期刊
EPILEPSIA
卷 50, 期 -, 页码 34-44出版社
WILEY
DOI: 10.1111/j.1528-1167.2009.02295.x
关键词
Mice; Rat; Epilepsy; Epileptogenesis; Malformation
资金
- National Institutes of Health [K02 NS045583, R01 NS056872]
- Tuberous Sclerosis Alliance
- Citizens United for Research in Epilepsy
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS056872, K02NS045583] Funding Source: NIH RePORTER
P>Focal cortical dysplasia (FCD) and related malformations of cortical development (MCDs) represent an increasingly recognized cause of medically intractable epilepsy. However, the underlying mechanisms of epileptogenesis are poorly understood, and treatments for epilepsy due to various cortical malformations are often limited or ineffective. Animal models offer a number of advantages for investigating cellular and molecular mechanisms of epileptogenesis and developing novel, rational therapies for MCD-related epilepsy. This review highlights specific examples of how animal models have been useful in addressing several clinically relevant issues about epilepsy due to FCDs and related cortical malformations, including the pathologic and clinical features, etiologic factors, localization of the epileptogenic zone, neuronal and astrocytic contributions to epileptogenesis, and the development of antiepileptogenic therapies.
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