Article
Biochemistry & Molecular Biology
Teresa Bellon, Olga Gonzalez-Valle, Elena Sendagorta, Victoria Lerma, Javier Martinez Del Rio, Celia Martinez, Guillermo Servera, Carlos Gonzalez-Herrada, Lucia Cachafeiro, Jose A. Lorente, Rosario Cabanas, Pedro Herranz, Francisco de Abajo
Summary: This study found a positive correlation between IL-15 serum levels and the percentage of detached skin in SJS/TEN patients. Higher expression levels of IL-15 and IL-15RA genes were found in affected skin. The results suggest that the effects of IL-15 in SJS/TEN patients may be dependent on the expression of its private receptor IL-15R alpha in affected skin.
Review
Pharmacology & Pharmacy
Lin Cheng
Summary: Adverse drug reactions, particularly SJS and TEN, are a significant public health concern with high mortality rates and ineffective treatment options. Factors such as infections, mutations in drug metabolic enzymes, and immune responses contribute to SJS/TEN development. Future research directions include epigenetics, metabolites, and regulatory T cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hua-Ching Chang, Tsung-Jen Wang, Ming-Hsiu Lin, Ting-Jui Chen
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases caused by drugs. The effectiveness of systemic immunomodulating treatments for SJS/TEN is still controversial, but cyclosporine and biologic anti-TNF-alpha have shown promising results. Combination treatments are also being explored. Large-scale randomized controlled trials are needed for more definitive evidence. Advances in understanding the pathogenesis of SJS/TEN may inspire the discovery of potential therapeutic targets.
Article
Medicine, General & Internal
Rannakoe J. Lehloenya
Summary: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) have high mortality rates and lack consensus on therapeutic interventions. International collaboration is needed to standardize research endpoints. The limitations of using BSA as the sole determinant of disease severity and the potential of artificial intelligence, biomarkers, and PET/CT scan are discussed.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Soumya Pamnani, Sanket S. Bakshi, Sourya Acharya
Summary: Toxic epidermal necrolysis (TEN) is a severe disease associated with Stevens-Johnson syndrome (SJS). Adverse medication reactions, primarily caused by pharmaceutical drugs, contribute highly to the incidence rates of TEN, leading to significant skin and mucous membrane disintegration.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Mayumi Ueta
Summary: SJS/TEN with SOC is an acute inflammatory reaction that affects mucosa and skin, with cold medicines identified as the main causative drugs. Specific genes such as TLR3, PTGER3, and IKZF1 have been found to be significantly associated with SJS/TEN with SOC. In chronic stage, tear cytokines such as IL-8, IL-6, and IFN-gamma were upregulated, while IP-10 was downregulated, contributing to the chronic ocular surface inflammation in these patients.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Sara Sabourirad, Reza Mortezaee, Majid Mojarad, Atieh Eslahi, Yahya Shahrokhi, Bita Kiafar, Lida Jarahi, Saman Afkhami Ardakani, Shima Farrokhi
Summary: This study found an association between HLA-B*1502 allele and lamotrigine-induced SJS/TEN in an Iranian population, but not with phenytoin-induced SJS/TEN.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Min-Hui Chi, Wen-Hung Chung, Rosaline Chung-Yee Hui, Chun-Bing Chen, Chun-Wei Lu, Tsu-Man Chiu, David Hui-Kang Ma, Chuang-Wei Wang, Chin-Yi Yang
Summary: This study investigated the causes, clinical course, outcomes, and complications of SJS and TEN in children. The results showed that pediatric patients with SJS/TEN had good outcomes, few long-term complications, and a low mortality rate. Mycoplasma was identified as the most common infectious cause in pediatric SJS/TEN, and common long-term sequelae included ocular discomfort, nail dystrophy, and skin dyschromia.
JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Ekaterina A. Nikitina, Daria S. Fomina, Ulyana A. Markina, Sergey S. Andreev, Yuri V. Streltsov, Tatiana S. Kruglova, Marina S. Lebedkina, Alexander V. Karaulov, Maryana A. Lysenko
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare syndromes characterized by necrotic skin and mucosal lesions. Drug-induced mechanisms are the most common cause, with certain drugs posing a higher risk. There is no gold standard treatment, but TNF-α inhibitors have shown promise in SJS/TEN cases.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Ting-Jung Hsu, Hsu-Hang Yeh, Chih-Hung Lee, Kwei-Lan Liu
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal adverse drug reactions. The most common culprit drug is carbamazepine, which has a strong association with HLA-B*15:02. There is no statistically significant correlation between in-hospital stay and the average daily dose of corticosteroids.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Pan Lv, Jiangxia Huang, Qianru Yang, Ting Yang, Xianwei Cao, Ougen Liu, Zhibin Zhang
Summary: This study analyzed the expression profiles of circRNAs in peripheral blood mononuclear cells of SJS/TEN patients and found a correlation between circRNA expression and disease severity. Specifically, hsa_circ_0083619 was identified as a potential indicator for SJS/TEN severity and a circRNA-miRNA-mRNA network was constructed. The study suggests that the hsa_circ_0083619/miR-18a-5p/BCL2L10 axis may play a role in the pathogenesis of SJS/TEN.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Qian Zhang, Ali Raza Shaikh, Thomas Yoon, Shreeja Shah, James W. Mahoney
Summary: Toxic epidermal necrolysis (TEN) is a severe dermatological emergency with high mortality, distinguished from Stevens-Johnson syndrome (SJS) by the percentage of body surface area affected. Certain medications are correlated with triggering TEN. Due to the rarity of the disease, many general Internists lack experience and resources, necessitating awareness of important management aspects for prompt clinical decisions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Eri Tsukagoshi, Yoichi Tanaka, Yoshiro Saito
Summary: Drug-related Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse drug reactions, with predicting their onset remaining challenging. Pharmacogenomic information on drug labels may differ among countries, but CPIC guidelines provide a scientifically sound goal for future pharmacogenomic implementation.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Yasmin Chia Chia Liew, Karen Jui Lin Choo, Choon Chiat Oh, Shiu Ming Pang, Yi Wei Yeo, Haur Yueh Lee
Summary: This study evaluated the differences between Mycoplasma-related and drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. The results showed no significant differences in baseline characteristics and extent of involvement, but significant differences in mortality rates between the two groups.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
ShengYang Bertrand Lian, Choon Chiat Oh, Yi Wei Yeo, Haur Yueh Lee
Summary: This case series documents the incidence of various nail changes as a sequelae to Stevens-Johnson syndrome/toxic epidermal necrolysis.
Article
Immunology
Chi-Chang Sung, Jau-Hau Horng, Shih-Hong Siao, I-Tsu Chyuan, Hwei-Fang Tsai, Pei-Jer Chen, Ping-Ning Hsu
Summary: This study identified ASGM1-positive liver-resident CD8 T cells as the major effector immune cells that mediate anti-HBV immunity, working in coordination with TRM cells and other immune cells to clear HBV.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chonlaphat Sukasem, Jirawat Pratoomwun, Patompong Satapornpong, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Pawinee Rerknimitr, Pattamon Lertpichitkul, Apichaya Puangpetch, Nontaya Nakkam, Parinya Konyoung, Usanee Khunarkornsiri, Wareeporn Disphanurat, Chutika Srisuttiyakorn, Oranuch Pattanacheewapull, Sirimas Kanjanawart, Thachanan Kongpan, Pansu Chumworathayi, Niwat Saksit, Jackrapong Bruminhent, Wichittra Tassaneeyakul, Wasun Chantratita, Munir Pirmohamed
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Medicine, General & Internal
Ying-Ho Lai, Yu-An Chung, Yun-Chun Wu, Chi-Tai Fang, Pei-Jer Chen
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Ming-Lung Yu, Pei-Jer Chen, Chia-Yen Dai, Tsung-Hui Hu, Chung-Feng Huang, Yi-Hsiang Huang, Chao-Hung Hung, Chun -Yen Lin, Chen-Hua Liu, Chun-Jen Liu, Cheng-Yuan Peng, Han-Chieh Lin, Jia-Horng Kao, Wan -Long Chuang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Gastroenterology & Hepatology
Yasuhiro Asahina, Chun-Jen Liu, Edward Gane, Yoshito Itoh, Norifumi Kawada, Yoshiyuki Ueno, Jin Youn, Chen-Yu Wang, Joe Llewellyn, Takuma Matsuda, Anuj Gaggar, Hongmei Mo, Hadas Dvory-Sobol, Gerald Crans, Wan-Long Chuang, Pei-Jer Chen, Nobuyuki Enomoto
HEPATOLOGY RESEARCH
(2020)
Article
Allergy
Chuang-Wei Wang, Wichittra Tassaneeyakul, Chun-Bing Chen, Wei-Ti Chen, Yu-Chuan Teng, Cheng-Yang Huang, Chonlaphat Sukasem, Chun-Wei Lu, Yun-Shien Lee, Siew-Eng Choon, Nontaya Nakkam, Rosaline Chung-Yee Hui, Yen-Hua Huang, Ya-Ching Chang, Yang Yu-Wei Lin, Chee-Jen Chang, Tsu-Man Chiu, Wasun Chantratita, Parinya Konyoung, Chaw-Ning Lee, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Warayuwadee Amornpinyo, Niwat Saksit, Pawinee Rerknimitr, Yu Huei Huang, Shang-Hung Lin, Chao-Kai Hsu, Cheng-Chi Chan, Yu- Lin, Shuen-Iu Hung, Wen-Hung Chung
Summary: The study identified HLA-B*13:01 as an important genetic factor associated with co-trimoxazole-induced severe cutaneous adverse reactions (SCAR) in Asians.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Tung Chao, Hsueh-Tzu Shih, Shih-Chin Hsu, Pei-Jer Chen, Yu-Shan Fan, Yung-Ming Jeng, Zhao-Qing Shen, Ting-Fen Tsai, Zee-Fen Chang
Summary: Genotoxic insult leads to damages in nuclear and mitochondrial DNA with autophagy induction. The study reveals that specific nuclear DNA damage alone does not require autophagy for repair, unless there is mitochondrial DNA damage present. Furthermore, autophagy suppression causes increased mitochondrial permeability, releasing mitochondrial ENDOG to the nuclei and sustaining nuclear DNA damage.
Article
Virology
Chun-Ming Hong, You-Yu Lin, Chun-Jen Liu, Ya-Yun Lai, Shiou-Hwei Yeh, Hung-Chih Yang, Jia-Horng Kao, Shih-Jer Hsu, Yi-Hsiang Huang, Sheng-Shun Yang, Hsing-Tao Kuo, Pin-Nan Cheng, Ming-Lung Yu, Pei-Jer Chen
Summary: About 4% of population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. Taiwan National Health Insurance reimburses genotype-specific and pangenotype DAAs for chronic hepatitis C disease. Adherence is an important cause of failure clinically, while common resistance-associated substitutions include NS5A-L31, NS5A-Y93, NS5BC316 for genotype-specific DAAs and NS5A-L31, NS5A-A/Q/R30, NS5A-Y93 for pangenotype DAAs.
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Review
Oncology
Chiao-Ling Li, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: Cell-free tumor DNA (ctDNA) is a promising tumor marker that can reflect tumor burden, behavior, and prognosis. However, there are still challenges to be addressed before ctDNA can be used as a tumor marker. We propose using exogenous viral DNA integration to generate virus-host chimera DNA (vh-DNA) as a potential new biomarker. vh-DNA may overcome detection problems and serve as a universal marker for monitoring tumor expansion or burden related to oncogenic viruses.
Article
Medicine, General & Internal
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Shang-Chin Huang, Tai-Chung Tseng, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao
Summary: This study found a strong correlation between serum M2BPGi levels and the severity of hepatic fibrosis in patients with HCV infection, and identified specific cutoff values that can be used for accurate diagnosis.
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chun-Jen Liu, Wan-Ting Yang, Chen-Yang Hsu, Chun-Ming Hong, Tung-Hung Su, Cheng-Hsueh Tsai, Chi-Ling Chen, Hung-Chih Yang, Chen-Hua Liu, Hsiu-Hsi Chen, Pei-Jer Chen, Jia-Horng Kao
Summary: In patients with chronic hepatitis B virus infection, higher levels of HBcrAg are associated with increased risk of cirrhosis. Among patients with intermediate viral load, HBcrAg <10 KU/mL defines a low-risk group for disease progression.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
T. Singto, W. Tassaneeyakul, S. Porasuphatana
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Cell Biology
Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding-Shinn Chen, Pei-Jer Chen
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Cell Biology
Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen, Hurng-Yi Wang
JOURNAL OF BIOMEDICAL SCIENCE
(2020)