Review
Chemistry, Multidisciplinary
Andrew R. Willmer, Jiayi Nie, Mery Vet George De la Rosa, Winnie Wen, Steven Dunne
Summary: Clofazimine can be used to construct inert and stimulus responsive drug depots within cells. It self-assembles into stable drug inclusions that accumulate in macrophages and can be activated to combat infections.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Orestis Kontogiannis, Dimitrios Selianitis, Nefeli Lagopati, Natassa Pippa, Stergios Pispas, Maria Gazouli
Summary: The medical application of nanotechnology in drug delivery has made significant progress in treating various human diseases, offering advantages such as targeted drug delivery, low toxicity, and personalized medicine. Innovative drug delivery carriers using polymers, surfactants, and their combinations have been developed and tested pre-clinically, enabling simultaneous delivery of multiple therapeutic entities and combining therapy with diagnosis. This review focuses on the applications of surfactant-based, polymer-based, and mixed surfactant-polymer nanoparticle drug formulations in the medical field, providing detailed information on the materials used, formulation steps, physicochemical characteristics, and pharmacokinetic behavior of these systems.
Article
Biochemistry & Molecular Biology
Ankur Sood, Varun Arora, Sadhana Kumari, Ankita Sarkar, S. Senthil Kumaran, Shubhra Chaturvedi, Tapan K. Jain, Garima Agrawal
Summary: This study reports the fabrication of multifunctional nanoparticles with a gold shell over an iron oxide core, combining magnetic properties and surface plasmon resonance. The nanoparticles, coated with thiolated pectin, show potential for drug delivery and MR imaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Pratikshya Sa, Sanjeeb K. Sahoo, Fahima Dilnawaz
Summary: Cancer is a major global health challenge, and the tumor microenvironment plays a vital role in tumor progression and drug resistance. Targeting the tumor microenvironment is a promising approach to advance cancer nanomedicine. Recent progress in understanding the tumor microenvironment and developing responsive nanoparticles has improved pharmacokinetics and efficacy of nanomedicine in overcoming drug resistance. This review discusses the components of the tumor microenvironment and the role of nanomedicine in combating drug resistance.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Vincent Lebreton, Norraseth Kaeokhamloed, Anastasiia Vasylaki, Gregory Hilairet, Adelie Mellinger, Jerome Bejaud, Patrick Saulnier, Frederic Lagarce, Florence Gattacceca, Samuel Legeay, Emilie Roger
Summary: This study investigated the pharmacokinetics of intact lipid nanocapsules after intravenous administration in rats, revealing that the elimination of FRET-LNCs was non-linear and dependent on size and surface modification, while the distribution was dependent on size. LNCs with PEG coating displayed a lower clearance than other formulations.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Applied
Xiaodong Sun, Maryam Keywanlu, Reza Tayebee
Summary: In the treatment of epilepsy, ZIF nanoparticles show potential in improving drug efficacy and reducing side effects. By loading common antiepileptic drugs into ZIF-8 and conducting release experiments, ZIF-8 was found to be an effective drug carrier. Additionally, through MTT experiments, the cytotoxicity of Gabapentin-ZIF-8 on cancer cells was confirmed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qiwen Guan, Xuan Wang, Danfeng Cao, Menghuan Li, Zhong Luo, Xiaoyuan Mao
Summary: This study reports a nanointegrated strategy to enhance the antiepileptic efficacy of phenytoin (PHT) by overcoming drug resistance mechanisms. PHT is incorporated into calcium phosphate nanoparticles and surface modified with a PEGylated BBB-penetrating TAT peptide. The resulting CaP@PHT-PEG-TAT nanoformulation effectively crosses the blood-brain barrier, taken up by epileptic neurons and subsequently degrades to release Ca2+ and PHT. The released Ca2+ inhibits cellular hypoxia and disrupts adenosine triphosphate generation, leading to the suppression of P-glycoprotein expression and drug efflux capacity to enhance PHT retention.
Article
Chemistry, Multidisciplinary
Santiago Correa, Emily L. Meany, Emily C. Gale, John H. Klich, Olivia M. Saouaf, Aaron T. Mayer, Zunyu Xiao, Celine S. Liong, Ryanne A. Brown, Caitlin L. Maikawa, Abigail K. Grosskopf, Joseph L. Mann, Juliana Idoyaga, Eric A. Appel
Summary: This study explores the ability of a slow-releasing injectable hydrogel depot to reduce toxicities of immunostimulatory drugs and improve treatment efficacy. The hydrogel-based delivery system demonstrates improved local cytokine induction and shows enhanced therapeutic effects in a melanoma model.
Article
Chemistry, Multidisciplinary
Lok Hin Law, Jianpan Huang, Peng Xiao, Yang Liu, Zilin Chen, Joseph H. C. Lai, Xiongqi Han, Gerald W. Y. Cheng, Kai-Hei Tse, Kannie W. Y. Chan
Summary: Image guided nose-to-brain drug delivery is a non-invasive method to monitor drug delivery to the brain. This study investigated the imaging of liposome-based drug delivery to the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). Liposomes loaded with a computed tomography (CT) contrast agent were administered intranasally and specific CEST contrasts were observed in the olfactory bulb and frontal lobe.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Applied
Mohamed Ahmed Mohamady Hussein, Ece Guler, Erkan Rayaman, Muhammet Emin Cam, Ali Sahin, Mariusz Grinholc, Demet Sezgin Mansuroglu, Yesim Muge Sahin, Oguzhan Gunduz, Mamoun Muhammed, Ibrahim M. El-Sherbiny, Mosaad Megahed
Summary: Dual-drug delivery systems were constructed using coaxial techniques, showing controlled drug release and improved performance of nanofibrous membranes, which have promising applications in tissue regeneration and wound healing.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Dylan E. Parsons, Soo Hyeon Lee, Young Joo Sun, Gabriel Velez, Alexander G. Bassuk, Mark Smith, Vinit B. Mahajan
Summary: The review discusses the challenges in effectively delivering drugs to the retina due to anatomical and physicochemical barriers in the eye, while introducing diverse administration routes and the corresponding pharmacokinetic profiles of ocular drugs. Peptidomimetics are highlighted as a growing class of retinal drugs with therapeutic potential and specificity, along with formulation strategies suggested to overcome pharmacokinetic hurdles in drug delivery.
Article
Biology
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford
Summary: The study presents the design and development of AZD0466, a drug-dendrimer conjugate, and uses preclinical and mathematical models to determine the optimal release rate of the drug for maximal therapeutic index. The optimized candidate shows improved efficacy and tolerability compared to AZD4320 alone, enabling progression of this promising dual Bcl-2/Bcl-x(L) inhibitor into clinical development.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
V. Manjusha, M. R. Rajeev, T. S. Anirudhan
Summary: Safe delivery of hydrophobic drugs to the tumor site is a challenging task for the scientific community. In this study, iron oxide nanoparticles coated chitosan with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) (CS-IONPs-METAC-PTX) were developed as a drug carrier for hydrophobic drug delivery. The drug carrier exhibited excellent therapeutic efficacy and selectivity when tested in cell lines, demonstrating its potential for PTX delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Cardiac & Cardiovascular Systems
Helene David, Aurore Ughetto, Philippe Gaudard, Maelle Plawecki, Nitchawat Paiyabhroma, Emma Zub, Pascal Colson, Sylvain Richard, Nicola Marchi, Pierre Sicard
Summary: The study utilized in vivo photoacoustic imaging to track changes in vascular oxygen saturation in multiple organs and the brain post-myocardial infarction. Results showed a correlation between LV sO(2) and cardiac dysfunction, with global hypoxia observed in the brain, kidney, and liver shortly after MI, but returning to pre-MI levels after 7 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Isabel Forner-Piquer, Adele Faucherre, Julia Byram, Marine Blaquiere, Frederic de Bock, Laurence Gamet-Payrastre, Sandrine Ellero-Simatos, Etienne Audinat, Chris Jopling, Nicola Marchi
Summary: In zebrafish larvae, exposure to high concentrations of glyphosate leads to behavioral and neurophysiological defects, while cellular and transcript signatures can be detected in response to low doses.
Article
Endocrinology & Metabolism
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David B. MacLeod, Philip N. Ainslie, Zeljko Dujic
Summary: In this study, it was found that prolonged apnea duration during voluntary asphyxia leads to increased cerebral blood flow and blood-brain barrier permeability. The study highlights the critical role of hypoxemia and hypercapnia in BBB disruption.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Chaitali Ghosh, Rosemary Myers, Christina O'Connor, Sherice Williams, Xuefeng Liu, Mohammed Hossain, Michael Nemeth, Imad M. Najm
Summary: This study reveals that blood-brain barrier dysfunction and metabolic disturbance may contribute to the occurrence of epilepsy through multiple mechanisms in a focal cortical dysplasia model, providing a potential direction for the treatment of refractory epilepsy.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Geoffrey Canet, Charleine Zussy, Celia Hernandez, Nathalie Chevallier, Nicola Marchi, Catherine Desrumaux, Laurent Givalois
Summary: This study reveals that chronic corticosterone (CORT) consumption is a main risk factor for Alzheimer's disease (AD) and suggests that glucocorticoid-based therapies should be prescribed with caution in populations with AD risk.
NEUROENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Erwin A. van Vliet, Nicola Marchi
Summary: The neurovascular unit (NVU) is a complex network involving different cells in the brain, including specialized brain endothelium, glial and mural cells, and neurons. Research suggests that dysfunction of the NVU is a common mechanism underlying late-onset seizures or epilepsy, neurological and neurodegenerative disorders associated with aging. Further studies also indicate that seizure activity may contribute to brain aging by causing regional NVU dysfunction, while cerebrovascular pathology may be linked to comorbidities. Diagnostic approaches tailored to seizure conditions in the elderly and disease-modifying strategies focusing on NVU restoration and control of inflammation are being explored. However, there are still knowledge gaps and clinical challenges in understanding seizure onset and conditions in an aging population.
Article
Clinical Neurology
Geoffrey Canet, Emma Zub, Charleine Zussy, Celia Hernandez, Marine Blaquiere, Valentin Garcia, Mathieu Vitalis, Frederic DeBock, Maria Moreno-Montano, Etienne Audinat, Catherine Desrumaux, Emmanuel Planel, Laurent Givalois, Nicola Marchi
Article
Biochemistry & Molecular Biology
Rosemary Westcott, Natalie Chung, Arnab Ghosh, Lisa Ferguson, William Bingaman, Imad M. Najm, Chaitali Ghosh
Summary: This study reveals that the different isoforms of glucocorticoid receptor (GR) at the blood-brain barrier (BBB) play important roles in the pathogenesis of drug-resistant epilepsy with focal cortical dysplasia (FCD). The expression of GR beta is upregulated in dysplastic brain tissue and is associated with age and gender. The findings suggest that GR beta could serve as a potential biomarker and therapeutic target for dysplasia in epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Charlotte Oris, Julie Durif, Marion Rouzaire, Bruno Pereira, Damien Bouvier, Samy Kahouadji, Mathieu Abbot, Marina Brailova, Sylvain Lehmann, Christophe Hirtz, Philippe Decq, Bernard Dusfour, Nicola Marchi, Vincent Sapin
Summary: This study evaluated the use of seven blood biomarkers for sport-related concussions. Only S100B and GFAP remained stable over the course of a season. The individual percentage change of S100B and NFL concentrations measured 36 hours after concussion was significantly different between non-resolutive and resolutive cases.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Shreya Louis, Robyn M. Busch, Dennis Lal, Jennifer Hockings, Olivia Hogue, Marcia Morita-Sherman, Deborah Vegh, Imad Najm, Chaitali Ghosh, Peter Bazeley, Charis Eng, Lara Jehi, Daniel M. Rotroff
Summary: In this pilot study, the researchers investigated the role of genetic and molecular biomarkers in predicting seizure outcomes after brain surgery for drug-resistant epilepsy. They found that certain SNPs in the ABCB1 gene were associated with post-operative seizure outcomes and could serve as independent predictors of outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
N. Cresto, A. Janvier, N. Marchi
Summary: While seizures involve neuronal events, other brain cells also play a significant role in synaptic transmission. The blood-brain barrier and neuro-glio-vascular unit regulate the brain's homeostasis by maintaining the composition of the interstitial fluid. Damage to the blood-brain barrier and neuroinflammation are mechanisms that sustain abnormal neuronal discharges, which are associated with various pathological conditions. The understanding of the role of the blood-brain barrier and neuroinflammation in epilepsy could lead to the development of biomarkers for predicting disease progression and the discovery of new diagnostic and therapeutic approaches.
REVUE NEUROLOGIQUE
(2023)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Neurosciences
Valentin Garcia, Marine Blaquiere, Alicia Janvier, Noemie Cresto, Carla Lana, Athenais Genin, Helene Hirbec, Etienne Audinat, Adele Faucherre, Emmanuel L. Barbier, Sophie Hamelin, Philippe Kahane, Chris Jopling, Nicola Marchi
Summary: This study reveals the association between mechanosensitive channel PIEZO1 and inflammatory responses in the central nervous system, particularly in the context of epilepsy. The expression of PIEZO1 is increased in epileptogenic regions of the brain and correlates with pro-inflammatory biomarkers. Additionally, TNF alpha is identified as a direct regulator of PIEZO1 expression. These findings highlight the potential significance of PIEZO1 in neuro-inflammatory processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Veronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common chronic liver disease, especially in obese individuals. This study suggests that the nuclear receptor CAR may play a role in the pathogenesis of NAFLD and could be a potential therapeutic target. In mice, deletion of CAR led to a NASH-like hepatic transcriptomic signature and astrogliosis in the hypothalamus of female mice.
Article
Immunology
Anais Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Mueller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe
Summary: Understanding the pathological mechanisms of chronic traumatic brain injury (TBI) could lead to new therapeutic approaches. This study examined the role of meningeal lymphatic vessel dysfunction in modifying post-TBI pathology. The results showed that preexisting dysfunction of meningeal lymphatic vessels did not impact the structural brain damage and post-TBI behavior, but was associated with increased activation of microglia over time.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)