期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 35, 期 2, 页码 235-239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2012.12.011
关键词
Air pollution; Polycyclic aromatic hydrocarbons; Epithelial cells; Inflammation; Chemokines; Epidermal growth factor receptor
资金
- Research Council of Norway [185620]
1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively. Tumor necrosis factor-a converting enzyme (TACE), which cleaves membrane-bound transforming growth factor (TGF)-alpha, activating the epidermal growth factor receptor (EGFR), may regulate proinflammatory responses induced by a variety of endogenous and exogenous agents. The present results suggest that CXCL8, but not CCL5 responses in 1-NP- or 1-AP-exposed cells required TACE/TGF-alpha/EGFR-signaling. The findings strengthen the notion that TACE/TGF-alpha/EGFR-signaling is central in epithelial CXCL8-regulation upon exposure to multiple airborne pollutants. (C) 2013 Elsevier B.V All rights reserved.
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