4.5 Review

Seizures in multiple sclerosis

期刊

EPILEPSIA
卷 49, 期 6, 页码 948-953

出版社

BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2008.01565.x

关键词

multiple sclerosis; seizure; epilepsy; convulsions; treatment

向作者/读者索取更多资源

Seizures have long been recognized to be part of the disease spectrum of multiple sclerosis (MS). While they occur in only a minority of patients with MS, epileptic seizures can have serious consequences. The treatment of MS can be epileptogenic, and antiepileptic treatment can conversely worsen the symptoms of MS. In this article we present an overview of the current literature on the epidemiology, clinical presentation, pathology, imaging, prognosis and treatment of epileptic seizures in MS.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Clinical Neurology

Repurposing Domperidone in Secondary Progressive Multiple Sclerosis A Simon 2-Stage Phase 2 Futility Trial

Marcus W. Koch, Kayla Sage, Sharanjit Kaur, Janet Kim, Graziela Cerchiaro, V. Wee Yong, Gary R. Cutter, Luanne M. Metz

Summary: In this phase 2 futility trial, treatment with the generic drug domperidone did not show efficacy in reducing disability progression in secondary progressive multiple sclerosis (SPMS). Patients with higher prolactin levels during the study had a significantly lower risk of disability progression, indicating a potential avenue for further investigation.

NEUROLOGY (2021)

Article Clinical Neurology

Smoking, obesity, and disability worsening in PPMS: an analysis of the INFORMS original trial dataset

Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: In primary progressive MS (PPMS) patients, smoking was found to be associated with disability worsening, while obesity showed no significant correlation. Over three years of follow-up, smoking and BMI were not linked to physical and cognitive disability worsening risk.

JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

MRI brain volume loss, lesion burden, and clinical outcome in secondary progressive multiple sclerosis

Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: The study investigated the association between MRI outcomes and physical and cognitive disability worsening in people with SPMS using data from the ASCEND trial. Results showed that while there was no association between MRI measures and EDSS or SDMT worsening, worsening in T25FW and NHPT was associated with specific MRI outcomes. The study concluded that standard MRI outcomes may not be useful surrogates of disability measures in SPMS.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Clinical Neurology

Early first-line treatment response and subsequent disability worsening in relapsing-remitting multiple sclerosis

Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Jerry S. Wolinsky, Fred D. Lublin, Eva Strijbis, Gary Cutter

Summary: This study investigated the risk factors associated with early treatment failure in RRMS and found that early treatment failure was related to NEDA-3 failure at 36 months, but not to subsequent disability worsening. The majority of NEDA-3 failures were due to MRI activity. Further research into defining treatment success and failure in RRMS is necessary.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

Impact of clinical outcomes and imaging measures on health-related quality of life in secondary progressive MS

Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: HRQOL measures were most associated with EDSS and T25FW, less so with NHPT and SDMT, and not associated with lesional and volumetric imaging outcomes.

MULTIPLE SCLEROSIS JOURNAL (2022)

Editorial Material Clinical Neurology

Multiple Sclerosis Diagnostic Criteria Moving Ahead or Walking in Place?

Gary R. Cutter, Marcus W. Koch

NEUROLOGY (2022)

Article Immunology

Serum HGF and APN2 are associated with disability worsening in SPMS

Isabelle Tottenham, Marcus Koch, Carlos Camara-Lemarroy

Summary: This study analyzed circulating biomarkers of hypoxia and angiogenesis in patients with Secondary Progressive MS (SPMS) and found that concentrations of glucose transporter-1 (Glut-1) were higher, while levels of angiopoietin-2 (APN2) and hepatocyte growth factor (HGF) were lower, in SPMS patients with disability worsening.

JOURNAL OF NEUROIMMUNOLOGY (2022)

Article Clinical Neurology

The timed 25-foot walk is a more sensitive outcome measure than the EDSS for PPMS trials: an analysis of the PROMISE clinical trial dataset

Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: This study found that using timed 25-foot walk (T25FW) as the primary outcome measure might be more useful than the Expanded Disability Status Scale (EDSS) in clinical trials for primary progressive MS (PPMS), and using T25FW could shorten the duration of clinical trials. Additionally, the presence of contrast-enhancing lesions (CELs) at baseline was associated with disability outcomes.

JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

The MSIS-29 and SF-36 as outcomes in secondary progressive MS trials

Eva M. M. Strijbis, Pavle Repovic, Jop Mostert, James D. Bowen, Bernard M. J. Uitdehaag, Gary Cutter, Marcus W. Koch

Summary: This study investigated the performance of patient-reported outcome measures (PROMs) as longitudinal outcomes in individuals with secondary progressive multiple sclerosis (SPMS). The results showed minimal changes in PROM scores over the 2-year follow-up period, with no consistent trend in improvement or worsening. These findings suggest caution in using PROMs as primary outcome measures in SPMS trials.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Clinical Neurology

Serum neurofilament-light and glial fibrillary acidic protein levels in hydroxychloroquine-treated primary progressive multiple sclerosis

Carlos Camara-Lemarroy, Claudia Silva, Jit Gohill, V. Wee Yong, Marcus Koch

Summary: In this cohort of patients with inactive PPMS, HCQ treatment attenuated the increase of NfL and GFAP after 6 months of treatment and up to 18 months of follow-up, suggesting a treatment effect of HCQ over these biomarkers. RNFL thickness, a marker of neuroaxonal atrophy, was associated with disability worsening and should be explored further as a prognostic marker in this population.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Article Clinical Neurology

The nine hole peg test as an outcome measure in progressive MS trials

Marcus W. Koch, Pavle Repovic, Jop Mostert, James D. Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: This study used patient-level data from two large randomized controlled trials to investigate the performance of alternative scoring methods for the nine-hole peg test (NHPT) in progressive multiple sclerosis (MS). The results showed that the standard NHPT and dominant hand (DH) or non-dominant hand (NDH) alternatives had minimal change, while the NHPT using either hand (EH) resulted in more worsening events. Non-ambulatory patients with progressive MS had more NHPT worsening, especially when using the EH NHPT. Therefore, NHPT can be used as the primary outcome measure in clinical trials involving non-ambulatory patients, but further research is needed to assess its precision in this population.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2023)

Article Clinical Neurology

Threshold definitions for significant change on the timed 25-foot walk and nine-hole peg test in primary progressive multiple sclerosis

Marcus W. Koch, Pavle Repovic, Jop Mostert, James D. Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, Gary Cutter

Summary: This study investigates the short-term variation in T25FW and NHPT using patient-level original trial data and compares it with disability change at 12-month follow-up in people with PPMS. The traditional =20% change threshold for T25FW and NHPT represents a reasonable compromise between reducing false change events and achieving a large number of change events during follow-up.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Article Clinical Neurology

Association between age and inflammatory disease activity on magnetic resonance imaging in relapse onset multiple sclerosis during long-term follow-up

Eline Coerver, Sophie Janssens, Aroosa Ahmed, Mark Wessels, Zoe van Kempen, Bas Jasperse, Frederik Barkhof, Marcus Koch, Jop Mostert, Bernard Uitdehaag, Joep Killestein, Eva Strijbis

Summary: Inflammatory disease activity in multiple sclerosis (MS) decreases with advancing age, and this study investigated the relation between age and MRI measures of inflammatory disease activity in a real-world cohort of people with relapse onset MS.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Article Clinical Neurology

Longitudinal Changes in Cognitive Test Scores in Patients With Relapsing-Remitting Multiple Sclerosis An Analysis of the DECIDE Dataset

Nina Castrogiovanni, Jop Mostert, Pavle Repovic, James D. D. Bowen, Bernard M. J. Uitdehaag, Eva M. M. Strijbis, Gary R. R. Cutter, Marcus W. W. Koch

Summary: This study used data from a large clinical trial to describe the change in Symbol Digit Modalities Test (SDMT) and Paced Auditory Serial Addition Test (PASAT) over up to 144 weeks of follow-up. The findings showed that both SDMT and PASAT scores steadily improved throughout the follow-up period, most likely due to a practice effect. Therefore, caution should be exercised when interpreting these cognitive outcome measures as longitudinal outcomes in clinical trials.

NEUROLOGY (2023)

Meeting Abstract Clinical Neurology

Hydroxychloroquine Modifies Angiogenesis Factors in Primary Progressive Multiple Sclerosis

H. Yong, I. E. Tottenham, C. Silva, M. W. Koch, C. Camara-Lemarroy

MULTIPLE SCLEROSIS JOURNAL (2023)

暂无数据