Article
Infectious Diseases
Amina Nawal Bahoussi, Yan-Yan Guo, Pei-Hua Wang, Amina Dahdouh, Changxin Wu, Li Xing
Summary: Zoonotic hepatitis E, caused by swine hepatitis E virus (sHEV), is endemic in China. Our study found that sHEV genotype 4 (sHEV4) dominates in China and identified eight potential recombination events, including one intergenotype recombination event that could pose a significant threat to human health.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Giovanni Ianiro, Marina Monini, Maria Grazia Ammendolia, Luca De Sabato, Fabio Ostanello, Gabriele Vaccari, Ilaria Di Bartolo
Summary: This study successfully cultivated different subtypes of HEV-3 isolated from pig feces using a previously established protocol for HEV cultivation on human lung cells. Sequence analysis showed no insertion in the hypervariable region of the genomes and revealed a few mutations acquired during the growth on cells. The protocol allowed for quick production of a high amount of virus in serum-free medium and will be used for future experiments on virus infectivity.
Article
Veterinary Sciences
Zhijie Jian, Youyou Li, Zhiwen Xu, Jun Zhao, Fengqin Li, Huidan Deng, Xiangang Sun, Ling Zhu
Summary: The study successfully established a rat infection model, demonstrating that porcine hepatitis E virus can infect rats across species and viral RNA can be detected in multiple tissues and organs. This provides new insights and scientific basis for studying the mechanism of HEV infection and preventing HEV infection.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Giovanni Ianiro, Eleonora Chelli, Luca De Sabato, Marina Monini, Fabio Ostanello, Ilaria Di Bartolo
Summary: This study evaluated the prevalence of HEV infection among pigs of different ages along the production chain and how long the virus can persist in the farm environment. The results showed a 23.8% positivity rate of HEV-RNA in pigs on a farm in Northern Italy, indicating the circulation of HEV-3 strain in pigs before slaughtering.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Patrizio Lorusso, Elisabetta Bonerba, Annamaria Pandiscia, Anna Mottola, Angela Di Pinto, Roberta Piredda, Valentina Terio
Summary: This study aimed to assess the occurrence and genetic variability of HEV in wild boars. It found a prevalence of 26.7% in wild boar liver samples, all identified as HEV-3c subtype. Further research is needed to investigate virus viability and its link to human seroprevalence.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Dieudonne Tialla, Assana Cisse, Georges Anicet Ouedraogo, Judith M. Huebschen, Zekiba Tarnagda, Chantal J. Snoeck
Summary: This study investigated the role of cows in the epidemiology of HEV in Burkina Faso and the habits of farmers in terms of dairy product consumption. The results showed that the concomitant presence of pigs on cattle farms could increase the risk of HEV exposure in cows, but the risk of infection associated with raw cow dairy product consumption was considered low.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Helene Larrue, Florence Abravanel, Jean-Marie Peron
Summary: HEV infection is a global disease with different transmission routes in developing and developed countries. Diagnosis is based on antibody and PCR testing, with ribavirin as the only validated treatment for chronic infection.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Carlo Bienkowski, Malgorzata Aniszewska, Monika Kowalczyk, Jolanta Popielska, Konrad Zawadka, Agnieszka Oldakowska, Maria Pokorska-Spiewak
Summary: This study aimed to evaluate the risk factors associated with Toxoplasma gondii infection in pregnant women. The results showed that living in rural areas and eating raw meat were independent risk factors for T. gondii infection during pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Siddharth Sridhar, Cyril Chik-Yan Yip, Kelvin Hon-Yin Lo, Shusheng Wu, Jianwen Situ, Nicholas Foo-Siong Chew, Kit-Hang Leung, Helen Shuk-Ying Chan, Sally Cheuk-Ying Wong, Anthony Wai-Shing Leung, Cindy Wing-Sze Tse, Kitty S. C. Fung, Owen Tak-Yin Tsang, Kam-Lun Hon, Vincent Chi-Chung Cheng, Ken Ho-Leung Ng, Kwok-Yung Yuen
Summary: This study investigated human HEV-C1 infections detected in Hong Kong, with a focus on outcomes in immunocompromised individuals. The findings showed that immunocompromised HEV-C1-infected patients frequently progress to persistent HEV-C1 infection, for which ribavirin is a suitable treatment option.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Eleonora Chelli, Elisabetta Suffredini, Paola De Santis, Dario De Medici, Santina Di Bella, Stefania D'Amato, Francesca Gucciardi, Annalisa Guercio, Fabio Ostanello, Vitantonio Perrone, Giuseppa Purpari, Gaia Sofia Scavia, Pietro Schembri, Bianca Maria Varcasia, Ilaria Di Bartolo
Summary: Hepatitis E is recognized as an emerging zoonotic disease in Europe, caused by an RNA virus transmitted through foodborne routes. The study investigated the prevalence of HEV-positive pigs during slaughtering, with results showing that the virus mainly resides in the liver rather than muscles, and the age of animals affects the positivity rate.
Article
Immunology
Claire Tinevez, Fanny Velardo, Anne-Gaelle Ranc, Damien Dubois, Helene Pailhories, Cyrielle Codde, Olivier Join-Lambert, Emmanuelle Gras, Stephane Corvec, Catherine Neuwirth, Clea Melenotte, Marie Dorel, Anne-Sophie Lagneaux, Maxime Pichon, Violaine Doat, Damien Fournier, Adrien Lemaignen, Leslie Bouard, Pierre Patoz, Genevieve Hery-Arnaud, Nadine Lemaitre, Celia Couzigou, Thomas Guillard, Elise Recalt, Emmanuelle Bille, Yaniss Belaroussi, Didier Neau, Charles Cazanave, Philippe Lehours, Mathilde Puges
Summary: This study investigated the clinical features and prognostic factors of Campylobacter spp. bacteremia. The results showed that Campylobacter spp. bacteremia mainly occurred in immunocompromised elderly individuals and had a high early mortality rate, but appropriate antimicrobial therapy could improve the survival rate.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Caroline Roberta Soares Salgado, Aldaleia do Nascimento e Silva, Igor Falco Arruda, Patricia Riddell Millar, Maria Regina Reis Amendoeira, Luciane Almeida Amado Leon, Raffaella Bertoni Cavalcanti Teixeira, Jorge Tiburcio Barbosa de Lima, Flavia Loewen Levy Chalhoub, Ana Maria Bispo de Filippis, Ana Beatriz Monteiro Fonseca, Jaqueline Mendes de Oliveira, Marcelo Alves Pinto, Andreza Soriano Figueiredo
Summary: The serological evidence of HEV circulation in Brazilian equines highlights the need for surveillance of HEV host expansion in a one-health approach.
Article
Parasitology
Marco Genchi, Alice Vismarra, Stefania Zanet, Simone Morelli, Roberta Galuppi, Giuseppe Cringoli, Riccardo Lia, Manuela Diaferia, Antonio Frangipane di Regalbono, Giulia Venegoni, Fabrizio Solari Basano, Antonio Varcasia, Stefania Perrucci, Vincenzo Musella, Emanuele Brianti, Alessia Gazzonis, Michele Drigo, Liliana Colombo, Laura Kramer
Summary: The study evaluated the prevalence of major feline parasites in Italy and identified risk factors associated with their occurrence. The overall prevalence of gastro-intestinal and broncho-pulmonary nematodes was 35.9%, while ectoparasite infestation rate was 35.7%. Risk factors for parasite infection included age, outdoor lifestyle, geographic area and lack of antiparasitic treatment.
PARASITES & VECTORS
(2021)
Article
Agriculture, Dairy & Animal Science
Mario Forzan, Maria Irene Pacini, Marcello Periccioli, Maurizio Mazzei
Summary: Hepatitis E virus (HEV) is a globally distributed waterborne and foodborne pathogen responsible for acute hepatitis in humans. In Europe and industrialised countries, the disease has mainly spread due to consumption of raw or undercooked meat and seafood. Health education programmes for hunters and consumers are essential to limit the diffusion of the pathogen to humans.
Article
Infectious Diseases
Amandine Dernoncourt, Mathilde Lacroix, Pierre Duhaut, Valery Salle, Jean Schmidt, Benjamin Batteux, Farida Hamdad
Summary: This study aimed to assess prognostic factors of invasive pasteurellosis. A retrospective cohort study found that abnormal coagulation function (prolonged prothrombin time) and low platelet counts were common factors in non-survivors. Furthermore, a history of neoplasia, evidence of bacteremia, and low hemoglobin level were identified as poor prognostic factors.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Surgery
Alexandre Challine, Andrea Lazzati, Bertrand Dousset, Thibault Voron, Jeremie H. Lefevre
Article
Gastroenterology & Hepatology
Melanie Calmels, Maxime K. Collard, Lauren O'Connell, Thibault Voron, Clotilde Debove, Najim Chafai, Yann Parc, Jeremie H. Lefevre
Summary: The study analyzed 200 patients who underwent redo-CRA/CAA after primary anastomotic failure, and found that 23% of patients developed severe postoperative complications, but 80% of patients successfully restored bowel continuity. Obesity was identified as a risk factor for redo-CRA/CAA failure, while male sex, age over 60 years, obesity, and history of pelvic radiotherapy were identified as predictive factors for success.
COLORECTAL DISEASE
(2022)
Article
Infectious Diseases
Mathieu Andraud, Pachka Hammami, Brandon H. Hayes, Jason A. Galvis, Timothee Vergne, Gustavo Machado, Nicolas Rose
Summary: African swine fever poses a significant threat to the swine industry, and understanding its transmission routes and control measures is crucial. A simulation model was developed to assess the spread of African swine fever in the commercial swine network in France, considering different transmission routes and surveillance measures.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Jeremy Lesueur, Sarah Walachowski, Sarah Barbey, Nathan Cebron, Rachel Lefebvre, Frederic Launay, Didier Boichard, Pierre Germon, Fabien Corbiere, Gilles Foucras
Summary: Recent developments in multiplex technologies have allowed for the detection of soluble proteins in various biological samples. Cytokine profiling using these technologies can provide a more accurate description of conditions related to infectious diseases or vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Marc Hilmi, Cindy Neuzillet, Jeremie H. Lefevre, Magali Svrcek, Sophie Vacher, Leonor Benhaim, Peggy Dartigues, Emmanuelle Samalin, Julien Lazartigues, Jean-Francois Emile, Eugenie Rigault, Nathalie Rioux-Leclercq, Christelle de la Fouchardiere, David Tougeron, Wulfran Cacheux, Pascale Mariani, Laura Courtois, Matthieu Delaye, Virginie Dangles-Marie, Astrid Lievre, Ivan Bieche
Summary: This study analyzed the association between the load of Fusobacterium nucleatum and clinical features, relapse, and survival in patients with anal squamous cell carcinoma (ASCC). The results showed that high F. nucleatum load is an independent favorable prognostic factor in patients with ASCC who underwent abdominoperineal resection.
Article
Immunology
Julian Roewe, Sarah Walachowski, Arjun Sharma, Kayleigh A. Berthiaume, Christoph Reinhardt, Markus Bosmann
Summary: Polyphosphates are polymers of inorganic phosphates that exist in all living cells and have various functions. This study demonstrates that long-chain polyphosphates induce the release of CXCL4 from macrophages and promote acute lung injury. Polyphosphates can synergize with other factors to enhance CXCL4 release. This research provides insights into the immunomodulatory role of polyphosphates and their potential contribution to lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Alexandra Nassar, Alexandre Challine, Lauren O'Connell, Thibault Voron, Najim Chafai, Clotilde Debove, Yann Parc, Jeremie H. Lefevre
Summary: The study assessed factors associated with maintaining a functional anastomosis in patients with anastomotic leakage (AL). After analyzing consecutive patients with AL after colorectal or coloanal anastomosis, it was found that 60.9% of patients had a functional anastomosis without a stoma after one year of surgery. Diabetes, neoadjuvant chemoradiotherapy, and Grade B or C leak significantly increased the risk of anastomotic failure at one year. The type of initial treatment and different types of anastomosis also influenced the risk of anastomotic failure.
Article
Surgery
Jeremy Nguyen, Jeremie H. Lefevre, Cecile Bouchet-Doumenq, Ben Creavin, Thibault Voron, Najim Chafai, Clotilde Debove, Yann Parc
Summary: This study aimed to assess the impact of surgical approach on morbidity, mortality, and oncological outcomes of synchronous (SC) and metachronous (MC) colorectal cancer (CRC). The study found that extensive colectomy should be preferred for SC patients to reduce morbidity and improve prognosis, while iterative colectomy can be safely performed for MC patients.
Article
Immunology
Sarah Walachowski, Koen Breyne, Thomas Secher, Celine Cougoule, Laurence Guzylack-Piriou, Evelyne Meyer, Gilles Foucras, Guillaume Tabouret
Summary: The study demonstrates that oral administration of beta-glucans can improve the outcome of Escherichia coli infection and reduce tissue damage caused by excessive inflammatory response, and this protective mechanism is not necessarily linked to immune system hyperactivation or immune training.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Viola Krenzlin, Johannes Schoche, Sarah Walachowski, Christoph Reinhardt, Markus P. Radsak, Markus Bosmann
Summary: Polyphosphates are highly conserved polymers found in all living cells. The administration of long-chain polyphosphates to mice resulted in proinflammatory responses and lung injury. These effects were attenuated after neutrophil depletion. Long-chain polyphosphates were found to modulate cytokine release and immune response in both mouse and human neutrophils. The findings suggest that polyphosphates could be a potential therapeutic target for bacterial infections.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Surgery
Penelope Raimbert, Thibault Voron, Sophie Laroche, Lauren O'Connell, Clotilde Debove, Alexandre Challine, Yann Parc, Jeremie H. Lefevre
Summary: This study retrospectively reported the results of ambulatory (day-case) appendectomy for acute appendicitis in a large consecutive cohort. By using the clinico-radiological St-Antoine score, eligible patients for ambulatory appendectomy can be identified, leading to a higher rate of early discharge.
Letter
Oncology
Romain Cohen, Thierry Andre, Jeremie H. Lefevre
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Line Alibert, Louis Betton, Antoine Falcoz, Gilles Manceau, Stephane Benoist, Philippe Zerbib, Juliette Podevin, Leon Maggiori, Antoine Brouquet, Gaelle Tyrode, Lucine Vuitton, Dewi Vernerey, Jeremie H. Lefevre, Zaher Lakkis
Summary: The KoCoRICCO study compared the outcomes of Kono-S anastomosis and conventional anastomosis in the treatment of Crohn's disease. The study found no significant difference in reducing endoscopic recurrence risk between Kono-S anastomosis and conventional anastomosis. Further long-term follow-up research is needed to determine the potential benefits of surgical recurrence.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Veterinary Sciences
Brandon H. Hayes, Timothee Vergne, Mathieu Andraud, Nicolas Rose
Summary: Modeling infectious diseases at the livestock-wildlife interface presents unique challenges. A scoping review of scientific literature revealed limited use of mathematical modeling in this context, mainly focusing on evaluating control strategies. Representing wildlife locations is often reliant on habitat suitability, while livestock species can be explicitly located. Exploring transmission dynamics and incorporating genomic data can enhance the value of such models.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Maxime Delsart, Francoise Pol, Barbara Dufour, Nicolas Rose, Christelle Fablet
Summary: In pig production, alternative farming systems are gaining popularity due to the growing demand for outdoor access and improved animal welfare. These systems allow pigs to exhibit a wider range of behaviors and have lower respiratory disease rates compared to conventional indoor systems. However, managing feeding, watering, temperature control, and predator prevention is more challenging in outdoor systems. Additionally, biosecurity measures are more difficult to implement, and there is a higher risk of zoonotic pathogens and challenges such as parasitism and piglet crushing.
INRA PRODUCTIONS ANIMALES
(2022)