Article
Neurosciences
Sebastian Dohm-Hansen, Francisco Donoso, Paul J. Lucassen, Gerard Clarke, Yvonne M. Nolan
Summary: This article discusses the potential role of the gut microbiome in connecting the pathogenesis of temporal lobe epilepsy (TLE) and hippocampal neurogenesis. Mechanisms associated with neuronal excitability, neuroinflammation, and gut microbial metabolites are highlighted as potential links between the gut microbiota and TLE.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Giuliana T. M. Cardoso, Walace Gomes-Leal, Edna C. S. Franco, Antonio Pereira Jr, Francinaldo L. L. Gomes, Ana Leda F. Brino, Silene M. A. Lima
Summary: Hippocampectomy does not lead to cognitive impairment and may induce compensatory neurogenesis in the remaining hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Peng Chen, Fuchao Chen, Yue Wu, Benhong Zhou
Summary: Accumulated data over the past four decades have confirmed the key role of adult hippocampal neurogenesis in a wide spectrum of hippocampal pathology, especially in epilepsy. Further exploration is needed to understand the effects of seizure-induced neurogenesis in the epileptic brain. Future research directions should focus on neural stem cells and epilepsy models to improve therapies and precision medicine for patients with epilepsy.
FRONTIERS IN NEUROLOGY
(2021)
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
In-Young Choi, Mi-La Cho, Kyung-Ok Cho
Summary: In this study, researchers identified a novel target, interleukin-17A (IL-17A), which may contribute to anxiety in temporal lobe epilepsy (TLE). By deleting the IL-17A gene, they were able to alleviate TLE-associated anxiety behavior and reduce seizure-induced aberrant neurogenesis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Raquel Montalban-Loro, Glenda Lassi, Anna Lozano-Urena, Ana Perez-Villalba, Esteban Jimenez-Villalba, Marika Charalambous, Giorgio Vallortigara, Alexa E. Horner, Lisa M. Saksida, Timothy J. Bussey, Jose Luis Trejo, Valter Tucci, Anne C. Ferguson-Smith, Sacri R. Ferron
Summary: The study discovered that Delta-like homolog 1 is expressed biallelically in the adult brain, specifically in the hippocampus, and plays a crucial role in adult neurogenesis. Reduction in Dlk1 levels triggers specific cognitive abnormalities that affect discriminating differences in environmental stimuli, highlighting the importance of selective absence of imprinting in this neurogenic niche.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Bokyung Song, Chong-Hyun Kim
Summary: The PLC81 null mouse model shows enhanced neurogenesis in the DG of the hippocampus, along with increased moving activity and seizures. The results suggest that PLC81 plays a cell-autonomous inhibitory role in the proliferation of adult neural stem/progenitor cells in vivo and the excitability of DG granule cells.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Muriel D. Mardones, Kunal Gupta
Summary: Mesial temporal lobe epilepsy (mTLE) is a life-threatening condition characterized by recurrent hippocampal seizures. This study used a mouse model to investigate the transcriptional dysregulation in different zones of the hippocampus during the epileptogenic period. The findings suggest that early gene expression changes related to cell signaling, migration, and proliferation may play a role in the development of mTLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo
Summary: This study provides a comprehensive understanding of how conditional deletion of Pten regulates the genesis of adult neural stem/progenitor cells in the dentate gyrus and subventricular zone. The results demonstrate that Pten deletion leads to successive increases in cell proliferation and immaturity, with the increase spreading to non-neurogenic areas as mice age. The study also reveals region-specific increases in apoptotic cells that parallel the increases in proliferating cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shanshan Zhao, Fangxi Liu, Wei Shi, Jialu Wang, Zhike Zhou, Xiaoqian Zhang
Summary: DL-NBP shows therapeutic potential for chronic temporal lobe epilepsy by promoting neurogenesis, improving cognitive function, and reducing epileptic seizures.
Article
Multidisciplinary Sciences
Bingfang Zhang, Lei Wang, Aisheng Zhan, Min Wang, Lanxiang Tian, Weixiang Guo, Yongxin Pan
Summary: Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. The authors show that in mice exposed to HMF, adult hippocampal neurogenesis and hippocampus-dependent learning are impaired and could be rescued by restoring ROS levels.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Minghua Fan, Yongqing Liu, Yongfeng Shang, Yanxue Xue, Jing Liang, Zhuo Huang
Summary: Through experimental research, it is found that JADE2 plays a key role in regulating synaptic plasticity and memory formation in hippocampal neurons, and it regulates synaptic function by transcriptional activation of Rac1.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Bryon M. Smith, Angela I. Saulsbery, Patricia Sarchet, Nidhi Devasthali, Dalia Einstein, Elizabeth D. Kirby
Summary: This study compares the efficiency and effects of two methods (injection and chow consumption) of tamoxifen administration in adult neurogenesis. The injection method results in higher recombination efficiency but disrupts neural progenitor cell proliferation, while the chow consumption method has lower recombination efficiency but increases neuronal differentiation.
Article
Neurosciences
Francisco Velasquez, Conor Dickson, Michelle L. Kloc, Carmel A. Schneur, Jeremy M. Barry, Gregory L. Holmes
Summary: There is evidence that brain oscillations are important for spatial cognition. Disruption of hippocampal rhythms impairs spatial cognition in rat pups. Early-life seizures cause deficits in spatial cognition. The study investigated whether modifying hippocampal rhythms following early-life seizures can improve spatial cognition.
NEUROBIOLOGY OF DISEASE
(2023)
