期刊
EPIDEMIOLOGY AND INFECTION
卷 139, 期 5, 页码 728-735出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268810001792
关键词
Emerging infections; infectious disease epidemiology; laboratory tests; plague; zoonoses
资金
- Defense Threat Reduction Agency, Fort Belvoir, VA
- WHO Kabul
- United States Naval Medical Research Unit no. 3, Cairo, Egypt
Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment. In late December 2007, an outbreak of acute gastroenteritis occurred in Nimroz Province of southern Afghanistan. Of the 83 probable cases of illness, 17 died (case fatality 20.5%). Being a case was associated with consumption or handling of camel meat (adjusted odds ratio 4.4, 95% confidence interval 2.2-8.8, P<0.001). Molecular testing of patient clinical samples and of tissue from the camel using PCR/electrospray ionization-mass spectrometry revealed DNA signatures consistent with Yersinia pestis. Confirmatory testing using real-time PCR and immunological seroconversion of one of the patients confirmed that the outbreak was caused by plague, with a rare gastrointestinal presentation. The study highlights the challenges of identifying infectious agents in low-resource settings; it is the first reported occurrence of plague in Afghanistan.
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