Editorial Material
Multidisciplinary Sciences
Maggie P. Lauria Sneideman, Victoria H. Meller
Summary: A protein that upregulates gene expression of the X chromosome has been discovered in male mosquitoes, which is crucial for equalizing gene expression between sexes in organisms with X and Y chromosomes.
Editorial Material
Multidisciplinary Sciences
David Lara-Astiaso, Brian J. P. Huntly
Summary: UTX protein regulates chromatin by condensing into liquid-like droplets, thereby suppressing tumor growth.
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Cell Biology
Miyoung Lee, Delaney K. K. Geitgey, Jamie A. G. Hamilton, Jeremy M. M. Boss, Christopher D. D. Scharer, Jennifer M. M. Spangle, Karmella A. A. Haynes, Curtis J. J. Henry
Summary: The relationship between obesity and T-ALL development is inverse, with obesity inducing cell death in T-ALL cells through epigenetic modifications. Epigenetic modifying drugs may be a potential treatment option for T-ALL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biology
Liwen Yang, Pingxian Zhang, Yifan Wang, Guihua Hu, Weijun Guo, Xiaofeng Gu, Li Pu
Summary: Synthetic epigenetics holds great potential in crop improvement. By studying epigenetic mechanisms and using innovative techniques, researchers can develop engineered smart crops that have higher yields and can actively adapt to internal and external environments.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
Review
Biochemistry & Molecular Biology
Diamantis I. Tsilimigras, Sofia-Iris Bibli, Gerasimos Siasos, Evangelos Oikonomou, Despina N. Perrea, Konstantinos Filis, Dimitrios Tousoulis, Fragiska Sigala
Summary: Atherosclerosis is a major cause of global mortality, and the efficacy of statins may be influenced by genetic and environmental factors, with certain lncRNAs potentially playing a role in atherosclerosis. Current research on the interplay between statins and lncRNAs implicated in atherosclerosis is limited.
Review
Microbiology
Bouchra Ezzamouri, Saeed Shoaie, Rodrigo Ledesma-Amaro
Summary: The microbial communities of the human body play a crucial role in human health, with potential for novel therapeutic and diagnostic interventions. The integration of systems biology approaches and synthetic biology can enhance the quality and impact of future studies on the human microbiome, highlighting important avenues for future research.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sylwia Wasiak, Laura M. Tsujikawa, Emily Daze, Dean Gilham, Stephanie C. Stotz, Brooke D. Rakai, Chris D. Sarsons, Li Fu, Salman Azhar, Ravi Jahagirdar, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski
Summary: Obese patients are at risk for Type 2 Diabetes Mellitus (T2DM) and Cardiovascular Disease (CVD). A lipid-rich diet promotes arterial changes by inducing hypertension, oxidative stress, and inflammation. This study aims to determine if BET inhibition can reduce lipid-rich diet-induced vascular inflammation in mice. The results show that BET inhibitors can reduce arterial inflammation caused by a high-fat diet, providing mechanistic insight into how BET inhibitors may reduce CVD risk in obese patients.
Editorial Material
Multidisciplinary Sciences
Felicia Kuperwaser, Itai Yanai
Summary: A comprehensive cell atlas of gene expression and regulation in human embryos has provided a unique opportunity for innovative investigation of development through multi-organ and multi-modal analysis.
Article
Genetics & Heredity
Felipe Mateus Pellenz, Daisy Crispim, Tais Silveira Assmann
Summary: This study used a systems biology approach to identify a set of highly interconnected genes associated with childhood obesity, providing comprehensive information on the genetic and molecular factors involved in the pathogenesis of this disease.
Article
Biochemistry & Molecular Biology
Glen E. Duncan, Ally Avery, Millissia Ben Maamar, Eric E. Nilsson, Daniel Beck, Michael K. Skinner
Summary: This study aimed to identify potential systemic DNA methylation alterations associated with obesity using an epigenome-wide association approach. The results demonstrate the feasibility of identifying systemic epigenetic biomarkers for obesity, which may have implications for preventative medicine and clinical management of the disease.
Editorial Material
Multidisciplinary Sciences
Amber Dance
Summary: Methods that combine imaging with sequencing are revealing the organizational principles of the genome and its impact on cell fates.
News Item
Multidisciplinary Sciences
Philip Ball
Summary: A pair of studies highlight ethical and legal concerns surrounding the status of lab-grown human embryo models.
Article
Immunology
Mohamed Helmy, Kumar Selvarajoo
Summary: The majority of human genome consists of non-coding genes, with about half made up of transposable elements, including endogenous retroviruses. While generally harmless, endogenous retroviruses have been linked to inflammatory diseases and cancer, posing a challenge in elucidating the mechanistic understanding between them.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anesthesiology
Morten Hylander Moller, Martin Ingi Sigurdsson, Klaus T. Olkkola, Marius Rehn, Arvi Yli-Hankala, Michelle S. Chew
Summary: The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine supports the clinical practice guideline Regional anaesthesia in patients on antithrombotic drugs - a joint ESAIC/ESRA guideline, which serves as a useful decision aid for Nordic anaesthesiologists providing regional anaesthesia to adult patients on antithrombotic drugs.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Nanna Sveinsdottir, Sunna Run Heidarsdottir, Arni Steinn Steinthorsson, Hera Johannesdottir, Alexandra Aldis Heimisdottir, Tomas Thor Kristjansson, Thorir Einarsson Long, Ingibjorg Gudmundsdottir, Martin Ingi Sigurdsson, Tomas Gudbjartsson
Summary: Patients with impaired renal function have higher risks of complications and mortality after coronary artery bypass grafting (CABG), and renal failure is a strong predictor of 30-day mortality.
Article
Medicine, General & Internal
Pordis Magnadottir, Leon Arnar Heitmann, Tinna Harper Arnardottir, Tomas Por Kristjansson, Per Martin Silverborn, Martin Ingi Sigurdsson, Tomas Gudbjartsson
Summary: This study examined the outcomes of PSP surgeries over a 28-year period in a whole nation, including incidence, patient characteristics, surgical details, complications, and recurrence rates. The results showed a decreasing trend in the incidence of PSP surgery, major early complications were rare, and the rate of recurrent pneumothorax requiring surgery was 6%.
Editorial Material
Medicine, General & Internal
Martin Ingi Sigurosson
Article
Anesthesiology
Luis G. Rabelo, Anna Bjornsdottir, Anna B. Jonsdottir, Sveinn G. Einarsson, Sigurbergur Karason, Martin Sigurdsson
Summary: Approximately 40% of elderly surgical patients have abnormal screening results for frailty, and these abnormal results are associated with an increased risk of adverse postoperative outcomes.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Helena Xiang Johannsdottir, Ingibjorg Jona Gudmundsdottir, Sigurbergur Karason, Martin Ingi Sigurdsson
Summary: This study investigates the association between pre-operative electrocardiography QTc interval and all-cause mortality in non-cardiac surgery patients. The results show that patients with a QTc interval between 480 and 519 ms have higher mortality rates after non-cardiac surgery, suggesting the presence of underlying cardiovascular risk.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Sigurdur B. B. Benediktsson, Sigurbergur Karason, Martin I. I. Sigurdsson
Summary: This retrospective cohort study found that pre-operative anaemia is common and associated with adverse outcomes. Patients with anaemia, regardless of red cell size, had a longer duration of anaemia prior to surgery and similar post-operative recovery. All types of anaemia were associated with higher rates of 30-day mortality, acute kidney injury, and readmission compared to non-anaemic patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Orthopedics
Maria Sigurdardottir, Martin Ingi Sigurdsson, Yngvi Olafsson, Solveig H. Sverrisdottir, Ingibjorg Gunnarsdottir, Emil L. Sigurdsson, Sigurbergur Karason
Summary: This study aimed to identify the prevalence of modifiable risk factors of surgical site infections (SSI) in patients undergoing primary elective total joint arthroplasty (TJA) receiving conventional pre-operative preparation, and to explore their association with infectious outcomes. The study found an association between obesity and dysglycemia/diabetes with superficial SSI.
Article
Anesthesiology
Jamie R. Privratsky, Matthew Fuller, Karthik Raghunathan, Tetsu Ohnuma, Raquel R. Bartz, Rebecca Schroeder, Thomas M. Price, Michael R. Martinez, Martin Sigurdsson, Michael R. Mathis, Bhiken Naik, Vijay Krishnamoorthy
Summary: This study aimed to determine the association of age and sex with postoperative AKI. The results showed that younger females have a lower risk of postoperative AKI, which gradually increases with age. These findings suggest that age-related changes in women should be further investigated as modifiers of postoperative AKI risk.
Article
Medicine, General & Internal
Emilie Zeuthen, Sine Wichmann, Martin Schonemann-Lund, Mikko J. J. Jarvisalo, Rebecka Rubenson-Wahlin, Martin I. I. Sigurosson, Erling Holen, Morten H. H. Bestle
Summary: Practices among Nordic ICU physicians in assessing, diagnosing, and treating fluid overload reveal variability in practice. A 5% increase in body weight is considered the minimum to support the diagnosis of fluid overload. Clinical examination findings are preferred for assessing, diagnosing, and treating fluid overload, with diuretics being the preferred treatment modality.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Martin Ingi Sigurosson, Michelle Chew, Klaus T. Olkkola, Marius Rehn, Maija-Liisa Kalliomaki, Morten Hylander Moller
Summary: The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine endorses the Saudi Critical Care Society clinical practice guidelines on venous thromboembolism prevention in adults with trauma, which have been reviewed for evidence-based integrity and endorsed by the same Scandinavian society. This guideline serves as a useful decision aid for Nordic anaesthesiologists managing adult trauma patients in the operating room and intensive care unit.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Anne Sofie Andreasen, Mik Wetterslev, Martin Ingi Sigurdsson, Jeppe Bove, Jesper Kjaergaard, Tayyba Naz Aslam, Kati Jarvela, Mette Poulsen, Lina De Geer, Arnav Agarwal, Maj-Brit Norregaard Kjaer, Morten Hylander Moller
Summary: New-onset or acute atrial fibrillation (NOAF) is prevalent in critically ill adult patients and is associated with adverse outcomes. However, there is limited evidence to support the optimal management of NOAF in this population, and no specific recommendations can be made regarding the choice of pharmacological agent or the use of direct current cardioversion.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
D. H. Magnusson, T. I. Albertsson, F. Jonsdottir, M. I. Sigurdsson
Summary: The use of hypnotic and sedative medication for sleep improvement is common, but long-term use is associated with increased risk of adverse events and mortality. This study aimed to determine the incidence and factors associated with new persistent use of hypnotic and sedative medication after surgical procedures. The results showed that although a small proportion of surgical patients initiate the use of these medications, a substantial proportion develop persistent use, which is associated with adverse outcomes.
Article
Surgery
porsteinn Ivar Albertsson, Freyja Jonsdottir, Sigurbergur Karason, Martin I. Sigurdsson
Summary: The study investigated the incidence of new and new persistent use of benzodiazepines among surgical patients. The findings showed that a small portion of patients started using benzodiazepines perioperatively, and half of them met the criteria for persistent use.
Article
Anesthesiology
Helga Thorsdottir, Thorir E. Long, Runolfur Palsson, Martin I. Sigurdsson
Summary: This study examined the incidence and risk factors of acute kidney injury (AKI) following orthopaedic surgeries in an Icelandic cohort. The results showed an increasing incidence of AKI and identified older age and reduced kidney function as risk factors. Patients who developed AKI had higher long-term mortality and accelerated progression of chronic kidney disease compared to those who did not.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
