Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Article
Behavioral Sciences
Haewon Roh, Won Kim, Junwon Kim, Ji Hyun Kim, Jong Hyun Kim
Summary: In surgically treated patients with unilateral MTLE, significant volume reductions were observed in multiple mesolimbic structures, and a substantial inverse correlation was found between the duration of epilepsy and the volumes of various mesolimbic structures. The study suggests that MTLE involves extensive mesolimbic structures beyond the hippocampus, and early surgical intervention may play a positive role in managing drug-resistant TLE.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Shameer Aslam, Ramiah Rajeshkannan, C. J. Sandya, Manjit Sarma, Siby Gopinath, Ashok Pillai
Summary: This study aimed to analyze statistically derived threshold values of volumetric MRI and FDG PET asymmetry for non-invasive detection/exclusion of temporal lobe epilepsy (TLE).
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Ioannis Mintziras, Louise Biermann, Kristina Krause, Marc-Philipp Bergmann, Marcus Belke, Christopher Nimsky, Maximilian Schulze, Adam Strzelczyk, Felix Rosenow, Katja Menzler, Susanne Knake
Summary: Temporal encephaloceles may be asymptomatic and are more common in patients with temporal lobe epilepsy compared to extratemporal lobe epilepsy and healthy controls. The size of TE could suggest epileptogenic potential.
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Xi Zhang, Guojun Zhang, Tao Yu, Cuiping Xu, Jin Zhu, Xiaoming Yan, Kai Ma, Runshi Gao
Summary: This study analyzed the surgical outcomes of patients with temporal lobe epilepsy (TLE) who underwent temporal and insular SEEG recordings. The findings suggest that insular involvement may be associated with failed anterior temporal lobectomy (ATL) and poorer seizure outcomes. The study also identified temporal-insular spreading time (TIST) as an independent predictor of postoperative seizure-free outcomes in these patients.
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Paula Agudelo Valencia, Nicole E. C. van Klink, Maryse A. van 't Klooster, Willemiek J. E. M. Zweiphenning, Banu Swampillai, Pieter van Eijsden, Tineke Gebbink, Martine J. E. van Zandvoort, Maeike Zijlmans
Summary: The study demonstrates that high frequency oscillations in pre-resection ioECoG may be valuable in assessing hippocampal sclerosis, hippocampal volume, and cognitive impairments in patients with temporal lobe epilepsy.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alexey M. Yakimov, Elena E. Timechko, Irina G. Areshkina, Anna A. Usoltseva, Kristina D. Yakovleva, Elena A. Kantimirova, Nikita Utyashev, Nikita Ivin, Diana V. Dmitrenko
Summary: Mesial temporal lobe epilepsy is the most common type of epilepsy and surgery is often the only treatment option. This study focuses on miR-654-3p as a potential biomarker for surgical outcome, while also considering other miRNAs as indicators of relapse. The research on miRNAs as predictive biomarkers of surgical outcome is urgent, but several factors need to be taken into account.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Kost Elisevich, Esmaeil Davoodi-Bojd, John G. Heredia, Hamid Soltanian-Zadeh
Summary: A prospective study was conducted on quantitative imaging applications for lateralizing epileptogenicity in patients with mesial temporal lobe epilepsy. Various neuroimaging modalities were evaluated, with multistructural analysis, multimodal model analysis, and PET showing the best predictive outcomes for surgical results. Continued exploration of combined optimal neuroimaging metrics will improve prediction models.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Danni Guo, Li Feng, Zhiquan Yang, Rong Li, Bo Xiao, Shirui Wen, Yangsa Du, Chijun Deng, Xuyang Wang, Dingyang Liu, Fangfang Xie
Summary: This study found that dynamic functional network connectivity (DFNC) analysis can help us understand the neural impairment mechanisms and brain network reorganization in drug-resistant temporal lobe epilepsy (TLE), and provide additional preoperative evaluation support for surgical treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Sergio Eiji Ono, Maria Joana Mader-Joaquim, Arnolfo de Carvalho Neto, Luciano de Paola, Gustavo Rengel Dos Santos, Carlos Eduardo Soares Silvado
Summary: The study found moderate associations between CA2/3 and visual memory in patients with TLE, as well as a correlation between CA4 and visual memory in cases of right hippocampal atrophy. No significant correlation was found between CA1 and memory test results, and there was also no significant correlation between verbal memory tests and specific hippocampal subfields. Further research is needed to confirm the clinical utility of these findings.
Review
Neurosciences
Robert Bartos, Jan Lodin, Tomas Marek, Martin Sames, Veronika Nemcova, Roman Liscak
Summary: This study presents a unique combined therapy for a brainstem hemangioblastoma not associated with von Hippel-Lindau disease. The case describes a 21-year-old patient who underwent surgery followed by stereotactic gamma knife radiosurgery for symptom relief and tumor progression.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Oncology
Jason Sheehan, Stylianos Pikis, Abdurrahman I. Islim, Ching-Jen Chen, Adomas Bunevicius, Selcuk Peker, Yavuz Samanci, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Violaine Delabar, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Dev Patel, Douglas Kondziolka, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Greg N. Bowden, Ronald J. Benveniste, Lawrence Dade Lunsford, Michael D. Jenkinson
Summary: This study compared the radiologic and neurological outcomes of expectant management and stereotactic radiosurgery (SRS) in asymptomatic meningioma patients. The results showed that SRS achieved better tumor control compared to active surveillance without increasing the risk of new neurological deficits in patients.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Adomas Bunevicius, Selcuk Peker, Yavuz Samanci, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Violaine Delabar, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Greg N. Bowden, Ronald J. Benveniste, Dev N. Patel, Douglas Kondziolka, Kenneth Bernstein, L. Dade Lunsford, Jason Sheehan
Summary: The study demonstrates that upfront stereotactic radiosurgery (SRS) for asymptomatic petroclival meningiomas provides excellent local tumor control with relatively low risk of complications. SRS can be considered as a treatment option at diagnosis or when growth is noted during active surveillance.
ACTA NEUROCHIRURGICA
(2022)
Article
Oncology
Georgios Mantziaris, Stylianos Pikis, Yavuz Samanci, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Violaine Delabar, David Mathieu, Cheng-chia Lee, Huai-che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Ronald J. Benveniste, Greg N. Bowden, Dev N. Patel, Douglas Kondziolka, Kenneth Bernstein, L. Dade Lunsford, Michael D. Jenkinson, Abdurrahman I. Islim, Jason Sheehan
Summary: This study compared the imaging and clinical outcomes of asymptomatic, skull-based meningiomas managed with either upfront stereotactic radiosurgery (SRS) or active surveillance. The results showed that SRS achieved superior local tumor control compared to active surveillance, with low morbidity rates.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Biochemical Research Methods
K. L. Pietersz, S. Pouw, J. Klima, Z. Ellederova, B. Bohuslavova, J. Chrastina, R. Liscak, D. Urgosik, Z. Starek, M. Crha, O. Lewis, M. Wooley, D. Johnson, C. C. Brouwers, M. Evers, J. Motlik, G. J. M. Martens, P. S. Konstantinova, B. Blits
Summary: The study evaluated alternate delivery routes for gene therapy in the brains of large animals, such as minipigs, and found that thalamic injection resulted in widespread gene transduction from the midbrain to the frontal cortex, while corona radiata injection only achieved partial transduction of the basal ganglia. Thalamic administration of AAV5 shows significant potential for indications where specific brain areas need to be transduced.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Clinical Neurology
Stylianos Pikis, Georgios Mantziaris, Yavuz Samanci, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Cheng-Chia Lee, Huai-Che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Jason Sheehan
Summary: This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for asymptomatic cavernous sinus meningiomas. The results showed that upfront SRS is a safe and effective treatment option, which can be considered at the time of initial diagnosis or during follow-up imaging.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Roman O. Kowalchuk, Ajay Niranjan, Cheng-Chia Lee, Huai-Che Yang, Roman Liscak, Khumar Guseynova, Manjul Tripathi, Narendra Kumar, Selcuk Peker, Yavuz Samanci, Judith Hess, Veronica Chiang, Christian Iorio-Morin, David Mathieu, Stylianos Pikis, Zhishuo Wei, L. Dade Lunsford, Daniel M. Trifiletti, Jason P. Sheehan
Summary: The study focuses on the efficacy and predictors of repeat stereotactic radiosurgery (SRS2) after local or marginal recurrence following prior SRS (SRS1). The results show that repeat SRS provides a high rate of local tumor control and a low rate of radiation necrosis. Factors such as smaller tumor volume and lower doses are associated with reduced risks of radiation necrosis and symptomatic radiation necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Clinical Neurology
Ching-Jen Chen, Dale Ding, Jeyan S. Kumar, Kathryn N. Kearns, Natasha Ironside, Huai-Che Yang, Akiyoshi Ogino, Hideyuki Kano, Roman Liscak, Jaromir May, Brian J. Williams, Michael J. Gigliotti, Kevin Cockroft, James McInerney, Scott Simon, Cheng-Chia Lee, Jason P. Sheehan
Summary: The study found that intracranial hemorrhage and recurrent arteriovenous shunting after complete nidal obliteration are rare in AVM patients treated with SRS, with each phenomenon harboring an annual risk of <1%. Routine postobliteration DSA may not be recommended, but long-term neuroimaging could be advisable for these patients.
Article
Oncology
Abdurrahman I. Islim, Georgios Mantziaris, Stylianos Pikis, Ching-Jen Chen, Adomas Bunevicius, Selcuk Peker, Yavuz Samanci, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Violaine Delabar, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Roman Liscak, Jaromir May, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Douglas Kondziolka, Herwin Speckter, Camilo Albert, Greg N. Bowden, Ronald J. Benveniste, Lawrence Dade Lunsford, Jason P. Sheehan, Michael D. Jenkinson
Summary: This study compared the outcomes of active surveillance and stereotactic radiosurgery (SRS) in patients with incidental frontobasal meningioma. The results showed that SRS improved radiological control, but both active surveillance and SRS had a similarly low risk of symptom development. Both active surveillance and SRS were acceptable treatment options for incidental frontobasal meningioma.
Article
Clinical Neurology
Stylianos Pikis, Adomas Bunevicius, Cheng-Chia Lee, Huai-Che Yang, Brad E. Zacharia, Roman Liscak, Gabriela Simonova, Manjul Tripathi, Narendra Kumar, David Mathieu, Remi Perron, Selcuk Peker, Yavuz Samanci, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Ajay Niranjan, L. Dade Lunsford, Nikolaos Mantziaris, Jason P. Sheehan
Summary: This multicenter study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) in the management of intracranial prostate cancer metastases. The results showed that SRS was a safe, well-tolerated, and effective treatment option for these patients.
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Clinical Neurology
Jason P. Sheehan, Stylianos Pikis, Abdurrahman Islim, David Mathieu, Roman Liscak, Manjul Tripathi, Douglas S. Kondziolka, Greg N. Bowden, L. Dade Lunsford, Michael D. Jenkinson
Meeting Abstract
Clinical Neurology
Ching-Jen Chen, Dale Ding, Cheng-chia Lee, Kathryn Kearns, Isaac J. Pomeraniec, Natasha Ironside, Douglas S. Kondziolka, Daniel M. Trifiletti, Roman Liscak, Kevin M. Cockroft, John Y. K. Lee, Jason P. Sheehan
Article
Clinical Neurology
David T. Asuzu, Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason P. Sheehan
Summary: This international multicenter study found that the majority of patients with meningiomas in direct contact with the anterior optic pathways achieved tumor control and preservation of visual function when treated with SRS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
I. Jonathan Pomeraniec, Zhiyuan Xu, Cheng-Chia Lee, Huai-Che Yang, Tomas Chytka, Roman Liscak, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, Luca Attuati, Piero Picozzi, Douglas Kondziolka, Monica Mureb, Kenneth Bernstein, David Mathieu, Michel Maillet, Akiyoshi Ogino, Hao Long, Hideyuki Kano, L. Dade Lunsford, Brad E. Zacharia, Christine Mau, Leonard C. Tuanquin, Christopher Cifarelli, David Arsanious, Joshua Hack, Ronald E. Warnick, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Herwin Speckter, Samir Patel, Dale Ding, Darrah Sheehan, Kimball Sheehan, Svetlana Kvint, Love Y. Buch, Alexander R. Haber, Jacob Shteinhart, Mary Lee Vance, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) is an effective treatment for pituitary adenomas, but the mechanism of delayed endocrine deficits is not well understood. This multicenter study aimed to evaluate radiation tolerance and identify predictors of delayed hypopituitarism after SRS for these tumors. The study found that tumor control was achieved in a high percentage of patients, but a significant number developed new loss of pituitary function, with certain factors such as tumor type, age, and radiation dose playing a role.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Nasser Mohammed, Yi-Chieh Hung, Zhiyuan Xu, Tomas Chytka, Roman Liscak, Manjul Tripathi, David Arsanious, Christopher P. Cifarelli, Marco Perez Caceres, David Mathieu, Herwin Speckter, Gautam U. Mehta, Gregory P. Lekovic, Jason P. Sheehan
Summary: This study examines the role of Gamma Knife radiosurgery (GKRS) in the treatment of NF2-associated meningiomas and evaluates the outcomes and complications. The results show that increasing the maximum dose and a lower number of meningiomas at presentation predict better tumor control. The study suggests that GKRS achieves effective tumor control with a low rate of complications in NF2-associated meningiomas.
JOURNAL OF NEUROSURGERY
(2022)