Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Wang, Xiaoting Luo, Haitao Pan, Xiaoyang Wang, Shangwen Xu, Hui Li, Zhiping Lin
Summary: Hippocampal radiomics models based on T2-FLAIR images can aid in the diagnosis of MTLE with HS, serving as biological markers for MTLE diagnosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Cedric Dusanter, Marion Houot, Marie Mere, Marisa Denos, Severine Samson, Bastien Herlin, Vincent Navarro, Sophie Dupont
Summary: The aim of this study was to evaluate the specific effects of antiseizure medications (ASMs) on cognition in a group of refractory patients with epilepsy. The results showed that the type and number of ASMs had a significant impact on cognition, especially topiramate (TPM) and sodium valproate (VPA). Based on the findings, it is recommended to reduce the total number of drugs received and avoid medications with unfavorable cognitive profiles.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Karl-Heinz Nenning, Olivia Fosleitner, Ernst Schwartz, Michelle Schwarz, Victor Schmidbauer, Gudrun Geisl, Christian Widmann, Susanne Pirker, Christoph Baumgartner, Daniela Prayer, Ekaterina Pataraia, Lisa Bartha-Doering, Georg Langs, Gregor Kasprian, Silvia B. Bonelli
Summary: The study found significant differences in connectivity between left and right TLE patients compared to healthy controls. Left TLE showed widespread impairment of task-positive language networks, while right TLE showed less pronounced alterations. Particularly, right TLE exhibited altered connectivity for cortical regions associated with the default mode network (DMN).
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Takahiro Tsuchiya, Takeshi Matsuo, So Fujimoto, Yasuhiro Nakata, Michiharu Morino
Summary: This study aimed to investigate the relationship between hippocampal sclerosis (HS) and hippocampal gray-white matter boundary blurring (HGWBB) and its impact on clinical outcomes. A total of 54 patients with temporal lobe epilepsy who underwent hippocampal resection were included. The HGWBB index was significantly lower on the affected side compared to the unaffected side, and this trend was more pronounced in the poor prognosis group. A prognostic scoring system combining multiple criteria showed high sensitivity (87.5%) and specificity (71.7%) in predicting seizure outcomes.
EPILEPSY & BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Pharmacology & Pharmacy
Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, Ramesh Sharanappa Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Poodipedi Sarat Chandra, Jyotirmoy Banerjee
Summary: The study identified that levels of kynurenic acid were reduced and quinolinic acid levels were raised in the hippocampus of patients with MTLE-HS, along with abnormal glutamatergic activities. Altered metabolism of tryptophan-kynurenine pathway metabolites in the hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin
Summary: This study revealed the molecular mechanisms of neuronal apoptosis in hippocampal sclerosis of intractable temporal lobe epilepsy patients through RNA sequencing and ceRNA network analysis, establishing a ceRNA network of lncRNA-mediated neuronal apoptosis in HS-TLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: The authors investigated the microvascular anatomy of the hippocampus and its implications for medial temporal tumor surgery, revealing the anatomical variability of the arterial supply and venous drainage of the hippocampus. The study found rich anastomoses between hippocampal arteries and highlighted the importance of understanding the vascular variability and network of the hippocampus for surgery in this region, including anterior temporal lobectomy with amygdalohippocampectomy and transsylvian selective amygdalohippocampectomy.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Yuming Li, Peiwen Liu, Qiuxing Lin, Dong Zhou, Dongmei An
Summary: This study conducted a systematic review and meta-analysis to evaluate the seizure and memory outcomes of temporal lobe epilepsy with different hippocampal sclerosis subtypes. The results showed no significant difference in seizure freedom and improved outcome between different subtypes, and the long-term seizure outcome and memory impairment remained controversial.
Article
Clinical Neurology
Wenbiao Xiao, Zhiquan Yang, Xiaoxin Yan, Li Feng, Lili Long, Tian Tu, Na Deng, Wenjuan Chen, Bo Xiao, Hongyu Long, Yi Zeng
Summary: This study investigated proteomic alterations in the DG region of TLE-HS patients and found that differentially expressed proteins were enriched in areas such as synaptic vesicle, mitochondrion, and cell-cell adhesion. A key protein module related to oxidative phosphorylation was also identified.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Hong Li, Fang Ding, Cong Chen, Peiyu Huang, Jingjing Xu, Zhong Chen, Shuang Wang, Minming Zhang
Summary: This study investigated the relationship between memory impairment and modular alterations in the hippocampal network of TLE patients. The results showed significant differences in modular properties between TLE-MD and TLE-MI patients in two distinct states, with dynamic modularity features having unique advantages in discriminating between the two memory phenotypes.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Koji Yoshimoto, Ryusuke Hatae, Satoshi O. Suzuki, Nobuhiro Hata, Daisuke Kuga, Yojiro Akagi, Takeo Amemiya, Yuhei Sangatsuda, Nobutaka Mukae, Masahiro Mizoguchi, Toru Iwaki, Koji Iihara
Article
Oncology
Yojiro Akagi, Koji Yoshimoto, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Takeo Amemiya, Yuhei Sangatsuda, Satoshi O. Suzuki, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara
BRAIN TUMOR PATHOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi O. Suzuki, Toru Iwaki, Marc Van Cauteren, Koji Iihara, Hiroshi Honda
BRITISH JOURNAL OF RADIOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryotaro Kamei, Koji Yoshimoto, Koji Iihara, Satoshi O. Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda
EUROPEAN RADIOLOGY
(2018)
Editorial Material
Medicine, General & Internal
Toyoshi Yanagihara, Nanae Seki, Akio Hiwatashi, Koichi Arimura, Satoshi O. Suzuki, Isamu Okamoto
Article
Clinical Neurology
Satoshi Suzuki, Ryosuke Tsuchimochi, Gorou Abe, Iwae Yu, Takuya Inoue, Hideaki Ishibashi
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Yuhei Sangatsuda, Nobuhiro Hata, Satoshi O. Suzuki, Yojiro Akagi, Ryusuke Hatae, Daisuke Kuga, Koji Yoshimoto, Seiya Momosaki, Toru Iwaki, Koji Iihara
Article
Clinical Neurology
Norihisa Maeda, Hiroyuki Honda, Satoshi O. Suzuki, Naoki Fujii, Jun-ichi Kira, Toru Iwaki
Article
Clinical Neurology
Reiji Hommyo, Satoshi O. Suzuki, Nona Abolhassani, Hideomi Hamasaki, Masahiro Shijo, Norihisa Maeda, Hiroyuki Honda, Yusaku Nakabeppu, Toru Iwaki
Article
Clinical Neurology
Hiroyuki Honda, Naokazu Sasagasako, Chang Shen, Masahiro Shijo, Hideomi Hamasaki, Satoshi O. Suzuki, Yoshio Tsuboi, Naoki Fujii, Toru Iwaki
PARKINSONISM & RELATED DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
Ryoo Yamamoto, Satoshi Suzuki, Rieko Sugawara, Jyunichi Isito, Hiroyuki Koizumi, Takayuki Momoo, Fumiaki Tanaka
Article
Clinical Neurology
Nobuya Murakami, Takato Morioka, Takafumi Shimogawa, Kimiaki Hashiguchi, Nobutaka Mukae, Kazuyoshi Uchihashi, Satoshi O. Suzuki, Koji Iihara
CHILDS NERVOUS SYSTEM
(2018)
Article
Clinical Neurology
Mihori Ryorin, Takato Morioka, Nobuya Murakami, Satoshi O. Suzuki, Nobuko Kawamura
CHILDS NERVOUS SYSTEM
(2018)
Article
Clinical Neurology
Satoshi Suzuki, Shinsuke Yasukawa, Ryosuke Tsuchimochi, Takuya Inoue
ACTA NEUROCHIRURGICA
(2018)
Article
Clinical Neurology
Masahiro Shijo, Hiroyuki Honda, Satoshi O. Suzuki, Hideomi Hamasaki, Masaaki Hokama, Nona Abolhassani, Yusaku Nakabeppu, Toshiharu Ninomiya, Takanari Kitazono, Toru Iwaki