Article
Public, Environmental & Occupational Health
Yue He, Jikai Wang, Ronghua Zhang, Lili Chen, Hexiang Zhang, Xiaojuan Qi, Jiang Chen
Summary: This study aimed to explore the epidemiological and etiological characteristics of Salmonella infection in Zhejiang Province, China from 2012-2021. The study found that Salmonella infections were most common during the summer, with a higher rate among children aged 0-4 years. Contaminated fruit and fruit products were the main cause of infections. Diarrhea, abdominal pain, fever, nausea, and vomiting were the main symptoms. The results of this study are important for controlling Salmonella infections.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Hannah M. Lunnemann, Nicolas G. Shealy, Michelle L. Reyzer, John A. Shupe, Emily H. Green, Uswah Siddiqi, D. Borden Lacy, Mariana X. Byndloss, Nicholas O. Markham
Summary: The mouse cecum exhibits gradients in epithelial tissue architecture and cell types along different axes. Metabolites and lipids analysis suggests functional differences along these axes. Infection models demonstrate unequal concentration of edema and inflammation along the mesenteric border and increased edema at the mesenteric border in Salmonella enterica serovar Typhimurium infection, as well as enrichment of goblet cells along the antimesenteric border. This research provides insights into the structural and functional differences within the mouse cecum.
Article
Public, Environmental & Occupational Health
Karthik Paranthaman, Piers Mook, Daniele Curtis, Edward-Wynne Evans, Emma Crawley-Boevey, Girija Dabke, Kevin Carroll, Jacquelyn McCormick, Timothy J. Dallman, Paul Crook
Summary: An outbreak surveillance system for Salmonella integrating whole genome sequencing and epidemiological data was developed in South East and London in 2016-17. A total of 230 unique 5-SNP WGS clusters of non-typhoidal Salmonella were identified, with 208 clusters not reported to the local health protection teams. Among the 22 clusters reported to HPTs, nine were active outbreak investigations, seven were below agreed thresholds, and six exceeded local thresholds, with four of the latter having a common source identified. This demonstrates the feasibility and effectiveness of a threshold-based surveillance system for directing public health resources towards non-typhoidal Salmonella clusters.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Agriculture, Dairy & Animal Science
Martyna Fratczak, Piotr Indykiewicz, Beata Dulisz, Jacek J. Nowakowski, Tomasz Janiszewski, Jan Szeptycki, Jaroslaw Wilczynski, Piotr Tryjanowski
Summary: This study investigated whether bird feeders can be a source of Salmonella spp., and found no presence of Salmonella spp. in the tested samples collected from feeders.
Article
Microbiology
Lapo Mughini-Gras, Angela H. A. M. van Hoek, Tryntsje Cuperus, Cecile Dam-Deisz, Wendy van Overbeek, Maaike van den Beld, Ben Wit, Michel Rapallini, Bart Wullings, Eelco Franz, Joke van der Giessen, Cindy Dierikx, Marieke Opsteegh
Summary: In Dutch broiler flocks, a heterogeneous population of (pESI-carrying) S. Infantis has been established with evidence of possible vertical transmission. These bacteria exhibit resistance to multiple antibiotics, with certain feed, antibiotic use, and cleaning practices posing risk factors. Further monitoring and control measures are recommended to address this issue.
VETERINARY MICROBIOLOGY
(2021)
Article
Food Science & Technology
Charles Robert Stilz, Steffany Cavallo, Katie Garman, John R. Dunn
Summary: The Food and Drug Administration's Egg Safety Rule requires producers with more than 3000 layer hens to have a Salmonella enterica serotype Enteritidis (SE) prevention plan. However, in Tennessee, four outbreaks of salmonellosis associated with eggs have occurred, with three farms not meeting the criteria for regulation and one farm operating in violation of the rule.
FOODBORNE PATHOGENS AND DISEASE
(2022)
Article
Immunology
Christy Tabarani, Alejandro De La Hoz, Audrey Wanger, Anthony R. Flores, Cesar A. Arias
Summary: This study retrospectively observed the Salmonella infections in 110 pediatric patients under 18 years old in a large hospital network in Houston from 2016 to 2021. The results showed that the infection rate was highest among children aged 0-5 years, and bloody diarrhea was most commonly reported among children aged 0-1 years. The clinical characteristics of Salmonella infections in the pediatric population were distinct. Special consideration should be given to empiric treatment for patients who have recently returned from the Indian subcontinent.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Katarzyna Graca-Pakulska, Wojciech Blogowski, Iwona Zawada, Anna Deskur, Krzysztof Dabkowski, Elzbieta Urasinska, Teresa Starzynska
Summary: Crohn's disease (CD) can affect the entire gastrointestinal tract, including the upper part. The prevalence, characteristics, and clinical significance of upper gastrointestinal tract involvement in CD patients, particularly the presence of stomach bamboo joint-like appearance (BJA), Helicobacter pylori status, and microscopic changes, were investigated. The study found that CD patients had a significantly higher prevalence of gastric and duodenal mucosal lesions, including inflammation, edema, ulcerations, and bulb deformation. BJA lesion was exclusively detected in CD patients. H.pylori negative gastritis was present in almost all CD patients.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Hyo Geun Choi, Ho Suk Kang, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Kyueng-Whan Min, Ha Young Park, Nan Young Kim, Mi Jung Kwon
Summary: This study investigated the incidence of gastrointestinal diseases during the COVID-19 pandemic. The results showed that ulcerative colitis, Crohn's disease, cholelithiasis, and esophageal reflux had significantly increased incidence rates during the pandemic, while infective enteritis and irritable bowel syndrome had decreased incidence rates. There were no significant changes in the incidence rates of other gastrointestinal diseases, and there were no seasonal variations in gastrointestinal disease occurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Laura Lorenzo-Rebenaque, Danish J. Malik, Pablo Catala-Gregori, Clara Marin, Sandra Sevilla-Navarro
Summary: This study demonstrates that microencapsulation of bacteriophages can enable targeted delivery to the gut and cecum of animals, providing a promising method to control Salmonella in poultry at any time during the rearing period.
Review
Gastroenterology & Hepatology
Yip Han Chin, Cheng Han Ng, Snow Yunni Lin, Sneha Rajiv Jain, Gwyneth Kong, Jeffery Wei Heng Koh, Darren Jun Hao Tan, David Eng Hui Ong, Mark Dhinesh Muthiah, Choon Seng Chong, Fung Joon Foo, Rupert Leong, Webber Pak Wo Chan
Summary: Upper gastrointestinal Crohn's disease (UGI-CD) is a significant subclassification of Crohn's Disease (CD) with a prevalence of 13%. It is most commonly found in the stomach and associated with concurrent ileocolonic involvement. Patients with L4-jejunal disease are more likely to require surgery.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Environmental Sciences
Arbor J. L. Quist, Mike Dolan Fliss, Timothy J. Wade, Paul L. Delamater, David B. Richardson, Lawrence S. Engel
Summary: Hurricane-induced flooding is associated with an increase in AGI emergency department visit rates, particularly among American Indian patients, patients aged 65 years and older, and Black patients. The impact of flooding may depend on the total storm rainfall or antecedent rainfall.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Liang Sun, Hexiang Zhang, Jiang Chen, Lili Chen, Xiaojuan Qi, Ronghua Zhang
Summary: Nontyphoidal Salmonella infection is a common cause of bacterial foodborne illness in Zhejiang Province, China. Key findings from a 10-year study show outbreaks were most commonly attributed to cross-contamination and improper storage temperature, with cooked meat products and cold-processed cakes being the main food vehicles. Actions to improve safety and quality of these products are crucial for public health intervention efforts.
FOODBORNE PATHOGENS AND DISEASE
(2021)
Review
Gastroenterology & Hepatology
Grigorios Leontiadis, George F. Longstreth
Summary: Evolutionary medicine integrates various scientific disciplines to provide explanations for the causes of many diseases, improving physicians' understanding of disease processes, care, and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Madison R. Turcotte, Joshua T. Smith, Jinfeng Li, Xinglu Zhang, Kristin L. Wolfe, Fengxiang Gao, Christopher S. Benton, Cheryl P. Andam
Summary: This study analyzed the genomes of Salmonella enterica isolates from New Hampshire using whole genome sequencing (WGS). The results showed a diverse population structure and evolutionary history, with multiple lineages and recent clonal expansion. The study also identified genes associated with antimicrobial resistance and emphasized the importance of implementing WGS-based surveillance and genomic data analyses in state public health laboratories.
Article
Urology & Nephrology
Peter Stenvinkel, Iain A. Gillespie, Jamie Tunks, Janet Addison, Florian Kronenberg, Tilman B. Drueke, Daniele Marcelli, Guntram Schernthaner, Kai-Uwe Eckardt, Juergen Floege, Marc Froissart, Stefan D. Anker
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Urology & Nephrology
Kai-Uwe Eckardt, Iain A. Gillespie, Florian Kronenberg, Sharon Richards, Peter Stenvinkel, Stefan D. Anker, David C. Wheeler, Angel L. de Francisco, Daniele Marcelli, Marc Froissart, Juergen Floege
KIDNEY INTERNATIONAL
(2015)
Article
Urology & Nephrology
Juergen Floege, Iain A. Gillespie, Florian Kronenberg, Stefan D. Anker, Ioanna Gioni, Sharon Richards, Ronald L. Pisoni, Bruce M. Robinson, Daniele Marcelli, Marc Froissart, Kai-Uwe Eckardt
KIDNEY INTERNATIONAL
(2015)
Article
Public, Environmental & Occupational Health
Iain A. Gillespie, Iain C. Macdougall, Sharon Richards, Vincent Jones, Daniele Marcelli, Marc Froissart, Kai-Uwe Eckardt
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2015)
Article
Public, Environmental & Occupational Health
Iain A. Gillespie, Juergen Floege, Ioanna Gioni, Tilman B. Drueeke, Angel L. de Francisco, Stefan D. Anker, Yumi Kubo, David C. Wheeler, Marc Froissart
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2015)
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Iain A. Gillespie, Kai-Uwe Eckardt, Florian Kronenberg, Sharon Richards, Tilman B. Drueke, Peter Stenvinkel, Ronald L. Pisoni, Bruce M. Robinson, Daniele Marcelli, Marc Froissart, Juergen Floege
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Article
Urology & Nephrology
Angel Luis Martin de Francisco, Iain Andrew Gillespie, Ioanna Gioni, Juergen Floege, Florian Kronenberg, Daniele Marcelli, David Collins Wheelers, Marc Froissart, Tilman Bernhard Drueke
Article
Medicine, General & Internal
Mary-Luz Rol, Fabienne Venet, Thomas Rimmele, Virginie Moucadel, Pierre Cortez, Laurence Quemeneur, David Gardiner, Andrew Griffiths, Alexandre Pachot, Julien Textoris, Guillaume Monneret
Article
Critical Care Medicine
Fabienne Venet, Julien Textoris, Sophie Blein, Mary-Luz Rol, Maxime Bodinier, Bertrand Canard, Pierre Cortez, Boris Meunier, Lionel K. Tan, Craig Tipple, Laurence Quemeneur, Frederic Reynier, Philippe Leissner, Christophe Vedrine, Yves Bouffard, Benjamin Delwarde, Olivier Martin, Thibaut Girardot, Cyrille Truc, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Guillaume Monneret, Thomas Rimmele
Summary: This study comprehensively described the immune profile in critically ill patients with different etiologies and found that immune alterations in severely injured patients after admission were associated with increased risk of secondary infections.
CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Francois Mallet, Lea Diouf, Boris Meunier, Magali Perret, Frederic Reynier, Philippe Leissner, Laurence Quemeneur, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Fabienne Venet, Guillaume Monneret, Alain Lepape, Thomas Rimmele, Lionel K. Tan, Karen Brengel-Pesce, Julien Textoris
Summary: The study analyzed blood DNAemia of TTV and herpesviruses in critically ill patients, finding a higher prevalence of herpesvirus DNAemia in sepsis patients and a potential delay in the return of immune homeostasis associated with herpesvirus DNAemia. EBV and TTV may serve as additional markers to predict clinical deterioration in ICU patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Jan-Alexis Tremblay, Florian Peron, Louis Kreitmann, Julien Textoris, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurence Quemeneur, Christophe Vedrine, Lionel K. Tan, Fabienne Venet, Thomas Rimmele, Guillaume Monneret
Summary: The study developed the REALIST score as a pragmatic approach to identify and stratify patients at high risk for secondary infection. It provides clinicians with a clear assessment of the immune status and could contribute to future trials of immune stimulation strategies.
ANNALS OF INTENSIVE CARE
(2022)
Article
Critical Care Medicine
Estelle Peronnet, Sophie Blein, Fabienne Venet, Elisabeth Cerrato, Aurore Fleurie, Jean-Francois Llitjos, Louis Kreitmann, Gabriel Terraz, Filippo Conti, Morgane Gossez, Thomas Rimmele, Julien Textoris, Anne-Claire Lukaszewicz, Karen Brengel-Pesce, Guillaume Monneret
Summary: This study evaluated the ability of a prototype multiplex polymerase chain reaction tool (IPP) to identify immunosuppressed ICU patients. The IPP gene set showed high accuracy and specificity in identifying patients who would benefit from immunostimulation therapy in personalized medicine.
CRITICAL CARE MEDICINE
(2023)
Correction
Infectious Diseases
Iain A. Gillespie, Eleanor Barnes, Ian C. K. Wong, Philippa C. Matthews, Graham S. Cooke, Craig Tipple, Robert C. Elston, Yunhao Liu, David A. Smith, Tingyan Wang, Jim Davies, Kinga A. Varnai, Oliver Freeman, Kenneth K. C. Man, Wallis C. Y. Lau, Ben Glampson, Xing Meng, Eleonora Morais, Sen Liu, Luca Mercuri, Naomi Boxall, Sarah Jenner, Stuart Kendrick, Jane Dong, Dickens Theodore
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Iain A. A. Gillespie, Eleanor Barnes, Ian C. K. Wong, Philippa C. C. Matthews, Graham S. S. Cooke, Craig Tipple, Robert C. C. Elston, Yunhao Liu, David A. A. Smith, Tingyan Wang, Jim Davies, Kinga A. A. Varnai, Oliver Freeman, Kenneth K. C. Man, Wallis C. Y. Lau, Ben Glampson, Xing Meng, Eleonora Morais, Sen Liu, Luca Mercuri, Naomi Boxall, Sarah Jenner, Stuart Kendrick, Jane Dong, Dickens Theodore
Summary: This study aimed to characterize patients with chronic HBV infection across different continents and determine their treatment need. The results showed that a considerable proportion of patients who were indicated for treatment were currently untreated, including many patients with fibrosis/cirrhosis.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Myriam Drysdale, Radmila Choate, Amanda E. Brunton, Simon Tiberi, Iain A. Gillespie, Noah Lininger, Susan B. Shrimpton, Mark Metersky, Nicole C. Lapinel, Pamela J. McShane, Christopher J. Richards, Colin Swenson, Hema Sharma, David Mannino, Bronchiectasis Investigator, NTM Res Registry Investigator
Summary: This study described the epidemiology, patient management, and treatment outcomes of nontuberculous mycobacterial (NTM) infections in patients with bronchiectasis enrolled in the United States Bronchiectasis and NTM Research Registry. The study found that a considerable proportion of NTM infections in these patients were untreated or treated after initial delay/observation, and MABSC infections were more likely to be treated and start treatment sooner than MAC infections.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2023)