期刊
EPILEPSIA
卷 50, 期 4, 页码 943-948出版社
WILEY
DOI: 10.1111/j.1528-1167.2008.01901.x
关键词
Ketogenic diet; Fenofibrate; Pentylenetetrazol; Status epilepticus; PPAR; antiepileptic drug
资金
- AEAC association
- Conseil REgional Nord-Pas-de-Calais et Centre hospitalier rEgional universitaire de Lille
The underlying mechanisms of the ketogenic diet (KD) remain unknown. Involvement of peroxisome proliferator-activated receptor-alpha (PPAR alpha) has been suggested. The aim of this study was to assess the anticonvulsant properties of fenofibrate, a PPAR alpha agonist. Wistar rats were fed at libitum during 14 days by regular diet, KD, regular diet containing 0.2% fenofibrate (F), or KD containing 0.2% fenofibrate (KD + F). Pentylenetetrazol (PTZ) threshold and latencies to the onset of status epilepticus induced by lithium-pilocarpine were used to assess diet treatments with anticonvulsive effects. Myoclonic and generalized seizure PTZ thresholds were increased in F- and KD-treated animals in comparison to control. No difference was observed between KD + F group and the others groups (control, F, KD). Latencies to the onset of status epilepticus were increased in F and KD groups compared to control. Fenofibrate exerts anticonvulsive properties comparable to KD in adult rats using PTZ and lithium-pilocarpine models. The underlying mechanisms such as PPAR alpha activation and others should be investigated. These findings may provide insights into future directions to simplify KD protocols.
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