期刊
ENVIRONMENTAL TOXICOLOGY
卷 30, 期 7, 页码 746-754出版社
WILEY
DOI: 10.1002/tox.21954
关键词
bifenthrin; enantioselectivity; endocrine disruption; gene expression
资金
- National Natural Science Foundation of China [21107098]
- Natural Science Foundation of Zhejiang Province [Z5090273]
- National Basic Research Program of China [2010CB126100]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13096]
Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF is a mixed compound containing cis isomers (cis-BF) including two enantiomers of 1R-cis-BF and 1S-cis-BF. In the present study, the two individual cis-BF enantiomers were separated by a preparative supercritical fluid chromatography. Then, four week-old adolescent male ICR mice were orally administered 1R-cis-BF and 1S-cis-BF separately daily for 3 weeks at doses of 0, 7.5 and 15 mg/kg/day, respectively. Results showed that the transcription status of some genes involved in cholesterol synthesis and transport as well as testosterone (T) synthesis in the testes were influenced by cis-BF enantiomers. Especially, we observed that the transcription status of key genes on the pathway of T synthesis including cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17-hydroxysteroid dehydrogenase (P45017)) were selectively altered in the testis of mice when treated with 1S-cis-BF, suggesting that it is the possible reason to explain why the lower serum T concentration in 1S-cis-BF treated group. Taken together, it concluded that both of the cis-BF enantiomers have the endocrine disruption activities, while 1S-cis-BF was higher than 1R-cis-BF in mice when exposed during the puberty. The data was helpful to understand the toxicity of cis-BF in mammals under enantiomeric level. (c) 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 746-754, 2015.
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