Review
Psychiatry
Qian Gao, Wei Sun, Yue-Rui Wang, Zi-Fa Li, Feng Zhao, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Ying Xing, Wei Liu, Sheng Wei
Summary: Premenstrual dysphoric disorder (PMDD) is characterized by suboptimal sensitivity to neuroactive steroid hormones. Core symptoms of PMDD, such as emotional instability, irritability, depression, and anxiety, are linked to increased stress sensitivity during the luteal phase of the menstrual cycle. This review explores the role of allopregnanolone (ALLO) in emotional regulation and the relationship between ALLO and gamma-aminobutyric acid A (GABA(A)) receptor subunits through experimental and clinical evidence. Changes in ALLO levels impact GABA(A) receptor sensitivity, which in turn affects the excitability of pyramidal neurons and contributes to PMDD-like behavior. Targeting GABA(A) receptors may offer potential treatment options for PMDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Liisa Hantsoo, Jennifer L. Payne
Summary: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder that is associated with hormonal fluctuations, and its underlying biology is not yet fully understood. Recent research suggests that abnormal central nervous system response to neuroactive steroid hormone fluctuations, alterations in serotonergic and GABA transmission, genetic heritability, and cellular vulnerability to sex hormones may contribute to PMDD. However, the findings have not yet been integrated into a complete description of PMDD's underlying biology, and a subtyping approach may be beneficial for future research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Endocrinology & Metabolism
Jordan C. Barone, Mitchell P. Butler, Ashley Ross, Anna Patterson, Melissa Wagner-Schuman, Tory A. Eisenlohr-Moul
Summary: Cyclic hormonal variations during the menstrual cycle contribute to multiple central nervous system disorders, such as premenstrual mood disorder, menstrual migraine, and catamenial epilepsy. However, these fields have operated independently without systematic communication. This scoping review examines existing research studies in these disorders to outline hormonal manipulation trials and identify gaps in the literature. Despite the heterogeneity of treatments and study designs, there is significant overlap in the neuroendocrine-based hormone sensitivity among these menstrual cycle-related disorders.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Erika Comasco, Helena Kopp Kallner, Marie Bixo, Angelica L. Hirschberg, Sara Nyback, Haro de Grauw, C. Neill Epperson, Inger Sundstrom-Poromaa
Summary: The study investigated the potential treatment of continuous treatment with a selective progesterone receptor modulator, ulipristal acetate (UPA), for premenstrual dysphoric disorder (PMDD). Results showed that the UPA group demonstrated a significant improvement in DRSP scores compared to the placebo group, particularly in depressive and anger/irritability symptoms.
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Estrada-Camarena Erika, Carolina Lopez-Rubalcava
Summary: Around 80% of women worldwide experience mild Premenstrual Disorders (PMD) during their reproductive life, with up to a quarter affected by moderate to severe symptoms. Ovarian hormones participate in PMDD symptoms, and their regulation may be altered. PMDD is a complex condition that requires consideration of multiple factors, particularly in animal models.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Psychology, Clinical
Sibel Nayman, Theresa Beddig, Iris Reinhard, Christine Kuehner
Summary: In women with premenstrual dysphoric disorder (PMDD), habitual mindfulness and reappraisal have a positive effect on momentary mood, but do not protect against premenstrual mood deterioration. Additionally, habitual mindfulness seems to buffer blunted cortisol activity in women with PMDD, especially during the menstrual phase.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Emily Robertson, Caroline Thew, Natalie Thomas, Leila Karimi, Jayashri Kulkarni
Summary: The findings of a clinical follow-up feasibility study suggest that treatment with nomegestrol acetate/17-beta estradiol is acceptable and effective in improving mood symptoms in PMDD patients. The majority of women reported a positive mood response, high adherence to the medication, and minimal side effects. Further research, such as a randomized controlled trial, is needed to confirm these results and explore the impact of this treatment on mood in PMDD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Ajna Hamidovic, Fatimata Soumare, Aamina Naveed, John Davis
Summary: This study investigated the association between progesterone, estradiol, and premenstrual food cravings. The results showed a protective effect of progesterone on premenstrual food cravings, based on prior research suggesting neurobiological overlaps between food and drug cravings. The study enrolled 37 non-illicit drug- or medication-using women and classified them as either premenstrual dysphoric disorder (PMDD) or control participants, based on daily ratings of symptoms. Blood samples were collected at eight clinic visits and analyzed using ultraperformance liquid chromatography tandem mass spectrometry. Hierarchical modeling revealed a significant inverse effect of progesterone on premenstrual food cravings, regardless of PMDD or control status.
Article
Clinical Neurology
Christophe Moderie, Philippe Boudreau, Ari Shechter, Paul Lesperance, Diane B. Boivin
Summary: The study found that intervention with exogenous melatonin increased urinary aMt6, reduced sleep onset latency, decreased slow-wave sleep, increased Stage 2 sleep, and improved symptoms in PMDD patients. Circadian parameters derived from 24-hour plasma melatonin and CBT did not differ significantly between intervention and baseline conditions, except for an increased melatonin mesor in the intervention condition. Ovarian hormones remained comparable between the two conditions.
Article
Psychiatry
Tory Eisenlohr-Moul, Madeline Divine, Katja Schmalenberger, Laura Murphy, Brett Buchert, Melissa Wagner-Schuman, Alyssa Kania, Sabina Raja, Adam Bryant Miller, Jordan Barone, Jaclyn Ross
Summary: This study found high rates of self-injurious thoughts and behaviors in individuals reporting a diagnosis of PMDD, emphasizing the need for further research on understanding and preventing STBs in PMDD. Clinical practice guidelines for PMDD should address comorbidities and include frequent screenings for suicide risk. STBs should be considered for inclusion in future updates of the DSM PMDD diagnostic criteria.
Article
Clinical Neurology
Christophe Moderie, Philippe Boudreau, Ari Shechter, Paul Lesperance, Diane B. Boivin
Summary: The study suggests that exogenous melatonin can increase urinary melatonin levels, reduce sleep onset latency, decrease slow-wave sleep, and increase stage 2 sleep in women with premenstrual dysphoric disorder (PMDD). Additionally, melatonin intervention improves mood and symptoms in these patients.
Article
Endocrinology & Metabolism
Maria Clara de Morais Faleiros Maranho, Vinicius Guandalini Guapo, Marcos Gonsalves de Rezende, Carolina Sales Vieira, Marcus Lira Brandao, Frederico Guilherme Graeff, Thelma Lovick, Cristina Marta Del-Ben
Summary: The study aimed to assess the potential effect of low doses of fluoxetine during the luteal phase in preventing or mitigating emotional PMS symptoms. The randomized, double-blind, placebo-controlled pilot study found that low doses of fluoxetine may have some potential in mitigating emotional PMS symptoms.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Computer Science, Cybernetics
Soyoung Ahn, Yongsoon Choi
Summary: This study developed a smart mirror called Smiley, which can only be seen when users smile, and evaluated its effects on women suffering from PMS. The results showed that smiling can change negative emotions caused by PMS and positively influence users' psychological stability and daily life.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Cell Biology
Mingzhou Gao, Hao Zhang, Ya Sun, Zhan Gao, Chunyan Sun, Fengqin Wei, Dongmei Gao
Summary: This study revealed that the GABRB2 gene plays a regulatory role in PMDD-like behaviors. The ALLO binding site may not be located on the β2 subunits, and abnormal expressions of the δ and ε subunits in the mouse brain, as well as neurotransmitter disturbance, may contribute to ALLO sensitivity.
Article
Clinical Neurology
Inger Sundstrom-Poromaa, Erika Comasco
Summary: Premenstrual symptoms are common among women of reproductive age, with 5% experiencing premenstrual dysphoric disorder (PMDD) during the luteal phase. Selective serotonin reuptake inhibitors are effective for many patients, but not all. Recent research shows that treatment with a selective progesterone receptor modulator (SPRM) significantly reduces the severity of PMDD symptoms, with minimal side effects.
Article
Thermodynamics
Manuela Crisan, Mihaela Petric, Gabriela Vlase, Titus Vlase, Anatolii V. Siminel, Paulina N. Bourosh, Lilia Croitor
Summary: Two new multicomponent crystal forms based on the 4-nitrobenzoic acid-diethanolamine system were synthesized and analyzed, revealing structural and thermal differences. The study also discussed the kinetic properties and photoluminescence performance of these compounds.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Dan Vlase, Titus Vlase, Madalin Bunoiu, Paula Sfirloaga, Alexandra-Gabriela Ursut, Gabriela Vlase
Summary: This study analyzed pottery sherds and clay samples from an archaeological rescue dig in the Transilvania Highway. The analysis aimed to determine the composition similarities between pottery sherds and soil samples, as well as the local origin of raw materials and pottery technology.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Gabriela Vlase, Dan Vlase, Iosif Vasile Ferencz, Paula Sfirloaga, Dorel Micle, Florin Manea, Titus Vlase
Summary: Thermal analysis and infrared spectroscopy were used to study mortar samples from different historical periods in south-western Transylvania, Romania. These techniques provide valuable information about the characteristics and construction techniques of the mortar samples, which is of great importance for the preservation of Romanian heritage.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Lilia Croitor, Gabriela Vlase, Titus Vlase, Paulina N. Bourosh, Yurii M. Chumakov, Manuela Crisan
Summary: The crystal structures and thermal characteristics of two polymorphs of methylethanolammonium 2-chloro-4-nitrobenzoate were analyzed using experimental and computational methods. The study focused on the synthesis of the polymorphs, structural characterization, intermolecular interactions, thermodynamic stability, and thermal decomposition kinetics. The results revealed distinct crystal packing arrangements and different numbers of independent molecules pairs in the asymmetric crystal unit. The alpha polymorph had a more stable lattice than the beta polymorph at high temperatures. The thermodynamic stability was determined by measuring melting points and heats of fusion. The alpha polymorph also exhibited higher activation energies compared to the beta polymorph in the thermal decomposition processes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Materials Science, Ceramics
Dan Vlase, Gabriela Vlase, Gabriela Ursut, Paula Sfirloaga, Florin Manea, Mihaela Budiul, Andrei Rotaru, Titus Vlase, Ion Creanga
Summary: This study aims to analyze pottery samples from the Foeni Tell - Orthodox Cemetery archaeological site in Romania. Results indicate that Foeni pottery was locally produced using a high plasticity clay and various minerals, with firing temperatures ranging from 550-600 degrees Celsius.
CERAMICS INTERNATIONAL
(2023)
Article
Thermodynamics
Cosmina Bengescu, Adriana Ledeti, Tudor Olariu, Denisa Circioban, Cornelia Muntean, Gabriela Vlase, Titus Vlase, Carmen Tomoroga, Anca Octavia Dragomirescu, Daniela Dascalu, Lenuta-Maria Suta, Ionut Ledeti, Marius Murariu
Summary: This study investigated ten samples containing promestriene (PRMS), including pure active pharmaceutical ingredient (API) and nine binary mixtures with commonly used excipients. The necessity of this study lies in the lack of reported physicochemical screening of PRMS in the literature. Additionally, the discontinuation of promestriene containing formulations in the Romanian pharmaceutical market since 2015, which caused health problems to a large number of patients, further supports the importance of this study. The results revealed that PRMS is compatible with all selected excipients, as confirmed by spectroscopy, X-ray diffraction patterns, and thermal analysis.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Thermodynamics
Mihaela Maria Budiul, Cristina Adela Marioane, Ionela-Amalia Bradu, Gabriela Vlase, Titus Vlase
Summary: A study was conducted to develop and characterize medicated jellies containing topiramate, using sodium alginate, gelatin, and pectin as gelling agents. The thermal behavior and potential interactions between topiramate, moist binary mixtures, and oral medicated jellies were analyzed using FTIR-UATR spectroscopy, UV-Vis spectroscopy, and thermogravimetry.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Multidisciplinary
Vasile Lozovan, Victor Ch. Kravtsov, Yurii M. Chumakov, Natalia V. Costriucova, Nikita Siminel, Oleg Petuhov, Titus Vlase, Gabriela Vlase, Alic Barba, Marina S. Fonari
Summary: Four new neutral metal-organic frameworks (MOFs) and three coordination complexes were synthesized using an azine-functionalized polymer synthesis strategy. These compounds exhibited diverse structures and optical properties, as well as demonstrated efficient capture of CO2 molecules.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Thermodynamics
Madalina Mateescu, Gabriela Vlase, Mihaela Maria Budiul, Bianca Denisa Cernusca, Titus Vlase
Summary: The objectives of this study were to formulate and evaluate medicated oral jellies containing Ambroxol HCl, the most commonly used mucolytic agent for chronic bronchitis, as well as medicated oral jellies containing Ibuprofen, a recognized nonsteroidal anti-inflammatory drug. The medicated jellies included different gelling agents such as gelatin, sodium alginate, and pectin. Compatibility studies were conducted to assess the interaction between Ibuprofen or Ambroxol and each component of the medicated jellies. Analysis was performed using FTIR-UATR and thermogravimetry.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Engineering, Chemical
Bianca Baul, Adriana Ledeti, Denisa Circioban, Amalia Ridichie, Titus Vlase, Gabriela Vlase, Francisc Peter, Ionut Ledeti
Summary: The stability of APIs and pharmaceutical formulations is crucial in pharmaceutical research and technology. Various factors such as light, air exposure, temperature, humidity, formulation composition, and packaging materials can affect the quality and stability of APIs and finished pharmaceutical products. This study analyzed the degradation kinetics of the antihypertensive drug moxonidine in different solid mixtures using FTIR spectroscopy and thermoanalytical methods. The results showed that excipients have a stabilizing effect on moxonidine, but the decomposition mechanism is complex.
Article
Thermodynamics
Dorinel Okolisan, Titus Vlase, Gabriela Vlase, Ionela-Amalia Bradu, Claudiu Avram
Summary: A new type of polysaccharide film containing amide-type anesthetics was synthesized in this study. The stability of these films suggests their potential use as carriers for local anesthesia.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Polymer Science
Ionela-Amalia Bradu, Titus Vlase, Madalin Bunoiu, Madalina Gradinaru, Alexandru Pahomi, Dorothea Bajas, Mihaela Maria Budiul, Gabriela Vlase
Summary: This study presents the synthesis of membranes based on anionic polysaccharides and cationic polysaccharides for transdermal delivery of methotrexate. The membranes suitable for the release of the active ingredient were validated through characterization.
Article
Plant Sciences
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Crina Andreea Sicoe, Maria Viorica Ciocalteu, Dumitru Daniel Herea, Ovidiu-Florin Ghirlea, Ioan Grozescu, Valentin Nanescu
Summary: The current nanomedicinal approach combines medicinal plants and nanotechnology to create new scaffolds with enhanced bioavailability, biodistribution, and controlled release. This study presents an innovative method for encapsulating herb in nanosized chitosan matrices, and investigates the properties and therapeutic effects of these nanocarriers. The results suggest that this new antioxidant vehicle has potential as a promising candidate in tumor therapeutic strategy.
Article
Engineering, Biomedical
Florin Borcan, Titus Vlase, Gabriela Vlase, Roxana Popescu, Codruta M. Soica
Summary: The study aims to develop and characterize polyurethane particles for the delivery of nucleosides. The samples show suitable size, stable properties, good penetration and release performance. Further clinical trials are required to test the synthesized products.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
