期刊
EPILEPSY & BEHAVIOR
卷 13, 期 3, 页码 511-522出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2008.05.007
关键词
epileptogenesis; critical connectivity; homeostasis; Hebbian learning; neuroplasticity; postictal state; post-traumatic epilepsy; neurostimulation
资金
- National Institutes of Health [1KL2RR025012-01]
- National Science Foundation
Plasticity is central to the ability of a neural system to learn and also to its ability to develop spontaneous seizures. What is the connection between the two? Learning itself is known to be a destabilizing process at the algorithmic level. We have investigated necessary constraints on a spontaneously active Hebbian learning system and find that the ability to learn appears to confer an intrinsic vulnerability to epileptogenesis on I hat system. We hypothesize that epilepsy arises as an abnormal learned response of such a system to certain repeated provocations. This response is a network-level effect. If epilepsy really is a learned response, then it should be possible to reverse it, that is, to unlearn epilepsy. Unlearning epilepsy may then provide a new approach to its treatment. (C) 2008 Elsevier Inc. All rights reserved.
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