期刊
EPIDEMIOLOGY AND INFECTION
卷 140, 期 7, 页码 1337-1342出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268811001671
关键词
Chikungunya virus; co-circulation; dengue virus; genotype; Delhi
资金
- National Centre for Disease Control (NCDC)
Independent outbreaks of dengue virus (DENV) infection and sporadic cases of chikungunya virus (CHIKV) have been recorded in the metropolitan city of Delhi on several occasions in the past. However, during a recent 2010 arboviral outbreak in Delhi many cases turned negative for DENV. This prompted us to use duplex reverse transcriptase-polymerase chain reaction (D-RT-PCR) to establish the aetiology of dengue/chikungunya through sequencing of CprM and E1 genes of dengue and chikungunya viruses. Interestingly, for the first time, both DENV and CHIKV co-circulated simultaneously and in equally dominant proportion during the post-monsoon period of 2010. DENV-1 genotype III and the East Central South African genotype of CHIKV were associated with post-monsoon spread of these viruses.
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