Article
Environmental Sciences
Wenjie Zhang, Xiaoming Xia, Jinhua Wang, Lusheng Zhu, Jun Wang, Guangchi Wang, Yangyang Chen, Young Mo Kim
Summary: The study utilized artificial soil poisoning method to investigate the antioxidative stress mechanism and gene changes of earthworms (Eisenia foetida) after exposure to nitenpyram. The toxic effects were analyzed comprehensively using the IBRv2 method, showing significant impact on the physiological and genetic levels of earthworms.
Article
Environmental Sciences
Yuanyuan Su, Huaiyuan Qi, Yipeng Hou, Mengyi Gao, Jie Li, Minggang Cai, Xiaoshan Zhu, Miao Chen, Chengjun Ge, Dongdong Fu, Zezheng Wang, Licheng Peng
Summary: This study investigates the effects of microplastics and benzo[a]pyrene (B[a]P) on the growth of Chaetoceros muelleri and their interactions. The results show that both microplastics and B[a]P inhibit the growth of C. muelleri, with stronger inhibition caused by polyethylene terephthalate (mPET). The combined effects of microplastics and B[a]P significantly enhance the inhibitory effects. These pollutants also reduce the content of photosynthetic pigments and inhibit the antioxidative enzymatic system of microalgae.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Immunology
Johirul Islam, Alpa Shree, Abul Vafa, Shekh M. Afzal, Sarwat Sultana
Summary: The study highlights the protective effect of Taxifolin on Benzo[a]pyrene-induced lung injury in mice, showing that Taxifolin suppresses oxidative stress and inflammation through stimulating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Andrea C. Crupkin, Ariana B. Fulvi, Fernando G. Iturburu, Sandra Medici, Julieta Mendieta, Ana M. Panzeri, Mirta L. Menone
Summary: Azoxystrobin is a widely used systemic fungicide that inhibits mitochondrial respiration in target fungi, but its effects on non-target organisms are not well studied. This research evaluated biomarkers of oxidative stress, hematological, physiological, and genotoxicity in cichlid fish exposed to environmentally relevant concentrations of AZX, showing negative effects at realistic concentrations and highlighting the importance of considering developmental stage on biomarker evaluation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Kaveri R. Washimkar, Manendra Singh Tomar, Sharmeen Ishteyaque, Akhilesh Kumar, Ashutosh Shrivastava, Madhav Nilakanth Mugale
Summary: Benzo[a]pyrene (B[a]P) plays a pivotal role in lung carcinogenesis. This study investigates the effects of B[a]P on cell biology and the changes in a B[a]P-induced lung cancer model, which may be related to the development of lung cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Lumin Sui, Ke Yan, Huiting Zhang, Junyu Nie, Xiaogan Yang, Chang-Long Xu, Xingwei Liang
Summary: Our study found that MV significantly alleviated oocyte meiotic defects and quality deterioration caused by BaP exposure, possibly by restoring BaP-mediated oocyte damage through reducing oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shaoying Gong, Jiachen Zheng, Junjie Zhang, Jianchun Han
Summary: This study investigated the effect of benzo[a]pyrene (B[a]P) on the function of intestinal epithelial barrier (IEB) and the protective effect of arabinogalactan (AG) against B[a]P-induced IEB dysfunction using a Caco-2 cell monolayer model. B[a]P was found to damage the IEB integrity by inducing cell cytotoxicity, oxidative stress, pro-inflammatory cytokine secretion, down-regulation of tight junction proteins, and activation of the AhR/MAPK signaling pathway. However, AG mitigated B[a]P-induced IEB dysfunction by inhibiting oxidative stress and pro-inflammatory factor secretion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Public, Environmental & Occupational Health
Martin Roursgaard, Monika Hezareh Rothmann, Juliane Schulte, Ioanna Karadimou, Elena Marinelli, Peter Moller
Summary: This study investigated the extraction of nanoplastic particles from food containers and found that these nanoparticles can cause genotoxicity in cell cultures, while their cytotoxic effects were limited.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Samira Barangi, Pardis Ghodsi, Adeleh Mehrabi, Soghra Mehri, A. Wallace Hayes, Gholamreza Karimi
Summary: This study investigated the potential protective impact of melatonin on cardiopulmonary toxicity induced by Benzo(a)pyrene (BaP). The results showed that melatonin exhibited a protective effect against BaP-induced heart and lung injury through the suppression of oxidative stress and apoptosis and the induction of the Sirt1/autophagy pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Samira Barangi, Pardis Ghodsi, Adeleh Mehrabi, Soghra Mehri, A. Wallace Hayes, Gholamreza Karimi
Summary: The study found that melatonin has a protective effect against BaP-induced heart and lung injury through suppressing oxidative stress and apoptosis, and inducing the Sirt1/autophagy pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Zhulin Wang, Lin Shi, Hao Li, Wei Song, Jianke Li, Li Yuan
Summary: This study demonstrates the pronounced benefits of selenium-enriched black soybean protein in preventing colon damage caused by benzo(a)pyrene, and these effects could be mediated by gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Zechang Li, Xiaoyu Cui, Fang Luo, Chunyan Zhou, Jiangyu Zhang, Liguo Xing
Summary: The genotoxicity of nitenpyram (NIT) has been evaluated using human bone marrow mesenchymal stem cells (hBMSCs), showing potential genotoxic effects through oxidative stress and dysregulation of various signaling pathways. Although the risk of NIT alone to human health is low, the synergistic or additive effects with other pesticides should be considered.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yumiao Zhou, Qiang Kong, Zhihao Lin, Jinyue Ma, Huanxin Zhang
Summary: The study reveals that B[a]P has an impact on the locomotor behavior of zebrafish, with different effects at different concentrations. Through RNA sequencing analysis, it was found that the affected genes are mainly involved in cardiomyocyte signaling pathways and locomotory behavior.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Jelena Radovanovic, Biljana Antonijevic, Marijana Curcic, Katarina Baralic, Stoimir Kolarevic, Zorica Bulat, Danijela Dukic-cosic, Aleksandra Buha Djordjevic, Branka Vukovic-Gacic, Dragana Javorac, Evica Antonijevic Miljakovic, Momir Carevic, Zoran Mandinic
Summary: Excessive fluoride exposure can lead to pathological changes in testicular tissues, affecting oxidative stress, essential elements levels, and DNA damage. SOD1 activity and DNA damage are the most sensitive indicators, with the lowest BMDLs at 0.1 µg F-/kg b.w. This study provides valuable insights for further research on the health risks associated with fluoride exposure in both human and animal populations.
ENVIRONMENTAL POLLUTION
(2022)