Review
Clinical Neurology
Andreu Massot-Tarrus, Seyed M. Mirsattari
Summary: Surgical treatment for pharmacoresistant temporal lobe epilepsy carries risks for language function. Predicting language function decline before surgery is as important as predicting seizure-free outcomes. The Wada test (WT) has traditionally been used for language lateralization, but it is invasive and does not localize language function. Functional magnetic resonance imaging (fMRI) has great potential as a noninvasive alternative, allowing localization and predictive value for postsurgical outcomes. This review focuses on the importance of language evaluation and the role of fMRI and WT in presurgical assessments.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Kirsten Herfurth, Yuval Harpaz, Julie Roesch, Nadine Mueller, Katrin Walther, Martin Kaltenhaeuser, Elisabeth Pauli, Abraham Goldstein, Hajo Hamer, Michael Buchfelder, Arnd Doerfler, Julian Prell, Stefan Rampp
Summary: The study examined the concordance between MEG and fMRI in the evaluation of language lateralization, showing left language dominance with high laterality indices in controls based on MEG beta power desynchronization.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Olivia Foesleitner, Benjamin Sigl, Victor Schmidbauer, Karl-Heinz Nenning, Ekaterina Pataraia, Lisa Bartha-Doering, Christoph Baumgartner, Susanne Pirker, Doris Moser, Michelle Schwarz, Johannes A. Hainfellner, Thomas Czech, Christian Dorfer, Georg Langs, Daniela Prayer, Silvia Bonelli, Gregor Kasprian
Summary: Epilepsy surgery is a recommended treatment for drug-resistant temporal lobe epilepsy, but can lead to postoperative language impairment. This study found widespread bilateral remodeling of language networks after surgery, with specific patterns in left and right TLE. Contralateral language recruitment before surgery is associated with better language outcomes post-surgery in both left and right TLE.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Danni Guo, Li Feng, Zhiquan Yang, Rong Li, Bo Xiao, Shirui Wen, Yangsa Du, Chijun Deng, Xuyang Wang, Dingyang Liu, Fangfang Xie
Summary: This study found that dynamic functional network connectivity (DFNC) analysis can help us understand the neural impairment mechanisms and brain network reorganization in drug-resistant temporal lobe epilepsy (TLE), and provide additional preoperative evaluation support for surgical treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jennifer I. Koop, Kevin Credille, Yang Wang, Michelle Loman, Ahmad Marashly, Irene Kim, Sean M. Lew, Mohit Maheshwari
Summary: The study examined the agreement of hemispheric lateralization as determined by fMRI and IAP in pediatric epilepsy surgery patients, showing a strong correlation and 70% agreement between the two methods, despite the presence of bilateral or atypical language representation in this pediatric sample.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Chifaou Abdallah, Helene Brissart, Sophie Colnat-Coulbois, Ludovic Pierson, Olivier Aron, Natacha Forthoffer, Jean-Pierre Vignal, Louise Tyvaert, Jacques Jonas, Louis Maillard
Summary: The study evaluated the decline in visual object naming in drug-resistant temporal lobe epilepsy patients after dominant temporal lobe resection according to the resection status of the basal temporal language area identified by cortical stimulation during stereoelectroencephalography. The results showed that resection of the basal temporal language area was associated with specific and early naming decline, with BTLA+ patients experiencing lower naming scores compared to their baseline even in the long run. Seamless mapping helps predict postoperative language outcomes after dominant temporal lobe resection.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Kangrun Wang, Fangfang Xie, Chaorong Liu, Ge Wang, Min Zhang, Jialinzi He, Langzi Tan, Haiyun Tang, Fenghua Chen, Bo Xiao, Yanmin Song, Lili Long
Summary: This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings. The results showed that patients and siblings exhibited abnormal brain network topology and impaired network connectivity. These abnormalities were more prevalent in unaffected siblings compared to the normal population and were not correlated with disease burden.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Xiaomin Pang, Xiulin Liang, Weiwei Chang, Zongxia Lv, Jingyuan Zhao, Peirong Wu, Xinrong Li, Wutong Wei, Jinou Zheng
Summary: This study aimed to investigate the modular architecture of functional networks in patients with temporal lobe epilepsy (TLE) and the role of the thalamus in these networks. The results showed that the thalamus plays a significant role in modular networks and may be a key neural mechanism underlying cognitive impairment in TLE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Xi Zhang, Guojun Zhang, Tao Yu, Cuiping Xu, Jin Zhu, Xiaoming Yan, Kai Ma, Runshi Gao
Summary: This study analyzed the surgical outcomes of patients with temporal lobe epilepsy (TLE) who underwent temporal and insular SEEG recordings. The findings suggest that insular involvement may be associated with failed anterior temporal lobectomy (ATL) and poorer seizure outcomes. The study also identified temporal-insular spreading time (TIST) as an independent predictor of postoperative seizure-free outcomes in these patients.
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Review
Biochemistry & Molecular Biology
Alexey M. Yakimov, Elena E. Timechko, Irina G. Areshkina, Anna A. Usoltseva, Kristina D. Yakovleva, Elena A. Kantimirova, Nikita Utyashev, Nikita Ivin, Diana V. Dmitrenko
Summary: Mesial temporal lobe epilepsy is the most common type of epilepsy and surgery is often the only treatment option. This study focuses on miR-654-3p as a potential biomarker for surgical outcome, while also considering other miRNAs as indicators of relapse. The research on miRNAs as predictive biomarkers of surgical outcome is urgent, but several factors need to be taken into account.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Mark W. Tenforde, Wesley H. Self, Yuwei Zhu, Eric A. Naioti, Manjusha Gaglani, Adit A. Ginde, Kelly Jensen, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, Tresa McNeal, Shekhar Ghamande, Kevin W. Gibbs, D. Clark Files, David N. Hager, Arber Shehu, Matthew E. Prekker, Heidi L. Erickson, Michelle N. Gong, Amira Mohamed, Nicholas J. Johnson, Vasisht Srinivasan, Jay S. Steingrub, Ithan D. Peltan, Samuel M. Brown, Emily T. Martin, Arnold S. Monto, Akram Khan, Catherine L. Hough, Laurence W. Busse, Caitlin ten Lohuis, Abhijit Duggal, Jennifer G. Wilson, Nida Qadir, Steven Y. Chang, Christopher Mallow, Carolina Rivas, Hilary M. Babcock, Jennie H. Kwon, Matthew C. Exline, Mena M. Botros, Adam S. Lauring, Nathan Shapiro, Natasha Halasa, James D. Chappell, Carlos G. Grijalva, Todd W. Rice, Ian D. Jones, William B. Stubblefield, Adrienne Baughman, Kelsey N. Womack, Jillian P. Rhoads, Christopher J. Lindsell, Kimberly W. Hart, Caitlin Turbyfill, Samantha Olson, Nancy Murray, Katherine Adams, Manish M. Patel
Summary: Among hospitalized adults, the effectiveness of the two-dose mRNA vaccine against COVID-19-associated hospitalization decreased from 90% to 82% after 6 months post-vaccination. This study highlights the limited long-term durability of protection provided by the COVID-19 mRNA vaccines against hospitalization.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Rehabilitation
Jessica Sparrow, Hannah Dagen, Allison Harris, Sarah Schwartzberg, Lucy Weathers, Megan Kibby, Jennifer L. Harman, Lisa M. Jacola
Summary: This study retrospectively examined the access to occupational therapy (OT) for infants and toddlers receiving cancer treatment. The results showed that the majority of infants and toddlers received an OT evaluation and many were recommended to continue OT services after returning home. There were differences in referrals to home or community-based OT services based on age and disease.
OTJR-OCCUPATIONAL THERAPY JOURNAL OF RESEARCH
(2023)
Article
Hematology
Andrew M. Heitzer, Jane E. Schreiber, Xiaomeng Yuan, Fang Wang, Haitao Pan, J. Carolyn Graff, Laura Murphy, Rebecca Rupff, Kathryn Russell, Winfred Wang, Jeremie H. Estepp, Jane S. Hankins, Jerlym S. Porter, Lisa M. Jacola
Summary: Children with sickle cell disease are at risk of neurobehavioural problems. This study found that preschool children with sickle cell disease had worse performance in executive function, working memory, and school readiness compared to healthy controls. The study also showed that the primary caregiver's college education was positively associated with school readiness in sickle cell disease patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Matthew W. McCarthy, Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart, G. Michael Felker, Dushyantha Jayaweera, Mark Sulkowski, Nina Gentile, Carolyn Bramante, Upinder Singh, Rowena J. Dolor, Juan Ruiz-Unger, Sybil Wilson, Allison DeLong, April Remaly, Rhonda Wilder, Sean Collins, Sarah E. Dunsmore, Stacey J. Adam, Florence Thicklin, George Hanna, Adit A. Ginde, Mario Castro, Kathleen McTigue, Elizabeth Shenkman, Adrian F. Hernandez
Summary: This study aimed to evaluate the efficacy of low-dose fluvoxamine (50 mg twice daily for 10 days) compared with placebo for the treatment of mild to moderate COVID-19. The results showed that treatment with fluvoxamine did not improve the time to sustained recovery compared with placebo. These findings do not support the use of fluvoxamine at this dose and duration in patients with mild to moderate COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, Melissa S. Stockwell, Katherine D. Ellingson, Karen Lutrick, Natalie M. Bowman, Emily E. Bendall, Ayla Bullock, James D. Chappell, Jessica E. Deyoe, Julie Gilbert, Natasha B. Halasa, Kimberly E. Hart, Sheroi Johnson, Ahra Kim, Adam S. Lauring, Jessica T. Lin, Christopher J. Lindsell, Son H. McLaren, Jennifer K. Meece, Alexandra M. Mellis, Miriana Moreno Zivanovich, Constance E. Ogokeh, Michelle Rodriguez, Ellen Sano, Raul A. Silverio A. Francisco, Jonathan E. Schmitz, Celibell Y. Vargas, Amy Yang, Yuwei Zhu, Edward A. Belongia, Carrie Reed, Carlos G. Grijalva
Summary: The COVID-19 pandemic resulted in a decrease in global influenza virus infections. However, there was an increased risk of influenza virus infection during the 2021-2022 influenza season due to loss of natural immunity and antigenic changes in circulating viruses.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Jennifer A. Lewis, Lauren R. Samuels, Jacy Weems, Daniel Park, Robert Winter, Christopher J. Lindsell, Carol Callaway-Lane, Carolyn Audet, Christopher G. Slatore, Renda Soylemez Wiener, Robert S. Dittus, Sunil Kripalani, David F. Yankelevitz, Claudia I. Henschke, Drew Moghanaki, Michael E. Matheny, Timothy J. Vogus, Christianne L. Roumie, Lucy B. Spalluto
Summary: This study evaluated the association between healthcare organizations' preparedness and change valence with lung cancer screening utilization. The results showed that higher readiness and change valence were associated with increased utilization of lung cancer screening.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Microbiology
Robert R. Lavieri, Erik R. Dubberke, Sarah K. McGill, Luther Bartelt, Stephanie A. Smith, Balint K. Pandur, Sharon E. Phillips, Krista Vermillion, Jana Shirey-Rice, Jill Pulley, Yaomin Xu, Christopher J. Lindsell, Nicole Zaleski, Rebecca Jerome, Ryan S. Doster, David M. Aronoff
Summary: We conducted a randomized controlled trial on the use of misoprostol for preventing recurrent C. difficile and analyzed our challenging experience. Despite careful screening and protocol modifications, the study was closed prematurely with only 7 participants enrolled over 3 years. We emphasize the importance of feasibility studies, inclusion of biomarker outcomes, and dissemination of findings for informing future research design and implementation successes.
Article
Critical Care Medicine
Stephanie G. Patterson, Celia K. Lamb, Wu Gong, Jackson Resser, Christopher J. Lindsell, Sara L. Van Driest, Ryan J. Stark
Summary: This study investigated the prevalence of pediatric Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (pPICS) in patients who died from sepsis-related causes. It found that nearly half of the pediatric patients with sepsis had pPICS. These patients were more likely to have underlying hematologic or oncologic disease or cardiac disease, and were also at a higher risk of fungal infections compared to patients without pPICS.
Article
Medicine, General & Internal
Shawniqua Williams Roberson, Samuel Nwosu, Erin M. Collar, Amy L. Kiehl, Fiona E. Harrison, Julie Bastarache, Jo Ellen Wilson, Matthew F. Mart, Jonathan E. Sevransky, E. Wesley Ely, Christopher J. Lindsell, James C. Jackson
Summary: This study aimed to investigate the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes in sepsis survivors. The results showed that treatment with vitamin C, thiamine, and hydrocortisone did not improve or worsen cognitive, psychological, and functional outcomes at 6 months compared to placebo.
Article
Medicine, General & Internal
Eva A. Mistry, Kimberly W. Hart, Larry T. Davis, Yue Gao, Charles J. Prestigiacomo, Shilpi Mittal, Tapan Mehta, Hayden LaFever, Pablo Harker, Hilary E. Wilson-Perez, Kalli A. Beasley, Neeharika Krothapalli, Emily Lippincott, Heather Stefek, Michael Froehler, Rohan Chitale, Matthew Fusco, Aaron Grossman, Peyman Shirani, Matthew Smith, Matthew N. Jaffa, Sharon D. Yeatts, Gregory W. Albers, Jonathan P. Wanderer, Juliana Tolles, Christopher J. Lindsell, Roger J. Lewis, Gordon R. Bernard, Pooja Khatri
Summary: This study aimed to determine the futility of lower systolic blood pressure (SBP) targets after successful endovascular therapy for acute ischemic stroke. The results showed that lower SBP targets (<140 mm Hg or <160 mm Hg) did not meet the prespecified criteria for futility compared with a higher target (≤180 mm Hg) among patients with acute ischemic stroke. However, the findings also suggested a low probability of benefit from lower SBP targets after endovascular therapy if tested in a future larger trial.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Anesthesiology
Britany L. Raymond, Brian F. S. Allen, Robert E. Freundlich, Crystal G. Parrish, Jennifer E. Jayaram, Jonathan P. Wanderer, Todd W. Rice, Christopher J. Lindsell, Kevin H. Scharfman, Mary L. Dear, Yue Gao, William D. Hiser, Matthew D. McEvoy
Summary: This study aims to investigate the impact of perioperative ketamine infusion on mature ERAS pathways. 1544 patients undergoing major abdominal surgery will be randomly allocated to receive either ketamine or placebo infusion. The primary outcome is length of stay, and secondary outcomes include various clinical endpoints.
BMC ANESTHESIOLOGY
(2023)
Correction
Medicine, General & Internal
S. Naggie, D. R. Boulware, C. J. Lindsell
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Pharmacology & Pharmacy
Tate D. Parrott, Matthew D. Wallace, Kristina M. Niehoff, Sarah H. Eble, Lauren Blumenfeld, Carla M. Sevin, Neesha N. Choma, Yue Gao, Leena Choi, Christopher J. Lindsell, Autumn D. Zuckerman
Summary: Patients with asthma and COPD often rely on inhaler therapy. This study assessed the appropriateness of long-acting inhaler regimens for hospitalized patients based on guidelines and insurance coverage. A pharmacist-led review found that 42% of inhalers were inappropriate, necessitating changes in therapy for over half of the patients. Interventions are needed to improve the appropriateness of prescribed inhalers and reduce disease progression and exacerbation risk.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
Article
Medicine, Research & Experimental
Kristian Thorlund, Davey Smith, Christopher Linsell, Nicholas White, Christopher Butler, David Boulware, Judith Currier, Ofir Harari, Edouard Lhomme, Nathalie Strub-Wourgaft, Stacey Adam, Edward Mills
Summary: Clinical trial endpoints should be carefully selected to inform policy- and decision-making, considering the preferences of different stakeholders. The selection of endpoints for COVID-19 clinical trials has been problematic, as they did not always match the usual efficacy endpoints required by guideline panels. This has made it difficult to compare and evaluate interventions timely. Selecting appropriate endpoints is crucial for researchers to provide reliable, valid, and interpretable results.
COMMUNICATIONS MEDICINE
(2023)
Article
Infectious Diseases
Jin H. Han, James C. Jackson, Onur M. Orun, Samuel M. Brown, Jonathan D. Casey, Lindsay Clark, Sean P. Collins, Kemberlyne Cordero, Adit A. Ginde, Michelle N. Gong, Catherine L. Hough, Theodore J. Iwashyna, Amy L. Kiehl, Alana Lauck, Lindsay M. Leither, Christopher J. Lindsell, Mayur B. Patel, Rameela Raman, Todd W. Rice, Nancy J. Ringwood, Karen L. Sheppard, Matthew W. Semler, B. Taylor Thompson, E. Wesley Ely, Wesley H. Self
Summary: This study aimed to identify potentially modifiable in-hospital factors associated with global cognition, post-traumatic stress disorder (PTSD) symptoms, and depression symptoms in patients hospitalized with acute COVID-19. The study found that the use of remdesivir was associated with significantly better cognitive function at 12 months. Delirium was associated with worsening PTSD and depression symptoms at 12 months. Multiple virtual visits per day during hospitalization were associated with fewer depression symptoms at 12 months.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)