4.5 Editorial Material

Methylation, a new epigenetic mark for protein stability

期刊

EPIGENETICS
卷 4, 期 7, 页码 429-433

出版社

TAYLOR & FRANCIS INC
DOI: 10.4161/epi.4.7.9787

关键词

E3 ligase; lysine methylation; non-histone proteins; protein stability; Set9

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Immunology

Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

Xiao-Dong Yang, Shao-Cong Sun

IMMUNOLOGICAL REVIEWS (2015)

Editorial Material Cell Biology

Talking to histone: methylated RelA serves as a messenger

Xiao-Dong Yang, Lin-Feng Chen

CELL RESEARCH (2011)

Article Developmental Biology

Distinct and mutually inhibitory binding by two divergent. β-catenins coordinates TCF levels and activity in C-elegans

Xiao-Dong Yang, Shuyi Huang, Miao-Chia Lo, Kota Mizumoto, Hitoshi Sawa, Wenqing Xu, Scott Robertson, Rueyling Lin

DEVELOPMENT (2011)

Article Developmental Biology

Functional analyses of vertebrate TCF proteins in C. elegans embryos

Scott M. Robertson, Miao-Chia Lo, Ranaan Odom, Xiao-Dong Yang, Jessica Medina, Shuyi Huang, Rueyling Lin

DEVELOPMENTAL BIOLOGY (2011)

Article Multidisciplinary Sciences

β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex

Xiao-Dong Yang, Tejas R. Karhadkar, Jessica Medina, Scott M. Robertson, Rueyling Lin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Oncology

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

FRONTIERS OF MEDICINE (2018)

Article Biochemistry & Molecular Biology

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome

Xiao-Dong Yang, Wenguo Li, Shuangyan Zhang, Dandan Wu, Xiaoli Jiang, Rong Tan, Xiaoyin Niu, Qijun Wang, Xuefeng Wu, Zhiduo Liu, Lin-Feng Chen, Jun Qin, Bing Su

EMBO JOURNAL (2020)

Article Biology

MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis

Ningbo Wu, Dongping Chen, Hongxiang Sun, Jianmei Tan, Yao Zhang, Tianyu Zhang, Yuheng Han, Hongzhi Liu, Xinxing Ouyang, Xiao-Dong Yang, Xiaoyin Niu, Jie Zhong, Zhengting Wang, Bing Su

Summary: The study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis, providing a potential target for intervention in T cell-mediated colitis. MAP3K2-deficient T cells have reduced ability to induce colitis and affect Th1 cell differentiation in the intestine rather than Th17 cells.

SCIENCE CHINA-LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein

Wenli Qian, Qi Li, Xinglong Wu, Wenguo Li, Qiwei Li, Jie Zhang, Mengying Li, Dan Zhang, Hongxia Zhao, Xiuqun Zou, Hao Jia, Lingqiang Zhang, Xiao-Dong Yang, Zhaoyuan Hou

ONCOGENE (2020)

Article Cell Biology

Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips

Xingchen Dong, Xiangming Hu, Yan Bao, Guo Li, Xiao-Dong Yang, James M. Slauch, Lin-Feng Chen

Summary: The study demonstrates that Brd4 plays a crucial role in regulating NLRC4 inflammasome activation during Salmonella typhimurium infection, by maintaining the expression of Naips. Deficiency of Brd4 leads to impaired inflammasome-dependent cytokine release and pyroptosis, highlighting a novel function of Brd4 in innate immunity against bacterial pathogens.

JOURNAL OF CELL BIOLOGY (2021)

Review Immunology

Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation

Dandan Wu, Zhenzhen Zhang, Xiaoli Jiang, Yaning Du, Shuangyan Zhang, Xiao-Dong Yang

Summary: Inflammasomes are multi-protein platforms assembled in response to microbial and danger signals, with recent evidence showing their assembly and activation at the centrosome, explaining the singularity and perinuclear location of activated inflammasomes. This reveals the previously unappreciated importance of the centrosome in controlling inflammasome assembly and related diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Spata2L Suppresses TLR4 Signaling by Promoting CYLD-Mediated Deubiquitination of TRAF6 and TAK1

Zhenzhen Zhang, Shuangyan Zhang, Xiaoli Jiang, Dandan Wu, Yaning Du, Xiao-Dong Yang

Summary: This study reveals that Spata2L acts as a regulator of CYLD, inhibiting the TLR4-dependent inflammatory response by enhancing CYLD-mediated deubiquitination of key signaling molecules. This finding provides new insights into the regulatory mechanisms of CYLD in TLR4 signaling and suggests potential targets for modulating TLR4-induced inflammation.

BIOCHEMISTRY-MOSCOW (2022)

Article Immunology

SESLA suppresses the activation of macrophages and dendritic cells after Gram-positive bacterial challenge

Xinru Jiang, Yanwu Xu, Tiannan Xiang, Hanxiao Zhang, Xiaodong Cheng, Xiao-Dong Yang, Hongyi Hu, Xin Jiang, Yuejuan Zheng

Summary: This study demonstrated the anti-inflammatory activity of SES (Secoeudesma sesquiterpenes lactone A) in gram-positive (G(+)) bacterial infections and uncovered its immunoregulatory role and potential mechanism.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2023)

Article Pediatrics

Association of elevated plasma CCL5 levels with high risk for tic disorders in children

Hai-zhen You, Jie Zhang, Yaning Du, Ping-bo Yu, Lei Li, Jing Xie, Yunhui Mi, Zhaoyuan Hou, Xiao-Dong Yang, Ke-Xing Sun

Summary: Abnormal levels of certain cytokines in the blood of children with tic disorders were found, and CCL5 was identified as a potential biomarker for TD development. This study provides evidence of the association between elevated CCL5 level and TD, and suggests that CCL5 could be a risk factor for TD development.

FRONTIERS IN PEDIATRICS (2023)

Article Medicine, Research & Experimental

SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation

Chenyang Guan, Xian Huang, Jinnan Yue, Hongrui Xiang, Samina Shaheen, Zhenyan Jiang, Yuexiao Tao, Jun Tu, Zhenshan Liu, Yufeng Yao, Wen Yang, Zhaoyuan Hou, Junling Liu, Xiao-Dong Yang, Qiang Zou, Bing Su, Zhiduo Liu, Jun Ni, Jinke Cheng, Xuefeng Wu

Summary: The study reveals that SIRT3-mediated deacetylation plays a crucial role in NLRC4 activation, aiding in the clearance of Salmonella typhimurium infection.

THERANOSTICS (2021)

暂无数据