Article
Obstetrics & Gynecology
Hetti von Hellens, Leea Keski-Nisula, Heidi Sahlman
Summary: Maternal use of paracetamol during pregnancy is associated with the development of preeclampsia, potentially due to reverse causation.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Pharmacology & Pharmacy
Katarzyna Grecka, Piotr Szweda
Summary: The study found synergistic interactions between antipyretics and ethanolic propolis extracts, but the effects may vary for certain antiseptics.
Letter
Medicine, General & Internal
Ahhyung Choi, Yunha Noh, Dong Keon Yon, Ju-Young Shin
Summary: This cohort study investigates the potential link between prenatal exposure to proton pump inhibitors and the risk of low birth weight.
Article
Chemistry, Multidisciplinary
Al-Shymaa Y. Mohammed, Amro K. F. Dyab, Fouad Taha, Ahmed I. A. Abd El-Mageed
Summary: This study explored the feasibility of encapsulating aspirin into Lycopodium clavatum L. sporopollenin microcapsules, and characterized the physico-chemical features of sporopollenin, pure aspirin, and sporopollenin loaded with aspirin. The controlled in vitro release of aspirin in a gastrointestinal environment was demonstrated.
Article
Public, Environmental & Occupational Health
Cecilia Hvitfeldt Fuglsang, Istvan Bakos, Kristina Laugesen, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This population-based cohort study in Denmark investigated the association between smoking during pregnancy and the risk of appendicitis in offspring. The results showed a slightly higher hazard rate for children of smoking mothers compared to nonsmokers. The association may be mediated by later-life exposures.
Article
Medicine, General & Internal
Esmee M. Breddels, Johanna Simin, Romina Fornes, Helene Lilja Engstrand, Lars Engstrand, Robin Bruyndonckx, Nele Brusselaers
Summary: This study found that the use of proton pump inhibitors during pregnancy is associated with an increased risk of pre-eclampsia, gestational diabetes, preterm birth, and being born small for gestational age, while it is associated with a decreased risk of being born large for gestational age.
Review
Environmental Sciences
Jia-le Wu, Ze-hua Liu, Qing-guang Ma, Lu Dai, Zhi Dang
Summary: This study summarized the occurrence and removal efficiency of ibuprofen and acetaminophen in municipal wastewater treatment plants across 30 countries. The removal efficiencies of these two drugs ranged from 6.5% to 100% and 14.3% to 100% respectively. Due to the high concentrations in influent, the presence of acetaminophen and ibuprofen in effluent may have adverse effects on aquatic organisms, thus advanced treatment is necessary.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Immunology
Ling Yang, Yao Meng, Yuxiang Shi, Hongxu Fang, Leying Zhang
Summary: This review focuses on the anatomical and immunological adaptations of the maternal liver during pregnancy, as well as the associated diseases. It also presents the factors that regulate hepatic immunology during pregnancy. These findings are important for the prevention of embryo loss, abortion, and pregnancy-associated liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
Laura J. O'Byrne, Safi G. Alqatari, Gillian M. Maher, Aoife M. O'Sullivan, Ali S. Khashan, Grainne P. Murphy, Fergus P. McCarthy
Summary: This study used the GRADE approach to analyze the pregnancy outcomes of women with chronic inflammatory disease exposed to biologic medications during pregnancy. The results showed comparable outcomes in pregnancies exposed to biologics, disease-matched controls, and pregnancies without chronic inflammatory disease.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Allergy
Masayoshi Zaitsu, Kenta Kono, Yoshihiko Hosokawa, Manabu Miyamoto, Keiko Nanishi, Sumiyo Okawa, Shinji Niki, Kyo Takahashi, Shigemi Yoshihara, Gen Kobashi, Takahiro Tabuchi
Summary: This study suggests that maternal use of heated tobacco products (HTPs) during pregnancy is associated with allergy in their offspring, and there is a dose-response relationship.
Review
Pediatrics
Qiang Zhang, Zhi-Cheng Zhang, Xue-Yu He, Zhen-Min Liu, Guang-Hui Wei, Xing Liu
Summary: The study found that maternal smoking during pregnancy increases the risk of congenital urogenital malformations in offspring, including urogenital teratogenesis, cryptorchidism, hypospadias, and kidney malformations. Similarly, paternal smoking during the mother's pregnancy also significantly increases the risk of malformations.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Ehsan Motevalizadeh, Andres Diaz-Lopez, Francisco Martin-Lujan, Josep Basora, Victoria Arija
Summary: This prospective cohort study conducted in Catalonia, Spain, aimed to examine the associations between sociodemographic, lifestyle, and clinical factors with cardiometabolic risk and its components during pregnancy. The study found that overweight/obesity, lower education level, and lack of physical activity were associated with an increased cardiometabolic risk in early pregnancy, while overweight/obesity, insufficient gestational weight gain, and higher social class were associated with a decreased cardiometabolic risk in the third trimester.
Article
Nutrition & Dietetics
Danielle N. Christifano, Kathleen M. Gustafson, Susan E. Carlson, Nasrin Sultanna, Alexandra Brown, Scott A. Sands, John Colombo, Byron J. Gajewski
Summary: Achieving maternal-newborn docosahexaenoic acid (DHA) equilibrium (EQ) is important for optimizing newborn DHA status. This study aimed to determine the daily DHA intake during pregnancy most likely to result in EQ. The results suggest that an intake of 650mg DHA/day is necessary to increase the potential for EQ at delivery.
Article
Obstetrics & Gynecology
Xiaoqin Liu, Line Kolding, Natalie Momen, Christiane Gasse, Lars Henning Pedersen
Summary: This study aimed to provide a comprehensive analysis based on information on terminated pregnancies, miscarriages, stillbirths, and live births. The findings suggest limited or no overall teratogenic effect of first-trimester antipsychotic exposure. Further studies with sufficient sample sizes are warranted for individual antipsychotics.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Environmental Sciences
Mahmudul Hasan, Katherine Alfredo, Sudhir Murthy, Rumana Riffat
Summary: This study investigated the biodegradation of pharmaceuticals and a natural organic surrogate by bacteria seeded from backwash water in the presence of oxygen. The results showed efficient removal of salicylic acid, moderate removal of acetaminophen, and poor removal of ibuprofen. ATP levels in the reactor were found to be correlated with biodegradation rates, oxygen uptake rate, and extracellular polymeric substances.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Public, Environmental & Occupational Health
Sissel Jessen Weissert, Ellen Margrethe Mikkelsen, Bjarke H. Jacobsen, Elizabeth E. Hatch, Amelia K. Wesselink, Lauren A. Wise, Kenneth J. Rothman, Henrik T. Sorensen, Anne Sofie Dam Laursen
Summary: This study found no meaningful association between consumption of organic food and fecundability in couples trying to conceive. However, slightly higher fecundability was observed among participants with less than 3 cycles of pregnancy attempt time when they consumed more organic food.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Donghao Lu, Yongfu Yu, Jonas F. Ludvigsson, Anna Sara Oberg, Henrik Toft Sorensen, Krisztina D. Laszlo, Jiong Li, Sven Cnattingius
Summary: This binational cohort study investigated the association between intrauterine growth restriction, represented by birth weight for gestational age (GA), and cardiovascular disease (CVD) risk in early adulthood. The study included over 3 million births from Sweden and Denmark. The results showed that individuals born severely small for GA or preterm had an increased risk of CVD. However, the association was attenuated when comparing individuals born SGA with their AGA siblings.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gencer Kurt, Helene M. L. Svane, Rune Erichsen, Uffe Heide-Jorgensen, Henrik T. Sorensen, Evan S. Dellon, Elizabeth T. Jensen
Summary: This study is a nationwide and registry-based case-control study that found an association between early-life exposures and eosinophilic esophagitis (EoE). Further research is needed to elucidate the mechanisms underlying the observed associations.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Judith Yargawa, Hannah Blencowe, Ellen Bradley, Yemisrach B. Okwaraji, Veronica Pingray, Luz Gibbons, Adrienne Gordon, Kara Warrilow, Enny S. Paixao, Ila Rocha Falcao, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raul Caulier-Cisterna, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Lili Abuladze, Mika Gissler, Mohammad Heidarzadeh, Maziar Moradi-Lakeh, Khalid A. Yunis, Ayah Al Bizri, Shamala D. Karalasingam, Ravichandran Jeganathan, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Luis Huicho, Hugo Guillermo Quezada-Pinedo, Kim Nail Cajachagua-Torres, Fawziya Alyafei, Mai AlQubaisi, Geum Joon Cho, Ho Yeon Kim, Neda Razaz, Jonas Soederling, Lucy K. Smith, Jennifer Kurinczuk, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Eric O. Ohuma, Joy E. Lawn
Summary: This study aims to examine the prevalence of novel newborn types among 165 million live births in 23 countries from 2000 to 2021. The distribution of newborn types varies across countries, with the highest prevalence of small newborn types in West Asian countries and large newborn types in European countries.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Behavioral Sciences
Nils Skajaa, Emil Bjerregaard Riahi, Szimonetta Komjathine Szepligeti, Erzsebet Horvath-Puho, Trine Toft Sorensen, Victor W. Henderson, Henrik Toft Sorensen
Summary: Using Danish nationwide registries, this study found that patients with type 2 diabetes and obesity had a reduced risk of ALS compared to the general population, especially among men and those aged 60 or above.
BRAIN AND BEHAVIOR
(2023)
Article
Hematology
Hanke M. G. Wiegers, Dora Kormendine Farkas, Erzsebet Horvath-Puho, Saskia Middeldorp, Nick van Es, Henrik T. Sorensen
Summary: The study aimed to estimate the incidence rate of superficial vein thrombosis (SVT) during pregnancy and the post-partum period, as well as the risk of subsequent venous thromboembolism. The results showed a low incidence rate of SVT, but a high risk of developing venous thromboembolism during the same pregnancy if SVT was diagnosed.
LANCET HAEMATOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Kristina Laugesen, Jonas Mengel-From, Kaare Christensen, Jorn Olsen, David M. Hougaard, Lasse Boding, Anja Olsen, Christian Erikstrup, Merete Lund Hetland, Estrid Hogdall, Alisa Kjaergaard, Erik Sorensen, Anja Brugmann, Eva Rabing Brix Petersen, Ivan Brandslund, Borge Nordestgaard, Gorm B. Jensen, Nils Skajaa, Frederikke Schonfeldt Troelsen, Cecilia Hvitfeldt Fuglsang, Lise Skovgaard Svingel, Henrik T. Sorensen
Summary: Denmark has a rich source of biobanks and a comprehensive healthcare system, which allows for the integration of biological specimens with clinical and demographic data for biobank research. This can contribute to a better understanding of disease etiology and personalized medicine.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sia Kromann Nicolaisen, Lars Pedersen, Daniel R. Witte, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: This study aimed to estimate the prevalence, incidence, mortality, and risk of progression to type 2 diabetes for individuals with HbA1c-defined prediabetes based on Danish nationwide population-based laboratory databases. The results showed that out of 100 Danish adults, 1.4 develop prediabetes each year, and they can be identified at an early stage in laboratory databases. Within five years, one in six individuals with prediabetes dies, and one in five progresses to diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Neurosciences
Kasper Bonnesen, Uffe Heide-Jorgensen, Henrik Toft Sorensen, Morten Schmidt
Summary: This study compared the discriminatory performance of the Danish comorbidity index for acute myocardial infarction (DANCAMI), the Charlson comorbidity index (CCI), the Elixhauser comorbidity index (ECI), and the CHA2DS2-VASc score in predicting ischemic stroke, cardiovascular mortality, and all-cause mortality after atrial fibrillation/flutter. The results showed that DANCAMI had similar predictive performance to CCI, ECI, and CHA2DS2-VASc for ischemic stroke and cardiovascular mortality risks. DANCAMI also had better predictive performance for all-cause mortality risk compared to the baseline and CHA2DS2-VASc.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Pediatrics
Elizabeth T. Jensen, Helene M. Svane, Rune Erichsen, Gencer Kurt, Uffe Heide-Jorgensen, Henrik T. Sorensen, Evan S. Dellon
Summary: This population-based case-control study in Denmark found an association between maternal and infant use of antibiotics and acid suppressants and increased risk of developing EoE. The risk was highest when exposure occurred near the time of delivery. Early life exposure may be a critical period for risk and risk mitigation.
Article
Health Care Sciences & Services
Henrik Toft Sorensen, Lars Pedersen, Nick van Es, Harry R. Bueller, Erzsebet Horvath-Puho
Summary: Despite improvements in cancer treatment, venous thromboembolism is strongly associated with poor long-term survival in cancer patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Hematology
Helle Jorgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid K. Braekkan, John-Bjarne Hansen, Henrik Toft Sorensen
Summary: This study examines the association between acute venous thromboembolism (VTE) and the risk of subsequent depression. Based on Danish nationwide registries, a population-based cohort of 64,596 individuals with incident VTE and a comparison cohort of 322,999 randomly selected individuals were established. The results show that VTE is associated with a 2.35-fold increased risk of depression compared to the comparison cohort, even after adjusting for socioeconomic status and comorbidities.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Psychology, Clinical
Gabriella Broms, Sonia Hernandez-Diaz, Krista F. Huybrechts, Brian T. Bateman, Eskild Bendix Kristiansen, Kristjana Einarsdottir, Anders Engeland, Kari Furu, Mika Gissler, Par Karlsson, Kari Klungsoyr, Anna-Maria Lahesmaa-Korpinen, Helen Mogun, Mette Norgaard, Johan Reutfors, Henrik Toft Sorensen, Helga Zoega, Helle Kieler
Summary: This study examined the safety of atomoxetine, an alternative treatment for attention-deficit/hyperactivity disorder (ADHD), during pregnancy. The results showed that there was no increased risk of major congenital malformations overall, as well as no statistically significant increased risk of cardiac and limb malformations.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)