Article
Clinical Neurology
Silvana Sarria-Estrada, Estevo Santamarina, Manuel Quintana, Deborah Pareto, Maria Sueiras, Cristina Auger, Manuel Toledo, Alex Rovira
Summary: This study analyzed MRI features in patients with status epilepticus (SE), finding abnormalities in over half of the patients. Longer SE duration and the presence of lateralized periodic discharges (LPDs) on EEG were associated with SE-related MRI abnormalities and the development of mesial temporal sclerosis (MTS).
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Veterinary Sciences
Patrick Roynard, Ann Bilderback, Curtis Wells Dewey
Summary: Ketamine 5 mg/kg IV bolus may be successful in treating RSE in dogs, but its efficacy in handling CS is limited. The incidence of adverse effects is low, but timing of administration should be carefully considered.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Clinical Neurology
Michael C. Jin, Jonathon J. Parker, Michael Zhang, Zack A. Medress, Casey H. Halpern, Gordon Li, John K. Ratliff, Gerald A. Grant, Robert S. Fisher, Stephen Skirboll
Summary: The occurrence of early and late PNSE was associated with specific neurosurgical pathologies and increased mortality. These findings provide a foundation for validating clinical and perioperative risk factors prospectively and help identify patients who require heightened diagnostic suspicion for PNSE.
JOURNAL OF NEUROSURGERY
(2021)
Article
Behavioral Sciences
Simona Lattanzi, Eugen Trinka, Francesco Brigo, Stefano Meletti
Summary: Status epilepticus (SE) is a life-threatening condition with potential long-term negative consequences. Short-term mortality prediction has the most evidence, but knowledge about long-term outcomes is limited. Prognostic predictors include etiology and other factors. Prognostic scores should be designed to allow repeated assessment during SE.
EPILEPSY & BEHAVIOR
(2023)
Article
Veterinary Sciences
Rory Fentem, Alberta de Stefani, Rodrigo Gutierrez Quintana, Emili Alcoverro, Gareth Michael Couper Jones, Pablo Amengual-Batle, Rita Goncalves
Summary: This study identified risk factors associated with short-term mortality and recurrence in dogs with status epilepticus (SE), providing valuable information for clinicians and dog owners.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Maria Cristina Cioclu, Antonietta Coppola, Manuela Tondelli, Anna Elisabetta Vaudano, Giada Giovannini, S. Krithika, Michele Iacomino, Federico Zara, Sanjay M. Sisodiya, Stefano Meletti
Summary: NEXMIF mutations are shown to cause DEE with eyelid myoclonia. Advanced neuroimaging techniques reveal brain changes affecting specific networks and the clinical phenotype.
FRONTIERS IN NEUROLOGY
(2021)
Article
Veterinary Sciences
Giulia Cagnotti, Sara Ferrini, Giorgia Di Muro, Giuliano Borriello, Cristiano Corona, Luca Manassero, Eleonora Avilii, Claudio Bellino, Antonio D'Angelo
Summary: The study investigated the use of constant rate infusion of benzodiazepines or propofol in dogs with epilepsy. The medications appeared to be well-tolerated and effective in controlling seizure activity in most patients, regardless of seizure etiology. Further research is needed to assess the effects of CRI duration on outcomes and complications.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Geriatrics & Gerontology
Jiale Hou, Haoyue Zhu, Ling Xiao, Charlie Weige Zhao, Guang Liao, Yongxiang Tang, Li Feng
Summary: The objective of this study was to investigate the cerebral metabolic changes in patients with temporal lobe epilepsy and impaired awareness seizures (TLE-IAS). The results showed abnormal cortical-subcortical metabolism in TLE-IAS patients, which correlated with the altered consciousness. These findings have important implications for guiding clinical treatments and improving the quality of life in TLE patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Diogo Vila Verde, Till Zimmer, Alessandro Cattalini, Marlene F. Pereira, Erwin van Vliet, Giuseppe Testa, Vadym Gnatkovsky, Eleonora Aronica, Marco de Curtis
Summary: The study found that seizures during FncSE may worsen brain tissue damage, while glial cells are only transiently activated in regions far from the lesion, suggesting that seizure activity during FncSE without local pathogenic factors does not lead to long-lasting detrimental changes.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Clinical Neurology
Simona Lattanzi, Markus Leitinger, Chiara Rocchi, Sergio Salvemini, Sara Matricardi, Francesco Brigo, Stefano Meletti, Eugen Trinka
Summary: New-onset refractory status epilepticus (NORSE) is a heterogeneous clinical presentation, with a large proportion of cases having unknown etiology, while autoimmune encephalitis is commonly identified in adult patients and infections are prevalent in pediatric cases. Global cooperation and multicenter research are crucial for improving the understanding of NORSE.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Critical Care Medicine
Samuel Snider, Michael W. K. M. Fong, Neal Nolan, Andres Rodriguez Ruiz, Wei Wang, Suzette LaRoche, Lawrence Hirsch, Jong Lee
Summary: This study aimed to identify clinical diagnoses and rhythmic and periodic electroencephalogram patterns (RPPs) associated with status epilepticus (SE) and seizures. Factors independently associated with SE included cardiac arrest, clinical seizures before continuous electroencephalogram (cEEG), brain neoplasms, and specific EEG patterns. These findings are important for tailoring cEEG monitoring for critically ill patients.
CRITICAL CARE MEDICINE
(2023)
Review
Medicine, General & Internal
Sulaiman Almohaish, Melissa Sandler, Gretchen M. Brophy
Summary: Time is crucial in the evaluation and treatment of seizures. Acute repetitive seizures and status epilepticus are medical emergencies that require immediate assessment and treatment for optimal therapeutic response. Benzodiazepines are considered first-line agents for rapid seizure control, but choosing the right route of administration is key.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Aynara C. Wulsin, Kimberly L. Kraus, Kevin D. Gaitonde, Venkat Suru, Salwa R. Arafa, Benjamin A. Packard, James P. Herman, Steve C. Danzer
Summary: The treatment with C108297 attenuated corticosterone hypersecretion, decreased the density of hilar ectopic granule cells, and reduced microglial proliferation following status epilepticus. However, it did not prevent mossy cell loss in treated mice. This suggests the potential of glucocorticoid receptor modulators as therapeutic agents for preventing brain pathology after status epilepticus.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Yanjie Zhou, Lily Zhang, Yuyan Hao, Liu Yang, Shanghua Fan, Zheman Xiao
Summary: This study explores the characteristics and mechanism of microglial activation after seizures and their effect on migraine. The results indicate that epilepsy facilitates migraine through FKN/CX3CR1 axis-mediated microglial activation in the cortex/thalamus/sp5c, accompanied by BDNF release. Blocking the FKN/CX3CR1 axis and microglial activation are potential therapeutic strategies for preventing and treating migraine in patients with epilepsy.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Muhlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth Francois, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rueber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Summary: Neuronal dysfunction caused by iron accumulation and reactive oxygen species may play a significant role in the epileptogenic process, while alterations in iron metabolism in the epileptic brain have not been extensively studied. Through clinical and animal experiments, as well as in vitro cell culture, the study revealed the mechanisms of iron in epilepsy pathology and antioxidant metabolism.
ACTA NEUROPATHOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Milagros Hidalgo de la Cruz, Paola Valsasina, Sarlota Mesaros, Alessandro Meani, Jovana Ivanovic, Vanja Martinovic, Jelena Drulovic, Massimo Filippi, Maria A. Rocca
Summary: In the study, it was found that abnormalities in sub-regional thalamic resting state functional connectivity in clinically isolated syndrome patients were associated with clinical disability and evolved over time. Some patients experienced multiple clinical relapses, but the median EDSS score remained stable.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Gorica D. Maric, Tatjana D. Pekmezovic, Sarlota T. Mesaros, Olivera S. Tamas, Jovana B. Ivanovic, Vanja N. Martinovic, Marko M. Andabaka, Aleksa Lj. Jovanovic, Nikola D. Veselinovic, Darija B. Kisic-Tepavcevic, Jelena S. Drulovic
Summary: The study found that the most common comorbidities in MS patients in Belgrade, Serbia were psychiatric and cardiovascular diseases, with depression and hypertension being the most prevalent single comorbidities. Type 2 diabetes was significantly more prevalent in patients with primary progressive MS compared to other MS phenotypes. The study also identified a positive correlation between number of comorbidities and progression index, as well as a higher risk of developing comorbidities in patients treated with disease-modifying therapies.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Gorica Maric, Tatjana Pekmezovic, Olivera Tamas, Nikola Veselinovic, Aleksa Jovanovic, Katarina Lalic, Sarlota Mesaros, Jelena Drulovic
Summary: The study found that hypertension significantly accelerated reaching irreversible disability levels (EDSS 4.0, 6.0, and 7.0), while the presence of any cardiovascular disease comorbidities and type 2 diabetes significantly accelerated reaching EDSS 4.0 and EDSS 6.0. In a multivariable model, higher progression index (PI) was identified as an independent predictor of cardiovascular disease occurrence in multiple sclerosis (MS) patients. In the case of type 2 diabetes, PI and MS phenotype were statistically significant in multivariable Cox regression analysis.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Laura Cacciaguerra, Loredana Storelli, Marta Radaelli, Sarlota Mesaros, Lucia Moiola, Jelena Drulovic, Massimo Filippi, Maria A. Rocca
Summary: This study applied a deep-learning algorithm to analyze brain MRIs of patients with NMOSD and NMOSD-like manifestations, finding that aquaporin-4-seronegative patients shared similar structural features with aquaporin-4-seropositive NMOSD patients. The algorithm successfully differentiated aquaporin-4-seropositive NMOSD and MS patients with a high accuracy, and suggested that aquaporin-4-seronegative patients should be included in the NMOSD category. Anti-MOG patients were found to have intermediate brain features between NMOSD and MS.
JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Jovana Ivanovic, Sarlota Mesaros, Tatjana Pekmezovic, Jelena Drulovic
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Gloria Dalla Costa, Sarlota Mesaros, Jelena Drulovic, Jovana Ivanovic, Alex Rovira, Mar Tintore, Xavier Montalban, Olga Ciccarelli, Wallace Brownlee, Katherine Miszkiel, Christian Enzinger, Michael Khalil, Frederik Barkhof, Eva M. M. Strijbis, Jette L. Frederiksen, Stig P. Cramer, Enrico Fainardi, Maria Pia Amato, Claudio Gasperini, Serena Ruggieri, Vittorio Martinelli, Giancarlo Comi, Maria A. Rocca
Summary: This study compares the performance of the 2017 revisions to the McDonald criteria with the 2010 criteria in diagnosing and predicting prognosis of multiple sclerosis (MS) in patients with clinically isolated syndrome (CIS). The results show that the 2017 criteria have higher sensitivity, lower specificity, and shorter time to MS diagnosis compared to the 2010 criteria.
Article
Clinical Neurology
Vanja Jovicevic, Jovana Ivanovic, Marko Andabaka, Olivera Tamas, Nikola Veselinovic, Nikola Momcilovic, Sarlota Mesaros, Tatjana Pekmezovic, Jelena Drulovic
Summary: This study investigated the demographic and clinical characteristics of NMOSD patients with COVID-19, as well as the safety data of COVID-19 vaccines in this population. The results showed overall favorable outcomes of COVID-19 in NMOSD patients and encouraging safety profile of the vaccines.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Mario Habek, Marko Andabaka, Alessandra Fanciulli, Gregor Brecl Jakob, Jelena Drulovic, Fabian Leys, Franziska Di Pauli, Harald Hegen, Michael Auer, Tatjana Pekmezovic, Sarlota Mesaros, Vanja Jovicevic, Anamari Junakovic, Gregor K. Wenning, Florian Deisenhammer, Tereza Gabelic, Barbara Barun, Ivan Adamec, Magdalena Krbot Skoric
Summary: This study aimed to determine the extent of sudomotor dysfunction in patients with neuromyelitis optica spectrum disorder (pwNMOSD) and compare it with patients with relapsing-remitting multiple sclerosis (pwRRMS). The results showed that sudomotor dysfunction is common in pwNMOSD, and symptoms are more frequent compared to pwRRMS. Age and diagnosis of neuromyelitis optica spectrum disorder were significant predictors for symptomatic sudomotor dysfunction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Monica Margoni, Elisabetta Pagani, Alessandro Meani, Loredana Storelli, Sarlota Mesaros, Jelena Drulovic, Frederik Barkhof, Hugo Vrenken, Antonio Gallo, Alvino Bisecco, Deborah Pareto, Jaume Sastre-Garriga, Olga Ciccarelli, Marios Yiannakas, Jacqueline Palace, Paolo Preziosa, Maria A. Rocca, Massimo Filippi
Summary: The T1w/T2w ratio can be used to evaluate the white matter and grey matter in patients with multiple sclerosis and healthy controls, and is associated with clinical disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Laura Cacciaguerra, Elisabetta Pagani, Marta Radaelli, Sarlota Mesaros, Vittorio Martinelli, Jovana Ivanovic, Jelena Drulovic, Massimo Filippi, Maria A. Rocca
Summary: In patients with NMOSD, there is an increased accumulation of brain water as indicated by the increased T2 relaxation time. This alteration could potentially be a useful marker for identifying patients with active disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Letter
Clinical Neurology
Vanja Jovicevic, Jovana Ivanovic, Nikola Momcilovic, Marko Andabaka, Olivera Tamas, Nikola Veselinovic, Danica Cujic, Marija Gnjatovic, Sarlota Mesaros, Tatjana Pekmezovic, Jelena Drulovic
Summary: This study evaluated the humoral response to SARS-CoV-2 infection and vaccination in NMOSD patients treated with different immunosuppressants. The results showed that the seroconversion rate was associated with the type of immunosuppressants used in patients after COVID-19 infection or vaccination.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Gorica Maric, Tatjana Pekmezovic, Sarlota Mesaros, Olivera Tamas, Nikola Veselinovic, Maja Budimkic Stefanovic, Aleksa Jovanovic, Jelena Drulovic
Summary: This study aimed to determine the burden of malignant diseases in MS patients in the Belgrade region. The results showed that MS patients in this region have a lower risk of developing malignancies compared to the general population.
NEUROLOGICAL SCIENCES
(2022)
Article
Cell Biology
Stojan Peric, Vladana Markovic, Ayse Candayan, Els De Vriendt, Nikola Momcilovic, Andrija Savic, Natasa Dragasevic-Miskovic, Marina Svetel, Zorica Stevic, Ivo Bozovic, Sarlota Mesaros, Jelena Drulovic, Ivana Basta, Igor Petrovic, Olivera Tamas, Milija Mijajlovic, Ivana Novakovic, Dragoslav Sokic, Albena Jordanova
Summary: The study analyzed the genetic causes of HSP in adult Serbian patients and found a high genetic diversity in this population. The findings have important implications for molecular diagnostics and broaden the knowledge on the genetic epidemiology of HSP.
Meeting Abstract
Clinical Neurology
M. Habek, M. Andabaka, A. Fanciulli, G. Brecl Jakob, J. Drulovic, F. Leys, F. Di Pauli, H. Hegen, M. Auer, T. Pekmezovic, S. Mesaros, V. Jovicevic, A. Junakovic, G. Wening, F. Deisenhammer, T. Gabelic, B. Barun, I. Adamec, M. Krbot Skoric
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Jelena Drulovic, Gordana Toncev, Congor Nadj, Dragana Obradovic, Jevto Erakovic, Sarlota Mesaros, Mirjana Cukic, Dejan Aleksic, Marko Andabaka, Jovana Ivanovic, Aleksa Jovanovic, Marina Kostic, Gorica Maric, Aleksandar Markovic, Vanja Martinovic, Aleksandra Parojcic, Stojan Peric, Lorand Sakalas, Vesna Suknjaja, Katarina Vesic, Sofija Vojvodic, Tijana Vukovic, Ralph H. B. Benedict, Tatjana Pekmezovic
Summary: This study assessed the reliability and validity of the Serbian version of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). The results showed a high prevalence of cognitive impairment in multiple sclerosis patients, with significant correlations between BICAMS scores and age, education, disease severity, and duration.
ACTA CLINICA CROATICA
(2022)