Review
Agriculture, Multidisciplinary
Zahra Batool, Jie-Hua Chen, Yao Gao, Louise Weiwei Lu, Haoxie Xu, Bin Liu, Mingfu Wang, Feng Chen
Summary: This article reviews the role of carotenoids in the prevention and development of Alzheimer's disease (AD). After analyzing the existing evidence, it is found that high-quality randomized controlled trials (RCTs) are lacking to confirm the neuroprotective role of carotenoids in AD. The article points out directions for future research in this field.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Johanna Michael, Diana Bessa de Sousa, Justin Conway, Erick Gonzalez-Labrada, Rodolphe Obeid, Julia Tevini, Thomas Felder, Birgit Hutter-Paier, Horst Zerbe, Nadine Paiement, Ludwig Aigner
Summary: The study reformulated the leukotriene receptor antagonist Montelukast (MTK) into a mucoadhesive film, which demonstrated significantly improved bioavailability in clinical studies. The oral film may reduce the non-responder rate in asthma patients and offer potential repurposing of MTK in other diseases. Additionally, the film showed promising penetration of the blood-brain barrier, suggesting potential therapeutic use in neurodegenerative diseases like dementias and stroke.
Review
Neurosciences
Karra D. Harrington, Shradha Vasan, Jee Eun Kang, Martin J. Sliwinski, Michelle H. Lim
Summary: This systematic review and meta-analysis examined the relationship between loneliness and cognitive function, showing that loneliness is associated with subtle impairment across multiple cognitive domains in older adults. These findings are important for understanding how loneliness affects cognitive function and providing valuable information for risk reduction and early detection strategies.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Carola M. E. Dopp, Hermijntje Drenth, Paul-Jeroen Verkade, Anneke F. Francke, Iris van der Heide
Summary: This systematic review evaluated interventions aimed at improving self-direction of people with dementia. The review found that these interventions focusing on identifying beliefs, strengths, values, goals, and meaningful activities, and facilitating communication with professionals and caregivers, could potentially benefit people with dementia. While positive effects on self-direction and well-being were observed, quantitative measurements showed inconsistent results across studies.
Review
Nutrition & Dietetics
Jenifer F. Kruger, Elaine Hillesheim, Amanda C. S. N. Pereira, Carolina Q. Camargo, Estela Rabito
Summary: Probiotic supplementation did not show significant benefits on cognitive function in individuals with dementia, but did improve certain metabolic markers. The current evidence is insufficient to support the clinical application of probiotics and synbiotics for individuals with dementia.
Review
Nutrition & Dietetics
Felix Bermejo-Pareja, Maria Jose Ciudad-Cabanas, Sara Llamas-Velasco, Ester Tapias-Merino, Jesus Hernandez Gallego, Marta Hernandez-Cabria, Luis Collado-Yurrita, Jesus Maria Lopez-Arrieta
Summary: Research suggests that milk and dairy may have potential preventive effects on elderly dementia-Alzheimer's disease, but the current conclusion is not clear. Prospective cohort studies starting from midlife hold promise to answer this question in the future.
Review
Cell Biology
Emma L. Twait, Britt Min, Magdalena Beran, Jet M. J. Vonk, Mirjam I. Geerlings
Summary: This systematic review and meta-analysis investigated the relationship between amyloid burden and white matter hyperintensities (WMH) in older adults without cognitive impairment. The findings revealed an association between amyloid pathology and WMH in cerebrospinal fluid (CSF) and positron emission tomography (PET), but the relationship in plasma remains unclear. Further studies should explore the relationship between plasma amyloid-beta and WMH to identify at-risk individuals in preclinical stages.
AGEING RESEARCH REVIEWS
(2023)
Review
Hematology
Sanny Scheffer, Dorien M. A. Hermkens, Louise van der Weerd, Helga E. de Vries, Mat J. A. P. Daemen
Summary: Alzheimer's disease is characterized by neurodegeneration, neuroinflammation, and cognitive decline. Cardiovascular disease has been identified as an important contributor to the development and progression of AD, known as the vascular hypothesis. Vascular risk factors are associated with an increased chance of developing AD, with chronic cerebral hypoperfusion suggested to play a key role in disease onset.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Zhuang Yao, Bin Liu, Yueyang Wang, Xiaohong Dong
Summary: Morning cortisol levels are elevated in patients with Alzheimer disease (AD) compared to cognitively normal individuals, suggesting potential diagnostic and prognostic value for AD. This systematic review and meta-analysis provides valuable insights into the association between cortisol levels and AD.
Review
Behavioral Sciences
Zhenrong Xiong, Xinming Li, Dejiang Yang, Chongyu Xiong, Qinggang Xu, Qi Zhou
Summary: This systematic review and meta-analysis indicates that cataract may be associated with cognitive impairment in older adults. However, the causal relationship between cataract and cognition remains unclear and requires further investigation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Cell Biology
Adrian Matysek, Lina Sun, Sumudu Perera Kimmantudawage, Lei Feng, Andrea B. Maier
Summary: Dementia is a prevalent condition in the elderly population and current medication options have limited therapeutic benefits. This systematic review explores the potential of novel therapeutic compounds that target nutrient sensing pathways, specifically the sirtuin pathway, to prevent cognitive decline or improve cognition in aging, MCI, and dementia. The review finds that while animal studies show promising results, there is a lack of translation to human populations.
AGEING RESEARCH REVIEWS
(2023)
Review
Geriatrics & Gerontology
Leonardo Santos Lopes da Silva, Marcio Fernando Tasinafo Junior, Leonardo da Silva Goncalves, Arthur Polveiro da Silva, Luis Felipe Pengo Almeida Leite, Laura Scatena Favero, Mateus do Carmo Bardella, Joao Gabriel Ribeiro de Lima, Carlos Roberto Bueno Junior, Camila de Moraes
Summary: This study conducted a systematic review and meta-analysis to examine the effects of multicomponent training on the cognitive function of older adults without cognitive impairment. The results showed that multicomponent training improves cognitive function in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Clinical Neurology
Johanna Thunell, Yi Chen, Geoffrey Joyce, Douglas Barthold, Paul G. Shekelle, Roberta Diaz Brinton, Julie Zissimopoulos
Summary: The study identified 29 drug classes associated with increasing or decreasing ADRD risk, with a need for further research in certain areas. Some areas of study still have limited evidence and require more data to support conclusions.
ALZHEIMERS & DEMENTIA
(2021)
Review
Urology & Nephrology
Reza Sari Motlagh, Fahad Quhal, Keiichiro Mori, Noriyoshi Miura, Abdulmajeed Aydh, Ekaterina Laukhtina, Benjamin Pradere, Pierre I. Karakiewicz, Dmitry V. Enikeev, Marina Deuker, Shahrokh F. Shariat
Summary: This study found that men with prostate cancer who received androgen deprivation therapy have a higher risk of developing dementia and/or Alzheimer's disease compared to those who did not receive the therapy, especially when the therapy lasted for more than 12 months.
JOURNAL OF UROLOGY
(2021)
Review
Medicine, General & Internal
Xunshu Cheng, Haorui Wang, Zhihuang Zheng, Ke Feng, Saixue Tang, Yuanyuan Liu, Ke Chen, Chenhao Bi, Mingzhou Gao, Lijin Ji
Summary: This study aimed to investigate the relationship between different stages of Alzheimer disease and intestinal flora. The results showed a correlation between the abundance and diversity of flora and treatment efficacy. These findings are crucial for developing new strategies for the prevention and treatment of Alzheimer disease.