Article
Clinical Neurology
Jonathan P. Scoville, Evan Joyce, Joshua Hunsaker, Jared Reese, Herschel Wilde, Amir Arain, Robert L. Bollo, John D. Rolston
Summary: The study showed that patients who underwent epilepsy mapping surgery via minimally invasive stereotactically placed SEEG electrodes had significantly lower opioid use compared to those who underwent the more invasive ECoG procedure. Additionally, there was a significant difference in pain scores between the two surgical groups.
OPERATIVE NEUROSURGERY
(2021)
Article
Neurosciences
Jeffrey Lim, Po T. Wang, Susan J. Shaw, Hui Gong, Michelle Armacost, Charles Y. Liu, An H. Do, Payam Heydari, Zoran Nenadic
Summary: This study aims to comprehensively characterize and model the propagation of artifacts in subdural ECoG stimulation. Through the analysis of data from four subjects, the study found specific temporal, spectral, and spatial characteristics of the artifacts, which can be used to improve artifact suppression techniques and inspire new strategies for artifact mitigation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hsiang-Yu Yu, Chun-Fu Lin, Chien-Chen Chou, Yi-Jiun Lu, Sanford P. C. Hsu, Cheng-Chia Lee, Chien Chen
Summary: HSL in lesional TLE showed satisfactory seizure and cognitive outcomes, with complete resection associated with seizure-free outcomes without aura. Intraoperative hippocampography-guided resection of apparently normal hippocampi should be performed cautiously and might not be necessary.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Clinical Neurology
James Flanary, Sam Daly, Caitlin Bakker, Alexander B. Herman, Michael C. Park, Robert McGovern, Thaddeus Walczak, Thomas Henry, Theoden Netoff, David P. Darrow
Summary: Visual review of intracranial electroencephalography (iEEG) is crucial for defining the zone of resection for epilepsy surgery. However, the reliability of visual review as a reference standard is still limited. This systematic literature review examines the existing evidence on the reliability of visual review and its implications for algorithm accuracy. The study found that the reliability of iEEG interpretation significantly affects the accuracy of algorithms in predicting the seizure onset zone (SOZ).
Review
Neurosciences
Mariana P. P. Branco, Simon H. H. Geukes, Erik J. J. Aarnoutse, Nick F. F. Ramsey, Mariska J. J. Vansteensel
Summary: In recent years, electocorticography (ECoG) has become an important tool for recording neural signals in the development of neural interfaces for clinical applications. The placement of ECoG electrodes can be either subdural (below the dura) or epidural (on top of the dura), and the choice between these modalities depends on the desired signal quality and risk of complications. The effects of the dura on signal quality and complications have been a topic of debate.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Arnau Dillen, Elke Lathouwers, Aleksandar Miladinovic, Uros Marusic, Fakhreddine Ghaffari, Olivier Romain, Romain Meeusen, Kevin De Pauw
Summary: The objective of this study is to demonstrate the feasibility of decoding lower limb movements from EEG data recordings and investigate the influence of neuroplastic adaptations on decoding performance. The results show that using BCI for lower limb prosthesis control is feasible and decoding performance is not affected by neuroplasticity-induced differences between healthy subjects and those with lower limb amputation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Moritz M. Nickel, Laura Tiemann, Vanessa D. Hohn, Elisabeth S. May, Cristina Gil Avila, Falk Eippert, Markus Ploner
Summary: The perception of pain is influenced by both somatosensory information and expectations, but the brain mechanisms involved in conveying these influences differ.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Mansoureh Fahimi Hnazaee, Maxime Verwoert, Zachary Freudenburg, Sandra M. A. van der Salm, Erik J. Aarnoutse, Sacha Leinders, Marc M. Van Hulle, Nick F. Ramsey, Mariska J. Vansteensel
Summary: This study investigates whether non-invasive scalp electroencephalography (EEG) can predict the performance of brain-computer interfaces (BCIs) based on electrocorticography (ECoG). By analyzing the experimental results of participants with locked-in syndrome (LIS) and healthy participants, it was found that EEG can detect the characteristics observed in ECoG signals. These findings provide new insights for predicting the performance of ECoG-BCIs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Rachel H. Muster, Jacob S. Young, Peter Y. M. Woo, Ramin A. Morshed, Gayathri Warrier, Sofia Kakaizada, Annette M. Molinaro, Mitchel S. Berger, Shawn L. Hervey-Jumper
Summary: Stimulation-induced seizures are rare but serious events during glioma surgery, with a higher occurrence when mapping the frontal lobe. The stimulation current level is not associated with identifying more functional cortical sites during the procedure.
Article
Engineering, Biomedical
Eleonora Borda, Danashi Imani Medagoda, Marta Jole Ildelfonsa Airaghi Leccardi, Elodie Genevieve Zollinger, Diego Ghezzi
Summary: Off-stoichiometry thiol-ene-epoxy (OSTE+) thermosets have low gas permeability and little absorption of dissolved molecules, allowing for low-temperature dry bonding without surface treatments. They can be manufactured via UV polymerisation and have gained attention for rapid prototyping of microfluidic chips and as a novel material for neural implants due to their mechanical properties and compatibility with standard clean-room processes.
Review
Chemistry, Analytical
Radek Martinek, Martina Ladrova, Michaela Sidikova, Rene Jaros, Khosrow Behbehani, Radana Kahankova, Aleksandra Kawala-Sterniuk
Summary: This paper presents various innovative methods for analyzing brain bioelectrical signals and compares both classical and advanced approaches for noise contamination removal.
Article
Neurosciences
Yuying Fan, Liping Dong, Xueyan Liu, Hua Wang, Yunhui Liu
Summary: High-frequency oscillations (HFOs) recorded noninvasively using methods such as scalp electroencephalography (EEG) and magnetoencephalography (MEG) are promising biomarkers for localizing the seizure onset zone (SOZ) in epilepsy. HFOs not only serve as useful biomarkers for the SOZ, but also have the potential to assess disease severity, monitor treatment, and evaluate prognostic outcomes. Additional research is needed for noninvasive recording methods of HFOs, and the future outlook appears promising despite existing challenges.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Biochemical Research Methods
Syed Muhammad Talha Zaidi, Samet Kocaturk, Tuncer Baykas, Mehmet Kocaturk
Summary: This study demonstrates, for the first time, trajectory-based control of a neuroprosthetic device by rodents using visual feedback. A novel behavioral paradigm and setup were described, allowing rats to reach two distant targets in a one-dimensional space. This research is of great importance for understanding the principles of information processing in neural circuits related to neuroprosthetic control and evaluating the performance of novel BMI technologies.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Clinical Neurology
Joshua C. Hunsaker, Jonathan P. Scoville, Evan Joyce, Jonathan Harper, Elena Kurudza, Matthew Sweney, Robert J. Bollo, John D. Rolston
Summary: Pediatric patients undergoing epilepsy mapping via SEEG require fewer opioids, have shorter hospital stays, and experience lower rates of complications compared to those undergoing ECoG.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Daniel R. Kramer, Morgan B. Lee, Michael Barbaro, Angad S. Gogia, Terrance Peng, Charles Liu, Spencer Kellis, Brian Lee
Summary: In this study, the feasibility of using a high-density mECoG grid in a somatosensory BCI system was demonstrated. By stimulating the hand area of the primary somatosensory cortex, it was possible to evoke sensations and record the location and description of perception.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Psychology, Biological
Yang Cao, Robert Oostenveld, Phillip M. Alday, Vitoria Piai
Summary: Decreases in oscillatory alpha- and beta-band power in spoken-word production are associated with motor preparation and conceptual-lexical retrieval processes. The spatial distribution of alpha and beta power decreases overlap in left posterior temporal and inferior parietal cortex regions.
Article
Biochemistry & Molecular Biology
Sam Norman-Haignere, Jenelle Feather, Dana Boebinger, Peter Brunner, Anthony Ritaccio, Josh H. McDermott, Gerwin Schalk, Nancy Kanwisher
Summary: This study developed a new method to investigate the neural code for music in the human auditory cortex using intracranial responses and fMRI. The results revealed that representations of music are fractionated into subpopulations selective for different types of music, with one subpopulation specialized for the analysis of songs.
Article
Neurosciences
David Brang, John Plass, Aleksandra Sherman, William C. Stacey, Vibhangini S. Wasade, Marcia Grabowecky, EunSeon Ahn, Vernon L. Towle, James X. Tao, Shasha Wu, Naoum P. Issa, Satoru Suzuki
Summary: Sounds can improve our ability to detect, localize, and respond to visual targets. This study used intracranial electroencephalography (iEEG) to investigate the impact of auditory information on visual cortex during passive listening. The results showed that visual cortex is sensitive to auditory onset and offset responses, but not to auditory entrainment. These findings provide insights into the interaction between auditory and visual processing in the brain.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Tao Xie, Zehan Wu, Gerwin Schalk, Yusheng Tong, Alessandro Vato, Nataly Raviv, Qinglong Guo, Huanpeng Ye, Xinjun Sheng, Xiangyang Zhu, Peter Brunner, Liang Chen
Summary: In this paper, an automated procedure using median nerve stimulation (MNS) to rapidly localize the central sulcus (CS) and create functional somatotopic maps is introduced.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Francesca Carota, Jan-Mathijs Schoffelen, Robert Oostenveld, Peter Indefrey
Summary: Language production involves complex computations, and recent neuromagnetic evidence suggests simultaneous meaning-to-speech mapping. This study used MEG to investigate the neural signals of human subjects overtly naming objects and found that word length and phonological neighborhood density influence the time course of word production.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mikkel C. Vinding, Robert Oostenveld
Summary: This study proposes a solution to protect the anonymity of research participants in MEG source analysis by using individualized warped templates instead of individual anatomical MRIs, which preserves the source reconstruction results while altering the anatomical and morphological fingerprint.
Article
Behavioral Sciences
Wesley T. Kerr, Hiroyuki Tatekawa, John K. Lee, Amir H. Karimi, Siddhika S. Sreenivasan, Joseph O'Neill, Jena M. Smith, L. Brian Hickman, Ivanka Savic, Nilab Nasrullah, Randall Espinoza, Katherine Narr, Noriko Salamon, Nicholas J. Beimer, Lubomir M. Hadjiiski, Dawn S. Eliashiv, William C. Stacey, Jerome Engel, Jamie D. Feusner, John M. Stern
Summary: This study found differences in brain morphology between patients with Functional Seizures (FS) and those with depression, anxiety, and obsessive-compulsive disorder. The results highlight the structural neuroimaging correlates of FS and suggest further research directions for exploring brain structural heterogeneity within FS.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Georgia Ramantani, M. Brandon Westover, Stephen Gliske, Johannes Sarnthein, Sridevi Sarma, Yujiang Wang, Maxime O. Baud, William C. Stacey, Erin C. Conrad
Summary: Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for almost a century. With the development of higher resolution digital EEG and analytical tools, there is a need to re-explore relevant methodology. This review provides an overview of the passive and active markers of cortical excitability in epilepsy based on EEG and discusses the techniques developed to identify these markers.
Article
Clinical Neurology
Ralph G. G. Andrzejak, Hitten P. P. Zaveri, Andreas Schulze-Bonhage, Marc G. G. Leguia, William C. C. Stacey, Mark P. P. Richardson, Levin Kuhlmann, Klaus Lehnertz
Summary: Significant progress has been made recently in seizure forecasting. Wearable and implantable devices that record various signals have provided valuable data for analyzing seizure dynamics. Network science approaches have also contributed to understanding the pre-ictal dynamics of epileptic brains. A key challenge now is to effectively communicate the results of seizure-forecasting algorithms to patients, caretakers, and clinicians.
Article
Neurosciences
Helena Cockx, Robert Oostenveld, Merel Tabor, Ecaterina Savenco, Arne van Setten, Ian Cameron, Richard van Wezel
Summary: This study aimed to assess the ability of fNIRS to detect the leg area of the primary motor cortex (M1) and distinguish it from the hand area. It also evaluated the differentiation capability of fNIRS between automatic and non-automatic movement processes. The results indicated that fNIRS is sensitive to leg activity in M1, but with lower sensitivity compared to finger activity, and rigorous correction for systemic fluctuations is necessary.
Review
Clinical Neurology
Stephen V. Gliske, William C. Stacey
Summary: The search for valid biomarkers to aid in epilepsy diagnosis and management is a major goal of the Epilepsy Research Benchmarks. However, the academic use of the word biomarker is often imprecise, leading to confusion and difficulty obtaining regulatory approval. To address this issue, the Food and Drug Administration and National Institutes of Health developed the BEST Resource to provide formal definitions and guidelines for biomarker research in epilepsy. By adopting these guidelines, researchers can improve reproducibility and better target the Epilepsy Benchmarks.
Article
Engineering, Biomedical
Tao Xie, Zehan Wu, Thomas J. Foutz, Xinjun Sheng, Xiangyang Zhu, Eric C. Leuthardt, Jon T. Willie, Liang Chen, Peter Brunner
Summary: This study developed a new method to estimate the modulatory effects on slow-wave activity, which is more reliable than conventional methods and does not require assumptions on the shape or stationarity of the slow-wave. The results showed a significant propagation of slow-wave modulation along the anterior-posterior axis of the cortex and the ability to monitor brain function during anesthesia.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Shashank Anand, Hohyun Cho, Markus Adamek, Harold Burton, Daniel Moran, Eric Leuthardt, Peter Brunner
Summary: High gamma coherence is a physiologically distinct phenomenon in sensory-motor tasks, indicating increased synaptic communication and requiring active task participation.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Vasileios Dimakopoulos, Jean Gotman, William Stacey, Nicolas von Ellenrieder, Julia Jacobs, Christos Papadelis, Jan Cimbalnik, Gregory Worrell, Michael R. Sperling, Maike Zijlmans, Lucas Imbach, Birgit Frauscher, Johannes Sarnthein
Summary: This study aims to evaluate the clinical relevance and generalizability of high-frequency oscillation (HFO) analysis in a large cohort from multiple independent epilepsy centers. By applying an automated algorithm to iEEG data recorded during sleep, clinically relevant HFOs are detected and their correlation with postsurgical seizure outcome is assessed.
BRAIN COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
