Article
Clinical Neurology
Kenneth A. Myers, Mark F. Bennett, Bronwyn E. Grinton, Gabriel Dabscheck, Eunice K. Chan, Luis E. Bello-Espinosa, Lynette G. Sadleir, Sabrina D'Alfonso, Amy L. Schneider, John A. Damiano, Michael S. Hildebrand, Melanie Bahlo, Samuel F. Berkovic, Jeffrey Buchhalter, Ingrid E. Scheffer
Summary: Rare genetic variants in CACNA1H do not significantly predict response to ETX in absence epilepsy patients, while there is an increased frequency of rare GABA-receptor gene variants in this patient population. Larger sample sizes are needed to further investigate the role of CACNA1H variants in predicting lack of response to ETX, and the enrichment of rare GABA-receptor variants suggests potential involvement of GABA receptor dysfunction in the pathophysiology of absence epilepsy.
Article
Clinical Neurology
Max Springer, Aya Khalaf, Peter Vincent, Jun Hwan Ryu, Yasmina Abukhadra, Sandor Beniczky, Tracy Glauser, Heinz Krestel, Hal Blumenfeld
Summary: This study aimed to develop a machine-learning method based on electroencephalography (EEG) features to predict behavioral impairment during spike-wave discharges (SWDs) in absence epilepsy. The best classifier achieved 100% predictive value for spared SWDs and 93% sensitivity in labeled data. In unlabeled data, the best classifier achieved 100% predictive value for spared SWDs, but with a lower sensitivity of 35%. These findings demonstrate the feasibility of using machine learning to predict impaired behavior during SWDs based on EEG features.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Neurosciences
Sophie Colombo, Haritha P. Reddy, Sabrina Petri, Damian J. Williams, Boris Shalomov, Ryan S. Dhindsa, Sahar Gelfman, Daniel Krizay, Amal K. Bera, Mu Yang, Yueqing Peng, Christopher D. Makinson, Michael J. Boland, Wayne N. Frankel, David B. Goldstein, Nathan Dascal
Summary: De novo mutations in GNB1 cause a neurodevelopmental disorder called GNB1 encephalopathy, characterized by global developmental delay and epilepsy. Mice carrying a pathogenic mutation recapitulate aspects of the disorder and display aberrant bursting activity in cortical neurons. The antiepileptic drug ethosuximide restores normal neuronal network behavior and suppresses spike-and-wave discharges both in vitro and in vivo.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Kana V. Mizuno, Edmund Capparelli, Tsuyoshi Fukuda, Min C. Dong, Peter L. Adamson, Jeffery Blumer, Avital O. Cnaan, Peggy D. Clark, Michael Reed, Shlomo A. Shinnar, Alexander A. Vinks, Tracy Glauser, Childhood Absence Epilepsy Study Grp Childhood Absence Epilepsy Study Grp
Summary: Ethosuximide has been identified as the best treatment option for new-onset childhood absence epilepsy (CAE), but a significant number of patients experience short-term treatment failure. This study aims to characterize the relationship between initial monotherapy with ethosuximide and treatment response, and to propose precision dosing guidance based on a model.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Clinical Neurology
Evgenia Sitnikova
Summary: This study investigates the alpha2-adrenergic mechanisms of absence status using a rat model. It suggests that activation of alpha2-adrenoreceptors can affect the thalamocortical system and regulate absence seizures. The duration of absence status is determined by the intensity of baseline absence seizures.
FRONTIERS IN NEUROLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Mingming Chen, Yajie Zhu, Renping Yu, Yuxia Hu, Hong Wan, Rui Zhang, Dezhong Yao, Daqing Guo
Summary: The strength of the GPe-TRN pathway and activity of GPe neurons play important roles in regulating absence seizures, with the pallido-cortical pathway and recurrent connection of GPe neurons contributing to this regulation. Enhancing the coupling strength of either the GPe-TRN pathway or pallido-cortical pathway can effectively terminate absence seizures. The bidirectional control of absence seizures by GPe neural activities can be modulated by the strength of the Ctx-TRN pathway.
Article
Clinical Neurology
Zi-ran Li, Chen-yu Wang, Wei-wei Lin, Yue-ting Chen, Xiao-qin Liu, Zheng Jiao
Summary: This study aims to explore optimal individualized remedial dosing regimens for delayed or missed doses of commonly used ASMs. Monte Carlo simulation based on population pharmacokinetic models was used to investigate six remedial strategies. The recommended remedial regimens were highly correlated with delayed time, scheduled dosing interval, and half-life of the ASM. The renal function and concomitant medication may also influence the remedial regimens.
Article
Engineering, Mechanical
Zhihui Wang, Lixia Duan
Summary: This study investigates the combined effects of thalamic feed-forward inhibition and feed-back inhibition on absence seizures. The results show that these two microcircuits play critical roles in eliminating absence seizures, with the feed-back inhibition of thalamus being stronger than the feed-forward inhibition.
NONLINEAR DYNAMICS
(2022)
Article
Medicine, General & Internal
Evgenia Sitnikova, Dmitrii Perevozniuk, Elizaveta Rutskova, Shukhrat Uzakov, Viktor A. A. Korshunov
Summary: Using a rat model, this study investigates the role of the hippocampus in absence epilepsy, revealing changes in hippocampal ripples and high frequency oscillations prior to and during seizure episodes.
Article
Clinical Neurology
Veronique Riban, Isabelle Heulard, Lucie Reversat, Hakim Si Hocine, Marc Verleye
Summary: Stiripentol has a significant antiseizure effect on absence seizures by inhibiting T-type calcium channels. This finding contributes to a better understanding of the mechanism of action of stiripentol and its specificity in the treatment of Dravet syndrome.
Article
Cell Biology
Ting Huang, Xuan Feng, Jiaqi Wang, Jingyi Zhou, Jianliu Wang
Summary: This study established a risk model based on calcium-related genes that can reliably predict the outcomes of patients with endometrial cancer (EC). Calcium-related and estrogen-response signalings were significantly enriched in the high-risk group. Furthermore, a calcium channel blocker, amlodipine (AM), showed significant potential for inhibiting cell proliferation and inducing cell cycle arrest in vitro and in vivo.
Article
Clinical Neurology
Mehmet Nuri Kocak, Remzi Arslan, Abdulmecit Albayrak, Erdal Tekin, Mustafa Bayraktar, Muhammet Celik, Zulkuf Kaya, Huseyin Bekmez, Taha Tavaci
Summary: Benidipine, either alone or in combination with valproic acid, was found to have significant antiepileptic efficacy and provided neuroprotection when combined with valproic acid in this study.
NEUROLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jacqueline Kaiser, Kevin Nay, Christopher R. Horne, Luke M. Mcaloon, Oliver K. Fuller, Abbey G. Muller, Douglas G. Whyte, Anthony R. Means, Ken Walder, Michael Berk, Anthony J. Hannan, James M. Murphy, Mark A. Febbraio, Andrew L. Gundlach, John W. Scott
Summary: Current pharmacological treatments for bipolar disorder are inadequate and lack revolutionary therapies due to limited efficacy, burdensome side-effects, and a poor understanding of the underlying disease mechanisms. Targeting the CaMKK2 enzyme shows promise as a new treatment strategy for bipolar disorder, as it is associated with the disease and its behaviors can be ameliorated by increasing CaMKK2 activity with lithium.
MOLECULAR PSYCHIATRY
(2023)
Article
Engineering, Biomedical
Tianlin Ying, Anthony N. Burkitt, Tatiana Kameneva
Summary: This study investigates the effects of extracellular potassium concentration and T-type calcium channel on epilepsy using microscopic and macroscopic models. The results show that increases in these factors can cause brain network transitions to pathological seizure-like dynamics within a limited range of network parameters. The slow-inhibitory synaptic gain has a stronger effect on network dynamics during transitions than the fast-inhibitory synaptic gain.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Clinical Neurology
Hongxia Ma, Yuxiong Guo, Zhihong Chen, Lingan Wang, Zhihong Tang, Jingwen Zhang, Qinfei Miao, Qiongxiang Zhai
Summary: The study identified mutations in SCN1A, SCN3A, and SCN9A genes as potential causes of EFS+ in the Southern Chinese Han population. These mutations led to varied clinical phenotypes in patients, including febrile seizures, Dravet Syndrome, etc.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Substance Abuse
Elias M. Klemperer, John R. Hughes, Laura J. Solomon, Peter W. Callas, James R. Fingar
Article
Psychology, Clinical
John R. Hughes, Laura J. Solomon, Catherine E. Peasley-Miklus, Peter W. Callas, James R. Fingar
ADDICTIVE BEHAVIORS
(2018)
Article
Psychology, Clinical
John R. Hughes, Peter W. Callas
ADDICTIVE BEHAVIORS
(2019)
Article
Substance Abuse
Elias M. Klemperer, John R. Hughes, Shelly Naud
NICOTINE & TOBACCO RESEARCH
(2019)
Editorial Material
Substance Abuse
John R. Hughes
NICOTINE & TOBACCO RESEARCH
(2018)
Article
Substance Abuse
Elias M. Klemperer, John R. Hughes, Shelly Naud
NICOTINE & TOBACCO RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Stephen T. Higgins, Cecilia L. Bergeria, Danielle R. Davis, Joanna M. Streck, Andrea C. Villanti, John R. Hughes, Stacey C. Sigmon, Jennifer W. Tidey, Sarah H. Heil, Diann E. Gaalema, Maxine L. Stitzer, Jeff S. Priest, Joan M. Skelly, Derek D. Reed, Janice Y. Bunn, Morgan A. Tromblee, Christopher A. Arger, Mollie E. Miller
PREVENTIVE MEDICINE
(2018)
Letter
Substance Abuse
John R. Hughes, Karl O. Fagerstrom, Jack E. Henningfield, Brad Rodu, Jed E. Rose, Saul Shiffman
Article
Substance Abuse
Elias M. Klemperer, John R. Hughes, Peter W. Callas, Joy A. Benner, Nicholas E. Morley
Article
Substance Abuse
Cecilia L. Bergeria, Sarah H. Heil, Danielle R. Davis, Joanna M. Streck, Stacey C. Sigmon, Janice Y. Bunn, Jennifer W. Tidey, Chris A. Arger, Derek D. Reed, Thomas Gallagher, John R. Hughes, Diann E. Gaalema, Maxine L. Stitzer, Stephen T. Higgins
DRUG AND ALCOHOL DEPENDENCE
(2019)
Article
Psychology, Clinical
Joanna M. Streck, John R. Hughes, Elias M. Klemperer, Alan B. Howard, Alan J. Budney
ADDICTIVE BEHAVIORS
(2019)
Article
Substance Abuse
Elias M. Klemperer, John R. Hughes, Peter W. Callas
NICOTINE & TOBACCO RESEARCH
(2019)
Article
Substance Abuse
Diann E. Gaalema, Jennifer W. Tidey, Danielle R. Davis, Stacey C. Sigmon, Sarah H. Heil, Maxine L. Stitzer, Michael J. DeSarno, Valeria Diaz, John R. Hughes, Stephen T. Higgins
NICOTINE & TOBACCO RESEARCH
(2019)
Article
Psychology, Clinical
Dustin C. Lee, Denise D. Walker, John R. Hughes, Mary F. Brunette, Emily Scherer, Catherine Stanger, Jean-Francois Etter, Samantha Auty, Alan J. Budney
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2019)
Meeting Abstract
Substance Abuse
John R. Hughes
AMERICAN JOURNAL ON ADDICTIONS
(2017)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)