Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Review
Anatomy & Morphology
Jackson Tyler Boonstra, Hugo McGurran, Yasin Temel, Ali Jahanshahi
Summary: This scoping review summarizes the pathological differences between tremor-dominance (TD) and non-tremor dominance (nTD) subtypes of Parkinson's disease (PD) and supports the mechanistic circuitry theories of PD motor symptom genesis.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Food Science & Technology
Ayane Ninomiya, Abdallah Mshaty, Asahi Haijima, Hiroyuki Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Winda Ariyani, Yuki Fujiwara, Sumiyasu Ishii, Nobutake Hosoi, Hirokazu Hirai, Izuki Amano, Noriyuki Koibuchi
Summary: Recent studies have suggested a possible link between perfluorooctane sulfonate (PFOS) and developmental disabilities. In this study, researchers examined the effects of early lactational PFOS exposure on motor coordination, social activity, and anxiety in male mice. The results showed impaired motor coordination and altered synaptic plasticity in the cerebellum of PFOS-exposed mice. These findings highlight the potential long-lasting effects of lactational PFOS exposure on cerebellar function.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Geriatrics & Gerontology
Elinor Tzvi, Richard Bey, Matthias Nitschke, Norbert Brueggemann, Joseph Classen, Thomas F. Muente, Ulrike M. Kraemer, Jost-Julian Rumpf
Summary: Research suggests individuals with Parkinson's disease have specific deficits in learning sequential movements, potentially linked to reduced hippocampal activity and increased substantia nigra activity. Disease-specific deficits were also observed in learning stimulus-response associations in Parkinson's patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Xue Zhang, Jing Wang, Jin-Zhao Gao, Xiao-Na Zhang, Kai-Xin Dou, Wan-Da Shi, An-Mu Xie
Summary: Inhibition of P2X4 receptor activity in Parkinson's disease may reduce symptoms and increase the expression of specific proteins, potentially alleviating the impact of the disease on the nervous system.
NEURAL REGENERATION RESEARCH
(2021)
Review
Neurosciences
Kathleen Carmichael, Rebekah C. Evans, Elena Lopez, Lixin Sun, Mantosh Kumar, Jinhui Ding, Zayd M. Khaliq, Huaibin Cai
Summary: This review focuses on a distinct group of dopamine-producing neurons, which show significant loss in Parkinson's disease patients. These neurons can be easily identified by selective expression of ALDH1A1 and play a crucial role in regulating movement intensity. The study summarizes the connectivity and functionality of these neurons, as well as the mechanisms regulating their activity and their implications for potential Parkinson's disease treatment.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Review
Clinical Neurology
Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han
Summary: Parkinson's disease is a common nervous system disease with motor retardation and resting tremor as its main manifestations. Early diagnosis of Parkinson's disease is difficult, but transcranial sonography has been widely used for its diagnosis and treatment. This article reviews the recent advances in the study of Parkinson's disease using transcranial sonography.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Health Care Sciences & Services
Niels Bergsland, Laura Pelizzari, Maria Marcella Lagana, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Baglio
Summary: This study demonstrates robust and clinically meaningful associations between substantia nigra microstructure and Parkinson's disease, particularly showing a significant correlation between axial diffusivity in SNpc and UPDRS III scores in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Esther Gramage, Jorge Saiz, Rosalia Fernandez-Calle, Yasmina B. Martin, Maria Uribarri, Marcel Ferrer-Alcon, Coral Barbas, Gonzalo Herradon
Summary: This study found that overexpression of PTN has a neuroprotective effect in a mouse model of Parkinson's Disease and identified potential lipid-related drug candidates for Parkinson's Disease.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Pablo Gomez-Rubio, Isabel Trapero, Omar Cauli, Cristina Buigues
Summary: This study analyzed the relationship between frailty syndrome and IL-6 levels obtained from saliva tests. The results showed a significant positive correlation between salivary IL-6 concentration and frailty score, with significant differences observed for weight loss and low physical activity. Receiver operating characteristic curve analysis demonstrated that IL-6 concentration can potentially be used as a biomarker for monitoring the progression of frailty syndrome.
Review
Endocrinology & Metabolism
Eugenia Vlachou, Anastasia Ntikoudi, Dimitra Anna Owens, Maria Nikolakopoulou, Thodoris Chalimourdas, Omar Cauli
Summary: This scoping review evaluates the effects of Cognitive Behavioral Therapy (CBT) on Type 2 diabetes mellitus (T2DM) patients in terms of depressive and anxiety symptoms, diabetes distress, and quality of life. The majority of the included studies demonstrate the benefits of CBT intervention in improving depressive symptoms, diabetes-related distress, and quality of life. However, some studies provide limited evidence supporting the use of CBT as an adjuvant therapy.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Francisco Miguel Martinez-Arnau, Cristina Buigues, Rosa Fonfria-Vivas, Omar Cauli
Summary: This study investigated the relationship between respiratory function and anthropometric variables and nutritional status in institutionalized elderly individuals. The results showed a significant correlation between respiratory function and skeletal muscle mass index and fat mass index. Additionally, high body mass index and triglyceride levels were associated with respiratory function.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Chemistry, Physical
Lorenzo Brognara, Massimiliano Fantini, Kavin Morellato, Gabriela Graziani, Nicola Baldini, Omar Cauli
Summary: This study explores the application of 3D printing in personalized foot orthoses. By comparing different data acquisition methods and printing materials, a customizable workflow is designed to enable podiatrists to easily design and personalize orthoses.
Article
Biochemistry & Molecular Biology
Javier Garcia-Sanchez, Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: This study aimed to evaluate the relationship between gonadal hormone concentrations in blood and frailty syndrome, as well as whether these hormone concentrations could predict the progression of frailty syndrome. The results showed that high androstenedione levels and low follicle-stimulating hormone (FSH) levels were significantly associated with the worsening of frailty syndrome. These hormone concentrations could be potential biomarkers to predict the progression of frailty syndrome.
Article
Nursing
Vanessa Ibanez-del Valle, Maria Luisa Ballestar-Tarin, Mayra Alejandra Mafla-Espana, Omar Cauli, Rut Navarro-Martinez
Summary: This study evaluated the relationship between insomnia and salivary IL-1 beta concentration in older individuals. It found a significant inverse correlation between IL-1 beta levels and insomnia symptoms. Factors such as depression, use of hypnotics, intake of caffeinated beverages, smoking, and alcohol use were also associated with insomnia in this population.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Dermatology
Mar Sempere-Bigorra, Lorenzo Brognara, Ivan Julian-Rochina, Antonio Mazzotti, Omar Cauli
Summary: This study explores the potential usefulness of gait analysis parameters using a single sensor unit to detect peripheral neuropathy in diabetic patients with diabetic foot. The study finds significant correlations between impaired deep sensory pathways and gait impairments in diabetic patients, as well as significant correlations between all gait parameters and the superficial sensory pathway. The findings suggest that inertial sensors could be a useful tool for diagnosing gait alterations and evaluating treatment effects in diabetic patients to improve gait and reduce the risk of falls.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Health Care Sciences & Services
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: Most elderly patients with metastatic prostate cancer should undergo a comprehensive geriatric assessment (CGA) to identify frailty syndrome, which is crucial for clinical decisions. Frailty is associated with lower quality of life and can affect the feasibility and side effects of treatments. Evaluation of frailty syndrome should be considered in clinical decision-making and when selecting the most appropriate active treatment for increased survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Manel Beamud-Cortes, Lorena Bermell-Marco, Jose Rubio-Briones, Omar Cauli
Summary: Prostate cancer is highly prevalent in males and is associated with frailty symptoms, including decreased gait speed and muscle strength, and increased insomnia symptoms, in patients undergoing androgen-deprivation therapy. Interventions should be implemented to address these issues and improve patient outcomes and quality of life.
Article
Geriatrics & Gerontology
Cristina Buigues, Olga Theou, Rosa Fonfria-Vivas, Francisco M. Martinez-Arnau, Kenneth Rockwood, Omar Cauli
Summary: Sarcopenia and frailty are common age-related conditions. This study investigated whether supplementation of leucine, an essential amino acid, could reduce frailty in older institutionalized individuals. The results showed that leucine did not significantly modify the frailty index in this population.
Article
Nutrition & Dietetics
Vanessa Ibanez-del Valle, Rut Navarro-Martinez, Omar Cauli
Summary: With university admission, there are major changes in students' daily habits that can lead to mental health problems. Adherence to a healthy diet, such as the Mediterranean diet, can be very beneficial for mental health. This study found that poor adherence to the Mediterranean diet was significantly associated with depressive symptoms among Spanish nursing students, highlighting the importance of prevention programs focused on health and mental health issues in universities.
Article
Biology
Mar Sempere-Bigorra, Ivan Julian-Rochina, Pilar Perez-Ros, Emmanuel Navarro-Flores, Francisco Miguel Martinez-Arnau, Omar Cauli
Summary: Aging and diabetes both contribute to neurological damage, and this study explores the relationships between peripheral sensory system decline and cognitive functions, symptoms of depression, and quality of life in older adults. The findings suggest that superficial sensitivity damage is related to cognitive impairment, while deep sensation alterations are related to depression and poor quality of life, with diabetes further strengthening these relationships.
Article
Biochemistry & Molecular Biology
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Manel Beamud-Cortes, Lorena Bermell-Marco, Jose Rubio-Briones, Omar Cauli
Summary: This study investigated the association between blood androgen concentrations and functional status and psychological alterations in prostate cancer patients receiving androgen deprivation therapy. The results showed a significant correlation between high concentrations of androstenedione and frailty syndrome, as well as a relationship between androstenedione levels and decreased gait speed.
Article
Medicine, Research & Experimental
Vanessa Ibanez-del Valle, Mayra Alejandra Mafla-Espana, Josep Silva, Omar Cauli, Alessandra Stacchiotti
Summary: Sleep disorders are common in older individuals, especially in those who are institutionalized. They are often comorbid with medical and neuro-psychiatric illnesses and associated with polypharmacy. This study found a significant correlation between salivary IL-6 and sleep parameters, with lower salivary IL-6 levels associated with worse sleep efficiency and more night awakenings. Actigraphy also detected alterations in sleep patterns in individuals with dementia. These results are important for future research and interventions aimed at improving sleep quality in institutionalized individuals.
Article
Medicine, General & Internal
Maria Luisa Ballestar-Tarin, Vanessa Ibanez-del-Valle, Omar Cauli, Rut Navarro-Martinez
Summary: This study analyzed substance misuse and its consequences in Spain using an internet survey. The results showed that age, smoking, and the type of substances used are associated with the social and personal consequences of drug abuse.
MEDICINA-LITHUANIA
(2022)
