期刊
EPILEPSIA
卷 49, 期 -, 页码 97-100出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2008.01848.x
关键词
Epilepsy; Kindling; Glycolysis; 2-deoxy-D-glucose; Ketogenic diet
资金
- The Charlie Foundation (CES) [NIH RO1 25020]
- Epilepsy Research Foundation New Therapy Development Project
- Wisconsin Alumni Research Foundation
Metabolic regulation of neuronal excitability is increasingly recognized as a factor in seizure pathogenesis and control. Inhibiting or bypassing glycolysis may be one way through which the ketogenic diet provides an anticonvulsant effect. 2-deoxy-D-glucose (2DG), a nonmetabolizable glucose analog that partially inhibits glycolysis, was tested in several acute and chronic seizure models. Acutely, 2DG decreases the frequency of high-K+-, bicuculline- and 4-aminopyridine-induced interictal bursts in the CA3 region of hippocampal slices; 2DG also exerts anticonvulsant effects in vivo against perforant path kindling in rats. Chronically, 2DG has novel antiepileptic effects by retarding the progression of kindled seizures. Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy.
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