Article
Clinical Neurology
Laura Mirandola, Daniela Ballotta, Francesca Talami, Giada Giovannini, Giacomo Pavesi, Anna Elisabetta Vaudano, Stefano Meletti
Summary: In drug-resistant temporal lobe epilepsy (TLE) patients, interictal epileptiform discharges (IED) were found to impact distant extra-temporal areas, particularly the motor/premotor cortex. Individual analysis revealed involvement of at least one Intrinsic Connectivity Network (ICN) in each patient's spike-related fMRI map.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Stephen D. Mayhew, Sebastian C. Coleman, Karen J. Mullinger, Cam Can
Summary: This study investigated age-related changes in inhibitory activity in the sensorimotor cortex and found that inhibitory activity decreases with age, leading to declines in motor ability and dexterity. Using a large dataset, the researchers observed that the magnitude and spatial extent of inhibitory activity decrease, while excitatory activity increases with age. The balance between inhibitory and excitatory activity also undergoes changes during the aging process.
Article
Neurosciences
Jan W. Kurzawski, Omer Faruk Gulban, Keith Jamison, Jonathan Winawer, Kendrick Kay
Summary: In this study, three neuroimaging datasets were reanalyzed, and it was found that there is a significant difference in the magnitude of the BOLD response in different locations of the primary visual cortex (V1). This difference may be related to the thickness, curvature, depth, and vascularization of the cortex. After correction, the difference in BOLD response decreased by half, suggesting that some of the differences may not be caused by neural activity.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Seyyed Mostafa Sadjadi, Elias Ebrahimzadeh, Mohammad Shams, Masoud Seraji, Hamid Soltanian-Zadeh
Summary: This paper explores the recent advances in combining fMRI and EEG for studying brain function and mapping epileptic seizure generation regions. The review discusses methodologies for data recording, artifact removal, and statistical analysis, highlighting the usefulness of EEG-fMRI in evaluating epilepsy patients for surgery. Results show that the affected brain regions by epileptic discharges may extend beyond the seizure onset zone.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eleonora Piccirilli, Carlo Sestieri, Loris Di Clemente, Andrea Delli Pizzi, Marco Colasurdo, Valentina Panara, Massimo Caulo
Summary: We investigated the effects of different types of left hemisphere lesions (gliomas, temporal lobe epilepsy and cavernous angioma) on intra-hemispheric language plasticity. Significant activation peak shifts were found in glioma patients compared to other groups (temporal lobe epilepsy and cavernous angioma) and healthy controls. Additionally, tumor location (anterior or posterior) also had a significant effect on language plasticity.
Article
Neurosciences
Liandong Lin, Da Chang, Donghui Song, Yiran Li, Ze Wang
Summary: This study investigates the relationship between brain entropy during resting state and brain activations and deactivations during task performance. The results show that lower brain entropy at rest is associated with stronger activations and deactivations in brain regions engaged by the tasks. Higher workload leads to more extensive negative correlations between resting brain entropy and task activations. These findings suggest that resting brain activity can predict task-related brain activity and may facilitate both task activations and deactivations.
Article
Neurosciences
Qingqing Zhang, Samuel R. Cramer, Kevin L. Turner, Thomas Neuberger, Patrick J. Drew, Nanyin Zhang
Summary: In this study, it was found that the multi-phase blood-oxygen-level dependent (BOLD) response observed in the visual cortices of unanesthetized rats during decreased illumination can be better explained by the high-frequency neuronal signal rather than non-neuronal physiological factors. The phases of the BOLD response were found to be reproducible and were not simply a result of the periodic stimulation structure.
Article
Clinical Neurology
Mariano Fernandez-Corazza, Rui Feng, Chengxin Ma, Jie Hu, Li Pan, Phan Luu, Don Tucker
Summary: The study compared the performance of MSP, sLORETA, and cMEM methods for epileptic source estimation using high-resolution electrical head models. Results showed that MSP performed similarly to sLORETA but slightly better than cMEM in terms of success rate. MSP and cMEM methods were more localized and did not require arbitrary selection of hyperparameters, making them better than sLORETA in terms of spatial dispersion. The three methods are complementary and can be used together in clinical practice.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Zhisen Li, Xiaoxia Hou, Yanli Lu, Huimin Zhao, Meixia Wang, Bo Xu, Qianru Shi, Qian Gui, Guanhui Wu, Mingqiang Shen, Wei Zhu, Qinrong Xu, Xiaofeng Dong, Qingzhang Cheng, Jibin Zhang, Hongxuan Feng
Summary: This study aimed to investigate the changes of brain network in epilepsy patients without intracranial lesions under resting conditions. The topological characteristics and functional connectivity of brain networks in non-lesional epilepsy patients were found to be altered. Abnormal functional connectivity may indicate reduced brain efficiency in epilepsy patients and could be a compensatory response to early stages of the disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Zoltan Nagy, Chloe Hutton, Gergely David, Natalie Hinterholzer, Ralf Deichmann, Nikolaus Weiskopf, S. Johanna Vannesjo
Summary: Sampling the BOLD response with high temporal resolution provides new opportunities to study the functioning of the human brain. This study presents a method that combines a sparse event-related stimulus paradigm with data reshuffling to achieve high temporal resolution while maintaining high signal levels.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siqi Cai, Zhifeng Shi, Shihui Zhou, Yuchao Liang, Lei Wang, Kai Wang, Lijuan Zhang
Summary: This study investigated the cerebrovascular dynamics in patients with cerebral glioma and their relevance to tumor aggressiveness using time-shift analysis and a decision tree model. The results showed that gliomas induced grade-specific cerebrovascular dysregulation in the entire brain, with altered time-shift features of systemic low-frequency oscillation signals.
Article
Clinical Neurology
Karin Trimmel, Lorenzo Caciagli, Fenglai Xiao, Louis A. van Graan, Matthias J. Koepp, Pamela J. Thompson, John S. Duncan
Summary: The study found that language networks in left temporal lobe epilepsy patients are particularly susceptible to dysfunction and reorganization. Early onset and long duration of epilepsy, as well as high seizure frequency, are associated with compromised activation and deactivation patterns of task-associated regions, which might explain the impaired naming performance in individuals with temporal lobe epilepsy.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Harm J. van Der Horn, Andrew B. Dodd, Tracey V. Wick, Cidney R. Robertson-Benta, Jessica R. Mcquaid, Anne K. Hittson, Josef M. Ling, Vadim Zotev, Sephira G. Ryman, Erik B. Erhardt, John P. Phillips, Richard A. Campbell, Robert E. Sapien, Andrew R. Mayer
Summary: There is an increasing amount of research suggesting that pediatric mild traumatic brain injury (pmTBI) may lead to cerebral pathophysiological processes that extend beyond the usual clinical recovery timeline. This study used fMRI to examine neural processes related to cognitive control in 181 pmTBI patients at sub-acute and early chronic stages post-injury. The results showed alterations in neural functioning during cognitive control up to 4 months post-injury, regardless of clinical recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Sebastian C. Schneider, Mario E. Archila-Melendez, Jens Goettler, Stephan Kaczmarz, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: By studying asymptomatic patients with arterial stenosis and healthy controls, this study demonstrates a negative association between homotopic BOLD-FC and capillary transit time heterogeneity (CTH) differences, suggesting that increasing CTH differences lead to BOLD-FC reductions. Simulations also show that increasing CTH corresponds to broadened and delayed CBF responses to ongoing neuronal activity.
Article
Multidisciplinary Sciences
Baerbel Herrnberger
Summary: Regressing voxel time course onto expected response is a common procedure in functional magnetic resonance imaging. The analysis of the time-derivative approach provides functional relations between time shift and regression coefficients, allowing for hemodynamic shifts of +/- 5 s, and explaining shape distortion and reconstruction behavior.
SCIENTIFIC REPORTS
(2022)