Article
Clinical Neurology
Xiaoli Zhang, Jiao Zeng, Xin Gu, Fan Zhang, Yongkai Han, Ping Zhang, Qun Wang, Renjun Gu
Summary: This study evaluated the risk factors associated with relapse after drug withdrawal in patients with seizure-free for 2 years, aiming to guide patients in seizure-free to assess the risk of drug withdrawal. The results showed that factors such as seizure type, seizure-free time before withdrawal, and EEG results before drug withdrawal were related to relapse. The study found that patients with partial seizures, a short seizure-free time before withdrawal, severe EEG abnormalities before drug reduction, and a long course of the disease are prone to relapse.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Medicine, General & Internal
Rod W. Hunt, Helen G. Liley, Deepika Wagh, Rachel Schembri, Katherine J. Lee, Andrew D. Shearman, Samantha Francis-Pester, Koert DeWaal, Jeanie Y. L. Cheong, Monika Olischar, Nadia Badawi, Flora Y. Wong, David A. Osborn, Victor Samuel Rajadurai, Peter A. Dargaville, Bevan Headley, Ian Wright, Paul B. Colditz
Summary: This randomized clinical trial aimed to determine whether active management of electrographic and clinical seizures in encephalopathic term or near-term neonates improved survival free of severe disability at 2 years compared with only treating clinically detected seizures. The study found that treating electrographic and clinical seizures with currently used anticonvulsants did not significantly reduce the rate of death or disability at 2 years in a heterogeneous group of neonates with seizures. Additionally, there was evidence that cognitive outcomes were worse in the group where both types of seizures were actively managed.
Article
Neurosciences
Xiaotong Yin, Yan Liu, Yang Guo, Limei Zhao, Guofei Li, Xiaoping Tan
Summary: The study found significant pharmacokinetic changes in newer antiepileptic drugs in women with epilepsy during pregnancy, highlighting the importance of therapeutic drug monitoring. It is recommended to monitor drug levels at least once per trimester and more frequently for women with poorly controlled seizures before pregnancy. Well-controlled seizures nine months before pregnancy can lower the risk of seizures during pregnancy, emphasizing the importance of pre-pregnancy counseling and seizure management.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Oscar Alcoreza, Sai Jagarlamudi, Andrew Savoia, Susan L. Campbell, Harald Sontheimer
Summary: This study demonstrates the in vivo efficacy of sulfasalazine (SAS) in reducing astrogliosis-mediated seizure burden in a mouse model. It suggests that targeting the astrocytic glutamate antiporter SXC could be a novel approach for treating epilepsy.
Review
Plant Sciences
Licia T. S. Pina, Adriana G. Guimaraes, Wagner B. da R. Santos, Marlange A. Oliveira, Thallita K. Rabelo, Mairim R. Serafini
Summary: This study reviewed 35 monoterpenes with anticonvulsive activity, which have the potential therapeutic effect on epilepsy by reducing seizure activity through targeting key pharmacological targets and reducing neuronal inflammation and oxidative stress caused by seizures. Monoterpenes may represent a promising alternative treatment option, but further research is needed to determine their mechanism of action and safety assessment.
Article
Clinical Neurology
Frank J. E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison A. Hitchcock, Cecilie M. Lander, Mervyn J. Eadie
Summary: During pregnancy, women with previously surgically treated epilepsy had poorer seizure control compared to those with only medically treated epilepsy. This contrasts with a previous study conducted in India on the same question.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Public, Environmental & Occupational Health
Ammar Abdulrahman Jairoun, Sabba Saleh Al-himyari, Moyad Shahwan, Nageeb Hassan, Saleh AL-Tamimi, Maimona Jairoun, Saed H. Zyoud, Abdullah S. Alshehri, Mustfa Faisal Alkhanani, Reem Hasaballah Alhasani, Adnan S. Alharbi, Fahad S. Alshehri, Ahmed M. Ashour, Nasser M. Alorfi
Summary: This study assessed the knowledge of UAE community pharmacists regarding women's issues in epilepsy. The findings revealed a good level of knowledge among community pharmacists, but certain clinical and demographic factors significantly influenced this knowledge. Targeted educational interventions can improve the knowledge and competence of community pharmacists in addressing women's issues in epilepsy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Amanuel Amare
Summary: This study in Ethiopia focused on assessing the clinical presentation, cause, and treatment outcome of patients with HIV infection presenting with seizures. The majority of patients had late-stage HIV infection with low CD4 counts, recent onset seizures, and high case-fatality rates. The common causes of seizures were central nervous system opportunistic infections, highlighting the importance of early diagnosis and treatment to improve outcomes for HIV-infected patients presenting with seizures.
BMC INFECTIOUS DISEASES
(2021)
Article
Behavioral Sciences
Chien-Chen Chou, Po-Tso Lin, Der-Jen Yen, Hsiang-Yu Yu, Shang-Yeong Kwan, Chien Chen, Yo-Tsen Liu, Yen-Cheng Shih, Szu-Ying Lin
Summary: This study examined adult patients with drug-resistant epilepsy admitted to an epilepsy monitoring unit between 2015 and 2018. The results showed no significant differences between patients taking new-generation AEDs and those taking conventional AEDs following withdrawal during V-EEG recording, with the majority of patients completing V-EEG monitoring within one week.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
A. Llaurado, M. Quintana, E. Fonseca, L. Abraira, M. Toledo, M. Requena, M. Olive, A. Ballve, D. Campos, M. Sueiras, E. Santamarina
Summary: This study aimed to determine whether the administration of antiepileptic drugs (AED) alters the likelihood of detecting epileptiform abnormalities in electroencephalographies (EEG) performed early after a first epileptic seizure. The results showed that previous administration of AEDs did not significantly affect the likelihood of detecting epileptiform abnormalities.
Article
Clinical Neurology
Zanfina Ademi, Clara Marquina, Piero Perucca, Alison Hitchcock, Janet Graham, Mervyn J. J. Eadie, Danny Liew, Terence J. J. O'Brien, Frank J. J. Vajda
Summary: The Raoul Wallenberg Australian Pregnancy Register (APR) has proven to be economically beneficial, with a significant return on investment and cost savings from both societal and health care perspectives. Over a 20-year time horizon, the APR has avoided 9,609 adverse pregnancy outcomes and reduced health care and societal costs by AUD 191 million and AUD 9.0 billion, respectively, making it a cost-effective program.
Article
Behavioral Sciences
Maria Paz Guerrero-Molina, Claudia Rodriguez-Lopez, Luisa Panades-de Oliveira, David Uriarte-Perez de Urabayen, Nicolas Garzo-Caldas, Cecilia E. Garcia-Cena, Rosa A. Saiz-Diaz, Julian Benito-Leon, Jesus Gonzalez de la Aleja
Summary: The study did not find significant differences in eye movement performance between patients with Genetic Generalized Epilepsy and Temporal Lobe Epilepsy, suggesting that the frontal cortical mechanisms responsible for these movements are not explicitly impaired in GGE patients.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Arjun Athreya, Rebecca E. Matthews, Daniel L. Drane, Leonardo Bonilha, Jon T. Willie, Robert E. Gross, Ioannis Karakis
Summary: This study investigated the success rate of ASMs withdrawal after MRg-LITT for ETLE and identified predictors of seizure recurrence. The observation period was 3 years, and 29% of patients who attempted ASMs reduction experienced seizure recurrence, but seizure control was regained after reinstituting ASMs. Higher pre-operative seizure frequency and occurrence of acute post-operative seizures were associated with an increased risk of seizure relapse after ASMs reduction.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Agriculture, Dairy & Animal Science
Sylvia Garcia-Belenguer, Laura Grasa, Olga Valero, Jorge Palacio, Isabel Luno, Belen Rosado
Summary: The study found differences in gut microbiota composition between epileptic dogs and control dogs, with drug-naive epileptic dogs showing significantly reduced abundance of GABA and SCFAs-producing bacteria, as well as bacteria associated with reduced risk for brain disease. Furthermore, the administration of antiepileptic drugs for a month did not alter the gut microbiota composition. These results may contribute to understanding canine idiopathic epilepsy and offer potential for exploring probiotic intervention as a therapeutic approach.
Review
Pharmacology & Pharmacy
Sonali Kumar, Diksha Attrish, Arpna Srivastava, Jyotirmoy Banerjee, Manjari Tripathi, P. Sarat Chandra, Aparna Banerjee Dixit
Summary: The review explores the role of HDACs in epilepsy, focusing on their action on non-histone substrates and the potential of HDACi as anti-epileptic drugs. It also discusses the importance of identifying novel targets of HDACs for more effective anti-epileptogenic therapy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
