期刊
EPIGENETICS
卷 9, 期 2, 页码 186-193出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.26792
关键词
MOZ; MORF; KAT6A; KAT6B; BRPF; ING5; histone; acetylation; PHD; reader
资金
- National Institutes of Health [GM096863, GM101664]
- Canadian Institutes of Health Research (CIHR) [MOP-97057]
- CIHR [MOP-64289]
The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.
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