina Trollmann, Markus Wolff, Frauke Hornemann, Kerstin A. Klotz, Julia Jacobs, Gerhard Kurlemann, Bernd A. Neubauer, Tilman Polster, Steffen Syrbe, Astrid Bertsche, Ulrich Bettendorf, Gerhard Kluger, Silke Flege, Felix Rosenow, Lara Kay, Adam Strzelczyk
Summary: This study measured the sleep quality of caregivers of patients with Dravet syndrome (DS) and assessed the impacts of mental health problems and caregiver burden on sleep quality. The results showed that sleep quality was severely affected among the caregivers, correlating with anxiety, comorbidities, and patients' sleep disturbances. Therefore, a holistic therapeutic approach should be implemented for patients with DS and their caregivers, focusing on the sleep quality and mental health of caregivers.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Clinical Neurology
Tatiana Vander, Tatiana Stroganova, Diya Doufish, Dawn Eliashiv, Tal Gilboa, Mordekhay Medvedovsky, Dana Ekstein
Summary: Ambulatory at home video-EEG monitoring (HVEM) may offer a more cost-effective and accessible option for epilepsy patients. However, longer periods of monitoring may be necessary to capture a sufficient number of seizures. This study quantitatively estimated the necessary length of HVEM for different diagnostic scenarios.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Pabitra Basnyat, Jussi Makinen, Jukka T. Saarinen, Jukka Peltola
Summary: This study evaluated the clinical utility of a semi-automated hybrid video/audio-based epilepsy monitoring system, Nelli(R), in a home setting. The results showed that the Nelli(R) hybrid system was able to recognize clinically relevant events and aid in clinical decision-making for new therapeutic interventions. Nelli(R) registration can optimize the monitoring and management of epileptic seizures.
EPILEPSY & BEHAVIOR
(2022)
Article
Computer Science, Information Systems
Kuo-Kai Shyu, Szu-Chi Huang, Lung-Hao Lee, Po-Lei Lee
Summary: This paper proposes a novel end-to-end deep-learning model for seizure detection without feature extraction. The model analyzes the multi-scales of original EEG signals using an inception module and a residual module. Experimental results on the Bonn dataset and the CHB-MIT dataset show that our model achieves better classification performance and lower computational complexity compared to existing end-to-end seizure detection models, with an average F1-score of 69.34% on the CHB-MIT dataset.
Review
Clinical Neurology
Rachel Penn, Dana Harrar, Lisa R. Sun
Summary: This study systematically reviewed the literature on seizures, epilepsy, and electroencephalography findings in pediatric moyamoya arteriopathy. The results showed that the characteristics, prevalence, and predictive factors for seizures in children with moyamoya are not well-established. However, some studies suggest that seizure symptoms and electroencephalographic abnormalities can improve after surgery.
PEDIATRIC NEUROLOGY
(2023)
Article
Behavioral Sciences
Irawan Mangunatmadja, Sofyan Ismael, Sudigdo Sastroasmoro, Frans D. Suyatna, Onno van Nieuwenhuizen, Alexander Cornelis van Huffelen
Summary: A study on children aged one month to three years with focal epilepsy found that the evolution of seizure type and baseline EEG rhythm were significantly associated with intractable epilepsy. These factors may serve as predictors for treatment resistance in children with focal epilepsy of this age range.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Philippa J. Karoly, Dominique Eden, Ewan S. Nurse, Mark J. Cook, Janelle Taylor, Sonya Dumanis, Mark P. Richardson, Benjamin H. Brinkmann, Dean R. Freestone
Summary: This study demonstrates that scheduling monitoring times based on personalized seizure risk forecasts can improve the yield of video-electroencephalography (vEEG) in epilepsy diagnosis and management. Forecasts can be developed at low cost from mobile seizure diaries, reducing the cost and risks associated with delayed or missed diagnosis.
Review
Clinical Neurology
Lubna Shakhatreh, Emma Foster, Pakeeran Siriratnam, Andrew Neal, Patrick W. Carney, Graeme D. Jackson, Terence J. O'Brien, Patrick Kwan, Zhibin Chen, Zanfina Ademi
Summary: This study aims to quantify changes in quality of life (QoL) for adults with drug-resistant epilepsy (DRE) after epilepsy surgery, and explore the clinicodemographic factors associated with these changes. A total of 16 studies comprising 1182 unique patients were included in the meta-analysis. The results demonstrate that epilepsy surgery has the potential to provide clinically meaningful improvements in QoL, and identify clinicodemographic factors associated with this outcome.
Article
Clinical Neurology
Masaya Katagiri, Z. Irene Wang, Tugba Hirfanoglu, Mubarak M. Aldosari, Thandar Aung, Shan Wang, Katsuya Kobayashi, Juan Bulacio, William Bingaman, Imad M. Najm, Andreas V. Alexopoulos, Richard C. Burgess
Summary: This study evaluated the relationships between ictal magnetoencephalography (MEG), magnetic resonance imaging (MRI), intracranial electroencephalography (ICEEG), surgery, and postoperative seizure outcome. The results showed that ictal MEG can contribute useful information for delineating the resection area in epilepsy surgery.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Pin-Yi Ko, Dwight Barry, Hillary Shurtleff, Jason Scott Hauptman, Ahmad Marashly
Summary: Excellent seizure and neuropsychology outcomes were observed after hemispherectomy in the study, with 86% of the cohort achieving freedom from seizures. The presence, lateralization, and evolution of pre-and postoperative EEG abnormalities were not predictive of the outcomes. Neuropsychological scores remained stable with no predictive value of EEG abnormalities.
WORLD NEUROSURGERY
(2022)
Review
Pediatrics
Lakshminarayanan Kannan, Puneet Jain, Dinesh Nayak
Summary: Video-EEG plays a crucial role in managing epileptic and non-epileptic paroxysmal events in children in India, improving sensitivity and specificity, categorizing diseases, and distinguishing different types of events.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Ailbhe Benson, Amre Shahwan
Summary: Seizure monitoring is crucial in diagnosing and managing epileptic seizures, helping to assess disease burden, select treatment methods, and make treatment decisions.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2021)
Review
Clinical Neurology
Robert S. Fisher, Jayant N. Acharya, Fiona Mitchell Baumer, Jacqueline A. French, Pasquale Parisi, Jessica H. Solodar, Jerzy P. Szaflarski, Liu Lin Thio, Benjamin Tolchin, Arnold J. Wilkins, Dorothee Kasteleijn-Nolst Trenite
Summary: Light stimulation can trigger seizures in certain individuals, especially in young people and those with specific forms of epilepsy. Photosensitive seizures can coexist with spontaneous seizures and have a genetic component. The exact mechanisms of photosensitive seizures are still unclear, but specific triggers such as flashes or color changes can provoke seizures. Prevention strategies include avoiding triggers, covering one eye, keeping a safe distance from screens, reducing contrast, and taking certain antiseizure medications. Visually-induced seizures pose significant public health risks, requiring ongoing scientific research, regulation, and public education.
Article
Clinical Neurology
Josef Parvizi, Michael J. Veit, Daniel A. N. Barbosa, Aaron Kucyi, Claire Perry, Jonathon J. Parker, Rajat S. Shivacharan, Fengyixuan Chen, Jennifer Yih, James J. Gross, Robert Fisher, Jennifer A. McNab, Jessica Falco-Walter, Casey H. Halpern
Summary: This study investigates the causal effect of electrical stimulation near the ventromedial region of the human hypothalamus on subjective experience. The findings suggest that stimulation in this area induces feelings of shame, sadness, and fear, but not rage or anger. The study also reveals the electrophysiological connectivity between the hypothalamus and other brain regions associated with emotional responses.
Article
Behavioral Sciences
Gabriel Martz, Robert S. Fisher, Bradley Folley, Gregory A. Panza, Fumika Ando, Corey McEachern, Alma Blinn, Joyce A. Cramer
Summary: This study aims to determine the Minimal Clinically Important Change (MCID) in the Personal Impact of Epilepsy Scale (PIES) to assess the improvement in patient clinical status and quality of life. The results show that a reduction of 8% in PIES scores is considered meaningful improvement. The PIES scale can be useful in clinical care and research.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Po-Chun Chu, Hsiang-Yu Yu, Cheng-Chia Lee, Robert Fisher, Hao-Li Liu
Summary: This study explores the efficacy and time course of pulsed ultrasound in suppressing epileptiform activity. The results show that pulsed ultrasound can modulate epileptiform activity for up to 7 weeks, reducing the number of spikes and bursts as well as the duration of bursts.
Article
Chemistry, Analytical
Jing Zhou, Adam Fogarty, Kristina Pfeifer, Jordan Seliger, Robert S. Fisher
Summary: This study examined the effects of 1 Hz motor cortex stimulation using repetitive magnetic stimulation (rTMS) on cortical activity. The findings showed a reduction in the P60 peak and an increase in the N100 peak after 1 Hz rTMS, suggesting enhanced slow inhibition. TMS-EEG may serve as a useful biomarker for evaluating brain excitability, but individual responses are highly variable and distinguishing merged peaks can be challenging.
Article
Clinical Neurology
Yi Li, Adam Fogarty, Babak Razavi, Pooneh Memar Ardestani, Jessica Falco-Walter, Katherine Werbaneth, Kevin Graber, Kimford Meador, Robert S. Fisher
Summary: High-density EEG (HD-EEG) assists in presurgical planning for refractory epilepsy patients, with a higher yield in patients with non-lesional MRIs. The concordance of HD-EEG dipole analysis localization and resection site is a favorable outcome indicator.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Review
Clinical Neurology
Michel Saenz-Farret, Marina A. J. Tijssen, Dawn Eliashiv, Robert S. Fisher, Kapil Sethi, Alfonso Fasano
Summary: The relationship between antiseizure drugs and movement disorders is complex and not adequately reviewed so far. Antiseizure drugs can both treat and induce movement disorders, and this review aims to describe the different effects and proposed mechanisms between 15 movement disorders and 24 antiseizure drugs.
Review
Clinical Neurology
Hugh D. Simpson, Andreas Schulze-Bonhage, Gregory D. Cascino, Robert S. Fisher, Barbara C. Jobst, Michael R. Sperling, Brian N. Lundstrom
Summary: Neuromodulation is a key therapeutic tool for drug-resistant epilepsy patients. This review summarizes available neuromodulation techniques, focusing on patient selection, programming initiation, and outpatient management. Vagus nerve stimulation, deep brain stimulation of the anterior nucleus of the thalamus, and responsive neurostimulation have all shown safety and significant seizure reduction in randomized controlled trials. The choice of neuromodulation technique can be tailored to individual patients based on their epilepsy characteristics, risk tolerance, and preferences.
Correction
Clinical Neurology
Michel Saenz-Farret, Marina A. J. Tijssen, Dawn Eliashiv, Robert S. Fisher, Kapil Sethi, Alfonso Fasano
Article
Clinical Neurology
Robert S. Fisher, Ryan J. McGinn, Erica L. Von Stein, Teresa Q. Wu, Kurt Y. Qing, Adam Fogarty, Babak Razavi, Chitra Venkatasubramanian
Summary: This article demonstrates the benefit of transcranial direct current stimulation (tDCS) in focal status epilepticus in the critical care setting. When conventional antiseizure medications and anesthetics are not effective, tDCS treatment can reduce seizures and spikes. The results showed significant improvement in interictal spikes and electrographic seizure frequency after tDCS treatment.
Article
Clinical Neurology
Teresa Q. Wu, Neda Kaboodvand, Ryan J. McGinn, Mike Veit, Zachary Davey, Anjali Datta, Kevin D. Graber, Kimford J. Meador, Robert Fisher, Vivek Buch, Josef Parvizi
Summary: In patients with presumed temporal lobe epilepsy, the pulvinar subregion of the thalamus is found to be involved earlier and more prominently than the ANT in the propagation of seizures, according to a study. This research provides evidence for the feasibility and safety of personalized thalamic neuromodulation.
Article
Clinical Neurology
Vibhor Krishna, Jesse Mindel, Francesco Sammartino, Cady Block, Alok Kumar Dwivedi, Jamie J. Van Gomple, Nathan Fountain, Robert Fisher
Summary: This article describes the initial experience of using unilateral anterior nucleus of the thalamus (ANT) focused ultrasound ablation (FUSA) in patients with treatment-refractory epilepsy. The results show that ANT FUSA is safe, feasible, and can significantly reduce seizure frequency.
Article
Engineering, Biomedical
Amin Noroozi, Maryam Ravan, Babak Razavi, Robert. S. S. Fisher, Ying-Ying Law, Mohammad. S. S. Hasan
Summary: In this paper, a more robust version of electromagnetic tomography technique, ReLORETA, is presented to localize brain sources in the presence of different forward model uncertainties. The proposed method accurately estimates the transformation of the lead field matrix distorted by uncertainties. Testing the method with simulated uncertainties and real data shows that ReLORETA is considerably more robust and accurate than eLORETA. Therefore, ReLORETA is a promising method for real-world clinical applications.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Clinical Neurology
Po-Chun Chu, Chen-Syuan Huang, Shan-Zhi Ing, Hsiang-Yu Yu, Robert S. S. Fisher, Hao-Li Liu
Summary: This study explores the behavioral effects and hippocampal restoration induced by pulsed ultrasound in an animal model of epilepsy. The results show that ultrasound protected the hippocampus and improved anxiety, limb usage, sociability, and learning in the animals. This study supports the existence of both neuroprotective and beneficial behavioral effects of low-intensity pulsed ultrasound in epilepsy.
Article
Clinical Neurology
Cuiping Xu, Lei Qi, Xueyuan Wang, Frederic L. W. V. J. Schaper, Di Wu, Tao Yu, Xiaoming Yan, Guangyuan Jin, Qiao Wang, Xiaopeng Wang, Xinqi Huang, Yuke Wang, Yuanhong Chen, Jinghui Liu, Yuping Wang, Andreas Horn, Robert S. Fisher, Liankun Ren
Summary: This study aimed to investigate whether the functional connectivity between the ANT-DBS sites and the seizure foci is associated with effective seizure control in refractory epilepsy.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
